A coastal cityscape with a large body of water, several ships, and ongoing construction on a prominent red building.

Luxury Hotels & Resorts in Mission Bay from AU$166

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Check availability on Mission Bay Luxury Hotels

Our top choices for Mission Bay luxury hotels

A spacious lobby with large windows, a seating area with a sofa and chairs, and a counter with a coffee station.

1. LUMA Hotel San Francisco

LUMA Hotel San Francisco
4.0 star property
Downtown San Francisco
9.6 out of 10, Exceptional, (2,621 reviews)
The price is AU$410
includes taxes & fees
2 Oct - 3 Oct
LUMA Hotel San Francisco
A modern hotel with a sleek exterior and a parked sports car in front.

2. Hotel VIA

Hotel VIA
4.0 star property
Downtown San Francisco
9.2 out of 10, Wonderful, (1,573 reviews)
The price is AU$341
includes taxes & fees
16 Oct - 17 Oct
Hotel VIA
A modern building facade with vertical wooden slats, a glass entrance, and a sign reading "La Société Bar & Cafe".

3. Hyatt Regency San Francisco Downtown SOMA

Hyatt Regency San Francisco Downtown SOMA
4.0 star property
Downtown San Francisco
9.4 out of 10, Exceptional, (1,284 reviews)
The price is AU$336
includes taxes & fees
16 Oct - 17 Oct
Hyatt Regency San Francisco Downtown SOMA
A spacious lobby with a staircase, comfortable seating areas, and large windows offering views of the city.

4. The Clancy, Autograph Collection by Marriott

The Clancy, Autograph Collection by Marriott
4.0 star property
Downtown San Francisco
9.2 out of 10, Wonderful, (1,005 reviews)
The price is AU$351
includes taxes & fees
23 Oct - 24 Oct
The Clancy, Autograph Collection by Marriott
A modern bar area with a curved ceiling and large windows offering a city view.

5. San Francisco Marriott Marquis

San Francisco Marriott Marquis
4.0 star property
Downtown San Francisco
8.8 out of 10, Excellent, (1,237 reviews)
The price is AU$333
includes taxes & fees
2 Oct - 3 Oct
San Francisco Marriott Marquis
A rooftop bar with tables, chairs, and a sofa, overlooking a city skyline at dusk.

6. Canopy by Hilton San Francisco SoMa

Canopy by Hilton San Francisco SoMa
4.0 star property
Downtown San Francisco
9.0 out of 10, Wonderful, (1,000 reviews)
The price is AU$386
includes taxes & fees
23 Oct - 24 Oct
Canopy by Hilton San Francisco SoMa
A cityscape with modern high-rise buildings, including a distinctive building with a large clock and a theater named "Blue Shield of California Theater".

7. W San Francisco

W San Francisco
4.5 star property
Downtown San Francisco
9.0 out of 10, Wonderful, (1,000 reviews)
  • cleanliness
    Indulge in an art deco retreat with pillowtop beds, designer bathrooms, and rainfall showers in city centre San Francisco.
The price is AU$344
includes taxes & fees
16 Oct - 17 Oct
W San Francisco
A modern interior with a fireplace, sofas, a coffee table, and a bookshelf.

8. Grand Hyatt San Francisco

Grand Hyatt San Francisco
4.0 star property
Union Square
9.0 out of 10, Wonderful, (1,009 reviews)
The price is AU$316
includes taxes & fees
23 Oct - 24 Oct
Grand Hyatt San Francisco
A hotel room with a large window, a sofa, two armchairs, a coffee table, a lamp, and a TV.

9. InterContinental San Francisco by IHG

InterContinental San Francisco by IHG
4.0 star property
Downtown San Francisco
9.2 out of 10, Wonderful, (1,088 reviews)
  • cleanliness
    Unwind in city centre SF sophistication with Michelin-star dining, health club, and indoor pool sanctuary.
The price is AU$422
includes taxes & fees
23 Oct - 24 Oct
InterContinental San Francisco by IHG
A marble-floored hallway leading to a living area with a sofa and a fireplace.

10. Galleria Park Hotel

Galleria Park Hotel
4.0 star property
Downtown San Francisco
9.6 out of 10, Exceptional, (1,026 reviews)
The price is AU$318
includes taxes & fees
23 Oct - 24 Oct
Galleria Park Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mission Bay Hotel Reviews

Grand Hyatt San Francisco

Grand Hyatt San Francisco

8/10 Good
"Hotel is in the center of Union Square ..A fellow Filipina who checked us in gave us a room with a very nice view of sunset. She's very helpful and accommodating"
Moises 4-night trip
Posted 5 hours ago
Grand Hyatt San Francisco

Frequently asked questions

Are you looking for a luxury hotel for your Mission Bay holiday?
Use Expedia to arrange your flight to Oakland, CA (OAK-Oakland Intl.) airport or San Francisco International Airport (SFO) airport, and then select from a variety of places to stay that will deliver the luxury you want. Amenities are an important consideration when you plan a trip, so we make it easy to get what you'd like to make your stay special. If you want a posh hotel with fine dining, a spa or several swimming pools, Expedia can assist you in finding the best luxury hotel experience that Mission Bay offers. Mission Bay has some interesting things to see and do including Chase Center and PIER 48 - Lot #39, so you might want to take in the local sights during your visit.
What's there to see and do in Mission Bay?
When you're in Mission Bay, enjoy exploring the sights and attractions here including Chase Center, PIER 48 - Lot #39 and Lefty O'Doul Bridge. If you have some spare time during your trip, you might want to check out Oracle Park and Pier 39.
How can I get around Mission Bay?
It's easier to get around town in style when you know your options. Nearby metro stations include UCSF/Chase Center Stop, Mission Rock Station and UCSF Mission Bay Stop.

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