Otay Mesa Travel Guide
Tourist Guide
Visit Otay Mesa
Popular places to visit
San Diego Zoo
One of the largest zoos in America housing around 4000 creatures, San Diego Zoo offers an enchanting and educational experience for visitors of all ages.
USS Midway Museum
A popular San Diego attraction where you can get on board the USS Midway and learn more about the realities of Navy life.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and acclaimed art galleries.
Mission Bay
Mission Bay is San Diego’s vast and beautiful outdoor playground with great weather and calm waters that seem made for watersports.
Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
Mission Beach
A seaside village and a popular spot for holiday-makers for over a century, which today still retains its antique charm.
Activities
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
Crossing Borders: Tijuana Day Trip from San Diego
Crossing Borders: Tijuana Day Trip from San Diego
Tijuana: Guided City Tour with Local Food and Beer Tasting
Our pick of the best Otay Mesa Hotel Deals
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
"We stayed May 29th for the Pitbull concert nearby. the rooms was great but the bathroom lock was missing the button, so we had to push it in with our nail. The lock worked and we were only there for night so we didn't feel like going down and complain just for a small thing. The complimentary breakfast ..."
Reviewed on 4 June 2026
Best Western Seven Seas
"Clean room"
Reviewed on 4 June 2026
The Sofia Hotel
"This hotel offered an exceptional stay defined by immaculate cleanliness and modern, upscale comfort."
Reviewed on 4 June 2026
Hard Rock Hotel San Diego
"Couldn't ask for more. Being able to rent the bike bikes was one of the highlights."
Reviewed on 4 June 2026
Wyndham San Diego Bayside
"Wouldn’t stay again dirty and outdated"
Reviewed on 4 June 2026
Days Inn by Wyndham San Diego Hotel Circle
"Very old, has bad smell inside the rooms. Don’t recommend"
Reviewed on 4 June 2026
Our guide on where to stay in Otay Mesa
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and USS Midway Museum are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Pacific Beach
The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.
Mission Beach
If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.
Otay Mesa Travel Guide
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