Otay Mesa Travel Guide
Tourist Guide
Popular places to visit
San Diego Zoo
One of the largest zoos in America housing around 4000 creatures, San Diego Zoo offers an enchanting and educational experience for visitors of all ages.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and acclaimed art galleries.
Mission Bay
Mission Bay is San Diego’s vast and beautiful outdoor playground with great weather and calm waters that seem made for watersports.
USS Midway Museum
A popular San Diego attraction where you can get on board the USS Midway and learn more about the realities of Navy life.
Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
Mission Beach
A seaside village and a popular spot for holiday-makers for over a century, which today still retains its antique charm.
Activities
Crossing Borders: Tijuana Day Trip from San Diego
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
Crossing Borders: Tijuana Day Trip from San Diego
Our pick of the best Otay Mesa Hotel Deals
The Sofia Hotel
Great stay, beautiful hotel. Not too far from the main strip in the gaslamp district or the train depot for people taking public transit. Plenty of stores and restaurants immediately around the hotel too. Valet staff were nice and very attentive too. Would recommend.
Reviewed on 13 May 2026
Manchester Grand Hyatt San Diego
The staff were extremely helpful. I loved the room and the view was absolutely amazing, I would say that was my favorite part! Parking is connected to the building and the gift shop had essentials that you may have forgotten. There’s a Starbucks connected to the hotel as well😊. I would 100% come ...
Reviewed on 13 May 2026
Paradise Point Resort & Spa
Good
Reviewed on 14 May 2026
Hard Rock Hotel San Diego
Front desk people was not helpful
Reviewed on 14 May 2026
The DEXTRO Little Italy, BW Premier Collection
In the pictures it perceives a much better hotel and you get there and it was just so run down. Needs some work. The room we stayed in was a bay view it wasn’t bad. The parking situation was terrible. The angling of the whole parking structure was off because the hotel is in the size of a circle. ...
Reviewed on 13 May 2026
Wyndham San Diego Bayside
Front desk service is outstanding!! Very knowledgeable and super helpful! Our room was across from the cruise port with a bay view that’s just stunning!
Reviewed on 14 May 2026
Other neighbourhoods around Otay Mesa
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.
Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
Hillcrest
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.
Mission Valley
Known for its stunning beaches and popular shops, there's plenty to explore in Mission Valley. Check out top attractions like Mission Valley Mall and Fashion Valley Mall, and jump on the metro at Hazard Center Station or Mission Valley Center Station to see more of the city.
Otay Mesa Travel Guide
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