Otay Mesa Travel Guide
Tourist Guide
Visit Otay Mesa
Stay near popular Otay Mesa attractions
Activities
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
AU$56
per adult
Crossing Borders: Tijuana Day Trip from San Diego
AU$130
per adult
94% of travellers recommend
From Tijuana: Valle de Guadalupe Shared Winery Tour
AU$120
per adult
100% of travellers recommend
Our pick of the best Otay Mesa Hotel Deals
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct San Diego CA
Fully refundableReserve now, pay when you stay
The price is AU$221 per night from 3 Sept to 4 Sept
AU$221
per night
3 Sept - 4 Sept
Stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...
Manchester Grand Hyatt San Diego
1 Market Pl San Diego CA
The price is AU$398 per night from 7 Sept to 8 Sept
AU$398
per night
7 Sept - 8 Sept
Stay at this business-friendly hotel in San Diego. Enjoy 6 restaurants, 3 bars/lounges and breakfast (surcharge). Our guests praise the pool and the helpful ...
9/10 Wonderful! (2,834 reviews)
"The room appeared to be newly refurbished and the bathroom was nice. The main lobby looks amazing."
Reviewed on 1 Sept 2026
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
The price is AU$295 per night from 6 Sept to 7 Sept
AU$295
per night
6 Sept - 7 Sept
Stay at this business-friendly hotel in San Diego. Enjoy free Wi-Fi, 3 restaurants and breakfast (surcharge). Our guests praise the pool and the restaurant in ...
8.4/10 Very good! (6,290 reviews)
"This place is in a great location. The free coffee is nice in the morning. The workout rooms are great, and the pool."
Reviewed on 1 Sept 2026
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
The price is AU$407 per night from 7 Sept to 8 Sept
AU$407
per night
7 Sept - 8 Sept
Stay at this beach resort in San Diego. Enjoy free Wi-Fi, 5 outdoor pools and a full-service spa. Our guests praise the pool and the helpful staff in their reviews. ...
The Dana on Mission Bay
1710 W Mission Bay Dr San Diego CA
The price is AU$293 per night from 8 Sept to 9 Sept
AU$293
per night
8 Sept - 9 Sept
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina and 2 hot tubs. Our guests praise the pool and the restaurant in their reviews. Popular attractions ...
9/10 Wonderful! (4,445 reviews)
"It was a great location with a nice boardwalk! The 2 pools were great - we felt like we were in Hawaii!! The restaurant was excellent!"
Reviewed on 31 Aug 2026
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
The price is AU$354 per night from 2 Sept to 3 Sept
AU$354
per night
2 Sept - 3 Sept
Stay at this hotel in San Diego. Enjoy free Wi-Fi, 2 restaurants and a nightclub. Our guests praise the helpful staff and the convenient parking in their reviews. ...
9/10 Wonderful! (4,285 reviews)
"Room was clean enough, some leftover stains on the sink when we walked in. Shower splashes underneath shower door and spills out. Toilet needs to be pushed a little bit back so it doesn’t keep refilling."
Reviewed on 1 Sept 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Our guide on where to stay in Otay Mesa
Find the best Otay Mesa areas for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Pacific Beach
The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Nova SD – discover Gaslamp Quarter, a destination also famous for its shopping.
Mission Beach
If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.
Otay Mesa Travel Guide
Explore a world of travel with Expedia
- Chula Vista Hotels
- B&B in Coronado
- Lgbt Welcoming Hotels in Coronado Cays
- Lgbt Welcoming Hotels in Coronado
- Coronado Hotels
- All Inclusive Hotels in San Diego County
- Casino Hotels in San Diego County
- San Diego County Hotels
- Cheap Hotels in Downtown San Diego
- Downtown San Diego Hotels
- East Village Hotels
- Gaslamp Quarter Hotels
- Jamul Hotels
- Guest Houses in La Mesa
- La Mesa Escape – House & Studio Getaway
- National City Hotels
- Otay Mesa West Hotels
- Hotels near Petco Park
- Condo Rentals in San Diego
- Hotels near San Diego Convention Center
- Cabin Rentals in San Diego County
- Accor Hotels in San Diego
- Adults Only Hotels in San Diego
- All Inclusive Hotels in San Diego
- Beach Hotels in San Diego
- Cheap Hotels in San Diego
- Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
- Extended Stay America Suites San Diego Mission Valley Stadium
- Family Game Room with Wet Bar
- Family Hotels in San Diego
- Heritage Inn San Diego
- Hilton Hotels in San Diego
- Ith San Diego Adventure Hostel
- Kings Inn San Diego
- Tides Edge
- Omni San Diego Hotel at the Ballpark
- Romantic Hotels in San Diego
- The Atwood Hotel San Diego
- The Westin San Diego Bayview
- Oceanfront Oasis in Pacific Beach
- Wyndham Hotels in San Diego
- San Diego Hotels
- Ranches in San Diego
- Serviced Apartments in San Diego
- Hotels near San Diego Zoo
- Fireplace
- Lgbt Welcoming Hotels in Terra Nova
- Flights to San Diego
- Flights from San Diego Intl.
- Flights from Brown Field Municipal
- Flights from Adelaide (ADL) to San Diego (SAN)
- Flights from Brisbane (BNE) to San Diego (SAN)
- Flights from Hobart (HBA) to San Diego (SAN)
- Flights from Honolulu (HNL) to San Diego (SAN)
- Flights from New York (JFK) to San Diego (SAN)
- Flights from Las Vegas (LAS) to San Diego (SAN)
- Flights from Las Vegas (LAS) to San Diego (SDM)
- Flights from Los Angeles (LAX) to San Diego (SAN)
- Flights from Melbourne (MEL) to San Diego (SAN)
- Flights from Perth (PER) to San Diego (SAN)
- Flights from San Francisco (SFO) to San Diego (SAN)
- Flights from Sydney (SYD) to San Diego (SAN)
- Flights from Calgary (YYC) to San Diego (SAN)
- Balboa Park
- Visit Cardiff-by-the-Sea
- Coronado Beach
- Visit Coronado
- Visit Imperial Beach
- Visit La Jolla
- Visit La Mesa
- Mission Beach Boardwalk
- Visit Oceanside
- Visit Rancho Santa Fe
- Visit Clairemont
- Visit San Diego Coast
- San Diego County Holidays
- Visit Hillcrest
- Visit Marina District
- Visit Mira Mesa
- Visit Mission Valley
- San Diego Museum of Art
- Visit Ocean Beach
- Visit Point Loma
- Visit Sunset Cliffs
- San Diego Zoo
- San Diego Holidays
- Visit San Diego
- Uss Midway Museum
