Otay Mesa Hotels, San Diego
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4890 Cheap Hotels in Otay Mesa - Specials, Reviews, & Last Minute Deals
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Otay Mesa
8.0 out of 10, Very good, (1557)
"Good comfortable beds good breakfast "
Andrey
The price is AU$221
includes taxes & fees
14 Dec - 15 Dec
Quality Suites San Diego Otay Mesa
Otay Mesa
7.0 out of 10, Good, (1003)
"Beautiful place "
Joe
The price is AU$170
includes taxes & fees
9 Dec - 10 Dec
The Horton Grand, Downtown/Gaslamp Quarter
Marina District, 24.3 km from Otay Mesa
9.0 out of 10, Wonderful, (2699)
"Clean facilities and friendly staff!"
EMMA
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Gaslamp Quarter, 24.1 km from Otay Mesa
9.0 out of 10, Wonderful, (1228)
"Very nice clean room and amenities and staff was pleasant and we love the location. "
Arnold
The price is AU$239
includes taxes & fees
14 Dec - 15 Dec
Hard Rock Hotel San Diego
Gaslamp Quarter, 24 km from Otay Mesa
9.0 out of 10, Wonderful, (3144)
"Great stay"
Laurence
The price is AU$333
includes taxes & fees
1 Jan - 2 Jan 2026
Palihotel San Diego Gaslamp Quarter
Gaslamp Quarter, 24.5 km from Otay Mesa
8.8 out of 10, Excellent, (2087)
"Room was spotless and location great. "
James
The price is AU$201
includes taxes & fees
10 Dec - 11 Dec
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Our guide on where to stay in Otay Mesa
Find the best Otay Mesa areas for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Gaslamp Quarter
The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.
Pacific Beach
Get to Pacific Beach after the sun goes down because this is the place to be in San Diego for partying.
Mission Beach
If you're spending some time in Mission Beach, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.
Ocean Beach
With a secluded sunbathing beach, swimming-only beach, special surf beach, volleyball beach and dog beach, San Diego’s “OB” sure takes beaches seriously.
Top Otay Mesa Hotel Reviews
Best Western Plus Marina Gateway Hotel
10/10 Excellent
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