Otay Mesa Hotels, San Diego
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Go beyond your typical stay in Otay Mesa
Check prices for these dates
4835 Cheap Hotels in Otay Mesa - Specials, Reviews, & Last Minute Deals
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
8.0 out of 10, Very good, (1487)
The price is AU$166
includes taxes & fees
19 Oct - 20 Oct
Quality Suites San Diego Otay Mesa
Quality Suites San Diego Otay Mesa
7.2 out of 10, Good, (1004)
The price is AU$173
includes taxes & fees
19 Oct - 20 Oct
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
9.0 out of 10, Wonderful, (1172)
The price is AU$230
includes taxes & fees
21 Oct - 22 Oct
Palihotel San Diego Gaslamp Quarter
Palihotel San Diego Gaslamp Quarter
8.8 out of 10, Excellent, (1920)
The price is AU$223
includes taxes & fees
21 Oct - 22 Oct
Hotel Zindel
Hotel Zindel
7.6 out of 10, Good, (555)
The Horton Grand, Downtown/Gaslamp Quarter
The Horton Grand, Downtown/Gaslamp Quarter
9.0 out of 10, Wonderful, (2610)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Our guide on where to stay in Otay Mesa
Find the best Otay Mesa areas for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Gaslamp Quarter
The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.
Pacific Beach
Get to Pacific Beach after the sun goes down because this is the place to be in San Diego for partying.
Mission Beach
If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.
Ocean Beach
With a secluded sunbathing beach, swimming-only beach, special surf beach, volleyball beach and dog beach, San Diego’s “OB” sure takes beaches seriously.
Frequently asked questions
Explore a world of travel with Expedia
- Hotels near 8th St Trolley Station
- B&B in Bonita
- Luxury Hotels in Bonita
- Bonita Hotels
- Hotels near Brown Field Municipal
- Castle Park Hotels
- Apartments in Chula Vista
- Hotels near Chula Vista Center
- Hotels near Chula Vista Elite Athlete Training Center
- Lgbt Welcoming Hotels in Chula Vista
- Chula Vista Hotels
- Motels in Chula Vista
- Resort in Chula Vista
- Lgbt Welcoming Hotels in Coronado Cays
- Dulzura Hotels
- Lgbt Welcoming Hotels in Eastlake
- Lgbt Welcoming Hotels in Eastlake Greens
- Emerald Hills Hotels
- All Inclusive Hotels in Encanto
- Lgbt Welcoming Hotels in Encanto
- Condo Rentals in Imperial Beach
- Beach Hotels in Imperial Beach
- Imperial Beach Hotels
- Resort in Imperial Beach
- Jamacha Hotels
- Farmstay in Jamul
- Lemon Grove Hotels
- Mount Hope Hotels
- Boutique Hotels in Mountain View
- Cheap Hotels in Mountain View
- Family Hotels in Mountain View
- Cheap Hotels in National City
- National City Hotels
- Hotels near Naval Base San Diego
- Hotels near North Island Credit Union Amphitheatre
- Ocean View Hills Hotels
- Cheap Hotels in Otay Mesa West
- Otay Mesa West Hotels
- Hotels near Palm Ave Trolley Station
- Paradise Hills Hotels
- Rancho San Diego Hotels
- Caravan Parks in San Diego Coast
- Adults Only Hotels in San Diego Coast
- Boutique Hotels in San Diego Coast
- Family Hotels in San Diego Coast
- Lgbt Welcoming Hotels in San Diego Coast
- San Diego Coast Hotels
- Resort in San Diego Coast
- San Diego Hotels
- Hotels near San Ysidro Border Crossing
- All Inclusive Hotels in San Ysidro
- San Ysidro Hotels
- Resort in San Ysidro
- Hotels near San Ysidro Transit Center Station
- Skyline Hotels
- Cottages in South Bay
- Beach Hotels in South Bay
- Cheap Hotels in South Bay
- South Bay Hotels
- Cheap Hotels in South San Diego
- Luxury Hotels in South San Diego
- South San Diego Hotels
- Spring Valley Hotels
- Lgbt Welcoming Hotels in Terra Nova
- All Inclusive Hotels in Valencia Park
- Flights to Chula Vista
- Flights to San Diego Coast
- Flights to San Ysidro
- Flights to South San Diego
- Flights from Brown Field Municipal
- Flights from Imperial Beach
- Flights from San Diego Coast
- Flights from Chula Vista
- Flights from San Ysidro
- Flights from Atlanta (ATL) to San Diego (SDM)
- Flights from Boston (BOS) to San Diego (SDM)
- Flights from Compton (CPM) to San Diego (SDM)
- Flights from Washington (DCA) to San Diego (SDM)
- Flights from Dallas (DFW) to San Diego (SDM)
- Flights from Ensenada (ESE) to San Diego (SDM)
- Flights from Las Vegas (LAS) to San Diego (SDM)
- Flights from Los Angeles (LAX) to San Diego (SDM)
- Flights from Livermore (LVK) to San Diego (SDM)
- Flights from Miami (MIA) to San Diego (SDM)
- Flights from San Francisco (SFO) to San Diego (SDM)
- Flights from Sydney (SYD) to San Diego (SDM)
- Flights from Vancouver (YVR) to San Diego (SDM)
Hotels Near San Diego, California
- Hotels in Downtown San Diego
- Hotels in Gaslamp Quarter
- Hotels in Pacific Beach
- Hotels in Mission Beach
- Hotels in Ocean Beach
- Hotels in Point Loma
- Hotels in Mission Valley
- Hotels in Old Town San Diego
- Hotels in Little Italy
- Hotels in North Pacific Beach
- Hotels in Crown Point
- Hotels in South Mission Beach
- Hotels in North Park
- Hotels in Carmel Valley
- Hotels in Hillcrest
- Hotels in La Playa
- Hotels in East Village
- Hotels in University City
- Hotels in Mid-City
- Hotels in Del Cerro
Hotels near popular San Diego Attractions
What kind of hotels are in Otay Mesa?
More accommodation types in Otay Mesa
- Holiday Homes in San Diego
- Apartments in San Diego
- Condo Rentals in San Diego
- Cottages in San Diego
- Guest Houses in San Diego
- Villas in San Diego
- Serviced Apartments in San Diego
- Resort in San Diego
- Motels in San Diego
- Hostels in San Diego
- B&B in San Diego
- Houseboats in San Diego
- Inns in San Diego
- Cabin Rentals in San Diego
- Caravan Parks in San Diego
- Residences in San Diego
Explore more hotels
- The DEXTRO Little Italy, BW Premier Collection
- Days Inn by Wyndham San Diego Hotel Circle
- Courtyard by Marriott San Diego Downtown Little Italy
- Wyndham Garden San Diego Near SeaWorld
- Kings Inn San Diego
- Legacy Resort Hotel & Spa
- The Sofia Hotel
- Sheraton San Diego Resort
- Hyatt Regency Mission Bay Spa and Marina
- Handlery Hotel
- Ramada Suites by Wyndham San Diego/Hotel Circle Area
- InterContinental San Diego by IHG
More ways to book
Expedia's Latest Trends
Hotels
Flights
Cars