Otay Mesa Hotels, San Diego

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Otay Mesa hotels

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.0 out of 10, Good, (1,005 reviews)
"The room was nice the beds comfortable I’ll stay there again."
United States
Leo
The price is AU$167
includes taxes & fees
25 Jan - 26 Jan
Quality Suites San Diego Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.0 out of 10, Very good, (1,599 reviews)
"Great place to stay. Really clean and helpful staff "
United States
Zulma
The price is AU$200
includes taxes & fees
25 Jan - 26 Jan
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Courtyard by Marriott Old Town

Courtyard by Marriott Old Town
3.0 star property
Old Town San Diego, 29.7 km from Otay Mesa
8.6 out of 10, Excellent, (1,003 reviews)
"Wonderful location and staff is outstanding!!"
United States
Kathleen
The price is AU$230
includes taxes & fees
30 Jan - 31 Jan
Courtyard by Marriott Old Town

Berkshire Motor Hotel

Berkshire Motor Hotel
2.5 star property
North Park, 26.7 km from Otay Mesa
8.4 out of 10, Very good, (1,001 reviews)
"Clean, very chill easy check in"
United States
Susana
The price is AU$143
includes taxes & fees
25 Jan - 26 Jan
Berkshire Motor Hotel

Westgate Hotel

Westgate Hotel
4.5 star property
24.9 km from Otay Mesa
9.0 out of 10, Wonderful, (1,003 reviews)
"Great stay"
United States
ESMERALDA
The price is AU$227
includes taxes & fees
24 Jan - 25 Jan
Westgate Hotel

Ocean Villa Inn

Ocean Villa Inn
2.5 star property
Ocean Beach, 33.7 km from Otay Mesa
8.0 out of 10, Very good, (1,150 reviews)
"Beds are super comfy clean and renovated"
United States
Esmeralda
Ocean Villa Inn

Sea Harbor Hotel

Sea Harbor Hotel
2.0 star property
30.1 km from Otay Mesa
8.6 out of 10, Excellent, (1,012 reviews)
"Super clean rooms and a great location "
United States
Mark
Sea Harbor Hotel

Springhill Suites San Diego Mission Valley

Springhill Suites San Diego Mission Valley
3.5 star property
28.2 km from Otay Mesa
9.2 out of 10, Wonderful, (1,000 reviews)
"Very friendly staff, quick check-in, spacious room, and very clean! Great place to stay! "
United States
Jodi
The price is AU$289
includes taxes & fees
30 Jan - 31 Jan
Springhill Suites San Diego Mission Valley

Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego
3.0 star property
Gaslamp Quarter, 24.2 km from Otay Mesa
9.4 out of 10, Exceptional, (1,002 reviews)
"Great location and stay. "
United States
Simran
The price is AU$213
includes taxes & fees
29 Jan - 30 Jan
Staypineapple, Hotel Z, Gaslamp San Diego

Fairfield Inn & Suites San Diego Old Town

Fairfield Inn & Suites San Diego Old Town
2.5 star property
Old Town San Diego, 29.4 km from Otay Mesa
8.8 out of 10, Excellent, (1,005 reviews)
"Great location, clean rooms, good breakfast"
United States
Jingyi
The price is AU$231
includes taxes & fees
8 Feb - 9 Feb
Fairfield Inn & Suites San Diego Old Town

Old Town Western Inn & Suites

Old Town Western Inn & Suites
2.5 star property
Old Town San Diego, 29.6 km from Otay Mesa
7.6 out of 10, Good, (1,004 reviews)
"Clean, good staff, quiet, good location "
United States
Raul
The price is AU$150
includes taxes & fees
1 Feb - 2 Feb
Old Town Western Inn & Suites

La Pensione Hotel

La Pensione Hotel
3.0 star property
Little Italy, 25.8 km from Otay Mesa
8.6 out of 10, Excellent, (1,898 reviews)
"Excellent location, top notch service and well priced hotel parking!"
Canada
Monika
La Pensione Hotel

Heritage Inn San Diego

Heritage Inn San Diego
2.0 star property
31.8 km from Otay Mesa
7.4 out of 10, Good, (1,215 reviews)
"Clean room, Friendly staff and easy parking. Great value for the price paid."
United States
ASIM
The price is AU$102
includes taxes & fees
25 Jan - 26 Jan
Heritage Inn San Diego

Ash&9th

Ash&9th
2.0 star property
24.7 km from Otay Mesa
8.4 out of 10, Very good, (268 reviews)
"Will stay again! "
United States
Darlene
The price is AU$133
includes taxes & fees
25 Jan - 26 Jan
Ash&9th

Best Western Plus Bayside Inn

Best Western Plus Bayside Inn
3.0 star property
25.4 km from Otay Mesa
9.0 out of 10, Wonderful, (1,008 reviews)
"Excellent stay!"
United States
D'ette
The price is AU$237
includes taxes & fees
22 Feb - 23 Feb
Best Western Plus Bayside Inn

Porto Vista Hotel Downtown

Porto Vista Hotel Downtown
3.5 star property
Little Italy, 25.8 km from Otay Mesa
6.8 out of 10, (1,213 reviews)
"Friendly staff, neat place to stay. Rooftop hot tub and bar were great perks, amazing location! "
United States
Sarah
Porto Vista Hotel Downtown

The Inn at Sunset Cliffs

The Inn at Sunset Cliffs
2.5 star property
Ocean Beach, 32.9 km from Otay Mesa
9.2 out of 10, Wonderful, (1,000 reviews)
"Great location, staff was so friendly and courteous, and amazing views!"
United States
Katrina
The price is AU$367
includes taxes & fees
25 Jan - 26 Jan
The Inn at Sunset Cliffs

Ocean Beach Hotel

Ocean Beach Hotel
3.0 star property
Ocean Beach, 33.5 km from Otay Mesa
8.8 out of 10, Excellent, (1,278 reviews)
"Super friendly staff. Impeccably clean rooms. Comfy bed. Beautiful place. We will back to stay longer next time!"
United States
Trinity
Ocean Beach Hotel

The Beau Downtown San Diego Gaslamp Quar

The Beau Downtown San Diego Gaslamp Quar
3.0 star property
Gaslamp Quarter, 24.5 km from Otay Mesa
8.8 out of 10, Excellent, (579 reviews)
"A very nice spot to stay in the gas lamp district. "
United States
Janet
The price is AU$210
includes taxes & fees
25 Jan - 26 Jan
The Beau Downtown San Diego Gaslamp Quar

Comfort Inn San Diego Airport At The Harbor

Comfort Inn San Diego Airport At The Harbor
3.5 star property
30.1 km from Otay Mesa
7.8 out of 10, Good, (1,264 reviews)
"Great room, clean property and courteous staff"
United States
Reginald D.
The price is AU$151
includes taxes & fees
9 Feb - 10 Feb
Comfort Inn San Diego Airport At The Harbor
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our guide on where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Pacific Beach

Get to Pacific Beach after the sun goes down because this is the place to be in San Diego for partying.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Ocean Beach

With a secluded sunbathing beach, swimming-only beach, special surf beach, volleyball beach and dog beach, San Diego’s “OB” sure takes beaches seriously.

Top Otay Mesa Hotel Reviews

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! Most room reservations are refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.
What is there to do in this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.

Explore a world of travel with Expedia