Otay Mesa Hotels, San Diego

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Our top choices for Otay Mesa hotels

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.0 out of 10, Very good, (1,667 reviews)
"Clean, great breakfast, good service."
United States
Sara
The price is AU$209
includes taxes & fees
15 Mar - 16 Mar
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.0 out of 10, Good, (1,006 reviews)
"Great staff.. location close to the airport!"
United States
Vivian
The price is AU$174
includes taxes & fees
5 Apr - 6 Apr
Quality Suites San Diego Otay Mesa

Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG
3.5 star property
29.8 km from Otay Mesa
8.0 out of 10, Very good, (1,016 reviews)
The price is AU$172
includes taxes & fees
5 Apr - 6 Apr
Crowne Plaza San Diego - Mission Valley by IHG

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
28.1 km from Otay Mesa
8.4 out of 10, Very good, (3,370 reviews)
"Love this hotel will always stay here when I come to San Diego "
United States
Darlene
The price is AU$267
includes taxes & fees
1 Apr - 2 Apr
Sheraton San Diego Resort

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
26.8 km from Otay Mesa
9.2 out of 10, Wonderful, (1,512 reviews)
"Stunning hotel, I could have stayed there all day looking at every little design detail. "
United States
Holly
The price is AU$374
includes taxes & fees
10 Mar - 11 Mar
Lafayette Hotel & Club

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.2 out of 10, Wonderful, (1,784 reviews)
"Very clean resort. "
United States
Petrina
Sycuan Casino Resort

Valli Hi Motel

Valli Hi Motel
2.5 star property
7.9 km from Otay Mesa
8.4 out of 10, Very good, (1,007 reviews)
"Excelente "
Mexico
Julio
Valli Hi Motel

Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel
2.5 star property
7.1 km from Otay Mesa
7.8 out of 10, Good, (1,646 reviews)
"Clean rooms and the breakfast was amazing "
United States
Vanessa
The price is AU$161
includes taxes & fees
15 Mar - 16 Mar
Best Western Chula Vista/Otay Valley Hotel

SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (587 reviews)
"Clean room and friendly staff "
United States
Michael
The price is AU$268
includes taxes & fees
22 Mar - 23 Mar
SpringHill Suites by Marriott Chula Vista Eastlake

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
31.3 km from Otay Mesa
7.4 out of 10, Good, (4,192 reviews)
"Good location friendly staff"
United States
Anya
The price is AU$162
includes taxes & fees
10 Mar - 11 Mar
Wyndham Garden San Diego Near SeaWorld

Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town

Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town
3.0 star property
30.8 km from Otay Mesa
9.2 out of 10, Wonderful, (707 reviews)
"Great place to stay, nice room Highly recommended !!"
United States
Wilfredo
The price is AU$269
includes taxes & fees
15 Mar - 16 Mar
Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town

Ocean Villa Inn

Ocean Villa Inn
2.5 star property
Ocean Beach, 33.7 km from Otay Mesa
8.0 out of 10, Very good, (1,196 reviews)
"Beds are super comfy clean and renovated"
United States
Esmeralda
Ocean Villa Inn

Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
28.8 km from Otay Mesa
9.2 out of 10, Wonderful, (1,068 reviews)
"great stay"
United States
Jose
The price is AU$222
includes taxes & fees
11 Mar - 12 Mar
Holiday Inn Express San Diego Airport - Old Town by IHG

Comfort Inn Sea World Area

Comfort Inn Sea World Area
3.5 star property
30.8 km from Otay Mesa
8.6 out of 10, Excellent, (3,453 reviews)
"Nice beds and breakfast, really convenient "
Canada
Margarita
The price is AU$169
includes taxes & fees
11 Mar - 12 Mar
Comfort Inn Sea World Area

Best Western Plus La Mesa San Diego

Best Western Plus La Mesa San Diego
2.5 star property
24.6 km from Otay Mesa
8.4 out of 10, Very good, (1,013 reviews)
"Room was clean, pleasant staff and great breakfast "
United States
Wendy
The price is AU$187
includes taxes & fees
15 Mar - 16 Mar
Best Western Plus La Mesa San Diego

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
25.7 km from Otay Mesa
8.4 out of 10, Very good, (6,089 reviews)
"Great place to stay"
United States
David
The price is AU$300
includes taxes & fees
11 Mar - 12 Mar
Wyndham San Diego Bayside

Hilton Garden Inn San Diego Old Town/SeaWorld Area

Hilton Garden Inn San Diego Old Town/SeaWorld Area
3.0 star property
Old Town San Diego, 30.5 km from Otay Mesa
8.8 out of 10, Excellent, (1,356 reviews)
"Great location, great price, nice hotel "
United States
Estela
The price is AU$214
includes taxes & fees
15 Mar - 16 Mar
Hilton Garden Inn San Diego Old Town/SeaWorld Area

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
9.0 out of 10, Wonderful, (1,225 reviews)
"Great stay"
United States
Elisa
The price is AU$191
includes taxes & fees
16 Mar - 17 Mar
Best Western Americana Inn

Ash&9th

Ash&9th
2.0 star property
24.7 km from Otay Mesa
8.2 out of 10, Very good, (399 reviews)
"Great location… stuff was really friendly "
United States
Aurora
The price is AU$127
includes taxes & fees
7 Apr - 8 Apr
Ash&9th

Old Town Western Inn & Suites

Old Town Western Inn & Suites
2.5 star property
Old Town San Diego, 29.6 km from Otay Mesa
7.6 out of 10, Good, (1,013 reviews)
"Clean, good staff, quiet, good location "
United States
Raul
Old Town Western Inn & Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our guide on where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

Get to Pacific Beach after the sun goes down because this is the place to be in San Diego for partying.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Ocean Beach

With a secluded sunbathing beach, swimming-only beach, special surf beach, volleyball beach and dog beach, San Diego’s “OB” sure takes beaches seriously.

Top Otay Mesa Hotel Reviews

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! Most room reservations are refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.
What is there to do in this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.

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