Otay Mesa Hotels, San Diego
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check prices for these dates
Our top choices for Otay Mesa hotels
Quality Suites San Diego Otay Mesa
Quality Suites San Diego Otay MesaOtay Mesa
7.0 out of 10, Good, (1,003 reviews)
"Good for short stay"
Yuki
The price is AU$162
includes taxes & fees
3 May - 4 May
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHGOtay Mesa
8.2 out of 10, Very good, (1,713 reviews)
"The location is great if you are crossing late from Tijuana to San Diego and you need to rest, the room is super clean, and very comfortable. "
Rafael Moreno
The price is AU$188
includes taxes & fees
3 May - 4 May
Ocean Villa Inn
Ocean Villa InnOcean Beach, 33.7 km from Otay Mesa
8.0 out of 10, Very good, (1,254 reviews)
"Basic beach motel. Served its purpose. Its old and dingy but it was quiet and safe. Manager was very nice. "
Karin
The price is AU$196
includes taxes & fees
30 Apr - 1 May
Studio 6 Suites San Ysidro, CA -San Diego South Bay
Studio 6 Suites San Ysidro, CA -San Diego South Bay6.9 km from Otay Mesa
8.0 out of 10, Very good, (1,621 reviews)
"Clean room, friendly and nice staff, easy parking and safe "
Erik
The price is AU$121
includes taxes & fees
3 May - 4 May
Best Western San Diego Pacific Beach/Mission Bay
Best Western San Diego Pacific Beach/Mission BayBay Park, 33.6 km from Otay Mesa
8.2 out of 10, Very good, (372 reviews)
"Great room. Staff was friendly. Easy access to trolley and free parking made getting around super easy. "
Jason
The price is AU$139
includes taxes & fees
10 May - 11 May
Sycuan Casino Resort
Sycuan Casino Resort28.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,876 reviews)
"This is a great hotel and casino. Very fun and clean atmosphere. No need to venture out for food Restaurants are great!!"
Frances
The price is AU$168
includes taxes & fees
4 May - 5 May
Lafayette Hotel & Club
Lafayette Hotel & Club26.8 km from Otay Mesa
9.4 out of 10, Exceptional, (1,620 reviews)
"This hotel is one of a kind. The pool area is stunning. Restaurants are great. Hip, busy scene at the bars and restaurants, yet quiet and cozy in your stylish room. The design of everything is over the top-- it was a treat to stay here. We'll be back."
Kelly
The price is AU$399
includes taxes & fees
30 Apr - 1 May
Best Western Chula Vista/Otay Valley Hotel
Best Western Chula Vista/Otay Valley Hotel7.1 km from Otay Mesa
7.8 out of 10, Good, (1,723 reviews)
"It was peaceful, clean, convenient and the staff was very friendly "
Jennifer
The price is AU$168
includes taxes & fees
10 May - 11 May
Sheraton San Diego Resort
Sheraton San Diego Resort28.1 km from Otay Mesa
8.4 out of 10, Very good, (3,498 reviews)
"The restaurants were amazing. Food was delicious and fresh. The pool was spacious and loved the poolside service. Plenty of seating options. The beds were very comfortable. Great airport shuttle. Loved the location. Close to harbor walk."
Helene
The price is AU$306
includes taxes & fees
10 May - 11 May
Wyndham Garden San Diego Near SeaWorld
Wyndham Garden San Diego Near SeaWorld31.3 km from Otay Mesa
7.4 out of 10, Good, (4,212 reviews)
"Over all great stay. Close to the arena which is the best perk! Over all clean and safe. On site security. Shopping and food near by."
Kevin
The price is AU$174
includes taxes & fees
30 Apr - 1 May
La Quinta Inn by Wyndham San Diego Chula Vista
La Quinta Inn by Wyndham San Diego Chula Vista12.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,602 reviews)
"Staff was friendly, and breakfast was excellent"
Royce
The price is AU$173
includes taxes & fees
25 May - 26 May
SpringHill Suites by Marriott Chula Vista Eastlake
SpringHill Suites by Marriott Chula Vista Eastlake10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (636 reviews)
"Clean and spacious room. Amazing outdoor pool/jacuzzi with outdoor seating and a nice fire pit. The bartender Mico is THEE BEST! "
Shatera
The price is AU$288
includes taxes & fees
10 May - 11 May
Old Town Western Inn & Suites
Old Town Western Inn & SuitesOld Town San Diego, 29.6 km from Otay Mesa
7.8 out of 10, Good, (1,006 reviews)
"Convenient location close to restaurants and activities. Room was huge and very clean. Friendly staff. "
Joanne
The price is AU$140
includes taxes & fees
3 May - 4 May
Bay Club Hotel & Marina
Bay Club Hotel & Marina29.2 km from Otay Mesa
9.2 out of 10, Wonderful, (3,547 reviews)
"Room was very clean, staff was friendly and location was amazing!!"
Erica
The price is AU$215
includes taxes & fees
5 May - 6 May
Comfort Inn Chula Vista San Diego South
Comfort Inn Chula Vista San Diego South13 km from Otay Mesa
8.2 out of 10, Very good, (1,455 reviews)
"Great breakfast lots of amenities. Good location, willstay again."
Dannell
The price is AU$168
includes taxes & fees
10 May - 11 May
Holiday Inn Express San Diego Airport - Old Town by IHG
Holiday Inn Express San Diego Airport - Old Town by IHG28.8 km from Otay Mesa
9.0 out of 10, Wonderful, (1,066 reviews)
"Staff was great- very helpful!!"
Jeffrey
The price is AU$226
includes taxes & fees
6 May - 7 May
Old Town Inn
Old Town Inn30.1 km from Otay Mesa
9.2 out of 10, Wonderful, (1,867 reviews)
"Loved the Old Town Inn - we'll stay here again the next time we visit San Diego. Room was very clean and very comfortable. Easy connection to the internet and convenient to areas of interest. The grounds are gorgeous and welcoming. We arrived before 3:00 check-in and were able to "pre-check in" so when we returned after 3:00, all we needed was the key and we were done! Super nice front desk staff, too. Thank you Old Town Inn!"
Peggy
The price is AU$251
includes taxes & fees
20 May - 21 May
Best Western Americana Inn
Best Western Americana Inn8 km from Otay Mesa
9.0 out of 10, Wonderful, (1,264 reviews)
"Clean room, nice staff, a simple breakfast, and free parking on site."
Nicole
The price is AU$194
includes taxes & fees
6 May - 7 May
Best Western Plus Marina Gateway Hotel
Best Western Plus Marina Gateway Hotel16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (3,797 reviews)
"Nice property. Had a good restaurant adjacent. "
Mr. or Ms.
The price is AU$233
includes taxes & fees
10 May - 11 May
Ocean Beach Hotel
Ocean Beach HotelOcean Beach, 33.5 km from Otay Mesa
8.8 out of 10, Excellent, (1,326 reviews)
"Location Location Location! Super friendly staff!
Love this place! Already booked 2 more trips to stay here again! "
Suzie
The price is AU$266
includes taxes & fees
10 May - 11 May
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Our guide on where to stay in Otay Mesa
Find the best Otay Mesa areas for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Pacific Beach
Get to Pacific Beach after the sun goes down because this is the place to be in San Diego for partying.
Mission Beach
If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.
Gaslamp Quarter
The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.
Ocean Beach
With a secluded sunbathing beach, swimming-only beach, special surf beach, volleyball beach and dog beach, San Diego’s “OB” sure takes beaches seriously.
Frequently asked questions
Explore a world of travel with Expedia
- Hotels near 8th St Trolley Station
- B&B in Bonita
- Luxury Hotels in Bonita
- Bonita Hotels
- Hotels near Brown Field Municipal
- Castle Park Hotels
- Apartments in Chula Vista
- Hotels near Chula Vista Center
- Hotels near Chula Vista Elite Athlete Training Center
- Lgbt Welcoming Hotels in Chula Vista
- Chula Vista Hotels
- Motels in Chula Vista
- Resort in Chula Vista
- Lgbt Welcoming Hotels in Coronado Cays
- Dulzura Hotels
- Lgbt Welcoming Hotels in Eastlake
- Lgbt Welcoming Hotels in Eastlake Greens
- Emerald Hills Hotels
- All Inclusive Hotels in Encanto
- Lgbt Welcoming Hotels in Encanto
- Condo Rentals in Imperial Beach
- Beach Hotels in Imperial Beach
- Imperial Beach Hotels
- Resort in Imperial Beach
- Jamacha Hotels
- Farmstay in Jamul
- Lemon Grove Hotels
- Mount Hope Hotels
- Boutique Hotels in Mountain View
- Cheap Hotels in Mountain View
- Family Hotels in Mountain View
- Cheap Hotels in National City
- National City Hotels
- Hotels near Naval Base San Diego
- Hotels near North Island Credit Union Amphitheatre
- Ocean View Hills Hotels
- Cheap Hotels in Otay Mesa West
- Otay Mesa West Hotels
- Hotels near Palm Ave Trolley Station
- Paradise Hills Hotels
- Rancho San Diego Hotels
- Caravan Parks in San Diego Coast
- Adults Only Hotels in San Diego Coast
- Boutique Hotels in San Diego Coast
- Family Hotels in San Diego Coast
- Lgbt Welcoming Hotels in San Diego Coast
- San Diego Coast Hotels
- Resort in San Diego Coast
- San Diego Hotels
- Hotels near San Ysidro Border Crossing
- All Inclusive Hotels in San Ysidro
- San Ysidro Hotels
- Resort in San Ysidro
- Hotels near San Ysidro Transit Center Station
- Skyline Hotels
- Cottages in South Bay
- Beach Hotels in South Bay
- Cheap Hotels in South Bay
- South Bay Hotels
- Cheap Hotels in South San Diego
- Luxury Hotels in South San Diego
- South San Diego Hotels
- Spring Valley Hotels
- Lgbt Welcoming Hotels in Terra Nova
- All Inclusive Hotels in Valencia Park
- Flights to Chula Vista
- Flights to San Diego Coast
- Flights to San Ysidro
- Flights to South San Diego
- Flights from Brown Field Municipal
- Flights from Imperial Beach
- Flights from San Diego Coast
- Flights from Chula Vista
- Flights from San Ysidro
- Flights from Atlanta (ATL) to San Diego (SDM)
- Flights from Boston (BOS) to San Diego (SDM)
- Flights from Compton (CPM) to San Diego (SDM)
- Flights from Washington (DCA) to San Diego (SDM)
- Flights from Dallas (DFW) to San Diego (SDM)
- Flights from Ensenada (ESE) to San Diego (SDM)
- Flights from Las Vegas (LAS) to San Diego (SDM)
- Flights from Los Angeles (LAX) to San Diego (SDM)
- Flights from Livermore (LVK) to San Diego (SDM)
- Flights from Miami (MIA) to San Diego (SDM)
- Flights from San Francisco (SFO) to San Diego (SDM)
- Flights from Sydney (SYD) to San Diego (SDM)
- Flights from Vancouver (YVR) to San Diego (SDM)