Otay Mesa West Hotels, San Diego
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check prices for these dates
Our top choices for Otay Mesa West hotels
Wyndham San Diego Bayside
Wyndham San Diego Bayside19.2 km from Otay Mesa West
8.4 out of 10, Very good, (5,994 reviews)
"Perfect location for cruise"
blasimar
The price is AU$286
includes taxes & fees
18 Jan - 19 Jan
The Bristol Hotel San Diego
The Bristol Hotel San Diego18.5 km from Otay Mesa West
8.6 out of 10, Excellent, (1,469 reviews)
"Newly remodeled rooms, clean and wonderful staff. "
Zoe
The price is AU$649
includes taxes & fees
9 Feb - 10 Feb
San Diego Mission Bay Resort
San Diego Mission Bay ResortMission Bay, 26.8 km from Otay Mesa West
8.4 out of 10, Very good, (1,336 reviews)
"Great place for our family getaway! Loved the S’mores on the beach! "
Dani
The price is AU$340
includes taxes & fees
2 Feb - 3 Feb
Paradise Point Resort & Spa
Paradise Point Resort & SpaMission Bay, 27.9 km from Otay Mesa West
8.6 out of 10, Excellent, (2,366 reviews)
"Great facility and amenities. We look forward to taking our family back again. "
Andy
The price is AU$288
includes taxes & fees
19 Jan - 20 Jan
Loews Coronado Bay Resort
Loews Coronado Bay Resort9.7 km from Otay Mesa West
8.8 out of 10, Excellent, (1,063 reviews)
"The staff and amenities were spectacular. "
Andrew
The price is AU$387
includes taxes & fees
8 Feb - 9 Feb
Westgate Hotel
Westgate Hotel18.5 km from Otay Mesa West
9.0 out of 10, Wonderful, (1,003 reviews)
"The hotel was a great stay. Beautiful lobby, large room and such a comfortable bed."
Victor
Sycuan Casino Resort
Sycuan Casino Resort31.2 km from Otay Mesa West
9.2 out of 10, Wonderful, (1,671 reviews)
"Very clean resort. "
Petrina
Hard Rock Hotel San Diego
Hard Rock Hotel San DiegoGaslamp Quarter, 17.5 km from Otay Mesa West
9.0 out of 10, Wonderful, (3,225 reviews)
"Great view easy checking in fun atmosphere and good food "
Sergio
The price is AU$701
includes taxes & fees
3 Feb - 4 Feb
The Dana on Mission Bay
The Dana on Mission BayMission Bay, 27.1 km from Otay Mesa West
9.0 out of 10, Wonderful, (3,990 reviews)
"We had a wonderful stay!"
Megan
The price is AU$307
includes taxes & fees
18 Jan - 19 Jan
The DEXTRO Little Italy, BW Premier Collection
The DEXTRO Little Italy, BW Premier Collection19.1 km from Otay Mesa West
9.0 out of 10, Wonderful, (912 reviews)
"Great stay. Would definitely stay again."
Zoraima
The price is AU$191
includes taxes & fees
22 Jan - 23 Jan
Manchester Grand Hyatt San Diego
Manchester Grand Hyatt San DiegoMarina District, 18.2 km from Otay Mesa West
9.0 out of 10, Wonderful, (2,882 reviews)
"Excellent stay...wonderful staff"
Michelle
The price is AU$420
includes taxes & fees
23 Jan - 24 Jan
Humphreys Half Moon Inn
Humphreys Half Moon Inn22.3 km from Otay Mesa West
9.2 out of 10, Wonderful, (2,738 reviews)
"Great stay, highly recommend."
Ryan
The price is AU$294
includes taxes & fees
2 Feb - 3 Feb
GreenTree Inn San Diego Mission Bay
GreenTree Inn San Diego Mission BayPacific Beach, 29.3 km from Otay Mesa West
8.0 out of 10, Very good, (1,902 reviews)
"The staff was very nice and great location"
Curtis
The price is AU$125
includes taxes & fees
25 Jan - 26 Jan
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Residence Inn by Marriott San Diego Downtown/Gaslamp QuarterGaslamp Quarter, 17.6 km from Otay Mesa West
9.0 out of 10, Wonderful, (1,246 reviews)
"Friendly staff, great location, excellent value overall "
Maryann
The price is AU$275
includes taxes & fees
18 Jan - 19 Jan
Hampton Inn San Diego/Mission Valley
Hampton Inn San Diego/Mission Valley23.5 km from Otay Mesa West
8.6 out of 10, Excellent, (1,364 reviews)
"Great breakfast-comfortable rooms-helpful staff-great location for events"
bill
The price is AU$165
includes taxes & fees
25 Jan - 26 Jan
Embassy Suites by Hilton San Diego Bay Downtown
Embassy Suites by Hilton San Diego Bay DowntownMarina District, 18.4 km from Otay Mesa West
9.0 out of 10, Wonderful, (1,576 reviews)
"Very easy vacation, convenient breakfast as well as location."
Kathy
The price is AU$380
includes taxes & fees
30 Jan - 31 Jan
The Sofia Hotel
The Sofia Hotel18.5 km from Otay Mesa West
8.6 out of 10, Excellent, (1,689 reviews)
"Great location and history to the hotel "
Stephanie
Best Western Seven Seas
Best Western Seven Seas22.9 km from Otay Mesa West
8.0 out of 10, Very good, (3,125 reviews)
"Breakfast was good and the staff was friendly and excellent. "
Thuan
The price is AU$120
includes taxes & fees
25 Jan - 26 Jan
Fairfield Inn & Suites by Marriott San Diego Pacific Beach
Fairfield Inn & Suites by Marriott San Diego Pacific BeachPacific Beach, 29 km from Otay Mesa West
8.8 out of 10, Excellent, (835 reviews)
"Great stay!"
Cynthia
The price is AU$156
includes taxes & fees
25 Jan - 26 Jan
Margaritaville Hotel San Diego Gaslamp Quarter
Margaritaville Hotel San Diego Gaslamp QuarterGaslamp Quarter, 17.6 km from Otay Mesa West
9.0 out of 10, Wonderful, (1,198 reviews)
"Perfect location in the Gaslamp District. Rooms were large & clean with friendly staff. "
Ginger
The price is AU$368
includes taxes & fees
30 Jan - 31 Jan
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Our guide on where to stay in Otay Mesa West
Find the best Otay Mesa West areas for the activities you enjoy most.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Mission Beach
If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.
Gaslamp Quarter
The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.
Pacific Beach
Get to Pacific Beach after the sun goes down because this is the place to be in San Diego for partying.
Ocean Beach
With a secluded sunbathing beach, swimming-only beach, special surf beach, volleyball beach and dog beach, San Diego’s “OB” sure takes beaches seriously.
Top Otay Mesa West Hotel Reviews
Hilton San Diego Mission Valley
10/10 Excellent
Frequently asked questions
Explore a world of travel with Expedia
- Hotels near 8th St Trolley Station
- Barrio Logan Hotels
- Hotels near Barrio Logan Station
- B&B in Bonita
- Luxury Hotels in Bonita
- Bonita Hotels
- Hotels near Brown Field Municipal
- Castle Park Hotels
- Apartments in Chula Vista
- Hotels near Chula Vista Center
- Hotels near Chula Vista Elite Athlete Training Center
- Lgbt Welcoming Hotels in Chula Vista
- Chula Vista Hotels
- Motels in Chula Vista
- Resort in Chula Vista
- Lgbt Welcoming Hotels in Coronado Cays
- Lgbt Welcoming Hotels in Eastlake
- Lgbt Welcoming Hotels in Eastlake Greens
- Emerald Hills Hotels
- Grant Hill Hotels
- Hotels near Hotel del Coronado
- Condo Rentals in Imperial Beach
- Beach Hotels in Imperial Beach
- Imperial Beach Hotels
- Resort in Imperial Beach
- Mount Hope Hotels
- Family Hotels in Mountain View
- Cheap Hotels in National City
- National City Hotels
- Hotels near Naval Base San Diego
- Hotels near North Island Credit Union Amphitheatre
- Ocean View Hills Hotels
- Cheap Hotels in Otay Mesa
- Otay Mesa Hotels
- Hotels near Palm Ave Trolley Station
- Paradise Hills Hotels
- Caravan Parks in San Diego Coast
- Adults Only Hotels in San Diego Coast
- Boutique Hotels in San Diego Coast
- Family Hotels in San Diego Coast
- Lgbt Welcoming Hotels in San Diego Coast
- Romantic Hotels in San Diego Coast
- Winery Hotels in San Diego Coast
- San Diego Coast Hotels
- Resort in San Diego Coast
- Hotels near San Diego-Coronado Bridge
- San Diego Hotels
- Hotels near San Ysidro Border Crossing
- All Inclusive Hotels in San Ysidro
- San Ysidro Hotels
- Resort in San Ysidro
- Hotels near San Ysidro Transit Center Station
- Skyline Hotels
- Cottages in South Bay
- Beach Hotels in South Bay
- Cheap Hotels in South Bay
- South Bay Hotels
- Cheap Hotels in South San Diego
- Luxury Hotels in South San Diego
- South San Diego Hotels
- Lgbt Welcoming Hotels in Terra Nova
- All Inclusive Hotels in Valencia Park
- Flights to Chula Vista
- Flights to San Diego Coast
- Flights to San Ysidro
- Flights to South San Diego
- Flights from Brown Field Municipal
- Flights from Imperial Beach
- Flights from Salt Lake City to San Diego Coast
- Flights from San Diego Coast
- Flights from Chula Vista
- Flights from San Ysidro
- Flights from Atlanta (ATL) to San Diego (SDM)
- Flights from Boston (BOS) to San Diego (SDM)
- Flights from Compton (CPM) to San Diego (SDM)
- Flights from Washington (DCA) to San Diego (SDM)
- Flights from Dallas (DFW) to San Diego (SDM)
- Flights from Ensenada (ESE) to San Diego (SDM)
- Flights from Las Vegas (LAS) to San Diego (SDM)
- Flights from Los Angeles (LAX) to San Diego (SDM)
- Flights from Livermore (LVK) to San Diego (SDM)
- Flights from Miami (MIA) to San Diego (SDM)
- Flights from San Francisco (SFO) to San Diego (SDM)
- Flights from Sydney (SYD) to San Diego (SDM)
- Flights from Vancouver (YVR) to San Diego (SDM)