Otay Mesa West Holidays

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Your Otay Mesa West Holiday

Otay Mesa West is beckoning! Whatever type of adventure you're planning, you can discover more of this neighbourhood with an Otay Mesa West holiday package. Plan enough time on your itinerary to see leading nearby sights such as Kaiser Permanente Otay Mesa Medical Offices during your trip to Otay Mesa West. Whatever your dream Otay Mesa West holiday may look like, you can turn it into reality with Expedia.

Our guide on where to stay in Otay Mesa West

Find the best Otay Mesa West areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa West
US Grant Hotel

Downtown San Diego

3 out of top 10 points of interest in this area
4.5/5(100 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Find hotels in Downtown San Diego

Our pick of the best Otay Mesa West Hotel Deals

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
The price is AU$904 per night from 3 Mar to 4 Mar
AU$904
3 Mar - 4 Mar
includes taxes & fees
8.8/10 Excellent! (3,289 reviews)
Room was very clean and luxurious

Reviewed on 5 Feb 2026

Hard Rock Hotel San Diego
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
The price is AU$311 per night from 1 Mar to 2 Mar
AU$311
1 Mar - 2 Mar
includes taxes & fees
8.6/10 Excellent! (2,402 reviews)
The staff were absolutely incredible!! We loved the hotel, restaurants and amenities!

Reviewed on 7 Feb 2026

Paradise Point Resort & Spa
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
Fully refundableReserve now, pay when you stay
The price is AU$192 per night from 22 Feb to 23 Feb
AU$192
22 Feb - 23 Feb
includes taxes & fees
8.8/10 Excellent! (1,025 reviews)
Totally better than i expected!!

Reviewed on 6 Feb 2026

The DEXTRO Little Italy, BW Premier Collection
See all 6,851 properties in Otay Mesa West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

How much does an Otay Mesa West holiday package cost?
Discover the best of Otay Mesa West from as little as . Choose from a wonderful selection of flights, hotels and rental cars to suit every style and budget. You can score even better deals when you add some experiences or tours to your package.
How do I get a cheap travel package to Otay Mesa West?
Booking an Otay Mesa West holiday package with Expedia is the easiest way to save. We have over 550 partner airlines and 1 000 000 properties across the globe. With such an awesome range to select from, you'll have no trouble putting together your next dream holiday.
Where should I stay in Otay Mesa West?
You'll want to stay where the action is. Many people book hotels around popular attractions, like Las Americas Premium Outlets, North Island Credit Union Amphitheatre and Aquatica.
How far in advance should I book my Otay Mesa West holiday?
Smart travellers will likely want to book early. You can normally start comparing international fares on Expedia up to a year before your intended flight. If you're booking last minute, don't despair. Low prices sometimes appear just weeks before departure dates.
What does an Expedia Otay Mesa West travel package include?
It all depends on what type of getaway you're contemplating. Otay Mesa West holiday deals can include hotels, car rentals and flights. You can mix and match to find the travel package that fits your needs. You can also add on experiences and activities after you've booked to score even bigger discounts.
What should I know before booking an Otay Mesa West travel package?
Get ready to save with an Expedia travel package. Bundle your airfares, rental cars and hotels and pick up fabulous discounts. You're not limited to hotels, though. Book with us and select from beach villas, mountain cabins and everything in between!
Can I choose my airline with an Otay Mesa West Expedia holiday package?
With a holiday package, you're the boss. Whether you'd like to fly to Otay Mesa West in economy or business class, simply pick from the available airline options. Expedia has access to over 550 partner airlines all over the world.
If I'm not able to travel, can I cancel my Otay Mesa West holiday package?
You can. We get that even the best-laid plans can go awry, so we're here to help if you need to make changes to your Otay Mesa West holiday package. You may be able to cancel or change your itinerary for free if you've booked within 24 hours. Your hotel, airline or car rental company may impose a fee if you booked more than 24 hours ago. Head to our Customer Service Portal for further information. Also, be sure to check your itinerary for the nitty-gritty on change fees.

Discover the most popular places to visit in Otay Mesa West

San Diego Zoo which includes a pond, zoo animals and landscape views

San Diego Zoo

One of the largest zoos in America housing around 4000 creatures, San Diego Zoo offers an enchanting and educational experience for visitors of all ages.

San Diego Zoo
Mission Beach featuring tropical scenes, street scenes and a beach

Mission Beach

A seaside village and a popular spot for holiday-makers for over a century, which today still retains its antique charm.

Mission Beach
Disney Wonder Cruise Ship. Halloween on the High Seas. #lifeatexpedia #golden

Port of San Diego

Explore the waterfront in San Diego with a trip to Port of San Diego. Wander the seaside and beautiful beaches in the area.

Port of San Diego

Activities

LEGOLAND® California Resort

LEGOLAND® California Resort

AU$93
per adult
84% of travellers recommend
LEGOLAND® California Resort
San Diego Old Town Trolley Hop-On Hop-Off Tour

San Diego Old Town Trolley Hop-On Hop-Off Tour

AU$80
per adult
94% of travellers recommend
San Diego Old Town Trolley Hop-On Hop-Off Tour
San Diego Whale Watching Tour

San Diego Whale Watching & Dolphin Cruise

AU$103
per adult
88% of travellers recommend
San Diego Whale Watching & Dolphin Cruise
See all activities in San Diego
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.