
Otay Mesa Holidays
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Our guide on where to stay in Otay Mesa

Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Our pick of the best Otay Mesa Hotel Deals

Sheraton San Diego Resort
Yes , nicest hotel I have ever seen
Reviewed on 15 Dec 2025

Lafayette Hotel & Club
Fun place with lots of energy. It is a big party almost all the time. Beware of loud music and this place is not for everyone, but it is very cool!
Reviewed on 15 Dec 2025

The DEXTRO Little Italy, BW Premier Collection
Room was clean with comfortable bed. View facing the habor is interesting.Outdoor facilities is well coming, nice sitting area. There is an adequate gymn, with treadmill , benche and various free weights, all and all fantastic to get a good workout. Staff are courteous and polite. I would stay again.. ...
Reviewed on 13 Dec 2025
Frequently asked questions
Discover the most popular places to visit in Otay Mesa

San Diego Zoo
One of the largest zoos in America housing around 4000 creatures, San Diego Zoo offers an enchanting and educational experience for visitors of all ages.

Port of San Diego
Explore the waterfront in San Diego with a trip to Port of San Diego. Wander the seaside and beautiful beaches in the area.

Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
Activities

Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster
















