Otay Mesa Holidays

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Our guide on where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
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Downtown San Diego

3 out of top 10 points of interest in this area
4.5/5(100 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Find hotels in Downtown San Diego

Our pick of the best Otay Mesa Hotel Deals

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
The price is AU$248 per night from 6 Jan to 7 Jan
AU$248
6 Jan - 7 Jan 2026
includes taxes & fees
8.2/10 Very Good! (3,178 reviews)
Yes , nicest hotel I have ever seen

Reviewed on 15 Dec 2025

Sheraton San Diego Resort
Lafayette Hotel & Club

Lafayette Hotel & Club

4 out of 5
2223 El Cajon Blvd San Diego CA
Fully refundableReserve now, pay when you stay
The price is AU$395 per night from 29 Dec to 30 Dec
AU$395
29 Dec - 30 Dec
includes taxes & fees
9.2/10 Wonderful! (1,336 reviews)
Fun place with lots of energy. It is a big party almost all the time. Beware of loud music and this place is not for everyone, but it is very cool!

Reviewed on 15 Dec 2025

Lafayette Hotel & Club
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
Fully refundableReserve now, pay when you stay
The price is AU$180 per night from 28 Dec to 29 Dec
AU$180
28 Dec - 29 Dec
includes taxes & fees
8.8/10 Excellent! (733 reviews)
Room was clean with comfortable bed. View facing the habor is interesting.Outdoor facilities is well coming, nice sitting area. There is an adequate gymn, with treadmill , benche and various free weights, all and all fantastic to get a good workout. Staff are courteous and polite. I would stay again.. ...

Reviewed on 13 Dec 2025

The DEXTRO Little Italy, BW Premier Collection
See all 4,906 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
All Inclusive Holidays
Cheap Holidays
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Cheap Holidays
beach holidays
Beach Holidays
Beach Holidays

Frequently asked questions

How much does an Otay Mesa holiday package cost?
Starting from as low as , a holiday package is your ticket to cheaper travel. Create your own Otay Mesa escape by choosing from our wide range of hotels, airfares and rental cars.
How do I get a cheap travel package to Otay Mesa?
Our Otay Mesa holiday packages mean plenty of savings for the savvy wanderer. For the best deal, simply bundle your hotel, flights and extras (such as activities) into a neat and tidy package. But impressive bargains are only the start of your next amazing adventure. When you book with Expedia, you'll have more than 550 air carriers and 1 000 000 hotel options all over the world to pick from. No matter your budget or style, there's a package that's perfect for you.
Where should I stay in Otay Mesa?
A getaway to Otay Mesa wouldn't be complete without paying a visit to North Island Credit Union Amphitheatre, Aquatica and White Water Canyon. Spend your evenings close to these tourist attractions and make sightseeing simple.
What are the top hotels in Otay Mesa?
Book a stay at Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel. It's one of this neighbourhood's most sought-after hotels. Another reputable option in Otay Mesa is Quality Suites San Diego Otay Mesa.
How far in advance should I book my Otay Mesa holiday?
Your best bet is to book early. Air carriers typically release flights around a year prior to departure, and this is an ideal opportunity to score some rock-bottom prices. Boss just told you to take your holiday time next month? That's alright! Expedia are never short on fantastic deals to send you on the getaway of your dreams, at a price you can afford.
What does an Expedia Otay Mesa travel package include?
It comes down to what you want. If you're travelling alone, you might decide to bundle flights and hotels. Bringing the entire family to Otay Mesa? A travel package that includes rental cars, flights and hotels might be a better fit. Expedia gives you the flexibility and freedom to tailor-make your travel package.
What should I know before booking an Otay Mesa travel package?
When you book your flights, hotels and car rentals together, you'll land terrific discounts. Whether you're organising an island getaway in a villa or prefer to stay in a cosy apartment in the city, Expedia can help make it happen.
Can I choose my airline with an Otay Mesa Expedia holiday package?
You can, and with over 550 airlines to select from worldwide, you have loads of choice. Look through the available options and find out which airline best suits your needs and budget.
If I'm not able to travel, can I cancel my Otay Mesa holiday package?
Don't worry if you're rethinking your Otay Mesa holiday package — it's possible to change or amend your booking. And if you've booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We get that life can sometimes throw a spanner in the works, so make your way to our Customer Service Portal if that happens. When you're ready to make changes, we're ready to help.

Discover the most popular places to visit in Otay Mesa

San Diego Zoo which includes a pond, zoo animals and landscape views

San Diego Zoo

4.5/5(26 reviews)

One of the largest zoos in America housing around 4000 creatures, San Diego Zoo offers an enchanting and educational experience for visitors of all ages.

San Diego Zoo
Port of San Diego

Port of San Diego

4.5/5(19 reviews)

Explore the waterfront in San Diego with a trip to Port of San Diego. Wander the seaside and beautiful beaches in the area.

Port of San Diego
Petco Park

Petco Park

4.5/5(10 reviews)

Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.

Petco Park

Activities

Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster

Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster

AU$173
per adult
Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster
Crossing Borders: Tijuana Day Trip from San Diego

Crossing Borders: Tijuana Day Trip from San Diego

AU$140
per adult
90% of travellers recommend
Crossing Borders: Tijuana Day Trip from San Diego
secret Tijuana your tour guide

Guided Tour on the Secret City Tijuana

AU$120
per adult
Guided Tour on the Secret City Tijuana
See all activities in San Diego
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.