Otay Mesa Travel Guide
Tourist Guide
Popular places to visit
San Diego Zoo
One of the largest zoos in America housing around 4000 creatures, San Diego Zoo offers an enchanting and educational experience for visitors of all ages.
USS Midway Museum
A popular San Diego attraction where you can get on board the USS Midway and learn more about the realities of Navy life.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and acclaimed art galleries.
Mission Bay
Mission Bay is San Diego’s vast and beautiful outdoor playground with great weather and calm waters that seem made for watersports.
Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
Mission Beach
A seaside village and a popular spot for holiday-makers for over a century, which today still retains its antique charm.
Activities
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
Crossing Borders: Tijuana Day Trip from San Diego
Crossing Borders: Tijuana Day Trip from San Diego
Tijuana: Guided City Tour with Local Food and Beer Tasting
Our pick of the best Otay Mesa Hotel Deals
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
"Everything was goos except the toilet height were for kindergarten way to low for older people"
Reviewed on 2 June 2026
Best Western Seven Seas
"I’ve never had a more horrible experience. The water was hot when I needed it to be cold and it was cold when I needed to be hot. It was loud at night and it was a dingy dirty and looked like something out of a horror movie they were ants randomly crawling up my arm when I was trying to sleep so ..."
Reviewed on 3 June 2026
The Sofia Hotel
"I stayed here many years ago and it has fallen from grace for sure. They used to have a lovely little restaurant which is now gone. The rooms feel like they’re in disrepair, the carpets, the walls, the furniture, the paint the tiles everything just feels so shabby and old. I would not stay here ..."
Reviewed on 3 June 2026
Hard Rock Hotel San Diego
"The location was great"
Reviewed on 3 June 2026
Wyndham San Diego Bayside
"Nice room hotel staff very friendly enjoyed our stay."
Reviewed on 3 June 2026
Days Inn by Wyndham San Diego Hotel Circle
"Great little place to stay. We went to sea world from Orange County and I didn’t want to drive back at night so we stayed just for the night. Room is just what you would expect. The highlight was the heated pool. San Diego is always cold at night so it was perfect for the kids."
Reviewed on 2 June 2026
Other neighbourhoods around Otay Mesa
East Village
Travellers choose East Village for its great bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and USS Midway Museum are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.
Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
Hillcrest
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.
Otay Mesa Travel Guide
Explore a world of travel with Expedia
- B&B in Bonita
- Luxury Hotels in Bonita
- Bonita Hotels
- Hotels near Brown Field Municipal
- Castle Park Hotels
- Apartments in Chula Vista
- Hotels near Chula Vista Center
- Hotels near Chula Vista Elite Athlete Training Center
- Lgbt Welcoming Hotels in Chula Vista
- Chula Vista Hotels
- Motels in Chula Vista
- Resort in Chula Vista
- Lgbt Welcoming Hotels in Coronado Cays
- Lgbt Welcoming Hotels in Eastlake
- Lgbt Welcoming Hotels in Eastlake Greens
- Condo Rentals in Imperial Beach
- Beach Hotels in Imperial Beach
- Imperial Beach Hotels
- Resort in Imperial Beach
- Cheap Hotels in National City
- National City Hotels
- Hotels near North Island Credit Union Amphitheatre
- Ocean View Hills Hotels
- Cheap Hotels in Otay Mesa West
- Otay Mesa West Hotels
- Hotels near Palm Ave Trolley Station
- Paradise Hills Hotels
- San Diego Hotels
- Hotels near San Ysidro Border Crossing
- All Inclusive Hotels in San Ysidro
- San Ysidro Hotels
- Resort in San Ysidro
- Hotels near San Ysidro Transit Center Station
- Skyline Hotels
- Cottages in South Bay
- Beach Hotels in South Bay
- Cheap Hotels in South Bay
- South Bay Hotels
- Cheap Hotels in South San Diego
- Luxury Hotels in South San Diego
- South San Diego Hotels
- Lgbt Welcoming Hotels in Terra Nova
- Flights to Chula Vista
- Flights to San Ysidro
- Flights to South San Diego
- Flights from Brown Field Municipal
- Flights from Imperial Beach
- Flights from Chula Vista
- Flights from San Ysidro
- Flights from Atlanta (ATL) to San Diego (SDM)
- Flights from Boston (BOS) to San Diego (SDM)
- Flights from Compton (CPM) to San Diego (SDM)
- Flights from Washington (DCA) to San Diego (SDM)
- Flights from Dallas (DFW) to San Diego (SDM)
- Flights from Ensenada (ESE) to San Diego (SDM)
- Flights from Las Vegas (LAS) to San Diego (SDM)
- Flights from Los Angeles (LAX) to San Diego (SDM)
- Flights from Livermore (LVK) to San Diego (SDM)
- Flights from Miami (MIA) to San Diego (SDM)
- Flights from San Francisco (SFO) to San Diego (SDM)
- Flights from Sydney (SYD) to San Diego (SDM)
- Flights from Vancouver (YVR) to San Diego (SDM)
- Visit Cardiff-by-the-Sea
- Visit Carlsbad
- Visit Catalina Island
- Visit Otay
- Visit Coronado
- Visit El Cajon
- Visit Encinitas
- Visit Imperial Beach
- Visit Jacumba
- Visit Julian
- Visit Country Club
- Visit La Jolla Village
- Visit La Jolla
- Len Moore Skate Park
- North Island Credit Union Amphitheatre
- Visit Townsite
- Visit Rancho Santa Fe
- Visit Clairemont
- Visit San Diego Coast
- Visit Gaslamp Quarter
- Visit Hillcrest
- Visit Logan Heights
- Visit Marina District
- Visit Mira Mesa
- Visit Miramar
- Visit Mission Valley
- Visit Ocean Beach
- Visit Pacific Beach
- Visit Pacific Highlands Ranch
- Visit Point Loma
- Visit Roseville - Fleet Ridge
- Visit Sunset Cliffs
- Visit San Diego
- San Ysidro Border Crossing
