Luxury Hotels & Resorts in Serra Mesa from AU$131

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Serra Mesa Luxury Hotels

Our top choices for Serra Mesa luxury hotels

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
El Cajon
9.4 out of 10, Exceptional, (1,928 reviews)
"Clean luxury amenities, very safe secure access."
United States
William
The price is AU$169
includes taxes & fees
26 May - 27 May
Sycuan Casino Resort

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
University Heights
9.4 out of 10, Exceptional, (1,657 reviews)
"The blend of historic charm with modern luxury is incredible"
United States
Haydee
The price is AU$394
includes taxes & fees
26 May - 27 May
Lafayette Hotel & Club

Loews Coronado Bay Resort

Loews Coronado Bay Resort
4.0 star property
Silver Strand
8.8 out of 10, Excellent, (1,089 reviews)
  • cleanliness
    Luxurious beachfront retreat features spa sanctuary, 3 outdoor pools, and premium pampering.
"Wonderful place to stay , staff was great facilities were wonderful , views were incredible !!! "
United States
christine
The price is AU$427
includes taxes & fees
25 May - 26 May
Loews Coronado Bay Resort

Fairmont Grand Del Mar

Fairmont Grand Del Mar
5.0 star property
Carmel Valley
9.4 out of 10, Exceptional, (978 reviews)
  • cleanliness
    Mediterranean luxury meets impeccable service at this 5-star spa resort with championship golf, multiple pools, and elegant dining venues.
"This was a very nice place, felt comfortable, clean and great staff. Things that could have made this place perfect. The room was quite a trek we were put in the last room which felt like a mile hike from the lounge and front desk. I liked the privacy tho and the view out of the balcony. In the morning I would have like more than one caffeinated coffee pods, as we had mostly decaf coffee in room for the morning. We called reception and they delivered promptly. Also; one of the lamps didn’t have...
United States
Karina
The price is AU$760
includes taxes & fees
21 May - 22 May
Fairmont Grand Del Mar

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay
8.6 out of 10, Excellent, (1,442 reviews)
"And above all that is luxurious i definitely recommend"
United States
Sherine
The price is AU$345
includes taxes & fees
25 May - 26 May
San Diego Mission Bay Resort

Pier South Resort, Autograph Collection by Marriott

Pier South Resort, Autograph Collection by Marriott
4.0 star property
Imperial Beach
8.4 out of 10, Very good, (1,003 reviews)
"Awesome beach view and Friendly staff."
United States
Gabriel
The price is AU$383
includes taxes & fees
21 May - 22 May
Pier South Resort, Autograph Collection by Marriott

Inn At Rancho Santa Fe

Inn At Rancho Santa Fe
5.0 star property
Covenant
9.6 out of 10, Exceptional, (161 reviews)
  • cleanliness
    Luxurious spa escape with fine dining and pool indulgence in charming Rancho Santa Fe for a truly pampered boutique experience.
"Every luxurious amenity was provided for our comfort."
United States
Susanne
The price is AU$595
includes taxes & fees
7 June - 8 June
Inn At Rancho Santa Fe

Rancho Bernardo Inn

Rancho Bernardo Inn
4.0 star property
Rancho Bernardo
8.8 out of 10, Excellent, (1,000 reviews)
"Properly is a little older, nothing luxurious, but definitely comfortable for families looking for something easy and convenient."
United States
FABIOLA
The price is AU$461
includes taxes & fees
21 May - 22 May
Rancho Bernardo Inn

Rancho Valencia Resort and Spa

Rancho Valencia Resort and Spa
5.0 star property
Rancho Santa Fe
9.8 out of 10, Exceptional, (146 reviews)
  • cleanliness
    Luxurious retreat boasts full-service spa, 2 pools, and tennis courts in serene suburban setting.
"Tennis courts and staff are top notch. Rooms are very large and luxurious. Staff is super accomodating and make you feel special. All in all, we felt like royalty."
United States
Rachel
The price is AU$2,015
includes taxes & fees
10 June - 11 June
Rancho Valencia Resort and Spa

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
Harbor Island
8.4 out of 10, Very good, (3,534 reviews)
"My stay at the Sheraton San Diego Hotel & Marina exceeded every expectation and provided the perfect mix of relaxation, luxury, and convenience."
United States
Mark
The price is AU$273
includes taxes & fees
25 May - 26 May
Sheraton San Diego Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Serra Mesa Hotel Reviews

Frequently asked questions

Are you looking for a luxury hotel for your Serra Mesa holiday?
Use Expedia to arrange your flight to San Diego, CA (MYF-Montgomery Field) airport or San Diego, CA (SAN-San Diego Intl.) airport, and then select from a variety of places to stay that will deliver the luxury you want. Amenities are important when you plan a trip, so we make it easy to get what you'd like to make your stay special. If you want an upscale hotel with fine dining, a spa or several swimming pools, Expedia can assist you in finding the best luxury hotel experience that Serra Mesa has to offer. Serra Mesa has some interesting things to see and do including Stadium Golf Center & Batting Cages, so you might want to take in the local sights during your visit.
What's there to see and do in Serra Mesa?
Take in the sights and attractions that Serra Mesa offers with a visit to San Diego Zoo, Mission Bay and Port of San Diego. If you have some spare time during your trip, you might want to check out USS Midway Museum and Petco Park.

Explore a world of travel with Expedia