Serra Mesa Holidays

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Your Serra Mesa Holiday

Take the stress and hassle out of organising your next escape with a Serra Mesa holiday package. Immerse yourself in the sights and sounds of this captivating neighbourhood and experience everything it has to offer. Your trip to Serra Mesa wouldn't be complete without a visit to big-name attractions nearby such as Snapdragon Stadium, Fashion Valley Mall and Mission Valley Mall. No matter what your dream Serra Mesa holiday may look like, you can make it a reality with Expedia.

Our guide on where to stay in Serra Mesa

Find the best Serra Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Serra Mesa
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Downtown San Diego

2 out of top 10 points of interest in this area
4.5/5(100 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Find hotels in Downtown San Diego

Our pick of the best Serra Mesa Hotel Deals

Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is AU$223 per night from 17 Aug to 18 Aug
AU$223
17 Aug - 18 Aug
includes taxes & fees
8/10 Very Good! (1,885 reviews)
"It was a nice, quiet area. Perfect for a lowkey getaway"

Reviewed on 20 Jul. 2025

Handlery Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is AU$298 per night from 27 July to 28 July
AU$298
27 July - 28 July
includes taxes & fees
8.2/10 Very Good! (5,767 reviews)
"Walking distance from everything"

Reviewed on 22 Jul. 2025

Wyndham San Diego Bayside
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is AU$433 per night from 28 July to 29 July
AU$433
28 July - 29 July
includes taxes & fees
9/10 Wonderful! (2,791 reviews)
"Enjoyed my stay at this place. Friendly and courteous staff"

Reviewed on 21 Jul. 2025

Manchester Grand Hyatt San Diego
See all 8,845 properties in Serra Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays

All Inclusive Holidays

All Inclusive Holidays
Cheap Holidays

Cheap Holidays

Cheap Holidays
beach holidays

Beach Holidays

Beach Holidays

Frequently asked questions

How much does a Serra Mesa holiday package cost?
Be ready to book, because a trip to Serra Mesa starts from just . When you bundle your hotels, flights and car rentals into a package, you'll land the lowest prices.
How do I get a cheap travel package to Serra Mesa?
One of the simplest ways to save dollars (and time) is to bundle your bookings with Expedia. Flights, hotels, activities and rental cars — we've got everything you need. Pick the combination that best suits you and watch your savings pile up. Of course, a travel package is never one-size-fits-all. That's why we offer more than 550 partner airlines and 1 000 000 hotel options worldwide, which lets you customize your Serra Mesa holiday.
Where should I stay in Serra Mesa?
Most visitors to Serra Mesa put both San Diego Zoo and Balboa Park on their itineraries. Why not go for a hotel that's close to these fantastic attractions?
What are the top hotels in Serra Mesa?
Get your escape off to an excellent start by locking in a room at Central Location - 3br/2ba. Stay Weekly. Clean. It's one of most sought-after properties in Serra Mesa. Another comfortable option is Newly Remodeled Beautiful Beach Bound And Centrally Located San Diego Home.
How far in advance should I book my Serra Mesa holiday?
It's difficult to pick the best time for airfares, but we normally say the earlier, the better. Most international flights on Expedia become available up to 12 months in advance. If you're booking late, fear not. Budget prices appear from time to time just weeks before departure dates.
What does an Expedia Serra Mesa travel package include?
From flights and hotels to rental cars, Expedia can help you craft a Serra Mesa package that's perfect for you. Holidaying for a few weeks? Consider a flight, hotel and rental car bundle. If your break is short, a flight and hotel deal could be what you're after. Experiences can also be added once you've made your booking. Our travel packages make it a cinch to plan and save.
What should I know before booking a Serra Mesa travel package?
You can save a tidy sum by combining your hotels, airfares and rental cars. Once you've made your booking, you can add on things like day tours or experiences. Your next unforgettable holiday is only a few clicks away.
Can I choose my airline with a Serra Mesa Expedia holiday package?
With a holiday package, you're the one in charge. Whether you'd like to fly to Serra Mesa in economy or first class, simply choose from the available airline options. Expedia has access to over 550 partner airlines all over the world.
If I'm not able to travel, can I cancel my Serra Mesa holiday package?
Plans can change in the blink of an eye, so yes. You may be able to cancel or alter your Serra Mesa holiday package at no cost if you've booked in the last 24 hours. For bookings made more than 24 hours ago, you can still make the necessary changes, but your car rental company, hotel or airline may impose a charge. Want more information? Check out our Customer Service Portal. We'll help make sure your getaway goes off without a hitch.

Discover the most popular places to visit in Serra Mesa

San Diego Zoo which includes a pond, zoo animals and landscape views

San Diego Zoo

One of the largest zoos in America housing around 4000 creatures, San Diego Zoo offers an enchanting and educational experience for visitors of all ages.

San Diego Zoo
Petco Park

Petco Park

Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.

Petco Park
Mission Beach

Mission Beach

A seaside village and a popular spot for holiday-makers for over a century, which today still retains its antique charm.

Mission Beach

Activities

LEGOLAND® California Resort

LEGOLAND® California Resort

AU$121
per adult
82% of travellers recommend
LEGOLAND® California Resort
San Diego City Lights Night Tour

San Diego City Lights Night Tour

AU$70
per adult
96% of travellers recommend
San Diego City Lights Night Tour
San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway

San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway

AU$188
per adult
86% of travellers recommend
San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway
See all activities in San Diego
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.