A residential area with houses, roads, and a hilly landscape.

Serra Mesa Hotels, San Diego

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Our top choices for Serra Mesa hotels

Valli Hi Motel

Valli Hi Motel
2.5 star property
28.3 km from Serra Mesa
8.4 out of 10, Very good, (1,026 reviews)
"Great place to stay."
United States
Allan
The price is AU$141
includes taxes & fees
5 July - 6 July
Valli Hi Motel

Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG
3.5 star property
6.4 km from Serra Mesa
8.4 out of 10, Very good, (1,022 reviews)
"great stay"
United States
David
The price is AU$203
includes taxes & fees
27 July - 28 July
Crowne Plaza San Diego - Mission Valley by IHG

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
10.1 km from Serra Mesa
8.4 out of 10, Very good, (3,528 reviews)
"Great location and shuttle service to and from the airport."
Canada
Malinda
The price is AU$354
includes taxes & fees
6 July - 7 July
Sheraton San Diego Resort

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
5.3 km from Serra Mesa
9.4 out of 10, Exceptional, (1,773 reviews)
"Beautiful hotel"
United States
Cuauhtemoc
The price is AU$430
includes taxes & fees
6 July - 7 July
Lafayette Hotel & Club

Heritage Inn San Diego

Heritage Inn San Diego
2.0 star property
9.1 km from Serra Mesa
7.2 out of 10, Good, (1,595 reviews)
"Great stay"
United States
Alyssa
The price is AU$120
includes taxes & fees
6 July - 7 July
Heritage Inn San Diego

GreenTree Inn San Diego Mission Bay

GreenTree Inn San Diego Mission Bay
2.5 star property
Pacific Beach, 7.3 km from Serra Mesa
8.0 out of 10, Very good, (2,209 reviews)
"THE BED WAS SO SOFT ROOM WAS SO CLEAN BREAKFAST WAS GREAT AND THE PRICE WAS KILLER FOR THE LOCATION really a great place to stay"
United States
Tyson
The price is AU$214
includes taxes & fees
7 July - 8 July
GreenTree Inn San Diego Mission Bay

Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
7.9 km from Serra Mesa
9.2 out of 10, Wonderful, (1,075 reviews)
"Staff was so great nice rooms really great stay"
United States
Amelia
The price is AU$262
includes taxes & fees
7 July - 8 July
Holiday Inn Express San Diego Airport - Old Town by IHG

The Alcala Hotel Mission Valley/Seaworld

The Alcala Hotel Mission Valley/Seaworld
2.5 star property
6.6 km from Serra Mesa
8.0 out of 10, Very good, (322 reviews)
"Staff was great and rooms were nice."
United States
Brittney
The price is AU$175
includes taxes & fees
6 July - 7 July
The Alcala Hotel Mission Valley/Seaworld

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
28.1 km from Serra Mesa
8.8 out of 10, Excellent, (1,315 reviews)
"The breakfast was great, the staff was helpful, and the room was clean and spacious!"
United States
Christopher
The price is AU$202
includes taxes & fees
19 July - 20 July
Best Western Americana Inn

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.8 km from Serra Mesa
9.4 out of 10, Exceptional, (1,992 reviews)
"Always a great stay"
United States
Jeanette
The price is AU$202
includes taxes & fees
12 July - 13 July
Sycuan Casino Resort

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
9 km from Serra Mesa
7.4 out of 10, Good, (4,156 reviews)
"Clean room, staff was very helpful, parking was easy and accessible!"
United States
Hector
The price is AU$214
includes taxes & fees
3 Aug - 4 Aug
Wyndham Garden San Diego Near SeaWorld

Hotel Z

Hotel Z
3.0 star property
Gaslamp Quarter, 10.4 km from Serra Mesa
9.4 out of 10, Exceptional, (1,037 reviews)
"Nice location"
United States
Rebecca
The price is AU$235
includes taxes & fees
2 Aug - 3 Aug
Hotel Z

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
9.9 km from Serra Mesa
8.4 out of 10, Very good, (6,234 reviews)
"Great place to stay if visiting san diego recommend"
United States
Carlos
The price is AU$305
includes taxes & fees
20 July - 21 July
Wyndham San Diego Bayside

California Suites Hotel

California Suites Hotel
2.0 star property
4.8 km from Serra Mesa
7.8 out of 10, Good, (2,678 reviews)
"Really great hotel for the price. We will definitely be staying here again with our little ones"
United States
Cristina
The price is AU$173
includes taxes & fees
2 Aug - 3 Aug
California Suites Hotel

Best Western Plus Hacienda Hotel Old Town

Best Western Plus Hacienda Hotel Old Town
3.0 star property
Old Town San Diego, 7.6 km from Serra Mesa
8.4 out of 10, Very good, (2,061 reviews)
"Excellent stay! Beautiful grounds and friendly staff."
United States
Rebecca
The price is AU$264
includes taxes & fees
5 July - 6 July
Best Western Plus Hacienda Hotel Old Town

Comfort Inn Sea World Area

Comfort Inn Sea World Area
3.5 star property
8.2 km from Serra Mesa
8.6 out of 10, Excellent, (3,846 reviews)
"Nice staff and good breakfast"
United States
Fernando
The price is AU$212
includes taxes & fees
3 Aug - 4 Aug
Comfort Inn Sea World Area

Bahia Resort Hotel

Bahia Resort Hotel
3.5 star property
Central Mission Beach, 10.7 km from Serra Mesa
8.8 out of 10, Excellent, (2,213 reviews)
"Beachfront rooms were great."
United States
Jon
The price is AU$527
includes taxes & fees
6 July - 7 July
Bahia Resort Hotel

Comfort Inn San Diego Airport At The Harbor

Comfort Inn San Diego Airport At The Harbor
3.5 star property
11.9 km from Serra Mesa
7.8 out of 10, Good, (1,563 reviews)
"harbor view n breakfast were good n friendly staff"
United States
Nercy
The price is AU$207
includes taxes & fees
3 Aug - 4 Aug
Comfort Inn San Diego Airport At The Harbor

Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy
4.0 star property
Little Italy, 9.3 km from Serra Mesa
9.0 out of 10, Wonderful, (766 reviews)
"Great location to"
United States
Nestor
The price is AU$279
includes taxes & fees
19 July - 20 July
Courtyard by Marriott San Diego Downtown Little Italy

The Encinitan Hotel & Suites

The Encinitan Hotel & Suites
3.0 star property
30.8 km from Serra Mesa
8.2 out of 10, Very good, (1,582 reviews)
"Great place to stay"
United States
joshua
The price is AU$314
includes taxes & fees
6 July - 7 July
The Encinitan Hotel & Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our guide on where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

Get to Pacific Beach after the sun goes down because this is the place to be in San Diego for partying.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Ocean Beach

With a secluded sunbathing beach, swimming-only beach, special surf beach, volleyball beach and dog beach, San Diego’s “OB” sure takes beaches seriously.

Top Serra Mesa Hotel Reviews

Recent Reviews in Serra Mesa

Frequently asked questions

What's it like in Serra Mesa?
Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
How many hotels can I expect to find in the Serra Mesa area?
Expedia has 39 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.
What can I see and do in this San Diego neighbourhood?
Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Snapdragon Stadium and Sharp Learning Resource Center are also worth a stop.

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