Serra Mesa Hotels, San Diego

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Our top choices for Serra Mesa hotels

Urban Boutique Hotel

Urban Boutique Hotel
3.0 star property
Little Italy, 9.3 km from Serra Mesa
8.6 out of 10, Excellent, (1,270 reviews)
"Great location, clean rooms, friendly staff"
United States
Beth
Urban Boutique Hotel

Gaslamp Plaza Suites

Gaslamp Plaza Suites
3.5 star property
Gaslamp Quarter, 10 km from Serra Mesa
9.0 out of 10, Wonderful, (1,031 reviews)
"Clean quiet friendly helpful staff convenient location will stay there again"
United States
David
The price is AU$193
includes taxes & fees
8 Mar - 9 Mar
Gaslamp Plaza Suites

GreenTree Inn San Diego Mission Bay

GreenTree Inn San Diego Mission Bay
2.5 star property
Pacific Beach, 7.3 km from Serra Mesa
8.0 out of 10, Very good, (1,963 reviews)
"Great stay"
United States
Lizeth
The price is AU$157
includes taxes & fees
10 Mar - 11 Mar
GreenTree Inn San Diego Mission Bay

La Pensione Hotel

La Pensione Hotel
3.0 star property
Little Italy, 9.3 km from Serra Mesa
8.6 out of 10, Excellent, (1,923 reviews)
"Great location and staff "
United States
morgan
The price is AU$216
includes taxes & fees
1 Apr - 2 Apr
La Pensione Hotel

Fairfield Inn & Suites San Diego Old Town

Fairfield Inn & Suites San Diego Old Town
3.0 star property
Old Town San Diego, 7.8 km from Serra Mesa
8.8 out of 10, Excellent, (1,013 reviews)
"Great location, clean rooms, good breakfast"
United States
Jingyi
The price is AU$233
includes taxes & fees
29 Mar - 30 Mar
Fairfield Inn & Suites San Diego Old Town

Heritage Inn San Diego

Heritage Inn San Diego
2.0 star property
9.1 km from Serra Mesa
7.4 out of 10, Good, (1,307 reviews)
"Clean room, staff was great during check in and checking out. "
United States
Amber
The price is AU$102
includes taxes & fees
24 Mar - 25 Mar
Heritage Inn San Diego

Ash&9th

Ash&9th
2.0 star property
9.4 km from Serra Mesa
8.2 out of 10, Very good, (390 reviews)
"Great location… stuff was really friendly "
United States
Aurora
The price is AU$131
includes taxes & fees
6 Apr - 7 Apr
Ash&9th

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
9 km from Serra Mesa
7.4 out of 10, Good, (4,185 reviews)
"Good location friendly staff"
United States
Anya
The price is AU$154
includes taxes & fees
12 Mar - 13 Mar
Wyndham Garden San Diego Near SeaWorld

SureStay Hotel by Best Western San Diego Pacific Beach

SureStay Hotel by Best Western San Diego Pacific Beach
2.5 star property
Pacific Beach, 7.3 km from Serra Mesa
8.0 out of 10, Very good, (1,551 reviews)
"Room was nice, clean, staff was friendly, "
United States
philip
The price is AU$152
includes taxes & fees
9 Mar - 10 Mar
SureStay Hotel by Best Western San Diego Pacific Beach

Comfort Inn Sea World Area

Comfort Inn Sea World Area
3.5 star property
8.2 km from Serra Mesa
8.6 out of 10, Excellent, (3,443 reviews)
"Nice beds and breakfast, really convenient "
Canada
Margarita
The price is AU$160
includes taxes & fees
12 Mar - 13 Mar
Comfort Inn Sea World Area

The Beau Hotel Gaslamp Quarter San Diego

The Beau Hotel Gaslamp Quarter San Diego
3.0 star property
Gaslamp Quarter, 9.9 km from Serra Mesa
9.0 out of 10, Wonderful, (631 reviews)
"Clean room, friendly staff, great location."
United States
Bruce
The price is AU$244
includes taxes & fees
6 Apr - 7 Apr
The Beau Hotel Gaslamp Quarter San Diego

Westgate Hotel

Westgate Hotel
4.5 star property
9.9 km from Serra Mesa
9.2 out of 10, Wonderful, (1,011 reviews)
"Great stay"
United States
ESMERALDA
Westgate Hotel

The Sofia Hotel

The Sofia Hotel
3.5 star property
10 km from Serra Mesa
8.6 out of 10, Excellent, (1,806 reviews)
"Great hotel "
United States
Alexander
The Sofia Hotel

Ocean Villa Inn

Ocean Villa Inn
2.5 star property
Ocean Beach, 11.7 km from Serra Mesa
8.0 out of 10, Very good, (1,191 reviews)
"Beds are super comfy clean and renovated"
United States
Esmeralda
Ocean Villa Inn

Sea Harbor Hotel

Sea Harbor Hotel
2.0 star property
12.2 km from Serra Mesa
8.6 out of 10, Excellent, (1,009 reviews)
"Super clean rooms and a great location "
United States
Mark
The price is AU$176
includes taxes & fees
8 Mar - 9 Mar
Sea Harbor Hotel

The Bristol Hotel San Diego

The Bristol Hotel San Diego
3.5 star property
9.9 km from Serra Mesa
8.6 out of 10, Excellent, (1,516 reviews)
"Great stay, great location, great staff."
United States
Jodie
The price is AU$233
includes taxes & fees
8 Mar - 9 Mar
The Bristol Hotel San Diego

La Quinta Inn & Suites by Wyndham San Diego Mission Bay

La Quinta Inn & Suites by Wyndham San Diego Mission Bay
3.0 star property
North Pacific Beach, 7.4 km from Serra Mesa
8.0 out of 10, Very good, (1,488 reviews)
"Great staff, clean rooms "
United States
Hala
The price is AU$188
includes taxes & fees
8 Mar - 9 Mar
La Quinta Inn & Suites by Wyndham San Diego Mission Bay

Comfort Inn San Diego Airport At The Harbor

Comfort Inn San Diego Airport At The Harbor
3.5 star property
11.9 km from Serra Mesa
7.8 out of 10, Good, (1,335 reviews)
"Great room, clean property and courteous staff"
United States
Reginald D.
The price is AU$161
includes taxes & fees
6 Apr - 7 Apr
Comfort Inn San Diego Airport At The Harbor

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
3.0 star property
Gaslamp Quarter, 10.6 km from Serra Mesa
9.0 out of 10, Wonderful, (1,286 reviews)
"Clean room, friendly staff, great location Very affordable rate Good breakfast variety "
United States
Mary
The price is AU$238
includes taxes & fees
2 Apr - 3 Apr
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego
3.0 star property
Gaslamp Quarter, 10.4 km from Serra Mesa
9.4 out of 10, Exceptional, (1,008 reviews)
"Great location and stay. "
United States
Simran
The price is AU$225
includes taxes & fees
6 Apr - 7 Apr
Staypineapple, Hotel Z, Gaslamp San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our guide on where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

Get to Pacific Beach after the sun goes down because this is the place to be in San Diego for partying.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Ocean Beach

With a secluded sunbathing beach, swimming-only beach, special surf beach, volleyball beach and dog beach, San Diego’s “OB” sure takes beaches seriously.

Top Serra Mesa Hotel Reviews

Frequently asked questions

What's it like in Serra Mesa?
Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
How many hotels can I expect to find in the Serra Mesa area?
Expedia has 37 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.
What can I see and do in this San Diego neighbourhood?
Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.

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