Serra Mesa Hotels, San Diego

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Serra Mesa hotels

Urban Boutique Hotel

Urban Boutique Hotel
3.0 star property
Little Italy, 9.3 km from Serra Mesa
8.6 out of 10, Excellent, (1,263 reviews)
"Great location, clean rooms, friendly staff"
United States
Beth
The price is AU$242
includes taxes & fees
12 Mar - 13 Mar
Urban Boutique Hotel

Gaslamp Plaza Suites

Gaslamp Plaza Suites
3.5 star property
Gaslamp Quarter, 10 km from Serra Mesa
9.0 out of 10, Wonderful, (1,027 reviews)
"Clean quiet friendly helpful staff convenient location will stay there again"
United States
David
The price is AU$191
includes taxes & fees
8 Mar - 9 Mar
Gaslamp Plaza Suites

GreenTree Inn San Diego Mission Bay

GreenTree Inn San Diego Mission Bay
2.5 star property
Pacific Beach, 7.3 km from Serra Mesa
8.0 out of 10, Very good, (1,955 reviews)
"Great stay"
United States
Lizeth
The price is AU$156
includes taxes & fees
8 Mar - 9 Mar
GreenTree Inn San Diego Mission Bay

La Pensione Hotel

La Pensione Hotel
3.0 star property
Little Italy, 9.3 km from Serra Mesa
8.6 out of 10, Excellent, (1,916 reviews)
"Great location and staff "
United States
morgan
La Pensione Hotel

Heritage Inn San Diego

Heritage Inn San Diego
2.0 star property
9.1 km from Serra Mesa
7.4 out of 10, Good, (1,295 reviews)
"Clean room, staff was great during check in and checking out. "
United States
Amber
The price is AU$100
includes taxes & fees
24 Mar - 25 Mar
Heritage Inn San Diego

Ash&9th

Ash&9th
2.0 star property
9.4 km from Serra Mesa
8.4 out of 10, Very good, (379 reviews)
"Great location… stuff was really friendly "
United States
Aurora
The price is AU$137
includes taxes & fees
12 Mar - 13 Mar
Ash&9th

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
9 km from Serra Mesa
7.4 out of 10, Good, (4,177 reviews)
"Good location friendly staff"
United States
Anya
The price is AU$144
includes taxes & fees
4 Mar - 5 Mar
Wyndham Garden San Diego Near SeaWorld

SureStay Hotel by Best Western San Diego Pacific Beach

SureStay Hotel by Best Western San Diego Pacific Beach
2.5 star property
Pacific Beach, 7.3 km from Serra Mesa
8.0 out of 10, Very good, (1,547 reviews)
"Room was nice, clean, staff was friendly, "
United States
philip
The price is AU$136
includes taxes & fees
4 Mar - 5 Mar
SureStay Hotel by Best Western San Diego Pacific Beach

Comfort Inn Sea World Area

Comfort Inn Sea World Area
3.5 star property
8.2 km from Serra Mesa
8.6 out of 10, Excellent, (3,430 reviews)
"Nice beds and breakfast, really convenient "
Canada
Margarita
The price is AU$158
includes taxes & fees
10 Mar - 11 Mar
Comfort Inn Sea World Area

The Sofia Hotel

The Sofia Hotel
3.5 star property
10 km from Serra Mesa
8.6 out of 10, Excellent, (1,794 reviews)
"Great hotel "
United States
Alexander
The price is AU$233
includes taxes & fees
11 Mar - 12 Mar
The Sofia Hotel

The Beau Downtown San Diego Gaslamp Quar

The Beau Downtown San Diego Gaslamp Quar
3.0 star property
Gaslamp Quarter, 9.9 km from Serra Mesa
8.8 out of 10, Excellent, (625 reviews)
"Clean room, friendly staff, great location."
United States
Bruce
The price is AU$251
includes taxes & fees
9 Mar - 10 Mar
The Beau Downtown San Diego Gaslamp Quar

Westgate Hotel

Westgate Hotel
4.5 star property
9.9 km from Serra Mesa
9.2 out of 10, Wonderful, (1,007 reviews)
"Great stay"
United States
ESMERALDA
The price is AU$265
includes taxes & fees
13 Mar - 14 Mar
Westgate Hotel

Ocean Villa Inn

Ocean Villa Inn
2.5 star property
Ocean Beach, 11.7 km from Serra Mesa
8.0 out of 10, Very good, (1,187 reviews)
"Beds are super comfy clean and renovated"
United States
Esmeralda
Ocean Villa Inn

Sea Harbor Hotel

Sea Harbor Hotel
2.0 star property
12.2 km from Serra Mesa
8.6 out of 10, Excellent, (1,007 reviews)
"Super clean rooms and a great location "
United States
Mark
Sea Harbor Hotel

The Bristol Hotel San Diego

The Bristol Hotel San Diego
3.5 star property
9.9 km from Serra Mesa
8.6 out of 10, Excellent, (1,513 reviews)
"Great stay, great location, great staff."
United States
Jodie
The price is AU$230
includes taxes & fees
8 Mar - 9 Mar
The Bristol Hotel San Diego

Comfort Inn San Diego Airport At The Harbor

Comfort Inn San Diego Airport At The Harbor
3.5 star property
11.9 km from Serra Mesa
7.8 out of 10, Good, (1,330 reviews)
"Spotless! Very kind and attentive staff at checkin! Very impressed and will be back! "
United States
Michelle
The price is AU$174
includes taxes & fees
10 Mar - 11 Mar
Comfort Inn San Diego Airport At The Harbor

La Quinta Inn & Suites by Wyndham San Diego Mission Bay

La Quinta Inn & Suites by Wyndham San Diego Mission Bay
3.0 star property
North Pacific Beach, 7.4 km from Serra Mesa
8.0 out of 10, Very good, (1,484 reviews)
"Great staff, clean rooms "
United States
Hala
The price is AU$176
includes taxes & fees
4 Mar - 5 Mar
La Quinta Inn & Suites by Wyndham San Diego Mission Bay

Best Western Yacht Harbor Hotel

Best Western Yacht Harbor Hotel
2.5 star property
11.8 km from Serra Mesa
8.6 out of 10, Excellent, (1,756 reviews)
"Well stay again love the location"
United States
Lynette
The price is AU$176
includes taxes & fees
5 Mar - 6 Mar
Best Western Yacht Harbor Hotel

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
3.0 star property
Gaslamp Quarter, 10.6 km from Serra Mesa
9.0 out of 10, Wonderful, (1,280 reviews)
"Clean room, friendly staff, great location Very affordable rate Good breakfast variety "
United States
Mary
The price is AU$234
includes taxes & fees
3 Apr - 4 Apr
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego
3.0 star property
Gaslamp Quarter, 10.4 km from Serra Mesa
9.4 out of 10, Exceptional, (1,006 reviews)
"Great location and stay. "
United States
Simran
The price is AU$239
includes taxes & fees
3 Apr - 4 Apr
Staypineapple, Hotel Z, Gaslamp San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our guide on where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

Get to Pacific Beach after the sun goes down because this is the place to be in San Diego for partying.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Ocean Beach

With a secluded sunbathing beach, swimming-only beach, special surf beach, volleyball beach and dog beach, San Diego’s “OB” sure takes beaches seriously.

Top Serra Mesa Hotel Reviews

Frequently asked questions

What's it like in Serra Mesa?
Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
How many hotels can I expect to find in the Serra Mesa area?
Expedia has 37 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.
What can I see and do in this San Diego neighbourhood?
Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.

Explore a world of travel with Expedia