Beginning of main content

Book on the go and pay later.

Search over 1,000,000 properties worldwide and 550 airlines worldwide.

Search over a million flights, hotels, packages, and more

No Expedia cancellation fee to change or cancel almost any hotel reservation.


10 Best Hotels in La Mesa

See all 2,818 properties in La Mesa

Estimated price for 1 night/2 adults

Lodge of La Mesa (A Quiet Hotel For Adults Only)

Lodge of La Mesa (A Quiet Hotel For Adults Only)

7911 University Ave, La Mesa, CA
Lodge of La Mesa (A Quiet Hotel For Adults Only)
  • Free Cancellation
  • Reserve now, pay when you stay
2.0 out of 5.0
 
 

Situated in La Mesa, this golf hotel is within 6 mi (10 km) of Viejas Arena, San Diego State University, and Grossmont College. Mission Trails Regional Park ...

AU$94 per night for 2 guests

23 Jun - 24 Jun
Heritage Inn La Mesa

Heritage Inn La Mesa

7851 Fletcher Pkwy, La Mesa, CA
Heritage Inn La Mesa
  • Free Cancellation
2.0 out of 5.0
 
 

Situated in the suburbs, this hotel is within 6 mi (10 km) of Viejas Arena, San Diego State University, and SDCCU Stadium. Grossmont College and Mission Trails ...

AU$176 per night for 2 guests

6 Jul - 7 Jul
Best Western Plus La Mesa San Diego

Best Western Plus La Mesa San Diego

9550 Murray Dr, La Mesa, CA
Best Western Plus La Mesa San Diego
  • Free Cancellation
  • Reserve now, pay when you stay
2.5 out of 5.0
 
 

Situated in La Mesa, this hotel is within 6 mi (10 km) of Grossmont College, Parkway Plaza, and Boomers El Cajon. Viejas Arena and Mission Trails Regional Park ...

AU$165 per night for 2 guests

30 Jun - 1 Jul
Days Inn & Suites by Wyndham San Diego SDSU

Days Inn & Suites by Wyndham San Diego SDSU

7475 El Cajon Blvd, La Mesa, CA
Days Inn & Suites by Wyndham San Diego SDSU
  • Free Cancellation
  • Reserve now, pay when you stay
2.0 out of 5.0
 
 

Located in the heart of La Mesa, this hotel is 2.6 mi (4.2 km) from Viejas Arena and 2.8 mi (4.4 km) from San Diego State University. Grossmont College and Mission ...

AU$143 per night for 2 guests

17 Jun - 18 Jun
Holiday Inn La Mesa

Holiday Inn La Mesa

8000 Parkway Dr, La Mesa, CA
Holiday Inn La Mesa
  • Free Cancellation
  • Reserve now, pay when you stay
3.0 out of 5.0
 
 

Situated in the business district, this hotel is within 6 mi (10 km) of Viejas Arena, San Diego State University, and SDCCU Stadium. Mission Trails Regional ...

AU$165 per night for 2 guests

30 Jun - 1 Jul
Motel 6 La Mesa CA

Motel 6 La Mesa CA

6952 University Ave, La Mesa, CA
Motel 6 La Mesa CA
  • Free Cancellation
2.0 out of 5.0
 
 

Situated near the airport, this hotel is 2.5 mi (4.1 km) from Viejas Arena and 2.7 mi (4.4 km) from San Diego State University. San Diego Bay and Mission Basilica ...

AU$160 per night for 2 guests

14 Jul - 15 Jul
Motel 6 San Diego - La Mesa

Motel 6 San Diego - La Mesa

7621 Alvarado Rd, La Mesa, CA
Motel 6 San Diego - La Mesa
  • Free Cancellation
2.0 out of 5.0
 
 

Situated in La Mesa, this motel is 2.8 mi (4.5 km) from San Diego State University and 3 mi (4.8 km) from Viejas Arena. Mission Trails Regional Park and Grossmont ...

AU$128 per night for 2 guests

17 Jun - 18 Jun
The Sofia Hotel

The Sofia Hotel

150 W Broadway, San Diego, CA
The Sofia Hotel
  • Free Cancellation
  • Reserve now, pay when you stay
3.5 out of 5.0
 
 

Located in Downtown San Diego, this historic hotel is within a 5-minute walk of Lyceum Theatre and Westfield Horton Plaza. Port of San Diego and B Street Cruise ...

AU$172 per night for 2 guests

30 Jun - 1 Jul
Paradise Point Resort & Spa

Paradise Point Resort & Spa

1404 Vacation Rd, San Diego, CA
Paradise Point Resort & Spa
  • Free Cancellation
  • Reserve now, pay when you stay
4.0 out of 5.0
 
 

Nestled on the beach, this San Diego resort is within 1 mi (2 km) of Mission Bay Park and Mission Bay. SeaWorld and Belmont Park are also within 3 mi (5 ...

AU$311 per night for 2 guests

20 Jun - 21 Jun
The Dana on Mission Bay

The Dana on Mission Bay

1710 W Mission Bay Dr, San Diego, CA
The Dana on Mission Bay
  • Free Cancellation
  • Reserve now, pay when you stay
3.5 out of 5.0
 
 

Situated by the ocean, this hotel is within 1 mi (2 km) of Mission Beach Boardwalk, Mission Bay, and Belmont Park. SeaWorld and Mission Beach are also within ...

AU$235 per night for 2 guests

1 Jul - 2 Jul
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

1 Market Pl, San Diego, CA
Manchester Grand Hyatt San Diego
  • Free Cancellation
4.0 out of 5.0
 
 

Located in Downtown San Diego, this spa hotel is within a 10-minute walk of Seaport Village, San Diego Convention Center, and USS Midway Museum. Port of San ...

AU$265 per night for 2 guests

30 Jun - 1 Jul
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

207 5th Ave, San Diego, CA
Hard Rock Hotel San Diego
    4.0 out of 5.0
     
     

    Located in Gaslamp Quarter, this spa hotel is within a 5-minute walk of Petco Park and San Diego Convention Center. Seaport Village and Westfield Horton Plaza ...

    AU$296 per night for 2 guests

    30 Jun - 1 Jul
    Sheraton San Diego Hotel and Marina

    Sheraton San Diego Hotel and Marina

    1380 Harbor Island Dr, San Diego, CA
    Sheraton San Diego Hotel and Marina
    • Free Cancellation
    • Reserve now, pay when you stay
    4.0 out of 5.0
     
     

    Located in Point Loma, this spa hotel is within 1 mi (2 km) of San Diego County Regional Airport Authority and Harbor Island. Maritime Museum of San Diego and ...

    AU$146 per night for 2 guests

    3 Jul - 4 Jul
    Wyndham San Diego Bayside

    Wyndham San Diego Bayside

    1355 N Harbor Drive, San Diego, CA
    Wyndham San Diego Bayside
    • Free Cancellation
    • Reserve now, pay when you stay
    4.0 out of 5.0
     
     

    Located in Downtown San Diego, this hotel is within a 5-minute walk of Maritime Museum of San Diego, Port of San Diego, and B Street Cruise Ship Terminal. USS ...

    AU$194 per night for 2 guests

    30 Jun - 1 Jul
    Marriott Marquis San Diego Marina

    Marriott Marquis San Diego Marina

    333 W Harbor Dr, San Diego, CA
    Marriott Marquis San Diego Marina
    • Free Cancellation
    • Reserve now, pay when you stay
    4.0 out of 5.0
     
     

    This family-friendly San Diego hotel is located on the waterfront, within a 5-minute walk of New Children's Museum and San Diego Convention Center. Seaport Village ...

    AU$278 per night for 2 guests

    21 Jun - 22 Jun
    California Suites Hotel

    California Suites Hotel

    5415 Clairemont Mesa Blvd, San Diego, CA
    California Suites Hotel
    • Free Cancellation
    • Reserve now, pay when you stay
    2.0 out of 5.0
     
     

    Located in Clairemont, this hotel is within 6 mi (10 km) of Westfield UTC, Mission Bay, and Hotel Circle. University of San Diego and Fashion Valley Mall are ...

    AU$114 per night for 2 guests

    17 Jun - 18 Jun
    Hilton San Diego Bayfront

    Hilton San Diego Bayfront

    1 Park Blvd, San Diego, CA
    Hilton San Diego Bayfront
    • Free Cancellation
    • Reserve now, pay when you stay
    4.0 out of 5.0
     
     

    This family-friendly San Diego hotel is located near the airport, within a 10-minute walk of San Diego Convention Center and Petco Park. Seaport Village and ...

    AU$289 per night for 2 guests

    17 Jun - 18 Jun
    The Westin San Diego

    The Westin San Diego

    400 W Broadway, San Diego, CA
    The Westin San Diego
    • Free Cancellation
    • Reserve now, pay when you stay
    4.0 out of 5.0
     
     

    Located in Downtown San Diego, this hotel is within a 10-minute walk of Museum of Contemporary Art San Diego, Port of San Diego, and Westfield Horton Plaza. ...

    AU$169 per night for 2 guests

    2 Jul - 3 Jul
    Wyndham Garden San Diego Near SeaWorld

    Wyndham Garden San Diego Near SeaWorld

    3737 Sports Arena Blvd, San Diego, CA
    Wyndham Garden San Diego Near SeaWorld
    • Free Cancellation
    • Reserve now, pay when you stay
    3.0 out of 5.0
     
     

    Located in Point Loma, this hotel is within 3 mi (5 km) of Old Town San Diego State Park, Mission Bay, and Hotel Circle. SeaWorld and Ocean Beach Park are also ...

    AU$178 per night for 2 guests

    23 Jun - 24 Jun
    Best Western Plus Island Palms Hotel & Marina

    Best Western Plus Island Palms Hotel & Marina

    2051 Shelter Island Dr, San Diego, CA
    Best Western Plus Island Palms Hotel & Marina
    • Free Cancellation
    • Reserve now, pay when you stay
    3.0 out of 5.0
     
     

    Located in Point Loma, this hotel is within 3 mi (5 km) of Shelter Island, Point Loma Nazarene University, and Sunset Cliffs Natural Park. Mission Bay and Ocean ...

    AU$199 per night for 2 guests

    30 Jun - 1 Jul

    Check prices on hotels in La Mesa

    Tonight 16 Jun. - 17 Jun.
    This weekend 21 Jun. - 23 Jun.
    Next weekend 28 Jun. - 30 Jun.

    Search Hotels near Top La Mesa Attractions

    Map

    Learn about La Mesa?

    Local experts explore every corner of La Mesa for you

    Kids in the City: San Diego

    Maximizing a vacation in San Diego for the youngest members of the family

    Expedia Guest Author
    Kids in the City: San Diego. Opens in a new window.

    Solstice splendor in San Diego

    Celebrating more than 14 hours of San Diego daylight

    Chloe Mulliner
    Solstice splendor in San Diego. Opens in a new window.

    Beach 101 in San Diego

    Finding San Diego's sand-soaked spots

    Trip Styler
    Beach 101 in San Diego. Opens in a new window.

    LGBT destination guide: San Diego

    Discovering great LGBT friendly options in America’s finest city

    No Vacation Required
    LGBT destination guide: San Diego. Opens in a new window.

    Family weekend at LEGOLAND

    Exploring LEGOLAND California Resort with a toddler, brick by brick

    Matt Villano
    Family weekend at LEGOLAND. Opens in a new window.

    Recent Reviews in La Mesa