Cheap flights from Johannesburg to Historic Route 66

View AU$1,142 flight on Wed, 29 Oct. 2025Opens in a new window

Popular airlines from Johannesburg to Historic Route 66

  • American Airlines

    American Airlines

  • Air France

    Air France

  • British Airways

    British Airways

  • Delta

    Delta

  • Emirates

    Emirates

  • Ethiopian Airlines

    Ethiopian Airlines

  • Etihad Airways

    Etihad Airways

  • Plan, book, fly with confidence

  • trending down icon

    Be in the know

    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon

    Book smarter

    Save up to 35% on select hotels after you book a flight*
  • payments icon

    Earn twice

    Earn your airline miles on top of our rewards
    Sign in

Cheap Flights from Johannesburg (JNB) to Historic Route 66 (CHI)

Prices were available within the past 7 days for one-way flights and round trip tickets for the period specified. Prices and availability are subject to change. Additional terms apply.

Swiss International Air Lines
Tue, 28 Oct. - Tue, 11 Nov.
JNB
Johannesburg
ORD
Chicago
AU$1,241 Return, found 17 hours ago
AU$1,241
Return
found 17 hours ago
Select Swiss International Air Lines flight, departing Tue, 28 Oct. from Johannesburg to Chicago, returning Tue, 11 Nov., priced at AU$1,241 found 17 hours ago
Etihad Airways
Tue, 28 Oct. - Tue, 11 Nov.
JNB
Johannesburg
ORD
Chicago
AU$1,276 Return, found 17 hours ago
AU$1,276
Return
found 17 hours ago
Select Etihad Airways flight, departing Tue, 28 Oct. from Johannesburg to Chicago, returning Tue, 11 Nov., priced at AU$1,276 found 17 hours ago
Lufthansa
Tue, 28 Oct. - Tue, 11 Nov.
JNB
Johannesburg
ORD
Chicago
AU$1,277 Return, found 17 hours ago
AU$1,277
Return
found 17 hours ago
Select Lufthansa flight, departing Tue, 28 Oct. from Johannesburg to Chicago, returning Tue, 11 Nov., priced at AU$1,277 found 17 hours ago
Turkish Airlines
Tue, 28 Oct. - Tue, 11 Nov.
JNB
Johannesburg
ORD
Chicago
AU$1,390 Return, found 17 hours ago
AU$1,390
Return
found 17 hours ago
Select Turkish Airlines flight, departing Tue, 28 Oct. from Johannesburg to Chicago, returning Tue, 11 Nov., priced at AU$1,390 found 17 hours ago
United
Tue, 2 Sep. - Tue, 9 Sep.
JNB
Johannesburg
ORD
Chicago
AU$1,447 Return, found 5 days ago
AU$1,447
Return
found 5 days ago
Select United flight, departing Tue, 2 Sep. from Johannesburg to Chicago, returning Tue, 9 Sep., priced at AU$1,447 found 5 days ago
Delta
Tue, 2 Sep. - Tue, 9 Sep.
JNB
Johannesburg
ORD
Chicago
AU$1,570 Return, found 5 days ago
AU$1,570
Return
found 5 days ago
Select Delta flight, departing Tue, 2 Sep. from Johannesburg to Chicago, returning Tue, 9 Sep., priced at AU$1,570 found 5 days ago

Find the cheapest month to fly from Johannesburg (JNB) to Chicago (ORD)

September is typically the cheapest month to fly

From AU$1,286 - AU$2,213 per traveller.

Graph displaying average flight prices per month

*Available to Expedia members.