Luxury Hotels & Resorts in Santo Spirito from AU$177

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Santo Spirito Luxury Hotels

Our top choices for Santo Spirito luxury hotels

Junior Suite (4 pax)

Palazzo Guicciardini

Palazzo Guicciardini
Historic Centre of Florence
9.2 out of 10, Wonderful, (150 reviews)
"Beautiful hotel, perfect location, excellent and helpful staff"
United States
Anonymous traveller
Palazzo Guicciardini
Breakfast area

La Terrazza su Boboli

La Terrazza su Boboli
Oltrarno
9.6 out of 10, Exceptional, (32 reviews)
"Un bel B&B con gestione molto professionale e cortese. Anche se non in centro, comodo al centro. La terrazza e' stupenda."
Italy
tito
La Terrazza su Boboli
Daily continental breakfast (EUR 14 per person)

UNA Hotels Vittoria Firenze

UNA Hotels Vittoria Firenze
4.0 star property
Oltrarno
8.4 out of 10, Very good, (1,001 reviews)
"Perfect stay! Not only was the check-in smooth, but everything else was also satisfying. The breakfast was delicious, the staff were friendly, and the location was ideal. There wasn't a single thing I didn't like. I’ll definitely be back!"
United States
JINHEE
The price is AU$177
includes taxes & fees
15 Mar - 16 Mar
UNA Hotels Vittoria Firenze
Rooftop terrace

Hotel Palazzo Guadagni

Hotel Palazzo Guadagni
3.0 star property
Historic Centre of Florence
9.0 out of 10, Wonderful, (202 reviews)
"Charming, quiet hotel which helped make our visit to Florence special. The room was spacious, super clean and comfortable. The Loggia fantastic and most importantly, everyone had a smile and was helpful. Best hotel in Florence for a personal and charming stay. "
United States
Anne
The price is AU$486
includes taxes & fees
17 Mar - 18 Mar
Hotel Palazzo Guadagni
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Santo Spirito Hotel Reviews

Hotel Palazzo Guadagni

Hotel Palazzo Guadagni

10/10 Excellent
"Charming, quiet hotel which helped make our visit to Florence special. The room was spacious, super clean and comfortable. The Loggia fantastic and most importantly, everyone had a smile and was helpful. Best hotel in Florence for a personal and charming stay. "
Anne 1-night trip
Posted 7 days ago
Hotel Palazzo Guadagni

Frequently asked questions

Are you searching for a great accommodation for your luxury getaway to Santo Spirito?
During your visit, you might want to enjoy the riverfront which Santo Spirito is known for.
What's the best luxury accommodation option in Santo Spirito?
Palazzo Guicciardini is a luxury guest house with in-room massages and a bar, and it's a popular choice for Expedia travellers looking for an elegant place to stay. Another upscale choice for your stay is B&B Monte Oliveto.
What's there to see and do in Santo Spirito?
Enjoy all that Santo Spirito has to offer when you visit Piazza Santo Spirito, Arno River and Piazza del Carmine. If you have a bit of extra time while you're in the area, you might want to check out Brancacci Chapel and Santo Spirito Basilica.

Explore a world of travel with Expedia