A grand church interior with high vaulted ceilings, large columns, and a central altar.

Luxury Hotels & Resorts in Santo Spirito from AU$128

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Santo Spirito Luxury Hotels

Our top choices for Santo Spirito luxury hotels

Suite | Room amenity

1. Torre di Bellosguardo

Torre di Bellosguardo
4.0 star property
Oltrarno
9.0 out of 10, Wonderful, (103 reviews)
The price is AU$898
includes taxes & fees
20 Aug - 21 Aug
Torre di Bellosguardo
Lobby

2. Hotel Horto Convento

Hotel Horto Convento
4.0 star property
Historic Centre of Florence
9.8 out of 10, Exceptional, (711 reviews)
The price is AU$216
includes taxes & fees
22 Aug - 23 Aug
Hotel Horto Convento
Suite

3. Palazzo Mannaioni Suites

Palazzo Mannaioni Suites
4.0 star property
Historic Centre of Florence
9.2 out of 10, Wonderful, (1,156 reviews)
The price is AU$212
includes taxes & fees
20 Aug - 21 Aug
Palazzo Mannaioni Suites
Daily continental breakfast for a fee

4. UNA Hotels Vittoria Firenze

UNA Hotels Vittoria Firenze
4.0 star property
Oltrarno
8.4 out of 10, Very good, (1,005 reviews)
The price is AU$142
includes taxes & fees
30 Aug - 31 Aug
UNA Hotels Vittoria Firenze
Exterior

5. Hotel Lungarno - Lungarno Collection

Hotel Lungarno - Lungarno Collection
5.0 star property
Historic Centre of Florence
9.6 out of 10, Exceptional, (632 reviews)
  • cleanliness
    Riverfront luxury indulges with a Michelin-starred restaurant and spa services steps away from Florence's iconic Ponte Vecchio.
The price is AU$1,102
includes taxes & fees
20 Aug - 21 Aug
Hotel Lungarno - Lungarno Collection
Restaurant

6. The Excelsior, a Luxury Collection Hotel, Florence

The Excelsior, a Luxury Collection Hotel, Florence
5.0 star property
Historic Centre of Florence
9.4 out of 10, Exceptional, (370 reviews)
  • cleanliness
    Historic Florence luxury awaits with a rooftop terrace, fine dining, and designer boutiques steps from Ponte Vecchio.
The price is AU$1,016
includes taxes & fees
22 Aug - 23 Aug
The Excelsior, a Luxury Collection Hotel, Florence
Seasonal outdoor pool, open 9:00 AM to 7:00 PM, pool umbrellas

7. Grand Hotel Minerva

Grand Hotel Minerva
4.0 star property
Historic Centre of Florence
9.6 out of 10, Exceptional, (1,002 reviews)
The price is AU$813
includes taxes & fees
25 Aug - 26 Aug
Grand Hotel Minerva
Couples treatment room(s), Turkish bath/hammam, body treatments

8. Helvetia & Bristol Firenze – Starhotels Collezione

Helvetia & Bristol Firenze – Starhotels Collezione
5.0 star property
Historic Centre of Florence
9.2 out of 10, Wonderful, (568 reviews)
  • cleanliness
    Indulge in historic Florence elegance with spa treatments, personalised service, and luxury accommodation steps from Ponte Vecchio.
The price is AU$825
includes taxes & fees
20 Aug - 21 Aug
Helvetia & Bristol Firenze – Starhotels Collezione
Exterior

9. Porta Rossa Hotel Firenze Colbert Collection

Porta Rossa Hotel Firenze Colbert Collection
5.0 star property
Historic Centre of Florence
9.4 out of 10, Exceptional, (1,002 reviews)
  • cleanliness
    Elegant 5-star historic hotel offers luxury amid Florence's treasures near Ponte Vecchio.
The price is AU$507
includes taxes & fees
23 Aug - 24 Aug
Porta Rossa Hotel Firenze Colbert Collection
Reception

10. Bernini Palace

Bernini Palace
5.0 star property
Historic Centre of Florence
9.8 out of 10, Exceptional, (1,011 reviews)
  • cleanliness
    Historic luxury meets modern elegance in this 5-star Florence hotel just steps from Uffizi Gallery and Ponte Vecchio.
The price is AU$602
includes taxes & fees
25 Aug - 26 Aug
Bernini Palace
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Santo Spirito Hotel Reviews

UNA Hotels Vittoria Firenze

UNA Hotels Vittoria Firenze

10/10 Excellent
"Very clean, nice rooms, staff and great breakfast / evening food in the restaurant. Location 20min walk to main Santa Maria Station."
Paul 3-night trip
Posted 3 days ago
UNA Hotels Vittoria Firenze
Hotel Palazzo Guadagni

Hotel Palazzo Guadagni

10/10 Excellent
"Historic vibes, clean room, nice view, helpful staff. Breakfast was included and all you can eat. Food was fresh and coffee was good."
Samuel 2-night trip
Posted 3 weeks ago
Hotel Palazzo Guadagni

Frequently asked questions

Are you searching for a great accommodation for your luxury getaway to Santo Spirito?
During your visit, you might want to enjoy the riverfront which Santo Spirito is known for.
What's the best luxury accommodation option in Santo Spirito?
Palazzo Guicciardini is a luxury guest house with in-room massages and a bar, and it's a popular choice for Expedia travellers looking for an elegant place to stay. Another upscale choice for your stay is B&B Monte Oliveto.
What's there to see and do in Santo Spirito?
Enjoy all that Santo Spirito has to offer when you visit Piazza Santo Spirito, Santo Spirito Basilica and Arno River. If you have a bit of extra time while you're in the area, you might want to check out Piazza del Carmine and Torrigiani Garden.

Explore a world of travel with Expedia