Santo Spirito Holidays

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to AU$750 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Santo Spirito Holiday

Walking, views and culture are just some of the things waiting for you when you book a Santo Spirito holiday package. Whether you're chasing relaxation, adventure or something else, this residential neighbourhood is where you can find it. Your trip to Santo Spirito wouldn't be complete without stopping by leading attractions nearby such as Piazza Santo Spirito, Santo Spirito Basilica and Brancacci Chapel. No matter what your dream Santo Spirito holiday looks like, you can make it a reality with Expedia.

Our guide on where to stay in Santo Spirito

Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
Historic Centre of Florence

Historic Centre of Florence

10 out of top 10 points of interest in this area

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Find hotels in Historic Centre of Florence

Our pick of the best Santo Spirito Hotel Deals

Hotel Horto Convento

Hotel Horto Convento

4 out of 5
Viale Ariosto, 13 Florence FI
Fully refundableReserve now, pay when you stay
The price is AU$533 per night from 30 Apr to 1 May
AU$533
30 Apr - 1 May
includes taxes & fees
9.8/10 Exceptional! (643 reviews)
Great hotel all around and great breakfast. Highly recommend and will go back when in Florence

Reviewed on 19 Apr 2026

Hotel Horto Convento
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4 out of 5
Via Maffia 9 - 17r Florence FI
The price is AU$434 per night from 26 Apr to 27 Apr
AU$434
26 Apr - 27 Apr
includes taxes & fees
9.2/10 Wonderful! (1,102 reviews)
Great location. Clean room. Great staff.

Reviewed on 22 Apr 2026

Palazzo Mannaioni Suites
La Torre Del Cestello

La Torre Del Cestello

Via Borgo San Frediano, 8 Florence FI
Fully refundable
The price is AU$280 per night from 4 May to 5 May
AU$280
4 May - 5 May
includes taxes & fees
9/10 Wonderful! (249 reviews)
The room was not at all as shown. The hotel lobby isn’t a lobby but a small room with a check in desk on the 3 floor. There is only a few rooms. This is not a hotel. The cafe/bar on the lower level is loud with extremely loud music and they go until 4 am. We could not sleep. The main chandelier in ...

Reviewed on 20 Apr 2026

La Torre Del Cestello
See all 497 properties in Santo Spirito
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
All Inclusive Holidays
Cheap Holidays
Cheap Holidays
Cheap Holidays
beach holidays
Beach Holidays
Beach Holidays

Frequently asked questions

How much does a Santo Spirito holiday package cost?
From just . Yes, you read that right. Our Santo Spirito packages are the best way to make your dollar go further. Bundle your favourite hotels, flights and rental car and explore this wonderful destination.
How do I get a cheap travel package to Santo Spirito?
If you love scoring a bargain, bundle your bookings into a Santo Spirito holiday package. Whether you need hotels, flights, activities or rental cars, you can book everything in one place. You'll have endless choice at your fingertips as well. Expedia has more than 550 partner airlines and 1 000 000 hotels across the globe to choose from. Fly with who you want, stay in a place you like and save precious dollars — now that's the ideal getaway!
What are the top hotels in Santo Spirito?
Reserve a room at Sweet Home Campuccio, 2 Double Bedrooms In San Frediano. It's one of this area's most sought-after hotels. Another well-known option in Santo Spirito is Residenza Oltrarno, An Elegant Apartment In The Historic Centre Of Florence.
How far in advance should I book my Santo Spirito holiday?
To score cheap prices, book as soon as you can. Airlines typically release tickets, along with some of the lowest fares, up to a year in advance. Hotels, activities and car rental should also be booked early to avoid disappointment. If you were hoping for a last-minute getaway in Santo Spirito, there are always lots of great deals on Expedia. Check them out now!
What does an Expedia Santo Spirito travel package include?
Rental cars, flights and hotels, or any combination of the three — it's totally up to you. Whether you're headed to Santo Spirito with the entire family or enjoying a solo break, there's a bundle to match every budget and style. Once you've made your booking, why not add on a couple of tours as well?
What should I know before booking a Santo Spirito travel package?
Locking in all the parts of your trip together is one of the best ways to save. Combine car rentals, airfares and hotels into a neat little package. But you're not restricted to hotels. Expedia features all sorts of properties, including holiday homes like oceanfront condos and city residences. The list goes on!
Can I choose my airline with a Santo Spirito Expedia holiday package?
Yes — and it's simple too. Expedia has access to more than 550 partner airlines all over the world. Our holiday packages give you the freedom to pick from available flights, hotels and activities that suit you.
If I'm not able to travel, can I cancel my Santo Spirito holiday package?
If your holiday plans in Santo Spirito have been upended, it's a relief to know that it is possible to cancel your booking. If you made your booking within the last 24 hours, you may be eligible for a refund. If your booking is older than that, your airline, hotel or car rental company may charge a fee. For more details, check our Customer Service Portal.

Discover the most popular places to visit in Santo Spirito

Piazza del Carmine

You can learn about the history of Florence with a trip to Piazza del Carmine. Amble around this vibrant area's riverfront or experience its fascinating museums.

Piazza del Carmine

Activities

City Sightseeing Florence Hop-on Hop-off

City Sightseeing Florence Hop-on Hop-off Bus Tour

AU$48
per adult
76% of travellers recommend
City Sightseeing Florence Hop-on Hop-off Bus Tour
Excursion to Pisa through the Tuscan Countryside

Florence: Pisa Tour through Tuscan Hills & Optional Tower Entry

AU$58
per adult
88% of travellers recommend
Florence: Pisa Tour through Tuscan Hills & Optional Tower Entry
Small-Group Wine Tasting Experience in the Tuscan Countryside

Small-Group Wine Tasting Experience in the Tuscan Countryside

AU$146
per adult
98% of travellers recommend
Small-Group Wine Tasting Experience in the Tuscan Countryside
See all activities in Florence
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.