Santo Spirito Holidays

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Your Santo Spirito Holiday

Walking, views and culture are just some of the things waiting for you when you book a Santo Spirito holiday package. Whether you're chasing relaxation, adventure or something else, this residential neighbourhood is where you can find it. Your trip to Santo Spirito wouldn't be complete without stopping by leading attractions nearby such as Piazza Santo Spirito, Santo Spirito Basilica and Brancacci Chapel. No matter what your dream Santo Spirito holiday looks like, you can make it a reality with Expedia.

Price found within the past 48 hours. Click for updated prices.
  • Reception
    Jul 12 - Jul 15

    Hotel La Pace + Flight

    Pisa City Centre
    3 nights
    3.0 star property
    8.6/10 - Excellent (1,000 reviews)
    "The hotel was fine, but I could hear the couple above me - they got up at 6.30am, I could hear singing, shower running, sounded like they kept dropping their suitcase. I ended up getting up early, too, as I knew I wouldn’t get back to sleep."
    Reviewed June 7, 2026
    Return • London (LTN) - Pisa (PSA)
    LTN - PSA • Direct PSA - LGW • Direct
    AU$633
    AU$525
    per traveller
    found 20 hours ago
    Hotel La Pace
  • Breakfast, lunch and dinner served
    Jul 12 - Jul 15

    Hotel San Ranieri + Flight

    Pisa
    3 nights
    4.0 star property
    8.8/10 - Excellent (1,007 reviews)
    Return • London (LTN) - Pisa (PSA)
    LTN - PSA • Direct PSA - LGW • Direct
    AU$931
    AU$742
    per traveller
    found 20 hours ago
    Hotel San Ranieri
  • Terrace/patio
    Jul 12 - Jul 15

    Hotel Minerva + Flight

    Pisa City Centre
    3 nights
    3.0 star property
    7.6/10 - Good (16 reviews)
    "It was great spot with great AC! :)"
    Reviewed September 19, 2025
    Return • London (LTN) - Pisa (PSA)
    LTN - PSA • Direct PSA - LGW • Direct
    AU$687
    AU$568
    per traveller
    found 20 hours ago
    Hotel Minerva
  • Beach
    Jul 12 - Jul 15

    Hotiday Room Collection - Calambrone + Flight

    Calambrone
    3 nights
    4.0 star property
    8.6/10 - Excellent (23 reviews)
    "This hotel has the best bedrooms I’ve ever stayed in a hotel. They were huge with every facility required, fridge, hairdryer, toiletries etc. The reception and restaurant staff at the hotel were brilliant, friendly, helpful and attentive. We ate evening meal a couple of times and the food is really good and good value. Could not fault the place."
    Reviewed May 17, 2026
    Return • London (LTN) - Pisa (PSA)
    LTN - PSA • Direct PSA - LGW • Direct
    AU$806
    AU$675
    per traveller
    found 20 hours ago
    Hotiday Room Collection - Calambrone
  • Lobby sitting area
    Jul 12 - Jul 15

    Hotel Villa Kinzica + Flight

    Pisa City Centre
    3 nights
    3.0 star property
    7.8/10 - Good (814 reviews)
    "Great hotel Great hotel, great location 3 minutes walking to pisa tower, excellent service , cooperative staff on reception especially Rashid, a lot of shopping markets and restaurants and cafes are all around, i recommend it very Strongly."
    Reviewed June 9, 2026
    Return • London (LTN) - Pisa (PSA)
    LTN - PSA • Direct PSA - LGW • Direct
    AU$674
    AU$578
    per traveller
    found 20 hours ago
    Hotel Villa Kinzica

Our guide on where to stay in Santo Spirito

Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
Historic Centre of Florence

Historic Centre of Florence

9 out of top 10 points of interest in this area

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Find hotels in Historic Centre of Florence

Our pick of the best Santo Spirito Hotel Deals

Hotel Horto Convento

Hotel Horto Convento

4 out of 5
Viale Ariosto, 13 Florence FI
Fully refundableReserve now, pay when you stay
The price is AU$284 per night from 2 July to 3 July
AU$284
2 July - 3 July
includes taxes & fees
9.8/10 Exceptional! (672 reviews)
"We booked our stay at Hotel Horto Convento, but were moved to their newer sister hotel,"

Reviewed on 5 June 2026

Hotel Horto Convento
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4 out of 5
Via Maffia 9 - 17r Florence FI
The price is AU$351 per night from 28 June to 29 June
AU$351
28 June - 29 June
includes taxes & fees
9.2/10 Wonderful! (1,124 reviews)
"Clean, spacious room. Wonderful location, couldn’t ask for more - highly recommended"

Reviewed on 3 June 2026

Palazzo Mannaioni Suites
La Torre Del Cestello

La Torre Del Cestello

Via Borgo San Frediano, 8 Florence FI
Fully refundableReserve now, pay when you stay
The price is AU$249 per night from 5 July to 6 July
AU$249
5 July - 6 July
includes taxes & fees
9/10 Wonderful! (261 reviews)
"Central city location"

Reviewed on 9 June 2026

La Torre Del Cestello
See all 509 properties in Santo Spirito
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

How much does a Santo Spirito holiday package cost?
From just . Yes, you read that right. Our Santo Spirito packages are the best way to make your dollar go further. Bundle your favourite hotels, flights and rental car and explore this wonderful destination.
How do I get a cheap travel package to Santo Spirito?
If you love scoring a bargain, bundle your bookings into a Santo Spirito holiday package. Whether you need hotels, flights, activities or rental cars, you can book everything in one place. You'll have endless choice at your fingertips as well. Expedia has more than 550 partner airlines and 1 000 000 hotels across the globe to choose from. Fly with who you want, stay in a place you like and save precious dollars — now that's the ideal getaway!
What are the top hotels in Santo Spirito?
Reserve a room at Sweet Home Campuccio, 2 Double Bedrooms In San Frediano. It's one of this area's most sought-after hotels. Another well-known option in Santo Spirito is Residenza Oltrarno, An Elegant Apartment In The Historic Centre Of Florence.
How far in advance should I book my Santo Spirito holiday?
To score cheap prices, book as soon as you can. Airlines typically release tickets, along with some of the lowest fares, up to a year in advance. Hotels, activities and car rental should also be booked early to avoid disappointment. If you were hoping for a last-minute getaway in Santo Spirito, there are always lots of great deals on Expedia. Check them out now!
What does an Expedia Santo Spirito travel package include?
Rental cars, flights and hotels, or any combination of the three — it's totally up to you. Whether you're headed to Santo Spirito with the entire family or enjoying a solo break, there's a bundle to match every budget and style. Once you've made your booking, why not add on a couple of tours as well?
What should I know before booking a Santo Spirito travel package?
Locking in all the parts of your trip together is one of the best ways to save. Combine car rentals, airfares and hotels into a neat little package. But you're not restricted to hotels. Expedia features all sorts of properties, including holiday homes like oceanfront condos and city residences. The list goes on!
Can I choose my airline with a Santo Spirito Expedia holiday package?
Yes — and it's simple too. Expedia has access to more than 550 partner airlines all over the world. Our holiday packages give you the freedom to pick from available flights, hotels and activities that suit you.
If I'm not able to travel, can I cancel my Santo Spirito holiday package?
If your holiday plans in Santo Spirito have been upended, it's a relief to know that it is possible to cancel your booking. If you made your booking within the last 24 hours, you may be eligible for a refund. If your booking is older than that, your airline, hotel or car rental company may charge a fee. For more details, check our Customer Service Portal.

Discover the most popular places to visit in Santo Spirito

Piazza del Carmine

You can learn about the history of Florence with a trip to Piazza del Carmine. Amble around this vibrant area's riverfront or experience its acclaimed art galleries.

Piazza del Carmine

Activities

City Sightseeing Florence Hop-on Hop-off

City Sightseeing Florence Hop-on Hop-off Bus Tour

AU$47
per adult
76% of travellers recommend
City Sightseeing Florence Hop-on Hop-off Bus Tour
Small-Group Wine Tasting Experience in the Tuscan Countryside

Small-Group Wine Tasting Experience in the Tuscan Countryside

AU$144
per adult
98% of travellers recommend
Small-Group Wine Tasting Experience in the Tuscan Countryside
Skip-the-Line Duomo: Priority-Access 30-Minute Guided Tour

Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

AU$32
per adult
82% of travellers recommend
Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour
See all activities in Florence
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.