South Main Hotels, Houston
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Our top choices for South Main hotels
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,004 reviews)
"Good parking"
joseph
The price is AU$131
includes taxes & fees
11 June - 12 June
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.2 out of 10, Good, (1,293 reviews)
"Would stay again!"
Austin
The price is AU$198
includes taxes & fees
11 June - 12 June
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,006 reviews)
"Clean & comfortable, super nice staff, good breakfast options, convenient to MDA."
Cleota
The price is AU$155
includes taxes & fees
11 June - 12 June
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,003 reviews)
"Very clean rooms and excellent staff"
Efrain
The price is AU$132
includes taxes & fees
9 June - 10 June
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (868 reviews)
"My stay was perfect "
Fredrick
The price is AU$144
includes taxes & fees
9 July - 10 July
Studio 6 Houston, TX – Pearland/Medical Center
Studio 6 Houston, TX – Pearland/Medical CenterSoutheast Houston, 12.9 km from South Main
9.4 out of 10, Exceptional, (96 reviews)
"Awesome staff, clean rooms and love the free parking! Thanks a lot for a great stay!"
Rorie
The price is AU$110
includes taxes & fees
6 July - 7 July
Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (273 reviews)
"Very nice hotel. New construction as of Spring 2026."
Casey
The price is AU$164
includes taxes & fees
9 June - 10 June
Downtowner Inns - Houston Downtown
Downtowner Inns - Houston DowntownMidtown, 9.1 km from South Main
9.2 out of 10, Wonderful, (160 reviews)
"Great place. The staff is very friendly and the place is clean."
Fernando
The price is AU$139
includes taxes & fees
9 June - 10 June
Crystal Inn Northeast Houston Downtown I-610
Crystal Inn Northeast Houston Downtown I-610Northside, 18.9 km from South Main
8.4 out of 10, Very good, (210 reviews)
"Great price and nice rooms"
Armando
The price is AU$148
includes taxes & fees
22 June - 23 June
Hotel Royale
Hotel Royale20.9 km from South Main
9.0 out of 10, Wonderful, (42 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
Jerome
The price is AU$122
includes taxes & fees
9 June - 10 June
Palace Inn Blue 290 W 43rd & Bingle Rd
Palace Inn Blue 290 W 43rd & Bingle Rd19.4 km from South Main
9.0 out of 10, Wonderful, (72 reviews)
"We loved it, very nice employees and very clean."
Jorge
The price is AU$151
includes taxes & fees
9 July - 10 July
Tru by Hilton Houston Webster NASA
Tru by Hilton Houston Webster NASA30.7 km from South Main
9.0 out of 10, Wonderful, (1,007 reviews)
"Definitely will stay here again. Great location near Great Wolf Lodge."
Deanndra
The price is AU$145
includes taxes & fees
28 June - 29 June
Hotel Park Place
Hotel Park PlaceSoutheast Houston, 12.1 km from South Main
8.8 out of 10, Excellent, (342 reviews)
"Great for the price and close to airport "
Tranecia
The price is AU$106
includes taxes & fees
7 July - 8 July
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG30.8 km from South Main
9.0 out of 10, Wonderful, (1,014 reviews)
"Wonderful enjoyed the stay and breakfast clean rooms"
Albert
The price is AU$146
includes taxes & fees
7 July - 8 July
Sonesta Simply Suites Houston – NASA Clear Lake
Sonesta Simply Suites Houston – NASA Clear Lake31.8 km from South Main
8.2 out of 10, Very good, (1,017 reviews)
"This is the third time I stayed here and I always love my stay!"
Deena
The price is AU$91
includes taxes & fees
9 June - 10 June
Quality Suites Houston Hobby Airport
Quality Suites Houston Hobby AirportSoutheast Houston, 13.3 km from South Main
8.4 out of 10, Very good, (1,251 reviews)
"Fantastic room great bed courteous and on time shuttle driver"
benjamin
The price is AU$103
includes taxes & fees
10 June - 11 June
SpringHill Suites by Marriott Houston Intercontinental Arprt
SpringHill Suites by Marriott Houston Intercontinental Arprt31.8 km from South Main
9.0 out of 10, Wonderful, (1,806 reviews)
"I had a great stay"
Datroynard
The price is AU$224
includes taxes & fees
5 July - 6 July
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
La Quinta Inn & Suites by Wyndham Houston Bush IAH South31.2 km from South Main
8.0 out of 10, Very good, (2,086 reviews)
"Clean convenient close to airport and food"
Brian
The price is AU$154
includes taxes & fees
9 June - 10 June
Doubletree by Hilton Houston Hobby Airport
Doubletree by Hilton Houston Hobby AirportSoutheast Houston, 14.5 km from South Main
8.8 out of 10, Excellent, (1,012 reviews)
"This was a great stay. We liked the suite, would have liked a microwave in there."
Sara
The price is AU$169
includes taxes & fees
5 July - 6 July
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham18.5 km from South Main
8.8 out of 10, Excellent, (1,209 reviews)
"The room was clean, staff was friendly, breakfast was great, and the area and location was nice and quiet."
Dr. Cherie
The price is AU$137
includes taxes & fees
9 June - 10 June
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 868 reviews | View | ||||||
 Wyndham Houston near NRG Park/Medical Center | 7.2 Good 1,293 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,004 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,003 reviews | View | ||||||
 Comfort Suites Houston Near Medical Center- NRG Stadium | 8.8 Excellent 11 reviews | View |
Our guide on where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Gerald D. Hines Waterwall Park.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Rothko Chapel while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
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