South Central Houston Hotels, Houston

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
10 Feb - 11 Feb
Tomorrow
11 Feb - 12 Feb
This weekend
13 Feb - 15 Feb
Next weekend
20 Feb - 22 Feb

Filter by

Guest rating
Guest rating
Star rating

Our top choices for South Central Houston hotels

Standard Room, 1 King Bed

Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown
2.0 star property
South Central Houston
8.2 out of 10, Very good, (59 reviews)
"great stay "
United States
Jordan
The price is AU$137
includes taxes & fees
12 Feb - 13 Feb
Downtowner Inns - Houston Downtown
Terrace/patio

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
South Central Houston
8.4 out of 10, Very good, (1,836 reviews)
"Always a great stay at this hotel with good staff nice rooms and good food "
United States
Diane
The price is AU$144
includes taxes & fees
22 Feb - 23 Feb
Hilton Houston Plaza/Medical Center
Outdoor pool, free pool cabanas, pool umbrellas

The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1,097 reviews)
"Excellent stay!"
United States
Travis
The price is AU$254
includes taxes & fees
15 Feb - 16 Feb
The Westin Houston Medical Center/Museum District
Breakfast and dinner served

DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites
4.0 star property
South Central Houston
8.4 out of 10, Very good, (518 reviews)
"Room accommodations for disability, clean, comfortable beds and bedding, and having a resturant on site. Thank you for a great stay!"
United States
Judy
The price is AU$151
includes taxes & fees
22 Feb - 23 Feb
DoubleTree by Hilton Houston Medical Center Hotel & Suites
American cuisine

Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District
4.0 star property
South Central Houston
9.0 out of 10, Wonderful, (1,000 reviews)
"Rooms were tidy, clean and comfortable bedding. Staff extremely courteous and accommodating. "
United States
Linda
The price is AU$357
includes taxes & fees
20 Feb - 21 Feb
Houston Marriott Medical Center/Museum District
Exterior

InterContinental Houston by IHG

InterContinental Houston by IHG
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1,003 reviews)
"Very clean room & responsive staff!"
United States
ERIC
The price is AU$302
includes taxes & fees
15 Feb - 16 Feb
InterContinental Houston by IHG
Reception

Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown
2.0 star property
South Central Houston
8.0 out of 10, Very good, (1,005 reviews)
"It was a quick stop for us and the room had everything we needed"
United States
Deiedra
The price is AU$117
includes taxes & fees
12 Feb - 13 Feb
Americas Best Value Inn Medical Center Downtown
House

Newly Built Modern 3 Bedroom Houston Home

Newly Built Modern 3 Bedroom Houston Home
2.0 star property
South Central Houston
10.0 out of 10, Exceptional, (2 reviews)
"The pictures do not do this property justice. The three story home has 3 beautiful bedrooms, each with luxurious bathrooms. The main bedroom and the living room has a small patio and then there's a rooftop seating area that is an excellent spot for gazing at the Houston night skyline. The quiet area is gated off a not too busy street in a beautiful neighborhood. We did have a couple of issues upon our arrival but the hosts were on top of it and had it resolved the next day. They have great...
United States
robin
The price is AU$497
includes taxes & fees
11 Feb - 12 Feb
Newly Built Modern 3 Bedroom Houston Home
Reception

Wanderstay Boutique Hotel

Wanderstay Boutique Hotel
2.0 star property
South Central Houston
9.8 out of 10, Exceptional, (62 reviews)
"Perfect space for my overnight stay but I had dreams of renting the full space for a family event in the future. "
United States
Marva
The price is AU$202
includes taxes & fees
15 Feb - 16 Feb
Wanderstay Boutique Hotel
Premium bedding, pillow-top beds, minibar, in-room safe

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.0 out of 10, Wonderful, (1,900 reviews)
"An amzing stay, great staff and overal luxery feeling"
United Kingdom
Wendy
Hotel Zaza Houston Museum District
Outdoor pool

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
South Central Houston
9.6 out of 10, Exceptional, (202 reviews)
"I absolutely loved my stay here!!"
United States
Daniella
The price is AU$363
includes taxes & fees
16 Feb - 17 Feb
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
Lobby

Hilton University of Houston

Hilton University of Houston
3.5 star property
South Central Houston
9.0 out of 10, Wonderful, (894 reviews)
"Nice place to stay"
United States
Alexandra
The price is AU$281
includes taxes & fees
23 Feb - 24 Feb
Hilton University of Houston
Exterior

La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B
3.5 star property
South Central Houston
9.8 out of 10, Exceptional, (549 reviews)
"Good rooms and location, great staff!"
United States
Eugene
The price is AU$272
includes taxes & fees
23 Feb - 24 Feb
La Maison in Midtown an urban B&B
House, 3 Bedrooms | Private kitchen

Sophisticated Urban Retreat With Skyline Views 3 Bedroom Home

Sophisticated Urban Retreat With Skyline Views 3 Bedroom Home
3.0 star property
South Central Houston
The price is AU$961
includes taxes & fees
23 Feb - 24 Feb
Sophisticated Urban Retreat With Skyline Views 3 Bedroom Home
Standard Room, 1 King Bed

Southmore Boulevard Motel

Southmore Boulevard Motel
2.0 star property
South Central Houston
5.6 out of 10, (229 reviews)
"A classical Motel like in a Movie. The staff was really kind and helpful."
United Kingdom
Lisa-Maria
The price is AU$111
includes taxes & fees
17 Feb - 18 Feb
Southmore Boulevard Motel
Free WiFi, bed sheets

Rodeway Inn & Suites Houston near Medical Center

Rodeway Inn & Suites Houston near Medical Center
2.0 star property
South Central Houston
6.0 out of 10, (498 reviews)
"Very economical. Great price for one night stay."
United States
AUGUSTIN
The price is AU$94
includes taxes & fees
11 Feb - 12 Feb
Rodeway Inn & Suites Houston near Medical Center
Lobby

Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl
2.5 star property
South Central Houston
5.8 out of 10, (1,017 reviews)
"It was all okay."
United States
Tekle
The price is AU$121
includes taxes & fees
15 Feb - 16 Feb
Extended Stay America Suites Houston Med Ctr Braeswood Bl
Apartment

The Green Haus Luxxe Cabana Rooftop Retreat

The Green Haus Luxxe Cabana Rooftop Retreat
2.0 star property
South Central Houston
10.0 out of 10, Exceptional, (1 review)
The price is AU$944
includes taxes & fees
11 Feb - 12 Feb
The Green Haus Luxxe Cabana Rooftop Retreat
Interior

Wanderstay Houston Hostel

Wanderstay Houston Hostel
2.0 star property
South Central Houston
8.2 out of 10, Very good, (192 reviews)
"This is an amazing place to stay."
United States
Darius
The price is AU$85
includes taxes & fees
11 Feb - 12 Feb
Wanderstay Houston Hostel
House

Paradise Palace Best Rooftop in HTX w Hot Tub

Paradise Palace Best Rooftop in HTX w Hot Tub
3.0 star property
South Central Houston
The price is AU$884
includes taxes & fees
12 Feb - 13 Feb
Paradise Palace Best Rooftop in HTX w Hot Tub
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in South Central Houston

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Exterior
La Maison in Midtown an urban B&B
3.5 star property
9.8
Exceptional
549 reviews
View
Outdoor pool
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
9.6
Exceptional
202 reviews
View
Exterior
InterContinental Houston by IHG
4.0 star property
9.2
Wonderful
1,003 reviews
View
Outdoor pool, free pool cabanas, pool umbrellas
The Westin Houston Medical Center/Museum District
4.0 star property
9.2
Wonderful
1,097 reviews
View
Premium bedding, pillow-top beds, minibar, in-room safe
Hotel Zaza Houston Museum District
4.5 star property
9.0
Wonderful
1,900 reviews
View

Our guide on where to stay in South Central Houston

Find the best South Central Houston areas for the activities you enjoy most.
Discovery Green featuring a garden, a city and street scenes

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Houston_TexasChildrensHospital_553248635389801905_9

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Taken in front of apartments. #UrbanJungle
Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

Menil Collection featuring interior views

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Rothko Chapel while you're exploring the area.

Top South Central Houston Hotel Reviews

DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites

10/10 Excellent
"Loved it "
Stephanie 1-night trip
Posted 3 days ago
DoubleTree by Hilton Houston Medical Center Hotel & Suites

Frequently asked questions

What's it like in South Central Houston?
Travellers are sure to enjoy a stay in Houston's South Central Houston neighbourhood. Make sure that you visit Children's Museum of Houston and Houston Natural Science Museum as part of your South Central Houston travel plans.
What's the best accommodation in South Central Houston?
Based on Expedia customer reviews, La Maison in Midtown an urban B&B is the highest ranked property in South Central Houston. This B&B is a short 5-minute walk from Westheimer Road, and it offers free breakfast and free parking. Other top choices in the neighbourhood include Wanderstay Boutique Hotel and The Westin Houston Medical Center/Museum District.
How many hotels can I expect to find in the South Central Houston area?
Expedia has 1082 hotels and other accommodation options in South Central Houston to choose from, making this an ideal home base for exploring the greater Houston area.
If I need to cancel my hotel reservation in South Central Houston, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals available in South Central Houston.
What is there to do around this Houston neighbourhood?
Spend some time exploring the great outdoors at Hermann Park, Cullen Sculpture Garden and James Turrell's Twilight Epiphany Skyscape. Children's Museum of Houston and Houston Natural Science Museum are some other stops worth a visit in the neighbourhood. Daikin Park, Shape Community Center and Project Row Houses are just a few of the places to visit in and around South Central Houston. H&PE Arena and Eldorado Ballroom are also worth a visit when you're out sightseeing in Houston.
How can I get around South Central Houston and the greater Houston area?
For a quick way to explore the city, catch a ride on metro transit at Elgin/Third Ward Station, TSU/UH Athletics District Station or Ensemble/HCC Station. If you want to venture out of town, M. D. Anderson Station is the closest train station. You can also catch a ride at Kinder Station.

Explore a world of travel with Expedia