South Central Houston Hotels, Houston

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
27 Mar - 28 Mar
Tomorrow
28 Mar - 29 Mar
This weekend
27 Mar - 29 Mar
Next weekend
3 Apr - 5 Apr

Filter by

Guest rating
Guest rating
Star rating

Our top choices for South Central Houston hotels

Outdoor pool, free pool cabanas, pool umbrellas

The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1,129 reviews)
"Great central location within the walking distance to many places. "
United States
Kasey
The price is AU$321
includes taxes & fees
29 Mar - 30 Mar
The Westin Houston Medical Center/Museum District
Exterior detail

Sentral Forme Houston

Sentral Forme Houston
4.5 star property
South Central Houston
10.0 out of 10, Exceptional, (1 review)
"Jerrick (front desk) was super friendly and helpful, and the room and amenities were great."
United States
Cade
The price is AU$272
includes taxes & fees
5 Apr - 6 Apr
Sentral Forme Houston
Exterior

Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown
2.0 star property
South Central Houston
8.4 out of 10, Very good, (88 reviews)
"Good hotel. great location. "
United States
Porfirio
The price is AU$140
includes taxes & fees
2 Apr - 3 Apr
Downtowner Inns - Houston Downtown
Exterior

InterContinental Houston by IHG

InterContinental Houston by IHG
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1,006 reviews)
"Amazing hotel. Beautiful property, wonderful customer service."
United States
LATOYA
The price is AU$323
includes taxes & fees
5 Apr - 6 Apr
InterContinental Houston by IHG
Premium bedding, pillow-top beds, minibar, in-room safe

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.0 out of 10, Wonderful, (1,928 reviews)
"Great vibe"
United States
Jennifer
The price is AU$458
includes taxes & fees
29 Mar - 30 Mar
Hotel Zaza Houston Museum District
Reception

Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown
2.0 star property
South Central Houston
8.0 out of 10, Very good, (1,001 reviews)
"Very clean room, staff was very good, felt safe"
United States
Gayle
The price is AU$168
includes taxes & fees
29 Mar - 30 Mar
Americas Best Value Inn Medical Center Downtown
Terrace/patio

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
South Central Houston
8.4 out of 10, Very good, (1,866 reviews)
"Very clean property, staff was helpful"
United States
Elton
The price is AU$187
includes taxes & fees
5 Apr - 6 Apr
Hilton Houston Plaza/Medical Center
American cuisine

Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District
4.0 star property
South Central Houston
9.0 out of 10, Wonderful, (1,000 reviews)
"Everything was great "
United States
Casey
The price is AU$336
includes taxes & fees
4 Apr - 5 Apr
Houston Marriott Medical Center/Museum District
Outdoor pool

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
South Central Houston
9.6 out of 10, Exceptional, (208 reviews)
"Every was excellent "
United States
Dolly
The price is AU$370
includes taxes & fees
31 Mar - 1 Apr
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
Exterior

La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B
3.5 star property
South Central Houston
9.8 out of 10, Exceptional, (564 reviews)
"Loved the area, the staff was super friendly and accomodating. "
United States
Silvia Alejandra
The price is AU$261
includes taxes & fees
8 Apr - 9 Apr
La Maison in Midtown an urban B&B
Breakfast and dinner served

DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites
4.0 star property
South Central Houston
8.4 out of 10, Very good, (546 reviews)
"Breakfast was pricey"
United States
Thomas
The price is AU$173
includes taxes & fees
12 Apr - 13 Apr
DoubleTree by Hilton Houston Medical Center Hotel & Suites
Reception

Wanderstay Boutique Hotel

Wanderstay Boutique Hotel
2.0 star property
South Central Houston
9.8 out of 10, Exceptional, (66 reviews)
"Great location will stay again "
United States
Jason
The price is AU$216
includes taxes & fees
1 Apr - 2 Apr
Wanderstay Boutique Hotel
House

Paradise Palace Best Rooftop in HTX w Hot Tub

Paradise Palace Best Rooftop in HTX w Hot Tub
3.0 star property
South Central Houston
The price is AU$1,570
includes taxes & fees
24 Apr - 25 Apr
Paradise Palace Best Rooftop in HTX w Hot Tub
Free WiFi, bed sheets

Rodeway Inn & Suites Houston near Medical Center

Rodeway Inn & Suites Houston near Medical Center
2.0 star property
South Central Houston
6.0 out of 10, (510 reviews)
"Very dirty place. No TV. Air conditioning did work."
United States
Gabriela
The price is AU$108
includes taxes & fees
26 Apr - 27 Apr
Rodeway Inn & Suites Houston near Medical Center
Standard Room, 1 King Bed

Southmore Boulevard Motel

Southmore Boulevard Motel
2.0 star property
South Central Houston
5.6 out of 10, (233 reviews)
"Quiet and comfortable rooms; good access to the area around. "
United States
Timothy
The price is AU$99
includes taxes & fees
1 Apr - 2 Apr
Southmore Boulevard Motel
Lobby

Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl
2.5 star property
South Central Houston
5.8 out of 10, (1,001 reviews)
"Everything was great! "
United States
Trina
The price is AU$124
includes taxes & fees
5 Apr - 6 Apr
Extended Stay America Suites Houston Med Ctr Braeswood Bl
Lobby

Hilton University of Houston

Hilton University of Houston
3.5 star property
South Central Houston
9.0 out of 10, Wonderful, (921 reviews)
"Booking was easy, staff was super friendly, and the location was perfect for what I needed! "
United States
Brandon
The price is AU$263
includes taxes & fees
13 Apr - 14 Apr
Hilton University of Houston
Room, 1 King Bed, Smoking

Golden Motel Near Houston Medical Center

Golden Motel Near Houston Medical Center
2.5 star property
South Central Houston
2.0 out of 10, (1 review)
"Room smelt like cigarettes burnt wholes in the wall and bed sheet all 6 walls had stains toilet seat look like someone stood on it "
United States
Jacari
The price is AU$97
includes taxes & fees
29 Mar - 30 Mar
Golden Motel Near Houston Medical Center
Interior

Wanderstay Houston Hostel

Wanderstay Houston Hostel
2.0 star property
South Central Houston
8.2 out of 10, Very good, (198 reviews)
"it was a great experience, staff was kind and helpful. "
United States
James
The price is AU$98
includes taxes & fees
8 Apr - 9 Apr
Wanderstay Houston Hostel
House

Houston 6 Bedroom Home

Houston 6 Bedroom Home
2.0 star property
South Central Houston
The price is AU$673
includes taxes & fees
1 Apr - 2 Apr
Houston 6 Bedroom Home
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in South Central Houston

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Exterior
La Maison in Midtown an urban B&B
3.5 star property
9.8
Exceptional
564 reviews
View
Reception
Wanderstay Boutique Hotel
2.0 star property
9.8
Exceptional
66 reviews
View
Exterior
InterContinental Houston by IHG
4.0 star property
9.2
Wonderful
1,006 reviews
View
Outdoor pool, free pool cabanas, pool umbrellas
The Westin Houston Medical Center/Museum District
4.0 star property
9.2
Wonderful
1,129 reviews
View
Lobby
Hilton University of Houston
3.5 star property
9.0
Wonderful
921 reviews
View

Our guide on where to stay in South Central Houston

Find the best South Central Houston areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Houston_TexasChildrensHospital_553248635389801905_9

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

Top South Central Houston Hotel Reviews

Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl

4/10 Poor
"The rolling cart was covered in dog hair and the halls are very hot. A person who cannot speak English well works the counter. No coffee in the rooms..its a place to stay in the medical district that isnt $500 a night."
Lisa 2-night trip
Posted 2 hours ago
Extended Stay America Suites Houston Med Ctr Braeswood Bl

Frequently asked questions

What's it like in South Central Houston?
Travellers are sure to enjoy a stay in Houston's South Central Houston neighbourhood. Make sure that you visit Children's Museum of Houston and Houston Natural Science Museum as part of your South Central Houston travel plans.
What's the best accommodation in South Central Houston?
Based on Expedia customer reviews, The Westin Houston Medical Center/Museum District is the highest ranked property in South Central Houston. This hotel is a short 7-minute walk from MD Anderson Cancer Center, and it offers a restaurant and an outdoor pool. Other top choices in the neighbourhood include MyCrib Houston Hostel and InterContinental Houston by IHG.
How many hotels can I expect to find in the South Central Houston area?
Expedia has 1043 hotels and other accommodation options in South Central Houston to choose from, making this an ideal home base for exploring the greater Houston area.
If I need to cancel my hotel reservation in South Central Houston, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals available in South Central Houston.
What is there to do around this Houston neighbourhood?
Spend some time exploring the great outdoors at Hermann Park, Cullen Sculpture Garden and Bagby Dog Park. Children's Museum of Houston and Houston Natural Science Museum are some other stops worth a visit in the neighbourhood. Toyota Center and Daikin Park are some popular places to visit in the area around South Central Houston. Shape Community Center and Project Row Houses are also worth a visit when you're out sightseeing in Houston.
How can I get around South Central Houston and the greater Houston area?
For a quick way to explore the city, catch a ride on metro transit at Elgin/Third Ward Station, TSU/UH Athletics District Station or Ensemble/HCC Station. If you want to venture out of town, M. D. Anderson Station is the closest train station. You can also catch a ride at Kinder Station.

Explore a world of travel with Expedia