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South Central Houston Hotels, Houston

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Check prices for these dates

Tonight
27 Dec - 28 Dec
Tomorrow
28 Dec - 29 Dec
Next weekend
2 Jan - 4 Jan
In two weeks
9 Jan - 11 Jan

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Our top choices for South Central Houston hotels

Premium bedding, pillow-top beds, minibar, in-room safe
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.0 out of 10, Wonderful, (1868)
"The staff made the stay worthwhile! Service was incredible and everyone was helpful and friendly. "
United States
lule
Hotel Zaza Houston Museum District
Double Room, 1 Queen Bed with Sofa bed
Wanderstay Boutique Hotel

Wanderstay Boutique Hotel

Wanderstay Boutique Hotel
2.0 star property
South Central Houston
9.8 out of 10, Exceptional, (58)
"Great location will stay again "
United States
Jason
The price is AU$165
includes taxes & fees
21 Jan - 22 Jan 2026
Wanderstay Boutique Hotel
Exterior
La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B
3.5 star property
South Central Houston
9.8 out of 10, Exceptional, (542)
"great neighborhood, friendly staff, and delicious breakfast"
United States
Anna
The price is AU$271
includes taxes & fees
6 Jan - 7 Jan 2026
La Maison in Midtown an urban B&B
Outdoor pool
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
South Central Houston
9.6 out of 10, Exceptional, (202)
" Beautiful relaxing love this place best I seen thank you"
United States
James
The price is AU$383
includes taxes & fees
8 Jan - 9 Jan 2026
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
Premium bedding, down duvets, pillow-top beds, in-room safe
Hilton University of Houston

Hilton University of Houston

Hilton University of Houston
3.5 star property
South Central Houston
9.0 out of 10, Wonderful, (889)
"Nice place to stay"
United States
Alexandra
The price is AU$256
includes taxes & fees
6 Jan - 7 Jan 2026
Hilton University of Houston
Daily buffet breakfast for a fee
DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites
4.0 star property
South Central Houston
8.4 out of 10, Very good, (479)
"Solid hotel and amenities"
United States
Kenneth
The price is AU$194
includes taxes & fees
25 Jan - 26 Jan 2026
DoubleTree by Hilton Houston Medical Center Hotel & Suites
Outdoor pool, free pool cabanas, pool umbrellas
The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1029)
"Excellent breakfast and bar"
United States
Misty
The price is AU$240
includes taxes & fees
29 Dec - 30 Dec
The Westin Houston Medical Center/Museum District
House
Newly Built Modern 3 Bedroom Houston Home

Newly Built Modern 3 Bedroom Houston Home

Newly Built Modern 3 Bedroom Houston Home
2.0 star property
South Central Houston
10.0 out of 10, Exceptional, (2)
"The pictures do not do this property justice. The three story home has 3 beautiful bedrooms, each with luxurious bathrooms. The main bedroom and the living room has a small patio and then there's a rooftop seating area that is an excellent spot for gazing at the Houston night skyline. The quiet area is gated off a not too busy street in a beautiful neighborhood. We did have a couple of issues upon our arrival but the hosts were on top of it and had it resolved the next day. They have great...
United States
robin
The price is AU$716
includes taxes & fees
18 Jan - 19 Jan 2026
Newly Built Modern 3 Bedroom Houston Home
Desk, free WiFi, bed sheets, alarm clocks
Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown
2.0 star property
South Central Houston
8.0 out of 10, Very good, (1001)
"Nice hotel"
United States
Robert Jeanmard
The price is AU$145
includes taxes & fees
28 Dec - 29 Dec
Americas Best Value Inn Medical Center Downtown
Reception
InterContinental Houston by IHG

InterContinental Houston by IHG

InterContinental Houston by IHG
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1001)
"Very clean room very polite staff"
United States
David
The price is AU$286
includes taxes & fees
30 Dec - 31 Dec
InterContinental Houston by IHG
Interior
Wanderstay Houston Hostel

Wanderstay Houston Hostel

Wanderstay Houston Hostel
2.0 star property
South Central Houston
8.4 out of 10, Very good, (189)
"Jj"
United States
diana
The price is AU$102
includes taxes & fees
28 Dec - 29 Dec
Wanderstay Houston Hostel
Lobby
Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District
4.0 star property
South Central Houston
9.0 out of 10, Wonderful, (1002)
"Comfortable bed, very clean, very good food, quite, friendly stuff and hotel shuttle works easy."
United States
Elena
The price is AU$297
includes taxes & fees
3 Jan - 4 Jan 2026
Houston Marriott Medical Center/Museum District
Exterior
Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown
2.0 star property
South Central Houston
7.8 out of 10, Good, (39)
"Check in staff was friendly and room was clean."
United States
Alfredo
The price is AU$139
includes taxes & fees
29 Dec - 30 Dec
Downtowner Inns - Houston Downtown
Standard Room, 1 King Bed
Southmore Boulevard Motel

Southmore Boulevard Motel

Southmore Boulevard Motel
2.0 star property
South Central Houston
5.6 out of 10, (226)
"A classical Motel like in a Movie. The staff was really kind and helpful."
United Kingdom
Lisa-Maria
The price is AU$94
includes taxes & fees
30 Dec - 31 Dec
Southmore Boulevard Motel
Sun deck
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
South Central Houston
8.4 out of 10, Very good, (1791)
"The hotel was great and convenient. Easy check in an check out. Will definitely stay again. "
United States
Allison
The price is AU$154
includes taxes & fees
3 Jan - 4 Jan 2026
Hilton Houston Plaza/Medical Center
Lobby
Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl
2.5 star property
South Central Houston
5.8 out of 10, (1000)
"Room was very large…"
United States
Veronica
The price is AU$102
includes taxes & fees
1 Jan - 2 Jan 2026
Extended Stay America Suites Houston Med Ctr Braeswood Bl
House, 3 Bedrooms | Private kitchen
Sophisticated Urban Retreat With Skyline Views 3 Bedroom Home

Sophisticated Urban Retreat With Skyline Views 3 Bedroom Home

Sophisticated Urban Retreat With Skyline Views 3 Bedroom Home
3.0 star property
South Central Houston
The price is AU$983
includes taxes & fees
29 Dec - 30 Dec
Sophisticated Urban Retreat With Skyline Views 3 Bedroom Home
House
Downtown Houston 3BR Bachelorette Escape

Downtown Houston 3BR Bachelorette Escape

Downtown Houston 3BR Bachelorette Escape
2.0 star property
South Central Houston
9.6 out of 10, Exceptional, (5)
"Everything was great. Look no further and book this property. "
United States
Iesheal
The price is AU$677
includes taxes & fees
11 Jan - 12 Jan 2026
Downtown Houston 3BR Bachelorette Escape
Apartment
The Green Haus Luxxe Cabana Rooftop Retreat

The Green Haus Luxxe Cabana Rooftop Retreat

The Green Haus Luxxe Cabana Rooftop Retreat
2.0 star property
South Central Houston
10.0 out of 10, Exceptional, (1)
The Green Haus Luxxe Cabana Rooftop Retreat
House
Spacious Houston 3bed3 Bath Family Townhome

Spacious Houston 3bed3 Bath Family Townhome

Spacious Houston 3bed3 Bath Family Townhome
2.0 star property
South Central Houston
6.8 out of 10, (3)
"This rental was beautiful very clean and spacious. The location is very convenient if you are visiting the downtown area and for local shopping. The host was prompt with communicating when needed. It is a three story rental so the only issue was how tiring the stairs could be since the elevator was not available to use. I would definitely recommend and book with this host and rental property again. "
United States
Candance
Spacious Houston 3bed3 Bath Family Townhome
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Our guide on where to stay in South Central Houston

Find the best South Central Houston areas for the activities you enjoy most.
Discovery Green which includes a high-rise building, a square or plaza and a city

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Menil Collection showing interior views and art

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Northside

While you're in Northside, take in top sights like The Heights Theater or Greenspoint Mall, and hop on the metro to see more of the city at Northline Transit Center/HCC Station or Melbourne/North Lindale Station.

Top South Central Houston Hotel Reviews

Wanderstay Houston Hostel

Wanderstay Houston Hostel

10/10 Excellent
"Jj"
diana 1-night trip
Posted 5 days ago
Wanderstay Houston Hostel

Frequently asked questions

What's it like in South Central Houston?
Travellers are sure to enjoy a stay in Houston's South Central Houston neighbourhood. Make sure that you visit Continental Club and Midtown Arts and Theater Center Houston as part of your South Central Houston travel plans.
What's the best accommodation in South Central Houston?
Based on Expedia customer reviews, Wanderstay Boutique Hotel is the highest ranked property in South Central Houston. This hotel offers free parking and free WiFi. Other top choices in the neighbourhood include MyCrib Houston Hostel and InterContinental Houston by IHG.
How many hotels can I expect to find in the South Central Houston area?
Expedia has 1155 hotels and other accommodation options in South Central Houston to choose from, making this an ideal home base for exploring the greater Houston area.
If I need to cancel my hotel reservation in South Central Houston, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals available in South Central Houston.
What is there to do around this Houston neighbourhood?
Spend some time exploring the great outdoors at Hermann Park, Cullen Sculpture Garden and James Turrell's Twilight Epiphany Skyscape. Continental Club and Midtown Arts and Theater Center Houston are some other stops worth a visit in the neighbourhood. Toyota Center and Daikin Park are some popular places to visit in the area around South Central Houston. Shape Community Center and Project Row Houses are also worth a visit when you're out sightseeing in Houston.
How can I get around South Central Houston and the greater Houston area?
For a quick way to explore the city, catch a ride on metro transit at Elgin/Third Ward Station, TSU/UH Athletics District Station or Ensemble/HCC Station.

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