South Central Houston Travel Guide
Tourist Guide
Visit South Central Houston
Popular places to visit
MD Anderson Cancer Center
If MD Anderson Cancer Center is what brings you to town, hopefully you'll have a chance to explore more of Houston.
Rice University
Enjoy the student vibe when you visit Rice University during your travels in Houston. Experience the area's lively festivals and fascinating museums.
Houston Zoo
With a huge collection of animals, a water park and a cinema, Houston Zoo is a great day out for the family.
University of Houston
Take a campus tour or just explore the area of University of Houston during your travels in Houston. Experience the great live music and lively festivals in this vibrant area.
Children's Museum of Houston
You can take time to visit Children's Museum of Houston during your travels to Houston. Experience the area's acclaimed art galleries and great live music.
Houston Natural Science Museum
You can spend time browsing the exhibits at Houston Natural Science Museum during your trip to Houston. Experience the area's great live music and acclaimed theatre scene.
Activities
Astroville Tunnel Tour of Downtown Houston (Air-Conditioned)
Houston: Holocaust Museum Houston Entry Ticket
Houston Museum of Natural Science: Butterfly Center Ticket
Houston: Children's Museum Houston Entry Ticket
Houston Rockets Basketball Game at Toyota Center
Houston: Houston Botanic Garden Entry Ticket
Our pick of the best South Central Houston Hotel Deals
Hotel Zaza Houston Museum District
Yes
Reviewed on 30 Mar 2026
Hilton Houston Plaza/Medical Center
Room was clean. Staff was great.
Reviewed on 1 Apr 2026
InterContinental Houston by IHG
Everyone is always friendly as usual!
Reviewed on 27 Mar 2026
The Westin Houston Medical Center/Museum District
Clean rooms, easy check in, friendly staff.
Reviewed on 1 Apr 2026
Americas Best Value Inn Medical Center Downtown
The sheets had stains all over them. The toilet leaked all over the floor. The outside of the building looks pretty updated, but the inside of the rooms were not good at all.
Reviewed on 1 Apr 2026
DoubleTree by Hilton Houston Medical Center Hotel & Suites
Check South Central Houston hotel availability
Other neighbourhoods around South Central Houston
Greater Third Ward
If you're spending time in Greater Third Ward, check out sights like Barbara Jordan & Mickey Leland Archives or Fertitta Center and hop on the metro to see more of the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Midtown
Midtown is well liked for its restaurants and live music. If you're hoping to get in some sightseeing, Houston Fire Museum and Midtown Arts and Theater Center Houston are top spots, and you can jump on the metro at McGowen Station or Ensemble/HCC Station to get around.
East Downtown Houston
The restaurants and live music are just a few things visitors like about East Downtown Houston. Shell Energy Stadium and Giant Beatles Statues are worthwhile spots to check out, and you can hop on the metro at Leeland/Third Ward Station or EaDo/Stadium Station to get around the larger area.
Museum District
Known for its abundant dining options and interesting museums, there's plenty to explore in Museum District. Top attractions like Children's Museum of Houston and Houston Natural Science Museum are major draws, and you can catch the metro at Museum District Station or Hermann Park/Rice U Station to see more of the city.
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Downtown Houston
Gourmet restaurants acclaimed theatres and top sights from Toyota Center to Daikin Park – discover Downtown Houston, a destination also famous for its sports teams.
