South Central Houston Travel Guide

Tourist Guide

South Central Houston
South Central Houston
South Central Houston
South Central Houston
South Central Houston

Popular places to visit

Activities


Our pick of the best South Central Houston Hotel Deals

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
The price is AU$381 per night from 25 May to 26 May
AU$381
25 May - 26 May
includes taxes & fees
Stay at this luxury hotel in Houston. Enjoy free Wi-Fi, a full-service spa and breakfast (surcharge). Our guests praise the helpful staff in their reviews. Popular ...
9.2/10 Wonderful! (1,006 reviews)
No breakfast instead a good coffee bar

Reviewed on 12 May 2026

Hotel Zaza Houston Museum District
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
The price is AU$180 per night from 24 May to 25 May
AU$180
24 May - 25 May
includes taxes & fees
Stay at this luxury hotel in Houston. Enjoy free Wi-Fi, 2 restaurants and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in their reviews. ...
8.4/10 Very Good! (1,914 reviews)
Breakfast was wonderful and the front desk staff were very helpful.

Reviewed on 16 May 2026

Hilton Houston Plaza/Medical Center
Sentral Forme Houston

Sentral Forme Houston

4.5 out of 5
5501 La Branch Street Houston TX
The price is AU$317 per night from 18 May to 19 May
AU$317
18 May - 19 May
includes taxes & fees
Stay at this luxury aparthotel in Houston. Enjoy a 24-hour fitness centre, parking (surcharge) and a 24-hour front desk. Popular attractions Toyota Center and ...
9/10 Wonderful! (32 reviews)
The hotel is beautiful but still under construction.

Reviewed on 16 May 2026

Sentral Forme Houston
InterContinental Houston by IHG

InterContinental Houston by IHG

4 out of 5
6750 Main St Houston TX
The price is AU$291 per night from 24 May to 25 May
AU$291
24 May - 25 May
includes taxes & fees
Stay at this business-friendly hotel in Houston. Enjoy free Wi-Fi, breakfast (surcharge) and a free local area shuttle. Our guests praise the helpful staff and ...
9.2/10 Wonderful! (1,003 reviews)
Check-in was quick and easy. The front desk was very friendly and accommodating. The shuttle service was very convenient for us because my husband had several appointments at MD Anderson so we used the shuttle service to get back and forth.

Reviewed on 13 May 2026

InterContinental Houston by IHG
The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

4 out of 5
1709 DRYDEN ROAD Houston TX
The price is AU$280 per night from 22 May to 23 May
AU$280
22 May - 23 May
includes taxes & fees
Stay at this business-friendly hotel in Houston. Enjoy breakfast (surcharge), room service and a 24-hour health club. Our guests praise the helpful staff and ...
9.2/10 Wonderful! (1,153 reviews)
We had a wonderful stay! Comfortable bed and great breakfast. Really nice staff. Walking distance to MD Anderson and healthy restaurants near by. Will be staying here for our MD Anderson visits.

Reviewed on 10 May 2026

The Westin Houston Medical Center/Museum District
Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown

2 out of 5
2510 Hamilton St Houston TX
The price is AU$143 per night from 19 May to 20 May
AU$143
19 May - 20 May
includes taxes & fees
Stay at this hotel in Houston. Enjoy free breakfast, free Wi-Fi and free parking. Popular attractions Toyota Center and Daikin Park are located nearby.
9.2/10 Wonderful! (135 reviews)
This is an older but well kept property. The runs have been updated and are comfortable.

Reviewed on 16 May 2026

Downtowner Inns - Houston Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.



South Central Houston Travel Guide

Choose two or more items and save on your trip: