South Main Hotels, Houston
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Our top choices for South Main hotels
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,006 reviews)
"Good parking"
joseph
The price is AU$149
includes taxes & fees
11 June - 12 June
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,007 reviews)
"Clean & comfortable, super nice staff, good breakfast options, convenient to MDA."
Cleota
The price is AU$163
includes taxes & fees
11 June - 12 June
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.2 out of 10, Good, (1,294 reviews)
"Would stay again!"
Austin
The price is AU$165
includes taxes & fees
11 June - 12 June
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,003 reviews)
"Very clean rooms and excellent staff"
Efrain
The price is AU$130
includes taxes & fees
7 July - 8 July
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (868 reviews)
"My stay was perfect "
Fredrick
The price is AU$153
includes taxes & fees
9 July - 10 July
Studio 6 Houston, TX – Pearland/Medical Center
Studio 6 Houston, TX – Pearland/Medical CenterSoutheast Houston, 12.9 km from South Main
9.4 out of 10, Exceptional, (99 reviews)
"Awesome staff, clean rooms and love the free parking! Thanks a lot for a great stay!"
Rorie
The price is AU$100
includes taxes & fees
11 June - 12 June
Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (274 reviews)
"Very nice hotel. New construction as of Spring 2026."
Casey
The price is AU$165
includes taxes & fees
11 June - 12 June
Downtowner Inns - Houston Downtown
Downtowner Inns - Houston DowntownMidtown, 9.1 km from South Main
9.2 out of 10, Wonderful, (160 reviews)
"Great place. The staff is very friendly and the place is clean."
Fernando
The price is AU$155
includes taxes & fees
8 July - 9 July
Hotel Royale
Hotel Royale20.9 km from South Main
9.0 out of 10, Wonderful, (42 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
Jerome
The price is AU$123
includes taxes & fees
11 July - 12 July
Tru by Hilton Houston Webster NASA
Tru by Hilton Houston Webster NASA30.7 km from South Main
9.0 out of 10, Wonderful, (1,010 reviews)
"Definitely will stay here again. Great location near Great Wolf Lodge."
Deanndra
The price is AU$133
includes taxes & fees
6 July - 7 July
Palace Inn Blue 290 W 43rd & Bingle Rd
Palace Inn Blue 290 W 43rd & Bingle Rd19.4 km from South Main
9.0 out of 10, Wonderful, (74 reviews)
"We loved it, very nice employees and very clean."
Jorge
The price is AU$154
includes taxes & fees
9 July - 10 July
Crystal Inn Northeast Houston Downtown I-610
Crystal Inn Northeast Houston Downtown I-610Northside, 18.9 km from South Main
8.4 out of 10, Very good, (212 reviews)
"Great price and nice rooms"
Armando
The price is AU$101
includes taxes & fees
24 June - 25 June
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG30.8 km from South Main
9.0 out of 10, Wonderful, (1,016 reviews)
"Wonderful enjoyed the stay and breakfast clean rooms"
Albert
The price is AU$145
includes taxes & fees
6 July - 7 July
Hotel Park Place
Hotel Park PlaceSoutheast Houston, 12.1 km from South Main
8.8 out of 10, Excellent, (342 reviews)
"Great for the price and close to airport "
Tranecia
The price is AU$107
includes taxes & fees
7 July - 8 July
Doubletree by Hilton Houston Hobby Airport
Doubletree by Hilton Houston Hobby AirportSoutheast Houston, 14.5 km from South Main
8.8 out of 10, Excellent, (1,017 reviews)
"This was a great stay. We liked the suite, would have liked a microwave in there."
Sara
The price is AU$181
includes taxes & fees
6 July - 7 July
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham18.5 km from South Main
8.8 out of 10, Excellent, (1,215 reviews)
"The room was clean, staff was friendly, breakfast was great, and the area and location was nice and quiet."
Dr. Cherie
The price is AU$138
includes taxes & fees
11 June - 12 June
Courtyard by Marriott Houston Intercontinental Airport
Courtyard by Marriott Houston Intercontinental Airport31.8 km from South Main
9.0 out of 10, Wonderful, (1,225 reviews)
"Very clean, Fabulous staff!!!"
Lynette
The price is AU$218
includes taxes & fees
5 July - 6 July
Sonesta Simply Suites Houston – NASA Clear Lake
Sonesta Simply Suites Houston – NASA Clear Lake31.8 km from South Main
8.2 out of 10, Very good, (1,020 reviews)
"This is the third time I stayed here and I always love my stay!"
Deena
The price is AU$117
includes taxes & fees
21 June - 22 June
Hotel Zaza Houston Museum District
Hotel Zaza Houston Museum District6.3 km from South Main
9.2 out of 10, Wonderful, (1,015 reviews)
"Great place to stay"
Gayathry
The price is AU$416
includes taxes & fees
6 July - 7 July
Club Quarters Hotel Downtown, Houston
Club Quarters Hotel Downtown, HoustonHouston Central Business District, 10.9 km from South Main
8.6 out of 10, Excellent, (4,228 reviews)
"Great location with many restaurants within walking distance."
Frank
The price is AU$169
includes taxes & fees
11 June - 12 June
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.6 Excellent 1,007 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 868 reviews | View | ||||||
 Wyndham Houston near NRG Park/Medical Center | 7.2 Good 1,294 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,006 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,003 reviews | View |
Our guide on where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Rothko Chapel while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews
Blossom Hotel Houston, Curio Collection by Hilton
10/10 Excellent
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