Cheap flights from Chicago to Northeast Missouri

View AU$72 flight on Thu, 21 Aug. 2025Opens in a new window

Popular airlines from Chicago to Northeast Missouri

  • Jetstar

    Jetstar

  • Qantas Airways

    Qantas Airways

  • Virgin Australia

    Virgin Australia

  • Scoot

    Scoot

  • American Airlines

    American Airlines

  • Emirates

    Emirates

  • United

    United

  • Plan, book, fly with confidence

  • trending down icon

    Be in the know

    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon

    Book smarter

    Save up to 35% on select hotels after you book a flight*
  • payments icon

    Earn twice

    Earn your airline miles on top of our rewards
    Sign in

Cheap Flights from Chicago (CHI) to Northeast Missouri (STL)

Prices were available within the past 7 days for one-way flights and round trip tickets for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, 20 Aug. - Thu, 21 Aug.
ORD
Chicago
STL
St. Louis
AU$141 Return, found 5 days ago
AU$141
Return
found 5 days ago
Select American Airlines flight, departing Wed, 20 Aug. from Chicago to St. Louis, returning Thu, 21 Aug., priced at AU$141 found 5 days ago
Southern Airways Express
Mon, 1 Sep. - Mon, 8 Sep.
ORD
Chicago
UIN
Quincy
AU$208 Return, found 6 days ago
AU$208
Return
found 6 days ago
Select Southern Airways Express flight, departing Mon, 1 Sep. from Chicago to Quincy, returning Mon, 8 Sep., priced at AU$208 found 6 days ago
United
Tue, 26 Aug. - Sat, 6 Sep.
ORD
Chicago
STL
St. Louis
AU$211 Return, found 5 days ago
AU$211
Return
found 5 days ago
Select United flight, departing Tue, 26 Aug. from Chicago to St. Louis, returning Sat, 6 Sep., priced at AU$211 found 5 days ago
American Airlines
Wed, 20 Aug. - Thu, 21 Aug.
ORD
Chicago
STL
St. Louis
AU$232 Return, found 5 days ago
AU$232
Return
found 5 days ago
Select American Airlines flight, departing Wed, 20 Aug. from Chicago to St. Louis, returning Thu, 21 Aug., priced at AU$232 found 5 days ago
Delta
Wed, 20 Aug. - Thu, 21 Aug.
MDW
Chicago
STL
St. Louis
AU$272 Return, found 5 days ago
AU$272
Return
found 5 days ago
Select Delta flight, departing Wed, 20 Aug. from Chicago to St. Louis, returning Thu, 21 Aug., priced at AU$272 found 5 days ago
Alaska Airlines
Sun, 31 Aug. - Sun, 7 Sep.
ORD
Chicago
STL
St. Louis
AU$735 Return, found 6 days ago
AU$735
Return
found 6 days ago
Select Alaska Airlines flight, departing Sun, 31 Aug. from Chicago to St. Louis, returning Sun, 7 Sep., priced at AU$735 found 6 days ago

Find the cheapest month to fly from Chicago (CHI) to St. Louis (STL)

August is typically the cheapest month to fly

From AU$139 - AU$355 per traveller.

Graph displaying average flight prices per month

*Available to Expedia members.