A historic building with ornate architecture and a modern skyscraper in the background.

Cheap Flights from Santa Cruz (VVI) to Santiago (SCL)

View AU$327 flight on Tue, 25 Aug 2026Opens in a new window

Popular airlines from Santa Cruz (VVI-Viru Viru Intl.) to Santiago Intl. Airport (SCL)

  • Be in the know

    Get alerts if flight prices drop or rise*

  • Book smarter

    Save up to 35% on select hotels after you book a flight*

  • Earn twice

    Earn your airline miles on top of our rewards
    Sign in

Cheap Flights from Santa Cruz (VVI) to Santiago (SCL)

Prices were available within the past 7 days for one-way flights and round trip tickets for the period specified. Prices and availability are subject to change. Additional terms apply.

Boliviana De Aviacion
Fri, 4 Dec - Sat, 12 Dec
VVI
Santa Cruz
SCL
Santiago
AU$585 Return, found 6 days ago
AU$585
Return
found 6 days ago
Select Boliviana De Aviacion flight, departing Fri, 4 Dec from Santa Cruz to Santiago, returning Sat, 12 Dec, priced at AU$585 found 6 days ago
Boliviana De Aviacion
Fri, 4 Dec - Sat, 12 Dec
VVI
Santa Cruz
SCL
Santiago
AU$602 Return, found 6 days ago
AU$602
Return
found 6 days ago
Select Boliviana De Aviacion flight, departing Fri, 4 Dec from Santa Cruz to Santiago, returning Sat, 12 Dec, priced at AU$602 found 6 days ago
Boliviana De Aviacion
Fri, 4 Dec - Sat, 12 Dec
VVI
Santa Cruz
SCL
Santiago
AU$655 Return, found 6 days ago
AU$655
Return
found 6 days ago
Select Boliviana De Aviacion flight, departing Fri, 4 Dec from Santa Cruz to Santiago, returning Sat, 12 Dec, priced at AU$655 found 6 days ago
Boliviana De Aviacion
Fri, 4 Dec - Sat, 12 Dec
VVI
Santa Cruz
SCL
Santiago
AU$701 Return, found 6 days ago
AU$701
Return
found 6 days ago
Select Boliviana De Aviacion flight, departing Fri, 4 Dec from Santa Cruz to Santiago, returning Sat, 12 Dec, priced at AU$701 found 6 days ago
Boliviana De Aviacion
Fri, 18 Sept - Mon, 21 Sept
VVI
Santa Cruz
SCL
Santiago
AU$726 Return, found 4 days ago
AU$726
Return
found 4 days ago
Select Boliviana De Aviacion flight, departing Fri, 18 Sept from Santa Cruz to Santiago, returning Mon, 21 Sept, priced at AU$726 found 4 days ago
LATAM Airlines Group
Fri, 4 Dec - Sat, 12 Dec
VVI
Santa Cruz
SCL
Santiago
AU$735 Return, found 6 days ago
AU$735
Return
found 6 days ago
Select LATAM Airlines Group flight, departing Fri, 4 Dec from Santa Cruz to Santiago, returning Sat, 12 Dec, priced at AU$735 found 6 days ago
LATAM Airlines Group
Thu, 1 Oct - Thu, 15 Oct
VVI
Santa Cruz
SCL
Santiago
AU$760 Return, found 2 days ago
AU$760
Return
found 2 days ago
Select LATAM Airlines Group flight, departing Thu, 1 Oct from Santa Cruz to Santiago, returning Thu, 15 Oct, priced at AU$760 found 2 days ago
LATAM Airlines Group
Wed, 30 Sept - Wed, 14 Oct
VVI
Santa Cruz
SCL
Santiago
AU$763 Return, found 2 days ago
AU$763
Return
found 2 days ago
Select LATAM Airlines Group flight, departing Wed, 30 Sept from Santa Cruz to Santiago, returning Wed, 14 Oct, priced at AU$763 found 2 days ago
LATAM Airlines Group
Wed, 30 Sept - Wed, 14 Oct
VVI
Santa Cruz
SCL
Santiago
AU$764 Return, found 2 days ago
AU$764
Return
found 2 days ago
Select LATAM Airlines Group flight, departing Wed, 30 Sept from Santa Cruz to Santiago, returning Wed, 14 Oct, priced at AU$764 found 2 days ago
LATAM Airlines Group
Fri, 4 Dec - Sat, 12 Dec
VVI
Santa Cruz
SCL
Santiago
AU$767 Return, found 6 days ago
AU$767
Return
found 6 days ago
Select LATAM Airlines Group flight, departing Fri, 4 Dec from Santa Cruz to Santiago, returning Sat, 12 Dec, priced at AU$767 found 6 days ago

Frequently asked questions

How much does a flight from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez) cost?
You can find one-way and return flights from VVI to SCL with Expedia. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see our cheapest fares first, and use the Price Tracking tool to receive alerts when VVI to SCL ticket fares go up or down.
What is the cheapest month to fly from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez)?
If you're looking for the cheapest time to fly from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez), November is typically your best bet. You can expect average return fares around AU$787 during this month. November often sees lower prices as it falls outside of peak holiday travel seasons, when demand tends to be lower. Other budget-friendly months to consider for this route include August and September.
Which airlines fly direct from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez)?
There are 2 airlines offering direct flights from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez). These are:
  • Boliviana De Aviacion operates 7 direct flights from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez) every week.
  • LATAM Airlines Group operates 7 direct flights from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez) every week.
What is the cheapest airline that flies from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez)?
Boliviana De Aviacion is one of the cheapest airlines offering nonstop return flights from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez), with tickets starting from around AU$757 for flights that can be booked for departure within the next year. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.
How do I find cheap flights from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez)?
To find a cheap flight from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best airline to fly with from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez)?
The best airline to fly with from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez) will differ from traveller to traveller. If you like to fly early, LATAM Airlines Group offers early morning flights. If price is the most important factor, Boliviana De Aviacion typically offers the lowest fares. Boliviana De Aviacion offers the most daily flights from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez), which is great if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.
What is the best time to fly from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez)?
The cheapest months to fly from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez) are typically November and September, with average return flights around AU$787. While December is the most popular month for this route, offering plenty of flight options, it's not the cheapest. If you're looking for the best value, aiming for November or September will likely give you more affordable fares.
How many flights per day from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez)?
There are approximately 8 connecting flights per day from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez). Some common connection points include El Alto Intl. (LPB), Guarulhos - Governor Andre Franco Montoro Intl. (GRU), and Jorge Chavez Intl. (LIM).
What is the earliest flight from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez)?
The earliest flight from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez) typically departs around 2:00 AM local time. This flight is operated by Aerolineas Argentinas. This is a seasonal service active in June, July, and August. An early departure like this can help you make the most of your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez)?
You'll generally find the most flights from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez) on a Tuesday, with around 6 flights available. This gives you a good selection for your travel plans. Major airlines on this route include LATAM Airlines Group, Boliviana De Aviacion, and Aerolineas Argentinas. Tuesdays offer notably more flight options compared to other days of the week.
What are the most popular departure times for flights from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez)?
The most popular departure times for flights from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez) are in the morning, from 6am to 9am. Many major carriers, including LATAM Airlines Group and Boliviana De Aviacion, offer flights during this window. Many travellers prefer this time as it allows for an early start to their journey, getting them to their destination with plenty of time left in the day.
How long does it take to fly from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez)?
A non-stop flight from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez) typically takes around 3 hours 18 minutes. This route covers a distance of approximately 1,910 kilometres. If you opt for a flight with one stop, your travel time will be longer, usually around 15 hours 30 minutes. Flights with two or more stops take even longer, averaging about 19 hours 48 minutes. Keep in mind that actual flight times can vary due to factors like wind patterns and air traffic, so it's always a good idea to allow for some extra time when planning your journey.
Can you fly business or first class from Santa Cruz (VVI) to Santiago (SCL)?
Select the "Business class" and "First class" filters when looking for Santa Cruz (VVI) to Santiago (SCL) flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez) flight with Expedia?
It's easy to earn miles on a Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Santiago (SCL) from Santa Cruz (VVI)?
If you're planning to travel to Santiago from Viru Viru Intl. (VVI), you can fly directly into Arturo Merino Benitez (SCL). Some flights may connect through major hubs like Guarulhos - Governor Andre Franco Montoro Intl. (GRU), El Alto Intl. (LPB), or Jorge Chavez Intl. (LIM) before reaching Santiago. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez) at the last minute?
Typically, booking a last minute flight from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez) flight and hotel package?
Securing a Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez)?
If you booked your Santa Cruz (VVI-Viru Viru Intl.) to Santiago (SCL-Arturo Merino Benitez) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Viru Viru Intl.
Destination airport
Arturo Merino Benitez
Return price
AU$585
Distance
1899 km
Average flight time
3 hours 11 mins

Book with confidence

Your quick guide to flights from Santa Cruz to Santiago

Pick up great flights from Santa Cruz to Santiago

With Expedia, you have your pick of flights a day with 20 airlines covering flights from Santa Cruz to Santiago. Whether you’re on a business trip, a family holiday or a luxury break, just enter your travel dates, hit search then check out your choice of flights. Select from return, one way or multi-city flights, and use the advance search tool if you want a direct or refundable flight. You can narrow your search to show you just your preferred cabin class and airline, too. It’s all easy. You can book direct flights from Santa Cruz to Santiago that take around hours.

Find cheap flights from Santa Cruz to Santiago

From the great flight deals with prices currently ranging from AU$585 to AU$767, you can choose to see the cheapest flights first. Generally, you can book the cheapest flights from Santa Cruz to Santiago around 4 to 6 weeks in advance. If your travel dates are flexible, try to avoid weekends and peak seasons – when you are more likely to grab the lowest prices. Even last minute, there are some impressive deals. The cheapest time to fly to Santiago is normally in December.

Reasons to book your flight from Santa Cruz to Santiago with Expedia

Expedia makes it easy to find, book, and travel, with everything you need all in one place. When you enter your travel details, find fantastic deals just for you on flight tickets from Santa Cruz to Santiago across all the main airline carriers, so you can save time, dollars, and hassle finding the perfect flight. If you think your plans could change, choose refundable flights so any changes won’t cost you more. Book your flight to Santiago right now and, if you join Expedia Rewards, you earn points this time and every time you travel with Expedia.

Your quick guide to flights from Santa Cruz to Santiago

Explore a world of travel with Expedia

*Available to Expedia members.