Cheap flights from Santa Cruz

View AU$360 flight on Tue, 7 July 2026Opens in a new window

Popular airlines from Santa Cruz

  • Avianca

    Avianca

  • Boliviana De Aviacion

    Boliviana De Aviacion

  • LATAM Airlines Group

    LATAM Airlines Group

  • GOL Linhas Aereas S.A.

    GOL Linhas Aereas S.A.

  • Copa

    Copa

  • United

    United

  • Air Europa

    Air Europa

    notification illustration

    Be in the know

    Get alerts if flight prices drop or rise*
    deals illustration

    Book smarter

    Save up to 35% on select hotels after you book a flight*
    trophy illustration

    Earn twice

    Earn your airline miles on top of our rewards
    Sign in

Cheapest flights from Santa Cruz

These prices were available within the past 7 days. Prices quoted are per person, return, for the period specified. Prices and availability are subject to change. Additional terms apply.

Boliviana De Aviacion
Thu, 8 Jan - Sat, 17 Jan
VVI
Santa Cruz
ASU
Asuncion
AU$691 Return, found 4 hours ago
AU$691
Return
found 4 hours ago
Select Boliviana De Aviacion flight, departing Thu, 8 Jan from Santa Cruz to Asuncion, returning Sat, 17 Jan, priced at AU$691 found 4 hours ago
GOL Linhas Aereas S.A.
Thu, 8 Jan - Sat, 17 Jan
VVI
Santa Cruz
ASU
Asuncion
AU$932 Return, found 4 hours ago
AU$932
Return
found 4 hours ago
Select GOL Linhas Aereas S.A. flight, departing Thu, 8 Jan from Santa Cruz to Asuncion, returning Sat, 17 Jan, priced at AU$932 found 4 hours ago
GOL Linhas Aereas S.A.
Thu, 8 Jan - Sat, 17 Jan
VVI
Santa Cruz
ASU
Asuncion
AU$994 Return, found 4 hours ago
AU$994
Return
found 4 hours ago
Select GOL Linhas Aereas S.A. flight, departing Thu, 8 Jan from Santa Cruz to Asuncion, returning Sat, 17 Jan, priced at AU$994 found 4 hours ago
Copa
Wed, 17 Sept - Mon, 1 Dec
VVI
Santa Cruz
PTY
Panama City
AU$1,073 Return, found 4 days ago
AU$1,073
Return
found 4 days ago
Select Copa flight, departing Wed, 17 Sept from Santa Cruz to Panama City, returning Mon, 1 Dec, priced at AU$1,073 found 4 days ago
Copa
Tue, 9 Sept - Fri, 19 Sept
VVI
Santa Cruz
MEX
Mexico City
AU$1,088 Return, found 2 days ago
AU$1,088
Return
found 2 days ago
Select Copa flight, departing Tue, 9 Sept from Santa Cruz to Mexico City, returning Fri, 19 Sept, priced at AU$1,088 found 2 days ago
Copa
Tue, 9 Sept - Wed, 17 Sept
VVI
Santa Cruz
MEX
Mexico City
AU$1,140 Return, found 2 days ago
AU$1,140
Return
found 2 days ago
Select Copa flight, departing Tue, 9 Sept from Santa Cruz to Mexico City, returning Wed, 17 Sept, priced at AU$1,140 found 2 days ago
LATAM Airlines Group
Wed, 10 Sept - Mon, 15 Sept
VVI
Santa Cruz
MEX
Mexico City
AU$1,153 Return, found 2 days ago
AU$1,153
Return
found 2 days ago
Select LATAM Airlines Group flight, departing Wed, 10 Sept from Santa Cruz to Mexico City, returning Mon, 15 Sept, priced at AU$1,153 found 2 days ago
avianca
Wed, 17 Sept - Mon, 1 Dec
VVI
Santa Cruz
PTY
Panama City
AU$1,181 Return, found 4 days ago
AU$1,181
Return
found 4 days ago
Select avianca flight, departing Wed, 17 Sept from Santa Cruz to Panama City, returning Mon, 1 Dec, priced at AU$1,181 found 4 days ago
Copa
Tue, 9 Sept - Mon, 15 Sept
VVI
Santa Cruz
MEX
Mexico City
AU$1,192 Return, found 2 days ago
AU$1,192
Return
found 2 days ago
Select Copa flight, departing Tue, 9 Sept from Santa Cruz to Mexico City, returning Mon, 15 Sept, priced at AU$1,192 found 2 days ago
Copa
Sat, 13 Sept - Wed, 17 Sept
VVI
Santa Cruz
MEX
Mexico City
AU$1,193 Return, found 2 days ago
AU$1,193
Return
found 2 days ago
Select Copa flight, departing Sat, 13 Sept from Santa Cruz to Mexico City, returning Wed, 17 Sept, priced at AU$1,193 found 2 days ago
*Available to Expedia members.