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5 Dec - 6 Dec
Tomorrow
6 Dec - 7 Dec
This weekend
5 Dec - 7 Dec
Next weekend
12 Dec - 14 Dec

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Top hotels and accommodation in Santa Cruz

Seasonal outdoor pool
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (345)
"Staff excellent, check in good and bar resturant really good."
United Kingdom
John
Travelling for leisure
The price is AU$203
11 Dec - 12 Dec
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Restaurant
Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3.0 star property
Santa Cruz
9.6 out of 10, Exceptional, (72)
"Ac works great."
Canada
Tristyn
Travelling for leisure
The price is AU$58
19 Dec - 20 Dec
Ibis Santa Cruz DE LA Sierra
Outdoor pool
Sun Hotel

Sun Hotel

3.5 star property
Santa Cruz
8.4 out of 10, Very good, (329)
"Helpful staff, clean rooms, and prompt shuttle service to and from the airport."
United States
Steven
Travelling for business
The price is AU$136
12 Dec - 13 Dec
Sun Hotel
Lounge
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (253)
"And the food at breakfast was great!"
United States
Quinton
Travelling with friends
The price is AU$97
11 Dec - 12 Dec
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Indoor pool, outdoor pool, pool umbrellas
Camino Real Hotel

Camino Real Hotel

4.5 star property
Santa Cruz
8.8 out of 10, Excellent, (407)
"Lovely staff Pool area great."
United Kingdom
Karl
The price is AU$273
25 Dec - 26 Dec
Camino Real Hotel
City view from property
HOTEL OSHO

HOTEL OSHO

3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (33)
"Excellent"
United States
Neysa
HOTEL OSHO
Reception
Hotel Cortez

Hotel Cortez

3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (122)
"I love the pool and garden area"
United States
Elizabeth
The price is AU$202
23 Dec - 24 Dec
Hotel Cortez
Outdoor pool, pool umbrellas, pool loungers
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

5.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (210)
"Great hotel, food and location albeit a little expensive "
United States
Reinaldo
The price is AU$168
12 Dec - 13 Dec
Marriott Santa Cruz de la Sierra Hotel
Exterior
Delfines Collection Hotel By Mercure

Delfines Collection Hotel By Mercure

3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (71)
"Clean comfortable rooms "
United States
mary
The price is AU$70
14 Dec - 15 Dec
Delfines Collection Hotel By Mercure
Exterior
Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra

5.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (103)
"Great location and very clean hotel."
United States
William
Travelling with friends
The price is AU$151
19 Dec - 20 Dec
Novotel Santa Cruz De La Sierra
Business Apartment, Terrace (Plus) | Terrace/patio
Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz

3.5 star property
Santa Cruz
8.6 out of 10, Excellent, (93)
"Come and go easily, intellectual and kind owners who are working hard to make the property improvements that will bring this hotel up to the next level. A family friendly environment with easy walking distance to everything you need. Bed was not the best, but I know they are upgrading so I appreciate the ongoing process. For a few nights stay, the deals are very fair prices. "
United States
Andrew
Apart Hotel Premium Suites Santa Cruz
Front of property
Chairú Eco Hotel

Chairú Eco Hotel

3.5 star property
Santa Cruz
9.6 out of 10, Exceptional, (45)
"Nice property. Would definitely stay there again and again. Only negative was on our last night there was a really noisy party next door that lasted until 2am. "
United States
Andrew
Chairú Eco Hotel
Reception
Lido Hotel

Lido Hotel

3.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (30)
"Very helpful and nice staff. Quiet location. near the central plaza. Great value "
United Kingdom
David
The price is AU$69
14 Dec - 15 Dec
Lido Hotel
Outdoor pool, open 9:00 AM to 10:00 PM, free pool cabanas
TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz

4.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (144)
"Nice stay with good service "
United States
Jianyuan
The price is AU$115
11 Dec - 12 Dec
TRYP by Wyndham Santa Cruz
Triple Room
Hotel Las Américas

Hotel Las Américas

3.0 star property
Santa Cruz
6.0 out of 10, (1)
"O chuveiro foi impossível tomar um.banho de qualidade "
Brazil
Jean
The price is AU$58
11 Dec - 12 Dec
Hotel Las Américas
Standard Room, 2 Single Beds
Hotel LP Santa Cruz Centro

Hotel LP Santa Cruz Centro

3.0 star property
Santa Cruz
8.0 out of 10, Very good, (280)
"Clean, friendly staff"
United States
Giovanna
Hotel LP Santa Cruz Centro
Outdoor pool, open 9:00 AM to 8:00 PM, pool loungers
Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol

3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (81)
"Good price, great hotel!"
United States
James
The price is AU$59
12 Dec - 13 Dec
Premium Suites Deluxe Aparthotel Equipetrol
Porch
Hotel Arenal

Hotel Arenal

3.5 star property
Santa Cruz
7.6 out of 10, Good, (59)
"Perfect hotel in a central location!"
United States
Max
The price is AU$95
31 Dec - 1 Jan 2026
Hotel Arenal
Massages
Swissôtel Santa Cruz De La Sierra

Swissôtel Santa Cruz De La Sierra

4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (81)
"very comfortable and excellent facilities and breakfast."
Australia
Joanna
Travelling with small children
The price is AU$224
1 Jan - 2 Jan 2026
Swissôtel Santa Cruz De La Sierra
Front of property – evening/night
Hotel LP Equipetrol

Hotel LP Equipetrol

3.5 star property
Santa Cruz
8.2 out of 10, Very good, (201)
"Nice place to stay"
United States
Ricardo
Hotel LP Equipetrol
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Great weekend hotel deals in Santa Cruz

Showing deals for:12 Dec - 14 Dec

Image gallery for HOTEL OSHO

City view from property

HOTEL OSHO

3.5 star property
Santa Cruz
9.2/10Wonderful (33 reviews)
17% off
Price is AU$140
for 2 nights, 1 room
AU$70 per night
HOTEL OSHO
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Our guide on where to stay in Santa Cruz

Find the best Santa Cruz areas for the activities you enjoy most. Learn more about Santa Cruz
Learn more about Santa Cruz

Hamacas

When in Hamacas, you can plan a visit to Santa Cruz Zoo and Las Brisas Shopping Center, some noteworthy sights in the nearby area.

Stay near popular Santa Cruz attractions

Plaza 24 de Septiembre which includes heritage elements and heritage architecture as well as a large group of people

Plaza 24 de Septiembre

4.4/5 (70 reviews)
Plaza 24 de Septiembre buzzes with local culture beneath swaying palms and colonial architecture. Climb the Cathedral's bell tower for spectacular city views while sampling authentic Bolivian coffee from vendors.
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San Lorenzo Cathedral featuring heritage elements, heritage architecture and a church or cathedral

San Lorenzo Cathedral

4.5/5 (36 reviews)
This grand neoclassical cathedral dominates Santa Cruz's skyline with its towering spires and ornate façade. Climb the bell tower at sunset for breathtaking panoramic views of the city.
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Learn more about Santa Cruz

Tropical energy pulses through Plaza 24 de Septiembre, where locals gather under palm trees and the Metropolitan Cathedral's twin towers stand watch. Biocentro Güembé offers rainforest trails with butterfly gardens, while the massive Ventura Mall provides air-conditioned shopping when afternoon temperatures climb.

See all hotels in Santa Cruz
San Lorenzo Cathedral showing a garden

Top Santa Cruz Hotel Reviews

Recent Reviews in Santa Cruz

HOTEL OSHO

HOTEL OSHO

10/10 Excellent
"Excellent"
Neysa 4-night trip
Posted 3 days ago
HOTEL OSHO

More cheap accommodation in Santa Cruz

Amaca Hostal

Amaca Hostal

249 Independencia Santa Cruz Departamento de Santa Cruz
Get rates

Frequently asked questions

What's the best place for a stay in Santa Cruz?
Ibis Santa Cruz DE LA Sierra is a favourite with Expedia customers. This hotel offers a restaurant and free parking. Reviews from our site also recommend Chairú Eco Hotel and Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel as top options for your trip. See all available top hotels, or vacation rentals in Santa Cruz.
What are some of the best holiday rentals that Santa Cruz has to offer?
Casa Vida: This highly rated holiday home rental in Santa Cruz is located in a rural location, and has an outdoor pool, a patio and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a full-sized fridge, a stovetop and a microwave, so that you can cook with friends or family. Kick off your shoes and enjoy yourself with a private garden and a selection of games. Some other homes for rent in Santa Cruz include Cozy and independent. Downtown house JH. and Jose Luis Noya. See all vacation rentals in Santa Cruz.
If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?
Yes! You'll find that most hotel room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz.
What's the best budget-friendly accommodation in Santa Cruz?
Based on our traveller reviews, residencial francia - Hostel is a top choice for a less expensive stay. Other choices for your budget-friendly stay include Residencial Ikandire II and Nomad Hostel. View all budget hotels in Santa Cruz.
What's the best family accommodation in Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a hotel with an outdoor pool and a restaurant, and it's a top choice on Expedia for families. Other choices for your child-friendly holiday include Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel and Novotel Santa Cruz De La Sierra. Also, attractions such as Santa Cruz Zoo and Play Land Amusement Park are fun for children of all ages. Find more child-friendly accommodations in Santa Cruz.
What's the best LGBTQ-friendly accommodation in Santa Cruz?
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia is a top LGBTQ-friendly hotel that features free breakfast and free Wi-Fi. Swissôtel Santa Cruz De La Sierra and Radisson Hotel Santa Cruz are other good choices for your holiday. See all available hotels listed as LGBTQ-friendly in Santa Cruz.
What's the best dog-friendly accommodation option in Santa Cruz?
Ibis Santa Cruz DE LA Sierra is a top hotel for people travelling with their pets, and offers a restaurant and free WiFi for its human guests. Two other good options for you and your pet's trip include HOTEL OSHO and Hotel LP Equipetrol. See more pet-friendly hotel accommodations in Santa Cruz.
What's the best luxury accommodation option in Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a luxury hotel with a full-service spa and a rooftop terrace, and it's a popular choice for Expedia travellers looking for an elegant place to stay. Novotel Santa Cruz De La Sierra and Camino Real Hotel are other upscale choices for your holiday. Find more luxury hotels in Santa Cruz.
What are some accommodation options with pools in Santa Cruz?
Sun Hotel is a top hotel with a children's pool, an outdoor pool and free buffet breakfast. A couple of other options that feature an on-site pool include Yotau All Suites Hotel and Buganvillas Hotel Suites & Spa. View all hotels with pools in Santa Cruz.
What is the best spa hotel in Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a top luxury spa hotel featuring a rooftop terrace, a fitness centre, tennis courts and a bar. Spend an afternoon at Hotel Spa where you'll find massage treatments. Other popular spa hotels in Santa Cruz include Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel and Hotel Cortez. See all spa hotels in Santa Cruz.
What's it like to stay in Santa Cruz?
Visitors to Santa Cruz will definitely enjoy the shopping. Tourists can also enjoy the city's cafés, zoo and cathedral. In Santa Cruz, there are 285 hotels and other accommodation options to choose from. Find out more about Santa Cruz.
What is there to see in Santa Cruz?
Cultural venues include Ethno-folkloric Museum, Cine Center and Sacred Art Museum. Landmarks like San Lorenzo Cathedral, Plaza 24 de Septiembre and Blacutt Square might be worth a visit. Natural beauty is on display at Guembe Biocenter, Lomas de Arena Regional Park and Arenal Park. Take a look at what more there is to see and do in Expedia's Santa Cruz guide.
How should I get around Santa Cruz?
If you want to venture outside the area, hop on a train at Santa Cruz de la Sierra Station. If you want to venture out around the area, you may want a rental car in Santa Cruz for your journey.
What's the weather like in Santa Cruz?
The hottest months are usually October and November, with an average temperature of 26°C, while the coldest months are June and July, with an average of 21°C. Average annual precipitation for Santa Cruz is 1208 mm.

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