Cheap flights from St. Louis to São Tomé Island

View AU$1,617 flight on Wed, 6 Aug. 2025Opens in a new window

Popular airlines from St. Louis to São Tomé Island

  • Jetstar

    Jetstar

  • Qantas Airways

    Qantas Airways

  • Virgin Australia

    Virgin Australia

  • Scoot

    Scoot

  • American Airlines

    American Airlines

  • Emirates

    Emirates

  • United

    United

  • Plan, book, fly with confidence

  • trending down icon

    Be in the know

    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon

    Book smarter

    Save up to 35% on select hotels after you book a flight*
  • payments icon

    Earn twice

    Earn your airline miles on top of our rewards
    Sign in

Cheap Flights from St. Louis (XLS) to São Tomé Island (TMS)

Prices were available within the past 7 days for one-way flights and round trip tickets for the period specified. Prices and availability are subject to change. Additional terms apply.

Alaska Airlines
Wed, 6 Aug. - Sun, 10 Aug.
SEA
Seattle
TMS
São Tomé Island
AU$4,579 Return, found 1 day ago
AU$4,579
Return
found 1 day ago
Select Alaska Airlines flight, departing Wed, 6 Aug. from Seattle to São Tomé Island, returning Sun, 10 Aug., priced at AU$4,579 found 1 day ago
Alaska Airlines
Wed, 6 Aug. - Sun, 10 Aug.
SEA
Seattle
TMS
São Tomé Island
AU$4,594 Return, found 1 day ago
AU$4,594
Return
found 1 day ago
Select Alaska Airlines flight, departing Wed, 6 Aug. from Seattle to São Tomé Island, returning Sun, 10 Aug., priced at AU$4,594 found 1 day ago
United
Wed, 6 Aug. - Sun, 10 Aug.
SEA
Seattle
TMS
São Tomé Island
AU$4,623 Return, found 1 day ago
AU$4,623
Return
found 1 day ago
Select United flight, departing Wed, 6 Aug. from Seattle to São Tomé Island, returning Sun, 10 Aug., priced at AU$4,623 found 1 day ago
Air Canada
Wed, 6 Aug. - Sun, 10 Aug.
SEA
Seattle
TMS
São Tomé Island
AU$4,679 Return, found 1 day ago
AU$4,679
Return
found 1 day ago
Select Air Canada flight, departing Wed, 6 Aug. from Seattle to São Tomé Island, returning Sun, 10 Aug., priced at AU$4,679 found 1 day ago
Lufthansa
Wed, 6 Aug. - Sun, 10 Aug.
SEA
Seattle
TMS
São Tomé Island
AU$4,902 Return, found 1 day ago
AU$4,902
Return
found 1 day ago
Select Lufthansa flight, departing Wed, 6 Aug. from Seattle to São Tomé Island, returning Sun, 10 Aug., priced at AU$4,902 found 1 day ago
TAP Portugal
Wed, 6 Aug. - Sun, 10 Aug.
SEA
Seattle
TMS
São Tomé Island
AU$8,591 Return, found 1 day ago
AU$8,591
Return
found 1 day ago
Select TAP Portugal flight, departing Wed, 6 Aug. from Seattle to São Tomé Island, returning Sun, 10 Aug., priced at AU$8,591 found 1 day ago
*Available to Expedia members.