South Main Hotels, Houston

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6 Dec - 7 Dec
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7 Dec - 8 Dec
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12 Dec - 14 Dec
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19 Dec - 21 Dec

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6797 Cheap Hotels in South Main - Specials, Reviews, & Last Minute Deals

Lobby
Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center

3.5 star property
South Main
7.2 out of 10, Good, (1196)
"Love this place. Been staying here for many years. "
United States
Reynaldo
The price is AU$157
includes taxes & fees
7 Dec - 8 Dec
Wyndham Houston near NRG Park/Medical Center
Lobby
Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium

2.5 star property
South Main
8.6 out of 10, Excellent, (1000)
"Was a great stay and rigjt next to the stadium all around recomended"
United States
Jason
The price is AU$154
includes taxes & fees
24 Dec - 25 Dec
Comfort Suites Houston near Medical Center- NRG Stadium
Hypo-allergenic bedding, in-room safe, individually decorated
Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center

2.5 star property
South Main
6.6 out of 10, (1001)
"Everything was great"
United States
Yeimi
The price is AU$97
includes taxes & fees
28 Dec - 29 Dec
Quality Inn & Suites NRG Park - Medical Center
Exterior
Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG

2.5 star property
South Main
7.4 out of 10, Good, (820)
"Yes the where"
United States
Robert
The price is AU$124
includes taxes & fees
24 Dec - 25 Dec
Candlewood Suites Houston Medical Center by IHG
Gazebo
Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center

3.0 star property
South Main
6.6 out of 10, (985)
"Great staff, excellent service and convenient to the area we were wanting to be. Room was clean and bed was very comfortable."
United States
Roy
The price is AU$122
includes taxes & fees
7 Dec - 8 Dec
Wingate Houston near NRG Park/Medical Center
Lobby
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4.0 star property
Houston Central Business District, 10.9 km from South Main
8.4 out of 10, Very good, (3930)
"Hotel was beautiful, room was great for the price"
United States
Sonya
The price is AU$141
includes taxes & fees
20 Dec - 21 Dec
Club Quarters Hotel Downtown, Houston
Exclusive Room, Multiple Beds, Non Smoking
Platinum Inn & Suites Webster

Platinum Inn & Suites Webster

3.0 star property
30.8 km from South Main
7.8 out of 10, Good, (1009)
"Great room, very friendly staff."
United States
Louis
The price is AU$98
includes taxes & fees
16 Dec - 17 Dec
Platinum Inn & Suites Webster
Lobby
Embassy Suites Houston Downtown

Embassy Suites Houston Downtown

3.5 star property
10.4 km from South Main
9.2 out of 10, Wonderful, (1004)
"Comfortable beds, clean room"
United States
Abdul Rasheed
The price is AU$190
includes taxes & fees
28 Dec - 29 Dec
Embassy Suites Houston Downtown
Property amenity
Holiday Inn Houston Downtown by IHG

Holiday Inn Houston Downtown by IHG

3.0 star property
Houston Central Business District, 10 km from South Main
8.6 out of 10, Excellent, (1584)
"Accommodating staff and clean room and shuttle services and great location. Room had a nice view."
United States
Add a new
The price is AU$170
includes taxes & fees
22 Dec - 23 Dec
Holiday Inn Houston Downtown by IHG
Standard Room, 2 Queen Beds
Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Crowne Plaza Houston Med Ctr-Galleria Area by IHG

3.5 star property
6.5 km from South Main
7.8 out of 10, Good, (1244)
"Really nice accommodations and the breakfast buffet was wonderful with many options and excellent service."
United States
Anastasha
The price is AU$111
includes taxes & fees
15 Dec - 16 Dec
Crowne Plaza Houston Med Ctr-Galleria Area by IHG
Lobby
Hampton Inn Houston Downtown

Hampton Inn Houston Downtown

2.5 star property
10.8 km from South Main
8.8 out of 10, Excellent, (1001)
"Great location… clean and great breakfast variety. "
United States
David L Rojas
The price is AU$182
includes taxes & fees
28 Dec - 29 Dec
Hampton Inn Houston Downtown
City view from property
The Whitehall Houston

The Whitehall Houston

4.0 star property
Houston Central Business District, 10 km from South Main
8.6 out of 10, Excellent, (1895)
"Great stay."
United States
Anita
The price is AU$211
includes taxes & fees
1 Jan - 2 Jan 2026
The Whitehall Houston
Reception
InterContinental Houston by IHG

InterContinental Houston by IHG

4.0 star property
Texas Medical Center, 4.1 km from South Main
9.2 out of 10, Wonderful, (1001)
"Clean room, excellent staff, kind and respectful."
United States
DIANA
The price is AU$282
includes taxes & fees
18 Dec - 19 Dec
InterContinental Houston by IHG
Lobby sitting area
Hyatt Place Houston Downtown

Hyatt Place Houston Downtown

3.0 star property
Houston Central Business District, 11 km from South Main
9.0 out of 10, Wonderful, (1562)
"Very close to great eating places"
United States
Leslie
The price is AU$197
includes taxes & fees
23 Dec - 24 Dec
Hyatt Place Houston Downtown
Exterior
Holiday Inn Express & Suites Houston IAH - Beltway 8 by IHG

Holiday Inn Express & Suites Houston IAH - Beltway 8 by IHG

2.5 star property
30 km from South Main
8.2 out of 10, Very good, (1029)
"Clean room, no pets is nice. The breakfast had lots of choices and the day staff were very pleasant. Shuttle to and from the airport for most of the day. I would stay again. "
United States
Mary
The price is AU$125
includes taxes & fees
14 Dec - 15 Dec
Holiday Inn Express & Suites Houston IAH - Beltway 8 by IHG
Outdoor pool
Tru by Hilton Houston Webster NASA

Tru by Hilton Houston Webster NASA

2.5 star property
30.8 km from South Main
9.0 out of 10, Wonderful, (1000)
"Friendly staff nice,clean and very close shopping center perfect place to stay for a stop before our cruise the following day."
United States
Marisol
The price is AU$137
includes taxes & fees
4 Jan - 5 Jan 2026
Tru by Hilton Houston Webster NASA
View from property
Magnolia Hotel Houston, A Tribute Portfolio Hotel

Magnolia Hotel Houston, A Tribute Portfolio Hotel

4.0 star property
Downtown Houston, 11.1 km from South Main
9.2 out of 10, Wonderful, (1309)
"Good location, beautiful room and seamless checkin"
United States
kanchana
The price is AU$225
includes taxes & fees
17 Dec - 18 Dec
Magnolia Hotel Houston, A Tribute Portfolio Hotel
Outdoor pool, open 6:00 AM to 10:00 PM, pool umbrellas, pool loungers
Hyatt Regency Houston/Galleria

Hyatt Regency Houston/Galleria

4.0 star property
The Galleria, 8.7 km from South Main
9.0 out of 10, Wonderful, (1162)
"Confortable bed, quiet ron and nice breakfast!"
United States
Juan
The price is AU$267
includes taxes & fees
11 Dec - 12 Dec
Hyatt Regency Houston/Galleria
Lobby
Cambria Hotel Houston Downtown Convention Center

Cambria Hotel Houston Downtown Convention Center

3.0 star property
Houston Central Business District, 11 km from South Main
8.8 out of 10, Excellent, (1696)
"The staff was very courteous!"
United States
shyann
The price is AU$173
includes taxes & fees
22 Dec - 23 Dec
Cambria Hotel Houston Downtown Convention Center
Exterior
Hilton Americas-Houston

Hilton Americas-Houston

4.0 star property
10.4 km from South Main
9.4 out of 10, Exceptional, (1581)
"Clean, great location and super convenient food options!"
United States
Valerie
The price is AU$256
includes taxes & fees
1 Jan - 2 Jan 2026
Hilton Americas-Houston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Our guide on where to stay in South Main

Find the best South Main areas for the activities you enjoy most.
Discovery Green which includes a high-rise building, a square or plaza and a city

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Menil Collection showing interior views and art

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area.

Northside

While you're in Northside, take in top sights like The Heights Theater or Greenspoint Mall, and hop on the metro to see more of the city at Northline Transit Center/HCC Station or Melbourne/North Lindale Station.

Top South Main Hotel Reviews

Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

10/10 Excellent
"NOICE!"
Michael 1-night trip
Posted 3 days ago
Club Quarters Hotel Downtown, Houston

Frequently asked questions

What is South Main like?
You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on Expedia customer reviews, Comfort Suites Houston near Medical Center- NRG Stadium is the highest ranked property in South Main. This hotel is a short 10-minute walk from NRG Stadium, and it offers free breakfast and a fitness centre. Other top choices in the neighbourhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.
How many hotels should I expect to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 64 South Main hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighbourhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.

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