Medical Center District Travel Guide

Tourist Guide

River walk in San Antonio
Tourists River Walk San Antonio Texas
Riverboat on the San Antonio River Walk, San Antonio, Texas, United States of America.
River walk in San Antonio
SanAntonio_SouthTexasMedicalCenter_6193120_01

Popular places to visit

Activities


Our pick of the best Medical Center District Hotel Deals

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
The price is AU$146 per night from 4 June to 5 June
AU$146
4 June - 5 June
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and a fitness centre. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (3,390 reviews)
"The safety box never worked. The rest, perfect"

Reviewed on 2 June 2026

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
Fully refundableReserve now, pay when you stay
The price is AU$167 per night from 20 June to 21 June
AU$167
20 June - 21 June
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy a free local area shuttle, room service and a 24-hour fitness centre. Our guests praise the helpful ...
8.6/10 Excellent! (1,069 reviews)
"Very good"

Reviewed on 1 June 2026

San Antonio Marriott Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

3 out of 5
9806 Interstate Hwy 10 W San Antonio TX
The price is AU$147 per night from 25 June to 26 June
AU$147
25 June - 26 June
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,336 reviews)
"Totally worth the money with all the freebies you get."

Reviewed on 2 June 2026

Drury Inn & Suites San Antonio Northwest Medical Center
Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

4 out of 5
105 S Saint Marys Street San Antonio TX
The price is AU$211 per night from 21 June to 22 June
AU$211
21 June - 22 June
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and 2 hot tubs. Our guests praise the breakfast and the pool in their reviews. ...
9.4/10 Exceptional! (4,705 reviews)
"Loved all the architecture of the place and all the history"

Reviewed on 3 June 2026

Drury Plaza Hotel San Antonio Riverwalk
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St San Antonio TX
The price is AU$239 per night from 25 June to 26 June
AU$239
25 June - 26 June
includes taxes & fees
Stay at this luxury hotel in San Antonio. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the helpful staff and the clean rooms in ...
9.4/10 Exceptional! (2,785 reviews)
"Great luxury hotel. It is a bit pricy. Although we had trouble with our mini-fridge it was broken, the hotel staff did respond the next day to fix it. We didnt get to use the occupancy fee credit that your automatically charged. Oh well. Great stay all around."

Reviewed on 2 June 2026

Hotel Valencia Riverwalk
Menger Hotel

Menger Hotel

3.5 out of 5
204 Alamo Plaza San Antonio TX
The price is AU$138 per night from 9 June to 10 June
AU$138
9 June - 10 June
includes taxes & fees
Stay at this historic hotel in San Antonio. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the pool and the bar in their reviews. ...
8.8/10 Excellent! (4,083 reviews)
"Minimum eating in the hotel itself. Really missed the formal dining room that use to be open for brunch and dinner."

Reviewed on 1 June 2026

Menger Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our guide on where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most.

Downtown San Antonio

A scenic riverfront great entertainment and top sights from San Antonio River to Alamo – discover Downtown San Antonio, a destination also famous for its historic sites.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

Uptown

If you're spending some time in Uptown, San Antonio River and Alamo Quarry Market are top sights worth seeing.

Stone Oak

Stone Oak is known for its abundant dining options, and you can plan a trip to Stone Ridge Market and Shops at Hardy Oak while you're in town.

La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.



Medical Center District Travel Guide

Choose two or more items and save on your trip: