Apartments in Defiance

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Check prices for these dates

Next weekend
20 Nov - 22 Nov
In two weeks
27 Nov - 29 Nov
In one month
11 Dec - 13 Dec
In two months
8 Jan - 10 Jan

Our top choices for Defiance apartments

A hotel entrance with a stone facade, a covered walkway, and a red car parked outside.

1. Great for Business Travelers! Pool + Gym

Great for Business Travelers! Pool + Gym
O'Fallon
7.0 out of 10, Good, (2 reviews)
"Property was dirty, kitchen hadn’t been cleaned. Microwave had food spilled all over inside. Place felt grimy."
United States
Jenny D.
The price is AU$288
includes taxes & fees
15 Nov - 16 Nov
Great for Business Travelers! Pool + Gym
A front door with a sign for '2nd St Loft' and a 'Self Check In' option.

2. 2nd Street Loft - Riverview

2nd Street Loft - Riverview
Washington
10.0 out of 10, Exceptional, (21 reviews)
"Everything was great room was very clean"
United States
Chance W.
The price is AU$300
includes taxes & fees
12 Dec - 13 Dec
2nd Street Loft - Riverview
A wooden deck with a view of a parking area at dusk.

3. Enjoyable 2-bedroom apartment at St. Peters; Near STL

Enjoyable 2-bedroom apartment at St. Peters; Near STL
St. Peters
8.0 out of 10, Very good, (1 review)
"Very clean and comfortable. Pretty well-appointed. Could use an extra blanket or two. Overall good experience and would consider going again."
United States
Ronda S.
The price is AU$392
includes taxes & fees
30 Nov - 1 Dec
Enjoyable 2-bedroom apartment at St. Peters; Near STL
A set of stone steps leading to a garage with a car parked inside.

4. Studio, sleeps 5, short drive to Hidden Valley Ski Resort, parks &concert venues

Studio, sleeps 5, short drive to Hidden Valley Ski Resort, parks &concert venues
Ballwin
8.0 out of 10, Very good, (25 reviews)
"Rooms were clean and everything we needed for our stay."
United States
Keith K.
The price is AU$203
includes taxes & fees
15 Nov - 16 Nov
Studio, sleeps 5, short drive to Hidden Valley Ski Resort, parks &concert venues
A two-story building with a balcony, a staircase, and a gated entrance.

5. 2nd Street -Deck Suite (back entrance)

2nd Street -Deck Suite (back entrance)
Washington
10.0 out of 10, Exceptional, (11 reviews)
"The property was clean and comfortable and everything you may need is there, walking distance was very close to everything in the area. Communication with the host was easy and quick responses, overall it was a great place to stay!"
United States
Melinda
The price is AU$278
includes taxes & fees
15 Nov - 16 Nov
2nd Street -Deck Suite (back entrance)
A modern kitchen with white cabinets, a black refrigerator, a stainless steel microwave, and a black oven. There are four blue bowls on a wooden table with a woven placemat.

6. Quiet 2BR Retreat on 7 Acres | Sleeps 6, Fast WiFi

Quiet 2BR Retreat on 7 Acres | Sleeps 6, Fast WiFi
Moscow Mills
10.0 out of 10, Exceptional, (14 reviews)
"Great place, nice neighborhood. "
United States
Julie L.
The price is AU$356
includes taxes & fees
15 Nov - 16 Nov
Quiet 2BR Retreat on 7 Acres | Sleeps 6, Fast WiFi
A hotel room with a bed, a desk, a chair, a lamp, and a telephone.

7. 1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed

1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed
Westport
9.4 out of 10, Exceptional, (43 reviews)
"Great spot!"
United States
Anonymous traveller
The price is AU$93
includes taxes & fees
17 Nov - 18 Nov
1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed
A spacious living room with hardwood floors, a white armchair, a sofa, and a TV on a stand.

8. The Cul-de-Sac Retreat

The Cul-de-Sac Retreat
Saint Charles
7.6 out of 10, Good, (10 reviews)
"Great house, great location - close to the St. Charles convention center"
United States
Joe H.
The Cul-de-Sac Retreat
A living room with a white sofa, two armchairs, a wooden coffee table, and a side table with a plant.

9. The FarmHouse 3bd/2ba B&B in MO Wine Country & Katy Trail

The FarmHouse 3bd/2ba B&B in MO Wine Country & Katy Trail
Marthasville
8.8 out of 10, Excellent, (6 reviews)
"This was the perfect place for my friends and I to stay in Marthasville. Lots of space and amenities. We did not use the complimentary breakfast, but is a great addition. Would recommend to anyone staying in the area. "
United States
Adam K.
The price is AU$662
includes taxes & fees
18 Nov - 19 Nov
The FarmHouse 3bd/2ba B&B in MO Wine Country & Katy Trail
A neatly made bed with a stack of folded towels, a bedside lamp, and a ceiling fan in a room with a large window and a wall-mounted artwork.

10. Home Near Main with Pet-Friendly Yard and Office

Home Near Main with Pet-Friendly Yard and Office
St. Charles Historic District
10.0 out of 10, Exceptional, (13 reviews)
"Very close to downtown St. Charles and the Kati Trail. The home is cute and bed is comfortable. Easy check in process and fenced in back yard was nice to have."
United States
Jessica S.
The price is AU$374
includes taxes & fees
12 Nov - 13 Nov
Home Near Main with Pet-Friendly Yard and Office
Free breakfast available on-site.

11. Studio | Lovely Suite Close to Edward Jones!

Studio | Lovely Suite Close to Edward Jones!
Westport
The price is AU$374
includes taxes & fees
15 Nov - 16 Nov
Studio | Lovely Suite Close to Edward Jones!
A cozy living room with a brick wall, a white sofa with colorful cushions, a small black table, and a potted plant.

12. Prime Loft of Main Street

Prime Loft of Main Street
St. Charles Historic District
9.8 out of 10, Exceptional, (125 reviews)
"Great"
United States
Richard W.
The price is AU$381
includes taxes & fees
15 Nov - 16 Nov
Prime Loft of Main Street
A living room with a black leather sofa, two grey armchairs, a wooden coffee table, and a wall clock.

13. 6th street 101 - Walk to Main St

6th street 101 - Walk to Main St
St. Charles Historic District
9.0 out of 10, Wonderful, (4 reviews)
"Excellent"
United States
Scott N.
The price is AU$375
includes taxes & fees
15 Nov - 16 Nov
6th street 101 - Walk to Main St
A modern living room with a leather sofa, a wooden coffee table, and a leather armchair. There is a painting on the wall and a lamp on a side table.

14. Foundry Flat on Main with Free Parking

Foundry Flat on Main with Free Parking
St. Charles Historic District
10.0 out of 10, Exceptional, (1 review)
"Everything was exactly as described. St. Charles is an awesome place!"
United States
Michael
The price is AU$427
includes taxes & fees
15 Nov - 16 Nov
Foundry Flat on Main with Free Parking
A modern kitchen with stainless steel appliances, white cabinetry, and a brick accent wall.

15. Historic Main St. Customs House Upstairs Apartment

Historic Main St. Customs House Upstairs Apartment
St. Charles Historic District
9.6 out of 10, Exceptional, (39 reviews)
"Lovely place to stay!"
United States
Margaret A.
The price is AU$495
includes taxes & fees
17 Nov - 18 Nov
Historic Main St. Customs House Upstairs Apartment
A modern kitchen with white cabinets, a built-in microwave, a stove, and a window providing natural light.

16. Pet-Friendly Duplex on Historic Main

Pet-Friendly Duplex on Historic Main
St. Charles Historic District
10.0 out of 10, Exceptional, (26 reviews)
"Great location"
United States
todd p.
The price is AU$390
includes taxes & fees
18 Nov - 19 Nov
Pet-Friendly Duplex on Historic Main
A staircase with white railings and a ceiling fan.

17. Amazing Renovated Historic Loft on Main Street

Amazing Renovated Historic Loft on Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (73 reviews)
"This was a prime spot for downtown activities! Near everything and not far from STL. Would absolutely stay here again!"
United States
Rebecca F.
The price is AU$381
includes taxes & fees
15 Nov - 16 Nov
Amazing Renovated Historic Loft on Main Street
A spacious living area with a wooden floor, a dining table with chairs, a flat-screen TV mounted on the wall, and a kitchen area with modern appliances.

18. The Lofts of North Main Street

The Lofts of North Main Street
St. Charles Historic District
9.6 out of 10, Exceptional, (197 reviews)
"Very cute place, walking distance to everything."
United States
Liberty A.
The price is AU$335
includes taxes & fees
12 Nov - 13 Nov
The Lofts of North Main Street
A row of multi-story buildings with commercial storefronts, including a cafe and a restaurant.

19. Dog-Friendly Studio on Historic Main Street

Dog-Friendly Studio on Historic Main Street
St. Charles Historic District
9.2 out of 10, Wonderful, (42 reviews)
"Had a wonderful stay. It was a Monday night so parking was very easy and the room was clean and comfortable. I would recommend this place 100% "
United States
Sarah C.
The price is AU$312
includes taxes & fees
15 Nov - 16 Nov
Dog-Friendly Studio on Historic Main Street
A hallway with a door, two potted plants, a doormat, and a view of a brick building through large windows.

20. Dog-Friendly 2BR Near Main Street

Dog-Friendly 2BR Near Main Street
Saint Charles
8.0 out of 10, Very good, (5 reviews)
"The best price-value ratio. Quiet neighborhood, close to the city center."
United States
Tamas P.
The price is AU$474
includes taxes & fees
22 Nov - 23 Nov
Dog-Friendly 2BR Near Main Street
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Top reviews in Defiance

An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.
TownePlace Suites by Marriott St. Louis Chesterfield

TownePlace Suites by Marriott St. Louis Chesterfield

TownePlace Suites by Marriott St. Louis Chesterfield
Chesterfield

10/10 Excellent

Great friendly accommodating staff
Australia
Raymond
Reviewed June 10, 2026
TownePlace Suites by Marriott St. Louis Chesterfield

Frequently Asked Questions

What's it like to stay at an apartment in Defiance?

You'll find 10 apartments to choose from in Defiance for your holiday.

Why would you choose apartments instead of traditional hotels?

An apartment is often more spacious than a traditional hotel room and comes with a kitchen, so you can cook some of your meals. Apartments are ideal for families who want the conveniences of home, and also for couples who want to stay away from the tourist areas.

What's the top apartment I should consider for a stay in Defiance?

Here are some of the top apartments in the area: 2 Queen Beds | Non-Smoking, Kitchen: Situated in Maryland Heights , 18.7 mi/30.1 km from the heart of Defiance. Includes free WiFi and a Smart TV . 1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed: Located 18.7 mi/30.1 km away in Maryland Heights . Free WiFi and a Smart TV are included . The Lofts of North Main Street: Located in St. Charles , 19.2 mi/30.8 km away. Includes free WiFi, a sofa bed and a Smart TV . Access to on-site laundry facilities is available on site . Driftwood Den | Boho 2BR | Dog-Friendly: It's located in St. Charles , 19 mi/30.6 km from Defiance. Includes free WiFi .

How many apartments will I find in Defiance?

Expedia has 10 apartments to book in Defiance.

What can I expect from the weather in Defiance?

Weather is only one factor, but it can really affect your travel plans, especially if you are planning a longer stay in Defiance. The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

What are the must-see places to visit in Defiance?

August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. While here, Yellow Farmhouse Winery and Chandler Hill Vineyards are other places worth a visit.

What's the best way to get to and around Defiance?

Knowing a bit about the transportation options can you save you a headache when you get to your destination. Fly into St. Louis, MO (SUS-Spirit of St. Louis), which is located 7.5 mi (12 km) from the heart of the city. Otherwise, look for flights into Lambert-St. Louis International Airport (STL), which is 23.5 mi (37.8 km) away. If you'd like to explore around the area, consider renting a car to explore more sights.