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Our top choices for Defiance hotels

The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1,631 reviews)
"Very cute place, recently updated clean and comfortable."
United States
David
The Wildwood Hotel

Super 8 by Wyndham Warrenton

Super 8 by Wyndham Warrenton
2.0 star property
Warrenton
7.4 out of 10, Good, (625 reviews)
"Room was clean. Staff very helpful, accommodating. "
United States
Ranata
The price is AU$97
includes taxes & fees
8 Feb - 9 Feb
Super 8 by Wyndham Warrenton

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
9.4 out of 10, Exceptional, (34 reviews)
"Super clean , quiet place "
United States
Phoenix
The price is AU$157
includes taxes & fees
2 Feb - 3 Feb
WoodSpring Suites St Peters-OFallon

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very good, (923 reviews)
"Clean rooms, pleasant staff."
United States
Karen
The price is AU$125
includes taxes & fees
21 Jan - 22 Jan
Quality Inn Foristell

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,009 reviews)
"Very good place to stay"
United States
Jasur
The price is AU$139
includes taxes & fees
2 Feb - 3 Feb
Sleep Inn & Suites O'Fallon MO - Technology Drive

Comfort Inn & Suites St. Louis - O'Fallon

Comfort Inn & Suites St. Louis - O'Fallon
2.5 star property
O'Fallon
7.6 out of 10, Good, (1,001 reviews)
"Nice room, good front desk help"
United States
jeffrey
The price is AU$120
includes taxes & fees
30 Jan - 31 Jan
Comfort Inn & Suites St. Louis - O'Fallon

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
3.0 star property
Maryland Heights
7.6 out of 10, Good, (1,007 reviews)
"The room was clean and spacious and the staff was really nice."
United States
D
The price is AU$113
includes taxes & fees
8 Feb - 9 Feb
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
8.0 out of 10, Very good, (1,081 reviews)
"Clean room, friendly staff and good breakfast"
United States
Elisabeth
The price is AU$146
includes taxes & fees
2 Feb - 3 Feb
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.4 out of 10, Good, (1,003 reviews)
"Nice place and nice people "
United States
Columbus
The price is AU$126
includes taxes & fees
25 Jan - 26 Jan
Baymont by Wyndham Warrenton

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very good, (1,008 reviews)
"Great location and friendly staff "
United States
Heather
The price is AU$168
includes taxes & fees
27 Jan - 28 Jan
Hampton Inn St. Charles St. Peters

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
Fenton
7.8 out of 10, Good, (1,138 reviews)
"Clean rooms, quiet, AC worked great and good breakfast "
United States
Karen
The price is AU$136
includes taxes & fees
2 Feb - 3 Feb
Wingate by Wyndham St. Louis/Fenton Route 66

Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (645 reviews)
"Easy check in accessible room, comfortable bed and chairs"
United States
Maurine
The price is AU$204
includes taxes & fees
31 Jan - 1 Feb
Hampton Inn St. Louis Wentzville

Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG
2.5 star property
Wentzville
9.4 out of 10, Exceptional, (863 reviews)
"Beautiful hotel, friendly staff, good breakfast."
United States
Erika
The price is AU$234
includes taxes & fees
31 Jan - 1 Feb
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Super 8 by Wyndham Eureka/Six Flags Nearby

Super 8 by Wyndham Eureka/Six Flags Nearby
2.0 star property
Eureka
7.0 out of 10, Good, (1,002 reviews)
"Chris was a great night host. He was kind, friendly, and very accommodating. "
United States
Kristi
The price is AU$111
includes taxes & fees
1 Feb - 2 Feb
Super 8 by Wyndham Eureka/Six Flags Nearby

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very good, (1,003 reviews)
"Great hotel for the money"
United States
Jere
The price is AU$133
includes taxes & fees
25 Jan - 26 Jan
Comfort Suites St Charles - St Louis

Comfort Inn Near Six Flags St. Louis

Comfort Inn Near Six Flags St. Louis
2.5 star property
Pacific
8.4 out of 10, Very good, (885 reviews)
"The room was impeccable and the front desk and custodial staff incredibly hospitable."
United States
Scott
The price is AU$155
includes taxes & fees
2 Feb - 3 Feb
Comfort Inn Near Six Flags St. Louis

Relax Inn Saint Charles

Relax Inn Saint Charles
2.0 star property
St. Charles
6.6 out of 10, (1,011 reviews)
"Great place to stay "
United States
Askar
The price is AU$106
includes taxes & fees
21 Jan - 22 Jan
Relax Inn Saint Charles

Sonesta Simply Suites St Louis Earth City

Sonesta Simply Suites St Louis Earth City
2.0 star property
Earth City
8.6 out of 10, Excellent, (813 reviews)
"Great place"
United States
Adam
The price is AU$130
includes taxes & fees
2 Feb - 3 Feb
Sonesta Simply Suites St Louis Earth City

Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield
3.0 star property
Chesterfield
9.6 out of 10, Exceptional, (1,057 reviews)
"The staff was super nice. "
United States
Timothy
The price is AU$225
includes taxes & fees
2 Feb - 3 Feb
Drury Plaza Hotel St. Louis Chesterfield

Country Inn & Suites by Radisson, St. Peters, MO

Country Inn & Suites by Radisson, St. Peters, MO
2.5 star property
St. Charles
8.2 out of 10, Very good, (1,000 reviews)
"Convenient spot for stopping through. Hallways smell a bit like cigarettes, room smelled a bit like body odor."
United States
James
The price is AU$149
includes taxes & fees
1 Feb - 2 Feb
Country Inn & Suites by Radisson, St. Peters, MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

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Frequently asked questions

What's the best place to stay in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, located 17.9 mi (28.8 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are The Wildwood Hotel and Ameristar Casino Resort and Spa. See all available top hotels, or vacation rentals in Defiance.
What are some of the best holiday rentals that Defiance has to offer?
The St. Charles Guest House, lovely historic home, fun for families and groups: This holiday home rental outside of Defiance is located on a river, and has a fireplace, a selection of games and air conditioning to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. See all vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
What are some accommodation options with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Features an indoor pool, an outdoor pool and buffet. The Wildwood Hotel and Ameristar Casino Resort and Spa are two additional hotels with an on-site pool. View all hotels with pools in Defiance.
How is it staying in Defiance?
Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station, Busch Stadium and Gateway Arch. In Defiance, there are 20 hotels and other accommodation options to choose from. Find out more about Defiance.
What should I do while I'm visiting Defiance?
Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River and Matson Hill Park Trailhead. A couple of additional sights to add to your itinerary are Yellow Farmhouse Winery and Chandler Hill Vineyards. Take a look at what more there is to see and do in Expedia's Defiance guide.
What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

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