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5 Mar - 6 Mar
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6 Mar - 7 Mar
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6 Mar - 8 Mar
Next weekend
13 Mar - 15 Mar

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Our top choices for Defiance hotels

Indoor pool

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.4 out of 10, Good, (1,002 reviews)
"Nice place and nice people "
United States
Columbus
The price is AU$119
includes taxes & fees
9 Mar - 10 Mar
Baymont by Wyndham Warrenton
Exterior

Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.6 out of 10, Excellent, (876 reviews)
"Service, cleanliness and breakfast were all very agreeable "
United States
James
The price is AU$145
includes taxes & fees
22 Mar - 23 Mar
Holiday Inn Express St. Louis West - O'Fallon by IHG
Reception

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
8.0 out of 10, Very good, (1,116 reviews)
"Great room, great people, great breakfast "
United States
Jaiden
The price is AU$146
includes taxes & fees
5 Apr - 6 Apr
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Lobby

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very good, (946 reviews)
" Clean room friendly staff easy access"
United States
Steve
The price is AU$109
includes taxes & fees
22 Mar - 23 Mar
Quality Inn Foristell
Standard Room, 2 Queen Beds

Super 8 by Wyndham Warrenton

Super 8 by Wyndham Warrenton
2.0 star property
Warrenton
7.4 out of 10, Good, (631 reviews)
"It all went well . Room has been remodeled it was nice ."
United States
Charles
The price is AU$88
includes taxes & fees
23 Mar - 24 Mar
Super 8 by Wyndham Warrenton
Premium bedding, desk, iron/ironing board, free WiFi

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,009 reviews)
"Friendly staff, clean room, comfy bed, excellent breakfast buffet."
United States
Kathy
The price is AU$132
includes taxes & fees
15 Mar - 16 Mar
Sleep Inn & Suites O'Fallon MO - Technology Drive
Room, 2 Queen Beds, Non Smoking

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
Fenton
8.0 out of 10, Very good, (1,151 reviews)
"Clean rooms, quiet, AC worked great and good breakfast "
United States
Karen
The price is AU$130
includes taxes & fees
9 Mar - 10 Mar
Wingate by Wyndham St. Louis/Fenton Route 66
Standard Room, 2 Queen Beds, Non Smoking

Comfort Inn & Suites Chesterfield - St. Louis

Comfort Inn & Suites Chesterfield - St. Louis
2.5 star property
Chesterfield
7.8 out of 10, Good, (1,001 reviews)
"Enjoying the relaxing stay!"
United States
Naikia
The price is AU$143
includes taxes & fees
15 Mar - 16 Mar
Comfort Inn & Suites Chesterfield - St. Louis
Exterior

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
9.0 out of 10, Wonderful, (47 reviews)
"Super clean , quiet place "
United States
Phoenix
The price is AU$149
includes taxes & fees
9 Mar - 10 Mar
WoodSpring Suites St Peters-OFallon
Lobby sitting area

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
3.0 star property
Maryland Heights
7.4 out of 10, Good, (1,010 reviews)
"Our stay was very nice. I love the room and the space! Food could be better, but overall it was a good stay for the price."
United States
Dominica
The price is AU$126
includes taxes & fees
2 Apr - 3 Apr
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
Lobby

Best Western Plus St. Louis West-Westport

Best Western Plus St. Louis West-Westport
2.5 star property
Maryland Heights
8.0 out of 10, Very good, (1,053 reviews)
"This place is always good. Been there +10 times."
United States
Federico Gavuzzo
The price is AU$130
includes taxes & fees
6 Apr - 7 Apr
Best Western Plus St. Louis West-Westport
Exterior

Holiday Inn Express & Suites St Peters by IHG

Holiday Inn Express & Suites St Peters by IHG
2.5 star property
St. Peters
9.4 out of 10, Exceptional, (395 reviews)
"Parking was easy and the room was nice."
United States
Martha
The price is AU$196
includes taxes & fees
5 Apr - 6 Apr
Holiday Inn Express & Suites St Peters by IHG
Terrace/patio

Courtyard by Marriott St. Louis St. Peters

Courtyard by Marriott St. Louis St. Peters
3.0 star property
St. Peters
9.0 out of 10, Wonderful, (679 reviews)
"Clean spacious room, friendly staff, provided extra pillows upon request. Easy check in and check out! "
United States
Renee
The price is AU$196
includes taxes & fees
22 Mar - 23 Mar
Courtyard by Marriott St. Louis St. Peters
Terrace/patio

Holiday Inn St. Louis Arpt West-Earth City by IHG

Holiday Inn St. Louis Arpt West-Earth City by IHG
3.5 star property
Earth City
7.6 out of 10, Good, (1,001 reviews)
"It’s near to the exit to the highway "
United States
Gabriel
The price is AU$159
includes taxes & fees
29 Mar - 30 Mar
Holiday Inn St. Louis Arpt West-Earth City by IHG
Room, Accessible

Super 8 by Wyndham O'Fallon MO/St. Louis Area

Super 8 by Wyndham O'Fallon MO/St. Louis Area
2.0 star property
O'Fallon
6.8 out of 10, (1,000 reviews)
"Staff was awesome and accomodating. Room and price was great. "
United States
Anthony
The price is AU$119
includes taxes & fees
22 Mar - 23 Mar
Super 8 by Wyndham O'Fallon MO/St. Louis Area
Lobby

Country Inn & Suites by Radisson, St. Peters, MO

Country Inn & Suites by Radisson, St. Peters, MO
2.5 star property
St. Charles
8.0 out of 10, Very good, (1,001 reviews)
"Always a fantastic stay "
United States
Tim
The price is AU$137
includes taxes & fees
29 Mar - 30 Mar
Country Inn & Suites by Radisson, St. Peters, MO
Lobby

Days Inn by Wyndham St Peters/St Charles

Days Inn by Wyndham St Peters/St Charles
2.0 star property
St. Peters
6.2 out of 10, (1,004 reviews)
"Room was excellent and clean"
United States
catherine
The price is AU$113
includes taxes & fees
10 Mar - 11 Mar
Days Inn by Wyndham St Peters/St Charles
43-inch LED TV with digital channels, TV

Comfort Inn & Suites St. Louis - O'Fallon

Comfort Inn & Suites St. Louis - O'Fallon
2.5 star property
O'Fallon
7.6 out of 10, Good, (1,003 reviews)
"Nice room, good front desk help"
United States
jeffrey
The price is AU$146
includes taxes & fees
29 Mar - 30 Mar
Comfort Inn & Suites St. Louis - O'Fallon
Lobby

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
St. Peters
9.4 out of 10, Exceptional, (1,003 reviews)
"Comfortable room. Quiet even though next to interstate. Excellent food "
United States
Geo
The price is AU$179
includes taxes & fees
15 Mar - 16 Mar
Drury Inn & Suites St. Louis St. Peters
Cleanliness standards

Relax Inn Saint Charles

Relax Inn Saint Charles
2.0 star property
St. Charles
6.8 out of 10, (1,003 reviews)
"Clean room very nice staff it’s nice"
United States
Mercedez
The price is AU$99
includes taxes & fees
7 Mar - 8 Mar
Relax Inn Saint Charles
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Missouri wineries have some of the most superb wine we've ever tasted! We recommend sipping on some chambourcin while basking in the sunshine.
Photo by Pages of Travel
Open Photo by Pages of Travel

Chandler Hill Vineyards

This elegant Missouri winery showcases local and California wines from its hillside setting. Savour varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.
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Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri

August A. Busch Memorial Conservation Area

This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment.
See properties

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

Recent Reviews in Defiance

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

6/10 Okay
"Very poor water pressure in the shower, sink didn’t drain nicely, and hotel is dated. "
Jody Charles 3-night trip
Posted 8 hours ago
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

More cheap accommodation in Defiance

Relax Inn Saint Charles

Relax Inn Saint Charles

3800 Harry S Truman Blvd St. Charles MO
The price is AU$99 per night from 7 Mar to 8 Mar
AU$99
7 Mar - 8 Mar
includes taxes & fees
6.8/10 (1,003 reviews)

Frequently asked questions

What's the best place to stay in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, located 17.9 mi (28.8 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are The Wildwood Hotel and Ameristar Casino Resort and Spa. See all available top hotels, or vacation rentals in Defiance.
What are some of the best holiday rentals that Defiance has to offer?
St. Charles 1860's Gem - Sleeps 6!: This holiday home rental outside of Defiance is located on a river, and has a garden, a selection of books and air conditioning to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge and a stovetop. See all vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
What are some accommodation options with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Features an indoor pool, an outdoor pool and buffet. The Wildwood Hotel and Ameristar Casino Resort and Spa are two additional hotels with an on-site pool. View all hotels with pools in Defiance.
How is it staying in Defiance?
Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station and Busch Stadium. In Defiance, there are 19 hotels and other accommodation options to choose from. Find out more about Defiance.
What should I do while I'm visiting Defiance?
Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River and Matson Hill Park Trailhead. A couple of additional sights to add to your itinerary are Chandler Hill Vineyards and Sugar Creek Winery. Take a look at what more there is to see and do in Expedia's Defiance guide.
What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

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