Defiance Hotel & Accommodation Deals 2026 from AU$109 - Compare prices by date

A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Go beyond your typical stay in Defiance

Pet friendly

Apartment

Pool

Cottage

Spa pool

Condo

Family friendly

Waterpark

Chalet

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Defiance hotels

A hotel room with two beds, a desk with a chair, a television, and a window with curtains.

An indoor swimming pool with clear water, marked depth lines, and a lifeguard chair.

A hotel lobby with a seating area, a reception desk, and a flat-screen TV mounted on the wall.

A bathroom with a granite countertop sink, a mirror, a toilet, and two framed artworks on the wall.

1. Holiday Inn Express St. Louis West - O'Fallon by IHG

O'Fallon

David

AU$166

includes taxes & fees

13 Sept - 14 Sept

A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

A formal dining table set for six with a vase of white flowers, candles, and a view of buildings through large windows.

A modern bathroom with a large mirror, white vanity, and a bathtub.

A hotel room with a large bed, a bedside lamp, a telephone, a mirror, and a bathroom with a sink and towel rack.

2. The Wildwood Hotel

Wildwood

Hailey

AU$144

includes taxes & fees

30 Sept - 1 Oct

A hotel room with a bed, a sofa, a coffee table, and wall art.

A Sleep Inn & Suites hotel with a modern brick facade, a covered entrance, and a parking lot.

An indoor swimming pool with a clear view of the outside, a metal ladder, and a ceiling with recessed lighting.

A hotel lobby with a reception desk, seating area, and a large potted plant.

3. Sleep Inn & Suites O'Fallon MO - Technology Drive

O'Fallon

Linda

AU$136

includes taxes & fees

27 Sept - 28 Sept

A hotel room with two beds, a desk, a chair, a TV, and a large window.

A modern dining area with a brick fireplace, yellow and blue chairs, and a blue sofa.

A spacious lobby with a blue sofa set, a reception desk, and a modern chandelier.

A hotel with a central courtyard, a fountain, and a parking lot with several cars.

4. Comfort Inn & Suites Chesterfield - St. Louis

Chesterfield

Jessica

AU$141

includes taxes & fees

13 Sept - 14 Sept

An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.

A multi-story hotel with a brick facade, a covered outdoor seating area with a fire feature, and a sign indicating it is a Marriott property.

A hotel room with a large bed, bedside lamps, a TV, a desk, and a bathroom.

A hotel room with a sofa, a side table, a lamp, a flat-screen TV, and a bed with a red blanket.

5. TownePlace Suites by Marriott St. Louis Chesterfield

Chesterfield

Bobbi jo

AU$210

includes taxes & fees

13 Sept - 14 Sept

A hotel lobby with a sectional sofa, a fireplace, a flat-screen TV, and framed artwork on the walls.

A multi-story hotel with a central entrance featuring a covered patio area.

A Staybridge Suites hotel sign with a modern building in the background.

A swimming pool with clear blue water, surrounded by a patio area with outdoor seating and a building with multiple windows in the background.

6. Staybridge Suites O'Fallon Chesterfield by IHG

O'Fallon

Norman

AU$183

includes taxes & fees

7 Sept - 8 Sept

A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.

A shop with a variety of snacks and beverages, including a refrigerated section with drinks and a display of packaged snacks.

A spacious lobby with a fireplace, comfortable seating, a large painting, and a view of the kitchen area.

A spacious lobby with a sofa, a coffee station, and a reception desk.

7. Hilton Garden Inn St. Louis/O'Fallon MO

O'Fallon

Kassie

AU$202

includes taxes & fees

13 Sept - 14 Sept

An outdoor patio area with wicker furniture and a central fire feature.

A modern hotel lobby with a bar area, seating arrangements, and a reception desk.

A Courtyard Marriott hotel with a parking lot and a green shuttle service.

A modern hotel lobby with a reception desk, seating area, and a television screen displaying a map.

8. Courtyard by Marriott St. Louis Chesterfield

Chesterfield

Kelly

AU$188

includes taxes & fees

4 Oct - 5 Oct

A hotel room with a large bed, a desk, a TV, and a view of a pool through the glass door.

A building with a prominent stone chimney, a large overhang, and a staircase leading to the entrance.

Two people in a swimming pool with colorful inflatable rings.

A lobby with a grand staircase, two patterned sofas, a glass coffee table, and a large mirror.

9. Holiday Inn St. Louis West Six Flags by IHG

Eureka

Rob

AU$164

includes taxes & fees

21 Sept - 22 Sept

A courtyard with a central seating area, surrounded by trees and a building with a pitched roof.

A store interior with a 'Treats' sign, snack shelves, and a chalkboard with a welcome message.

A modern hotel room with a large window, a desk with a flat-screen TV, a comfortable seating area, and a decorative wall piece.

A reception desk with a "WELCOME TO THE SHOW ME STATE" sign, a wooden counter, and a Hilton Honors sign.

10. Hampton Inn & Suites St. Louis/Chesterfield

Chesterfield

Jodi

AU$178

includes taxes & fees

13 Sept - 14 Sept

A modern kitchen area with a breakfast bar, a coffee machine, and a refrigerator displaying menu options.

A conference room with a long table, six chairs, a flat-screen TV, and framed pictures on the wall.

A swimming pool with a clear view of the surrounding area, including a door and a window with a view of the outside.

A modern hotel lobby with a seating area, a map mural, and a television.

11. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Chesterfield

NEBAHAT

AU$174

includes taxes & fees

4 Oct - 5 Oct

A spacious lobby with a stone fireplace, seating area, and a bar with high stools.

A hotel lobby with a seating area featuring two armchairs, a round coffee table, and a flat-screen TV mounted on a wooden wall.

A hotel pantry stocked with beverages and snacks, a refrigerated display case, and a sign reading "The Market".

A modern living room with a fireplace, a flat-screen TV, a sofa, a coffee table, and a dining area.

12. Residence Inn by Marriott O'Fallon

O'Fallon

Gerald

AU$225

includes taxes & fees

20 Sept - 21 Sept

A spacious lobby with a high ceiling, a dining area, and a kitchen in the background.

A hotel room with a bathroom, a bed, a nightstand, and a window.

A modern hotel lobby with a computer desk, a flat-screen TV, and a ceiling fan.

A lobby with a checkered carpet, a marble coffee table, two armchairs with patterned cushions, a sofa, and a dining table with chairs.

13. Quality Inn Near Six Flags St. Louis

Pacific

Diane

AU$157

includes taxes & fees

14 Sept - 15 Sept

An indoor swimming pool with a hot tub, clear signage, and a view of the outside through large windows.

A spacious living area with a blue wall, yellow armchairs, a blue sofa, and a wooden coffee table.

A modern dining area with yellow and blue chairs, a flat-screen TV, and a kitchen area with appliances.

A hotel room with two beds, a desk with a TV, a chair, and a lamp.

14. Comfort Inn Near Six Flags St. Louis

Pacific

David

AU$149

includes taxes & fees

24 Sept - 25 Sept

A spacious lobby with a central round table, two sofas, and a chandelier.

A hotel room with two beds, a patterned wall, and a view of the city through sheer curtains.

A buffet setup with various food items and a decorative vase of flowers.

A Drury Plaza hotel with a modern design, featuring a curved facade, large windows, and a Drury Plaza sign on the top.

15. Drury Plaza Hotel St. Louis Chesterfield

Chesterfield

Cassandra

AU$210

includes taxes & fees

8 Sept - 9 Sept

A spacious lobby with a high ceiling, a dining area, and a seating area with sofas and a coffee table.

An indoor swimming pool with clear blue water, a tiled floor, and a ceiling with square vents.

A hotel room with a bed, a dresser, a nightstand with a lamp, a framed map on the wall, and a carpeted floor.

A spacious lobby with a blue sofa, round coffee table, and blue chairs. There is a reception desk and a seating area with a high ceiling and large windows.

16. Drury Inn & Suites St. Louis St. Peters

St. Peters

Melanie

AU$176

includes taxes & fees

13 Sept - 14 Sept

A spacious living room with a large painting, a fireplace, a staircase, and modern furniture.

A hotel room with a large bed, two sofas, a desk, and a TV.

A swimming pool with tiled edges and a hot tub area, surrounded by windows and chairs.

A hotel room with a dining area, a fireplace, and a view of the outdoors.

17. Best Western Plus Washington Hotel

Washington

Michael Macumber

AU$205

includes taxes & fees

6 Sept - 7 Sept

A Super 8 hotel with a flat facade, multiple windows, and a parking lot.

A breakfast area with wooden cabinets, a coffee station, and a dining table with chairs.

A hotel room with a flat-screen TV, a wooden dresser, a beige sofa, a teal carpet, and a window with curtains.

A bathroom with a shower, a small white stool, and a towel rack.

18. Super 8 by Wyndham Eureka/Six Flags Nearby

Eureka

Rosa

AU$109

includes taxes & fees

16 Sept - 17 Sept

A multi-story hotel with a stone facade and a covered entrance.

A compact living space with a kitchenette, a dining area, and a workspace.

A compact hotel room with two beds, a desk with a chair, a television, a microwave, and a refrigerator.

A modern living room with a blue accent wall, a gray sofa, a dining table with chairs, and a coffee table.

19. WoodSpring Suites St Peters-OFallon

St. Peters

Ellen

AU$135

includes taxes & fees

6 Sept - 7 Sept

A spacious lobby with a brown leather sofa, multiple chairs, a coffee table with a skull decoration, and a large chandelier.

A large, multi-story hotel with the name "Doubletree by Hilton" prominently displayed on the facade.

A hotel room with orange furniture, a glass coffee table, a dining area with a table and chairs, and a patterned carpet.

An indoor tennis court with multiple courts, a net, and players.

20. DoubleTree by Hilton Hotel St. Louis - Chesterfield

Chesterfield

Shon

AU$185

includes taxes & fees

26 Sept - 27 Sept

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Defiance attractions

A wooden dock extending into a pond with lily pads, surrounded by lush greenery and a clear blue sky.

August A. Busch Memorial Conservation Area

8.6/10 (7 reviews)

This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment.

See properties

A glass of red wine on a wooden table with a vineyard in the background.

Chandler Hill Vineyards

7.8/10 (7 reviews)

This elegant Missouri winery showcases local and California wines from its hillside setting. Savour varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.

See properties

Historic Daniel Boone Home and Heritage Center

9.6/10 (4 reviews)

Step into the limestone home where Daniel Boone's son Nathan crafted a frontier masterpiece with seven fireplaces. Explore the surrounding historic village for an authentic glimpse into 19th-century pioneer life.

See properties

Sugar Creek Winery

8.0/10 (1 review)

Sip award-winning Missouri wines at this hillside vineyard along the scenic Katy Trail. Relax on covered decks with your own picnic while enjoying live weekend music and panoramic countryside views.

See properties

Yellow Farmhouse Winery

This boutique winery in Defiance, Missouri was known for its distinctive unfiltered wines and relaxed atmosphere. Visitors could enjoy tastings with live music while picnicking on scenic grounds with vineyard views.

See properties

Matson Hill Park Trailhead

Wander through 475 acres of rugged forest terrain with challenging hiking paths and gravity-flow mountain bike trails. The historic 1830s Hays Home offers a glimpse into pioneer life amid the natural splendour.

See properties

Broemmelsiek Park

This 494-acre natural playground offers nine miles of trails through forests and around serene lakes. Attend a monthly stargazing event at the astronomy viewing area for a uniquely celestial park experience.

See properties

Hamburg Trail Trailhead

This moderate 6.9-mile loop winds through the scenic Weldon Spring Conservation Area, connecting to the Katy Trail State Park. Spot native wildlife while traversing diverse landscapes of shaded woodlands and open fields.

See properties

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance

Top Defiance Hotel Reviews

Recent Reviews in Defiance

Sleep Inn & Suites O'Fallon MO - Technology Drive

10/10 Excellent

"The rooms were clean air conditioning was great staff were very friendly the breakfast was good"

Country Inn & Suites by Radisson, St. Charles Historic District

10/10 Excellent

"We enjoyed our stay near the old city streets and shops. Our hotel was by far the best in the St. Louis/St. Charles area. We had a wonderful breakfast and a swim in the pool! The room was big with a great view."

The Wildwood Hotel

10/10 Excellent

"The cleanliness and the architecture"

Drury Plaza Hotel St. Louis Creve Coeur

8/10 Good

"It was a nice stay. Much better than a motel 6 or some roadside motel. It was well kept and to standards."

Drury Plaza Hotel St. Louis Chesterfield

10/10 Excellent

"Quiet and restful room and convenient breakfast ."

Comfort Suites St Charles - St Louis

8/10 Good

"Good place"

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

10/10 Excellent

"Great breakfast buffet! Enjoyed the hot tub too!"

Hampton Inn St. Charles St. Peters

10/10 Excellent

"Very friendly staff. Clean and comfortable rooms."

Sonesta ES Suites St. Louis - Chesterfield

10/10 Excellent

"We had a great stay. Nice and quiet."

More cheap accommodation in Defiance

Quality Inn Foristell

12 Highway W Foristell MO

AU$132

9 Sept - 10 Sept

includes taxes & fees

Comfort Suites St Charles - St Louis

1400 S 5th St St. Charles MO

AU$133

4 Oct - 5 Oct

includes taxes & fees

8.4/10 Very good! (1,008 reviews)

Sleep Inn & Suites O'Fallon MO - Technology Drive

1147 Technology Drive O'Fallon MO

AU$136

27 Sept - 28 Sept

includes taxes & fees

9/10 Wonderful! (1,113 reviews)

Americas Best Value Inn & Suites St. Louis, St. Charles Inn

1310 Bass Pro Drive St. Charles MO

AU$146

6 Sept - 7 Sept

includes taxes & fees

Hampton Inn St. Charles St. Peters

3720 W Clay St St. Charles MO

AU$155

20 Sept - 21 Sept

includes taxes & fees

8/10 Very good! (1,001 reviews)

Country Inn & Suites by Radisson, St. Charles Historic District

1190 S Main St St. Charles MO

AU$217

4 Oct - 5 Oct

includes taxes & fees

9.4/10 Exceptional! (1,076 reviews)

Frequently asked questions

What is the best area to stay in Defiance?

The best area to stay in Defiance is directly within the village centre, particularly near the intersection of Highway F and Femme Osage Creek Road.This area is the heart of Defiance, offering a collection of local businesses, dining options, and access to the Katy Trail. It's a small, walkable village with a relaxed pace, surrounded by scenic vineyards and rolling hills. The historic Defiance Roadhouse is a popular landmark here.For couples looking for a romantic getaway, the village centre is ideal. You'll find boutique accommodation options, often with a focus on local wines and cuisine. It's great for enjoying leisurely meals, exploring the nearby wineries, and taking peaceful walks along the Katy Trail.Solo travellers seeking a peaceful retreat and outdoor activities will also find the village centre appealing.

When is the best time to go to Defiance?

The best times to go to Defiance are during the spring (late April to early June) and autumn (September to October) when the weather is pleasant and the natural beauty of the area is at its peak.Spring offers mild temperatures, making it ideal for outdoor activities like cycling and hiking along the Katy Trail. The vineyards begin to bud, and the countryside is lush and green. This period is particularly good for couples who enjoy scenic walks and wine tasting without the summer crowds.Autumn brings cooler, crisp air and the stunning transformation of the leaves, creating a picturesque backdrop for exploring the region. Many local wineries also host harvest festivals during this time. For those who appreciate outdoor beauty and a relaxed pace, this season provides an excellent experience.

Can I cancel my hotel reservation on Expedia?

You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if cancelled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Defiance.

How can I save on a hotel booking in Defiance with Expedia?

One Key™—Expedia's free travel rewards program—gives you instant access to discounts with Member Prices on Defiance hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.

How much is the nightly rate for a hotel in Defiance?

Prices for hotels in Defiance often vary, but you can find a great deal from AU$109 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.

Explore a world of travel with Expedia

Crestwood Holiday Rentals

Book Hotels in Defiance on Expedia.com

Search Defiance hotels

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Defiance

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for Defiance hotels

1. Holiday Inn Express St. Louis West - O'Fallon by IHG

2. The Wildwood Hotel

3. Sleep Inn & Suites O'Fallon MO - Technology Drive

4. Comfort Inn & Suites Chesterfield - St. Louis

5. TownePlace Suites by Marriott St. Louis Chesterfield

6. Staybridge Suites O'Fallon Chesterfield by IHG

7. Hilton Garden Inn St. Louis/O'Fallon MO

8. Courtyard by Marriott St. Louis Chesterfield

9. Holiday Inn St. Louis West Six Flags by IHG

10. Hampton Inn & Suites St. Louis/Chesterfield

11. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

12. Residence Inn by Marriott O'Fallon

13. Quality Inn Near Six Flags St. Louis

14. Comfort Inn Near Six Flags St. Louis

15. Drury Plaza Hotel St. Louis Chesterfield

16. Drury Inn & Suites St. Louis St. Peters

17. Best Western Plus Washington Hotel

18. Super 8 by Wyndham Eureka/Six Flags Nearby

19. WoodSpring Suites St Peters-OFallon

20. DoubleTree by Hilton Hotel St. Louis - Chesterfield

Stay near popular Defiance attractions

August A. Busch Memorial Conservation Area

Chandler Hill Vineyards

Historic Daniel Boone Home and Heritage Center

Sugar Creek Winery

Yellow Farmhouse Winery

Matson Hill Park Trailhead

Broemmelsiek Park

Hamburg Trail Trailhead

Learn more about Defiance

Top Defiance Hotel Reviews

Recent Reviews in Defiance

Sleep Inn & Suites O'Fallon MO - Technology Drive

Country Inn & Suites by Radisson, St. Charles Historic District

The Wildwood Hotel

Drury Plaza Hotel St. Louis Creve Coeur

Drury Plaza Hotel St. Louis Chesterfield

Comfort Suites St Charles - St Louis

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Hampton Inn St. Charles St. Peters

Sonesta ES Suites St. Louis - Chesterfield

More cheap accommodation in Defiance

Quality Inn Foristell

Comfort Suites St Charles - St Louis

Sleep Inn & Suites O'Fallon MO - Technology Drive

Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Hampton Inn St. Charles St. Peters

Country Inn & Suites by Radisson, St. Charles Historic District

Frequently asked questions

Explore a world of travel with Expedia

Go further with the Expedia app