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Our top choices for Defiance hotels

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.6 out of 10, Good, (1,005 reviews)
"The room was clean. The parking was easy."
United States
Chris
The price is AU$118
includes taxes & fees
26 Apr - 27 Apr
Baymont by Wyndham Warrenton

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
8.0 out of 10, Very good, (1,227 reviews)
"Everything was great for overnight stay. "
United States
Regina
The price is AU$152
includes taxes & fees
21 Apr - 22 Apr
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Super 8 by Wyndham Warrenton

Super 8 by Wyndham Warrenton
2.0 star property
Warrenton
7.4 out of 10, Good, (641 reviews)
"The parking was easy, the room was verry clean."
United States
Gary
The price is AU$84
includes taxes & fees
28 Apr - 29 Apr
Super 8 by Wyndham Warrenton

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
8.8 out of 10, Excellent, (92 reviews)
"Nice hotel with good staff."
United States
Michael
The price is AU$143
includes taxes & fees
22 Apr - 23 Apr
WoodSpring Suites St Peters-OFallon

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very good, (968 reviews)
"Staff was great, breakfast good and the room was clean and comfortable!!!"
United States
Chris
The price is AU$138
includes taxes & fees
26 Apr - 27 Apr
Quality Inn Foristell

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
Fenton
7.8 out of 10, Good, (1,194 reviews)
"Excellent staff and stay was pleasant "
United States
Jacob
The price is AU$137
includes taxes & fees
21 Apr - 22 Apr
Wingate by Wyndham St. Louis/Fenton Route 66

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,004 reviews)
"This was one of our best stays ever nice hot breakfast. Clean room nice staff will stay again "
United States
Lavania
The price is AU$138
includes taxes & fees
26 Apr - 27 Apr
Sleep Inn & Suites O'Fallon MO - Technology Drive

Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG
2.5 star property
Wentzville
9.4 out of 10, Exceptional, (897 reviews)
"Great location, clean, modern, killer shower and good bed! I would definitely recommend!"
United States
John
The price is AU$218
includes taxes & fees
26 Apr - 27 Apr
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Best Western Plus Fenton

Best Western Plus Fenton
2.5 star property
Fenton
9.2 out of 10, Wonderful, (269 reviews)
"Easy parking, friendly staff, clean and comfy rooms. "
United States
Jan
The price is AU$160
includes taxes & fees
26 Apr - 27 Apr
Best Western Plus Fenton

The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1,631 reviews)
"Staff was wonderful, location is great for our needs, and it was a quiet stay-which we loved. "
United States
Jessica
The price is AU$143
includes taxes & fees
4 May - 5 May
The Wildwood Hotel

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very good, (1,003 reviews)
"The breakfast was good. They had two different waffle choices every day. "
United States
Josephine
The price is AU$150
includes taxes & fees
10 May - 11 May
Comfort Suites St Charles - St Louis

Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (693 reviews)
"Very pet friendly. "
United States
Sara
The price is AU$203
includes taxes & fees
27 Apr - 28 Apr
Hampton Inn St. Louis Wentzville

Super 8 by Wyndham Union

Super 8 by Wyndham Union
2.0 star property
Union
8.2 out of 10, Very good, (646 reviews)
"Pet friendly "
United States
Theresa
The price is AU$130
includes taxes & fees
3 May - 4 May
Super 8 by Wyndham Union

Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis
3.0 star property
Valley Park
9.6 out of 10, Exceptional, (1,021 reviews)
"Very clean place with great food and friendly staff. "
Canada
Kara
The price is AU$181
includes taxes & fees
10 May - 11 May
Drury Inn & Suites Southwest St. Louis

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very good, (1,003 reviews)
"Everything was great as always at this location as i have stayed here many times"
United States
Gregory
The price is AU$183
includes taxes & fees
10 May - 11 May
Hampton Inn St. Charles St. Peters

Country Inn & Suites by Radisson, St. Peters, MO

Country Inn & Suites by Radisson, St. Peters, MO
2.5 star property
St. Charles
8.0 out of 10, Very good, (1,009 reviews)
"I had a wonderful stay"
United States
Samuel
The price is AU$143
includes taxes & fees
26 Apr - 27 Apr
Country Inn & Suites by Radisson, St. Peters, MO

Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
2.5 star property
Washington
9.2 out of 10, Wonderful, (674 reviews)
"Great stay and accommodations. The pool was very nice. "
United States
Shane
The price is AU$205
includes taxes & fees
26 Apr - 27 Apr
Best Western Plus Washington Hotel

Days Inn by Wyndham St Peters/St Charles

Days Inn by Wyndham St Peters/St Charles
2.0 star property
St. Peters
6.2 out of 10, (1,002 reviews)
"Parking was plentiful and close to the door from just about any location"
United States
Rebecca
The price is AU$114
includes taxes & fees
28 Apr - 29 Apr
Days Inn by Wyndham St Peters/St Charles

Holiday Inn Express Warrenton by IHG

Holiday Inn Express Warrenton by IHG
2.5 star property
Warrenton
9.0 out of 10, Wonderful, (535 reviews)
"Staff were so nice"
United States
Jennifer
The price is AU$209
includes taxes & fees
3 May - 4 May
Holiday Inn Express Warrenton by IHG

Relax Inn Saint Charles

Relax Inn Saint Charles
2.0 star property
St. Charles
6.8 out of 10, (1,004 reviews)
"Nice place and good price for the night "
United States
David
The price is AU$98
includes taxes & fees
26 Apr - 27 Apr
Relax Inn Saint Charles
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

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Frequently asked questions

What's the best place to stay in Defiance?
Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham and The Wildwood Hotel. See all available top hotels, or vacation rentals in Defiance.
What are some of the best holiday rentals that Defiance has to offer?
St. Charles 1860's Gem - Sleeps 6!: This holiday home rental outside of Defiance is located on a river, and has a garden, a selection of books and air conditioning to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge and a stovetop. See all vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
What are some accommodation options with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Offers an indoor pool, an outdoor pool and buffet. The Wildwood Hotel and Ameristar Casino Resort and Spa are two additional hotels with an on-site pool. View all hotels with pools in Defiance.
How is it staying in Defiance?
Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station, Enterprise Center and Busch Stadium. In Defiance, there are 19 hotels and other accommodation options to choose from. Find out more about Defiance.
What should I do while I'm visiting Defiance?
Natural beauty is on display at Matson Hill Park Trailhead, August A. Busch Memorial Conservation Area and Missouri River. A couple of additional sights to add to your itinerary are Chandler Hill Vineyards and Sugar Creek Winery. Take a look at what more there is to see and do in Expedia's Defiance guide.
What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

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