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5 Dec - 6 Dec
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Top hotels and accommodation in Defiance

Exterior
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG

2.5 star property
Wentzville
9.4 out of 10, Exceptional, (832)
"Clean room and friendly staff."
United States
Christy
Travelling with small children
The price is AU$188
includes taxes & fees
2 Jan - 3 Jan 2026
Holiday Inn Express & Suites Wentzville St Louis West by IHG
Exterior
WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon

2.5 star property
St. Peters
9.8 out of 10, Exceptional, (15)
"Tucked away, close to our leave point, very clean rooms!!!!"
United States
Tiesha
Travelling with partner
The price is AU$129
includes taxes & fees
8 Dec - 9 Dec
WoodSpring Suites St Peters-OFallon
Ballroom
The Wildwood Hotel

The Wildwood Hotel

3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1599)
"it was very nice and the hot tub"
United States
shanta
Travelling with partner
The price is AU$152
includes taxes & fees
18 Dec - 19 Dec
The Wildwood Hotel
Exterior
Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters

2.5 star property
St. Charles
8.0 out of 10, Very good, (1002)
"Very clean and excellent beds"
United States
Genevieve
Travelling for leisure
The price is AU$152
includes taxes & fees
14 Dec - 15 Dec
Hampton Inn St. Charles St. Peters
Courtyard
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

3.0 star property
Maryland Heights
7.4 out of 10, Good, (1002)
"Staff was nice and friendly gave me new towels when requested."
United States
Tony
Travelling for leisure
The price is AU$104
includes taxes & fees
5 Jan - 6 Jan 2026
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
Lobby sitting area
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3.0 star property
Fenton
8.0 out of 10, Very good, (1027)
"The front staff was friendly and provided washcloths and toilet paper with no issues"
United States
Ivy
Travelling for leisure
The price is AU$149
includes taxes & fees
14 Dec - 15 Dec
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Front of property – evening/night
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 star property
Maryland Heights
8.4 out of 10, Very good, (2205)
"This place had the cleanest and nicest bathroom of any hotel I have ever been in."
United States
Ashley
Travelling for leisure
The price is AU$158
includes taxes & fees
15 Dec - 16 Dec
Hollywood Casino & Hotel St. Louis
BBQ/picnic Area
Courtyard by Marriott St. Louis Chesterfield

Courtyard by Marriott St. Louis Chesterfield

3.0 star property
Chesterfield
9.0 out of 10, Wonderful, (575)
"Great hotel in a safe, vibrant area."
United States
Kevin
Travelling with family
The price is AU$157
includes taxes & fees
26 Dec - 27 Dec
Courtyard by Marriott St. Louis Chesterfield
Lobby
Comfort Inn & Suites St. Louis - O'Fallon

Comfort Inn & Suites St. Louis - O'Fallon

2.5 star property
O'Fallon
7.6 out of 10, Good, (1000)
"My daughter loved the pool."
United States
Eleazar
Travelling for leisure
The price is AU$129
includes taxes & fees
4 Jan - 5 Jan 2026
Comfort Inn & Suites St. Louis - O'Fallon
Reception
Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville

2.5 star property
Wentzville
9.0 out of 10, Wonderful, (637)
"Room was clean and very comfortable."
United States
Victoria
Travelling with small children
The price is AU$206
includes taxes & fees
2 Jan - 3 Jan 2026
Hampton Inn St. Louis Wentzville
Exterior
Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG

2.5 star property
O'Fallon
8.6 out of 10, Excellent, (828)
"Loved the modern feel, no carpet in the room!"
United States
Melissa
Travelling for leisure
The price is AU$148
includes taxes & fees
11 Dec - 12 Dec
Holiday Inn Express St. Louis West - O'Fallon by IHG
Front of property
Super 8 by Wyndham Eureka/Six Flags Nearby

Super 8 by Wyndham Eureka/Six Flags Nearby

2.0 star property
Eureka
7.0 out of 10, Good, (1000)
"I loved the water pressure in the shower"
United States
Nancy
Travelling for leisure
The price is AU$109
includes taxes & fees
1 Jan - 2 Jan 2026
Super 8 by Wyndham Eureka/Six Flags Nearby
Property amenity
Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton

2.5 star property
Warrenton
7.4 out of 10, Good, (1000)
"I would pay this 10 times over for a clean room and bathroom and comfortable bed"
United States
Laura
Travelling with partner
The price is AU$133
includes taxes & fees
7 Dec - 8 Dec
Baymont by Wyndham Warrenton
Lobby
Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive

2.5 star property
O'Fallon
8.8 out of 10, Excellent, (1001)
"Clean room and staff was very friendly"
United States
Craig
Travelling for leisure
The price is AU$154
includes taxes & fees
31 Dec - 1 Jan 2026
Sleep Inn & Suites O'Fallon MO - Technology Drive
Lobby sitting area
Hilton Garden Inn St. Louis/O'Fallon MO

Hilton Garden Inn St. Louis/O'Fallon MO

3.0 star property
O'Fallon
8.8 out of 10, Excellent, (712)
"Nice location, with a couple restaurants nearby."
United States
Kim
Travelling with family
The price is AU$156
includes taxes & fees
22 Dec - 23 Dec
Hilton Garden Inn St. Louis/O'Fallon MO
Free daily buffet breakfast
Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

2.5 star property
St. Charles Historic District
9.4 out of 10, Exceptional, (1001)
"Spacious, clean, aesthetically pleasing rooms and lobby."
United States
carey
The price is AU$201
includes taxes & fees
1 Jan - 2 Jan 2026
Country Inn & Suites by Radisson, St. Charles Historic District
Lobby
Quality Inn

Quality Inn

2.5 star property
Foristell
8.2 out of 10, Very good, (903)
"Room was spacious and comfortable."
United States
Bette
Travelling for leisure
The price is AU$143
includes taxes & fees
21 Dec - 22 Dec
Quality Inn
Exterior
Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis

2.5 star property
St. Charles
8.4 out of 10, Very good, (1001)
"I like the way the room organizes bathroom was clean staff friendly"
United States
Francoise
The price is AU$153
includes taxes & fees
21 Dec - 22 Dec
Comfort Suites St Charles - St Louis
Exterior
Best Western Plus Fenton

Best Western Plus Fenton

2.5 star property
Fenton
9.2 out of 10, Wonderful, (167)
"the room is very clean"
United States
Connie
The price is AU$185
includes taxes & fees
8 Dec - 9 Dec
Best Western Plus Fenton
Indoor pool
Holiday Inn St. Louis West Six Flags by IHG

Holiday Inn St. Louis West Six Flags by IHG

3.0 star property
Eureka
9.0 out of 10, Wonderful, (1002)
"Loved the pool, hot tub and arcade!"
United States
Crystal
Travelling for leisure
The price is AU$190
includes taxes & fees
15 Dec - 16 Dec
Holiday Inn St. Louis West Six Flags by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Missouri wineries have some of the most superb wine we've ever tasted! We recommend sipping on some chambourcin while basking in the sunshine.
Photo by Pages of Travel
Open Photo by Pages of Travel

Chandler Hill Vineyards

This elegant Missouri winery showcases local and California wines from its hillside setting. Savour varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.
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Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri

August A. Busch Memorial Conservation Area

This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment.
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Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

Recent Reviews in Defiance

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

10/10 Excellent
"Our family had a great stay. The accommodations were clean, welcoming & just what we needed. We were particularly impressed with Marsha who was at the front desk throughout our holiday stay making sure we had everything we needed. She is a wonderful brand ambassador for the Radisson organization."
Angie 2-night trip
Posted 2 days ago
Country Inn & Suites by Radisson, St. Charles Historic District

More cheap accommodation in Defiance

Relax Inn Saint Charles

Relax Inn Saint Charles

3800 Harry S Truman Blvd St. Charles MO
The price is AU$106 per night from 7 Dec to 8 Dec
AU$106
7 Dec - 8 Dec
includes taxes & fees
6.4/10 (999 reviews)

Frequently asked questions

What's the best place to stay in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, located 17.9 mi (28.8 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are Hollywood Casino & Hotel St. Louis and The Wildwood Hotel. See all available top hotels, or vacation rentals in Defiance.
What are some of the best holiday rentals that Defiance has to offer?
Stunning 1890's Home - Sleeps 8!: This holiday home rental outside of Defiance is equipped with a BBQ, air conditioning and laundry facilities to help you feel comfortable during your stay. It has 4 bedrooms, as well as a kitchen with a dishwasher, a stovetop and a microwave, so that you can cook with friends or family. See all vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
What are some accommodation options with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Features an indoor pool, an outdoor pool and buffet. The Wildwood Hotel and Ameristar Casino Resort and Spa are two additional hotels with an on-site pool. View all hotels with pools in Defiance.
How is it staying in Defiance?
Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station and Gateway Arch. In Defiance, there are 20 hotels and other accommodation options to choose from. Find out more about Defiance.
What should I do while I'm visiting Defiance?
Natural beauty is on display at Matson Hill Park Trailhead, August A. Busch Memorial Conservation Area and Missouri River. A couple of additional sights to add to your itinerary are Yellow Farmhouse Winery and Chandler Hill Vineyards. Take a look at what more there is to see and do in Expedia's Defiance guide.
What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

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