Defiance Hotel & Accommodation Deals 2026 from AU$107 - Compare prices by date

A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

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Our top choices for Defiance hotels

A hotel room with two beds, a desk with a chair, a television, and a window with curtains.

A reception desk with a modern design, featuring a blue geometric wall and a wooden finish.

A hotel lobby with a seating area, a reception desk, and a flat-screen TV mounted on the wall.

A Holiday Inn Express hotel with a brick facade, a covered entrance, and a clear sky.

1. Holiday Inn Express St. Louis West - O'Fallon by IHG

O'Fallon

Greg

AU$158

includes taxes & fees

25 Oct - 26 Oct

A hotel room with a bed, a sofa, a coffee table, and wall art.

A Sleep Inn & Suites hotel with a modern brick facade, a covered entrance, and a parking lot.

A restaurant with wooden tables and chairs, a blue wall with white floral patterns, and a counter with a coffee machine.

A hotel lobby with a reception desk, seating area, and a large potted plant.

2. Sleep Inn & Suites O'Fallon MO - Technology Drive

O'Fallon

Matthew

AU$140

includes taxes & fees

8 Nov - 9 Nov

An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.

A hotel room with a sofa, a side table, a lamp, a flat-screen TV, and a bed with a red blanket.

A multi-story hotel with a brick facade, a covered outdoor seating area with a fire feature, and a sign indicating it is a Marriott property.

A modern kitchen with wooden cabinets, a stainless steel countertop, and various appliances including a coffee maker and a rice cooker.

3. TownePlace Suites by Marriott St. Louis Chesterfield

Chesterfield

Thomas

AU$216

includes taxes & fees

26 Oct - 27 Oct

A multi-story hotel with a central entrance featuring a covered patio area.

A hotel room with a sofa, armchair, bedside table, lamp, TV, and a bed with patterned bedding.

A hotel lobby with a sectional sofa, a fireplace, a flat-screen TV, and framed artwork on the walls.

A hotel with a swimming pool, outdoor seating, and a covered patio area.

4. Staybridge Suites O'Fallon Chesterfield by IHG

O'Fallon

Norman

AU$182

includes taxes & fees

25 Oct - 26 Oct

A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

A hotel room with a large bed, a bedside lamp, a telephone, a mirror, and a bathroom with a sink and towel rack.

A formal dining table set for six with a vase of white flowers, candles, and a view of buildings through large windows.

A spacious living area with a staircase, a large painting, and a chandelier.

5. The Wildwood Hotel

Wildwood

Lori

AU$139

includes taxes & fees

26 Oct - 27 Oct

A modern dining area with a brick fireplace, yellow and blue chairs, and a blue sofa.

A hotel room with two beds, a desk, a mirror, and a wardrobe.

A picnic area with tables and benches, surrounded by grass and trees.

A hotel with a brick facade, multiple parking spaces, and a grassy area in the foreground.

6. Comfort Inn & Suites Chesterfield - St. Louis

Chesterfield

Brenda

AU$146

includes taxes & fees

25 Oct - 26 Oct

A spacious lobby with a stone fireplace, seating area, and a bar with high stools.

A multi-story hotel with a central entrance, large windows, and a well-maintained lawn.

A hotel pantry stocked with beverages and snacks, a refrigerated display case, and a sign reading "The Market".

A hotel lobby with a seating area featuring two armchairs, a round coffee table, and a flat-screen TV mounted on a wooden wall.

7. Residence Inn by Marriott O'Fallon

O'Fallon

Rianna

AU$222

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.

A spacious lobby with a sofa, a coffee station, and a reception desk.

A shop with a variety of snacks and beverages, including a refrigerated section with drinks and a display of packaged snacks.

A hotel with a covered entrance, multiple flags, and a well-maintained lawn.

8. Hilton Garden Inn St. Louis/O'Fallon MO

O'Fallon

Duane

AU$185

includes taxes & fees

1 Nov - 2 Nov

An outdoor patio area with wicker furniture and a central fire feature.

A hotel room with a bed, a sofa, a desk, and a chair.

A modern hotel lobby with a bar area, seating arrangements, and a reception desk.

A modern hotel lobby with a reception desk, seating area, and a television screen displaying a map.

9. Courtyard by Marriott St. Louis Chesterfield

Chesterfield

Kelly

AU$179

includes taxes & fees

19 Nov - 20 Nov

A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

A hotel room with two beds, a sofa, a small table, a lamp, and a framed abstract painting on the wall.

A hotel room with three computer workstations, each with a monitor, keyboard, and a lamp.

A swimming pool with a tiled deck, a sunlit room with a view, and a seating area with chairs.

10. Hyatt Place St. Louis/Chesterfield

Chesterfield

Debbie

AU$201

includes taxes & fees

25 Oct - 26 Oct

A modern kitchen area with a breakfast bar, a coffee machine, and a refrigerator displaying menu options.

A coffee station with two coffee machines and a display of coffee pods and cups.

A hotel room with two beds, a blue sofa, a small table, and a kitchenette.

A pool area with a blue pool lift chair, a pool user capacity sign, and a tiled wall.

11. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Chesterfield

Terry

AU$179

includes taxes & fees

16 Nov - 17 Nov

A spacious lobby with a central round table, two sofas, and a chandelier.

A Drury Plaza hotel with a modern design, featuring a curved facade, large windows, and a Drury Plaza sign on the top.

A hotel room with two beds, a patterned wall, and a view of the city through sheer curtains.

A buffet setup with various food items and a decorative vase of flowers.

12. Drury Plaza Hotel St. Louis Chesterfield

Chesterfield

Chasity

AU$217

includes taxes & fees

25 Oct - 26 Oct

Two people in a swimming pool with colorful inflatable rings.

A lobby with a grand staircase, two patterned sofas, a glass coffee table, and a large mirror.

A buffet counter with a variety of food items, including pastries and beverages, and a person serving.

A spacious lobby with a stone fireplace, a chandelier, and a staircase.

13. Holiday Inn St. Louis West Six Flags by IHG

Eureka

Rob

AU$218

includes taxes & fees

16 Nov - 17 Nov

A courtyard with a central seating area, surrounded by trees and a building with a pitched roof.

A modern hotel room with a large window, a desk with a flat-screen TV, a comfortable seating area, and a decorative wall piece.

A modern dining area with a long table, multiple chairs, and pendant lighting.

A reception desk with a "WELCOME TO THE SHOW ME STATE" sign, a wooden counter, and a Hilton Honors sign.

14. Hampton Inn & Suites St. Louis/Chesterfield

Chesterfield

Vijay

AU$198

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with a high ceiling, a dining area, and a kitchen in the background.

A lobby with a checkered carpet, a marble coffee table, two armchairs with patterned cushions, a sofa, and a dining table with chairs.

An indoor swimming pool with stone flooring, white walls, and a green stripe. There are chairs and a door with a sign.

A hotel room with a bathroom, a bed, a nightstand, and a window.

15. Quality Inn Near Six Flags St. Louis

Pacific

Chantelle

AU$139

includes taxes & fees

9 Nov - 10 Nov

A hotel room with a large bed, a desk with a TV, a chair, a window with curtains, and a nightstand with a lamp.

An indoor swimming pool with a hot tub, clear signage, and a view of the outside through large windows.

A spacious living area with a blue wall, yellow armchairs, a blue sofa, and a wooden coffee table.

A hotel room with two beds, a desk with a TV, a chair, and a lamp.

16. Comfort Inn Near Six Flags St. Louis

Pacific

Jade

AU$144

includes taxes & fees

9 Nov - 10 Nov

A spacious living room with a large painting, a fireplace, a staircase, and modern furniture.

A hotel room with a dining area, a fireplace, and a view of the outdoors.

An outdoor patio with a beige sofa set, two armchairs, and a table.

A swimming pool with tiled edges and a hot tub area, surrounded by windows and chairs.

17. Best Western Plus Washington Hotel

Washington

Shawn

AU$220

includes taxes & fees

25 Oct - 26 Oct

A spacious lobby with a brown leather sofa, multiple chairs, a coffee table with a skull decoration, and a large chandelier.

A hotel room with orange furniture, a glass coffee table, a dining area with a table and chairs, and a patterned carpet.

A large, multi-story hotel with the name "Doubletree by Hilton" prominently displayed on the facade.

A hotel room with a large bed, a desk with a chair, a television, a mirror, and a wardrobe.

18. DoubleTree by Hilton Hotel St. Louis - Chesterfield

Chesterfield

Saranne

AU$231

includes taxes & fees

30 Oct - 31 Oct

An outdoor patio with a built-in grill, seating area, and stone walls.

A spacious lounge area with a stone fireplace, comfortable seating, and a large TV screen.

An indoor swimming pool with clear glass walls, sunlit seating area, and lifeguard station.

A modern lobby with a stone accent wall, a flat-screen TV, a reception desk, seating area with sofas and ottomans, and a patterned rug.

19. Residence Inn by Marriott St. Louis Chesterfield

Chesterfield

Chelsea

AU$318

includes taxes & fees

25 Oct - 26 Oct

A Super 8 hotel with a flat facade, multiple windows, and a parking lot.

A breakfast area with wooden cabinets, a coffee station, and a dining table with chairs.

A hotel room with a bed, a desk, a chair, a nightstand, a lamp, and a large cityscape artwork on the wall.

A bathroom with a shower, a small white stool, and a towel rack.

20. Super 8 by Wyndham Eureka/Six Flags Nearby

Eureka

Mike

AU$107

includes taxes & fees

8 Nov - 9 Nov

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Stay near popular Defiance attractions

A glass of red wine on a wooden table with a vineyard in the background.

Chandler Hill Vineyards

7.8/10 (7 reviews)

This elegant Missouri winery showcases local and California wines from its hillside setting. Savour varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.

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A wooden dock extending into a pond with lily pads, surrounded by lush greenery and a clear blue sky.

August A. Busch Memorial Conservation Area

8.6/10 (7 reviews)

This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment.

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Historic Daniel Boone Home and Heritage Center

9.6/10 (4 reviews)

Step into the limestone home where Daniel Boone's son Nathan crafted a frontier masterpiece with seven fireplaces. Explore the surrounding historic village for an authentic glimpse into 19th-century pioneer life.

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Sugar Creek Winery

8.0/10 (1 review)

Sip award-winning Missouri wines at this hillside vineyard along the scenic Katy Trail. Relax on covered decks with your own picnic while enjoying live weekend music and panoramic countryside views.

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Yellow Farmhouse Winery

This boutique winery in Defiance, Missouri was known for its distinctive unfiltered wines and relaxed atmosphere. Visitors could enjoy tastings with live music while picnicking on scenic grounds with vineyard views.

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Broemmelsiek Park

This 494-acre natural playground offers nine miles of trails through forests and around serene lakes. Attend a monthly stargazing event at the astronomy viewing area for a uniquely celestial park experience.

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Matson Hill Park Trailhead

Wander through 475 acres of rugged forest terrain with challenging hiking paths and gravity-flow mountain bike trails. The historic 1830s Hays Home offers a glimpse into pioneer life amid the natural splendour.

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Hamburg Trail Trailhead

This moderate 6.9-mile loop winds through the scenic Weldon Spring Conservation Area, connecting to the Katy Trail State Park. Spot native wildlife while traversing diverse landscapes of shaded woodlands and open fields.

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Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance

Top Defiance Hotel Reviews

Recent Reviews in Defiance

Sonesta ES Suites St. Louis - Chesterfield

10/10 Excellent

"Friendly staff, very welcoming. Kitchen equipped with needed dinnerware & utensils to prepare your meals."

Studio 6 Extended Stay - St Louis, MO - Westport/Craig Road

8/10 Good

"it’s quite acceptable"

The Wildwood Hotel

10/10 Excellent

"first class hotel at reasonable prices. Hotel conglomerates, this operation has your lessons to learn..."

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

8/10 Good

"We enjoyed the free continental breakfast. There was a mixture of hot and “cold” items. There was even a fountain soda machine turned on! The thing I didn’t care for was upon arriving to check in (for my double queen room), the attendant said there were no more rooms like that available and they would “upgrade” us to a suite with a king bed and a pullout sofa. I mentioned that was frustrating because I had reserved the double queen- that should ensure that’s what I got and I didn’t feel like the other was an upgrade because pull out beds are uncomfortable! After pushing some buttons on the computer, all of a sudden a room like we had reserved WAS available- just down the hall. That whole experience felt shady to me…I didn’t like it. The worker was plenty nice during it though."

Sleep Inn & Suites O'Fallon MO - Technology Drive

10/10 Excellent

"Amazing experience! I will stay here again and recommend to others. Thank you."

Drury Plaza Hotel St. Louis Chesterfield

8/10 Good

"Room was clean, but air return system had a high pitched noise that was annoying. Evening hors d'oeuvres were a nice touch along with the complimentary beverages"

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

10/10 Excellent

"check in was very easy and great fun, the lady on the front desk was very easy to chat to and very funny, its a shame we only stayed one night because the room was fantastic, spacious clean and the bed was very comfortable. I had a swim in the pool which was very nice. The hotel has easy access to freeways and there are restaurants nearby. I would certainly stay here again and was a bit sorry to leave, Highly recommended"

Hampton Inn St. Charles St. Peters

10/10 Excellent

"Fantastic place to stay! The staff was amazing!"

La Quinta Inn & Suites by Wyndham St. Louis Westport

10/10 Excellent

"Not the best"

More cheap accommodation in Defiance

Country Inn & Suites by Radisson, St. Peters, MO

3877 Veterans Memorial Pkwy St. Charles MO

AU$131

15 Nov - 16 Nov

includes taxes & fees

Quality Inn Foristell

12 Highway W Foristell MO

AU$131

19 Nov - 20 Nov

includes taxes & fees

8.2/10 Very good! (1,003 reviews)

Sleep Inn & Suites O'Fallon MO - Technology Drive

1147 Technology Drive O'Fallon MO

AU$140

8 Nov - 9 Nov

includes taxes & fees

9/10 Wonderful! (1,144 reviews)

Comfort Suites St Charles - St Louis

1400 S 5th St St. Charles MO

AU$157

15 Nov - 16 Nov

includes taxes & fees

Hampton Inn St. Charles St. Peters

3720 W Clay St St. Charles MO

AU$196

25 Oct - 26 Oct

includes taxes & fees

8.2/10 Very good! (1,003 reviews)

Country Inn & Suites by Radisson, St. Charles Historic District

1190 S Main St St. Charles MO

AU$203

15 Nov - 16 Nov

includes taxes & fees

Frequently asked questions

What is the best area to stay in Defiance?

The best area to stay in Defiance is directly within the village centre, particularly near the intersection of Highway F and Femme Osage Creek Road.This area is the heart of Defiance, offering a collection of local businesses, dining options, and access to the Katy Trail. It's a small, walkable village with a relaxed pace, surrounded by scenic vineyards and rolling hills. The historic Defiance Roadhouse is a popular landmark here.For couples looking for a romantic getaway, the village centre is ideal. You'll find boutique accommodation options, often with a focus on local wines and cuisine. It's great for enjoying leisurely meals, exploring the nearby wineries, and taking peaceful walks along the Katy Trail.Solo travellers seeking a peaceful retreat and outdoor activities will also find the village centre appealing.

When is the best time to go to Defiance?

The best times to go to Defiance are during the spring (late April to early June) and autumn (September to October) when the weather is pleasant and the natural beauty of the area is at its peak.Spring offers mild temperatures, making it ideal for outdoor activities like cycling and hiking along the Katy Trail. The vineyards begin to bud, and the countryside is lush and green. This period is particularly good for couples who enjoy scenic walks and wine tasting without the summer crowds.Autumn brings cooler, crisp air and the stunning transformation of the leaves, creating a picturesque backdrop for exploring the region. Many local wineries also host harvest festivals during this time. For those who appreciate outdoor beauty and a relaxed pace, this season provides an excellent experience.

Can I cancel my hotel reservation on Expedia?

You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if cancelled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Defiance.

How can I save on a hotel booking in Defiance with Expedia?

One Key™—Expedia's free travel rewards program—gives you instant access to discounts with Member Prices on Defiance hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.

How much is the nightly rate for a hotel in Defiance?

Prices for hotels in Defiance often vary, but you can find a great deal from AU$107 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.

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Search Defiance hotels

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Defiance

Check prices for these dates

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Property class

Guest rating

Our top choices for Defiance hotels

1. Holiday Inn Express St. Louis West - O'Fallon by IHG

2. Sleep Inn & Suites O'Fallon MO - Technology Drive

3. TownePlace Suites by Marriott St. Louis Chesterfield

4. Staybridge Suites O'Fallon Chesterfield by IHG

5. The Wildwood Hotel

6. Comfort Inn & Suites Chesterfield - St. Louis

7. Residence Inn by Marriott O'Fallon

8. Hilton Garden Inn St. Louis/O'Fallon MO

9. Courtyard by Marriott St. Louis Chesterfield

10. Hyatt Place St. Louis/Chesterfield

11. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

12. Drury Plaza Hotel St. Louis Chesterfield

13. Holiday Inn St. Louis West Six Flags by IHG

14. Hampton Inn & Suites St. Louis/Chesterfield

15. Quality Inn Near Six Flags St. Louis

16. Comfort Inn Near Six Flags St. Louis

17. Best Western Plus Washington Hotel

18. DoubleTree by Hilton Hotel St. Louis - Chesterfield

19. Residence Inn by Marriott St. Louis Chesterfield

20. Super 8 by Wyndham Eureka/Six Flags Nearby

Stay near popular Defiance attractions

Chandler Hill Vineyards

August A. Busch Memorial Conservation Area

Historic Daniel Boone Home and Heritage Center

Sugar Creek Winery

Yellow Farmhouse Winery

Broemmelsiek Park

Matson Hill Park Trailhead

Hamburg Trail Trailhead

Learn more about Defiance

Top Defiance Hotel Reviews

Recent Reviews in Defiance

Sonesta ES Suites St. Louis - Chesterfield

Studio 6 Extended Stay - St Louis, MO - Westport/Craig Road

The Wildwood Hotel

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Sleep Inn & Suites O'Fallon MO - Technology Drive

Drury Plaza Hotel St. Louis Chesterfield

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Hampton Inn St. Charles St. Peters

La Quinta Inn & Suites by Wyndham St. Louis Westport

More cheap accommodation in Defiance

Country Inn & Suites by Radisson, St. Peters, MO

Quality Inn Foristell

Sleep Inn & Suites O'Fallon MO - Technology Drive

Comfort Suites St Charles - St Louis

Hampton Inn St. Charles St. Peters

Country Inn & Suites by Radisson, St. Charles Historic District

Frequently asked questions

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