A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Defiance Holiday Rentals

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Our top choices for Defiance holiday rentals

1. Lots of Space! Central to St Charles and STL. Newly Remodeled. Large Backyard!

Lots of Space! Central to St Charles and STL. Newly Remodeled. Large Backyard!
Pinehurst
8.6 out of 10, Excellent, (36 reviews)
"Great place with lots of space great area host is great!"
United States
Jacob L.
Lots of Space! Central to St Charles and STL. Newly Remodeled. Large Backyard!

2. 1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed

1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed
Westport
9.6 out of 10, Exceptional, (41 reviews)
"Great spot!"
United States
Anonymous traveller
The price is AU$102
includes taxes & fees
14 Sept - 15 Sept
1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed

3. Great for Business Travelers! Comfortable Suite in St. Louis | BBQ Area

Great for Business Travelers! Comfortable Suite in St. Louis | BBQ Area
Westport
10.0 out of 10, Exceptional, (5 reviews)
"Everything from the staff to the amenities to the rooms were amazing! Definitely recommend staying here! "
Canada
Lashon C.
The price is AU$413
includes taxes & fees
13 Sept - 14 Sept
Great for Business Travelers! Comfortable Suite in St. Louis | BBQ Area

4. Historic Main St 2BR | Steps to Shops

Historic Main St 2BR | Steps to Shops
St. Charles Historic District
9.4 out of 10, Exceptional, (42 reviews)
"This property has a nice renovation while keeping a lot of its original character. Very clean and comfortable beds as well. The location couldn’t be better! We really enjoyed our stay."
United States
William O.
The price is AU$523
includes taxes & fees
9 Sept - 10 Sept
Historic Main St 2BR | Steps to Shops

5. Prime Loft of Main Street

Prime Loft of Main Street
St. Charles Historic District
9.8 out of 10, Exceptional, (116 reviews)
"Host was great. The cutest place in the perfect spot! "
United States
Anonymous traveller
The price is AU$365
includes taxes & fees
8 Sept - 9 Sept
Prime Loft of Main Street

6. The Lofts of North Main Street

The Lofts of North Main Street
St. Charles Historic District
9.6 out of 10, Exceptional, (189 reviews)
"It was great! Clean and great communication with host."
United States
Natalie H.
The price is AU$365
includes taxes & fees
8 Sept - 9 Sept
The Lofts of North Main Street

7. Amazing Renovated Historic Loft on Main Street

Amazing Renovated Historic Loft on Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (68 reviews)
"Lovely accommodations, very clean, well equipped, great location. "
United States
Emily B.
The price is AU$365
includes taxes & fees
8 Sept - 9 Sept
Amazing Renovated Historic Loft on Main Street

8. Historic Main Street Studio | Dog-Friendly

Historic Main Street Studio | Dog-Friendly
St. Charles Historic District
9.2 out of 10, Wonderful, (37 reviews)
"Had a wonderful stay. It was a Monday night so parking was very easy and the room was clean and comfortable. I would recommend this place 100% "
United States
Sarah C.
The price is AU$291
includes taxes & fees
13 Sept - 14 Sept
Historic Main Street Studio | Dog-Friendly

9. Main Street 2BR Apartment with Garage and Deck

Main Street 2BR Apartment with Garage and Deck
St. Charles Historic District
9.4 out of 10, Exceptional, (21 reviews)
"We loved our stay for Memorial Day weekend! It was the perfect space to unwind after a day of walking around historic Saint Charles. Our favorite spot was the back deck. Having the garage was so convenient and the space itself is really beautiful. The only thing we wish we had prepared for was a lack of basic kitchen cooking items. We bought breakfast food to cook but did not think to bring cooking oil/s&p. Would love to stay again sometime! We had a great weekend."
United States
Jennifer M.
The price is AU$422
includes taxes & fees
15 Sept - 16 Sept
Main Street 2BR Apartment with Garage and Deck

10. Historic 1908 Frenchtown Home

Historic 1908 Frenchtown Home
St. Charles Historic District
8.8 out of 10, Excellent, (26 reviews)
"Kitchen has a Kurig so be sure to get pods.The house is functional as a historic property but we really only used it as a place to sleep while in town for work. Getting ready with 3 people and one bath was slightly difficult as the bedroom didn't have a mirror so everyone required the bathroom, but the beds were comfy.It is a nice part of town, near the college and on a quiet one way street."
United States
Megan B.
The price is AU$459
includes taxes & fees
10 Sept - 11 Sept
Historic 1908 Frenchtown Home

11. Driftwood Den | Boho 2BR | Dog-Friendly

Driftwood Den | Boho 2BR | Dog-Friendly
St. Charles Historic District
10.0 out of 10, Exceptional, (6 reviews)
"Loved our stay here. Clean, comfortable, convenient. Couldn’t have been easier, in all aspects. Already plan to stay there again!!!"
United States
Kourtney S.
The price is AU$464
includes taxes & fees
10 Sept - 11 Sept
Driftwood Den | Boho 2BR | Dog-Friendly

12. HotTub-2br2b-near Historic Main Street

HotTub-2br2b-near Historic Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (19 reviews)
"Comfy beds, great location!"
United States
Jessie W.
The price is AU$420
includes taxes & fees
8 Sept - 9 Sept
HotTub-2br2b-near Historic Main Street

13. Historic 1805 Main Street 2BR

Historic 1805 Main Street 2BR
St. Charles Historic District
9.6 out of 10, Exceptional, (42 reviews)
"The location is excellent. "
United States
McRay H.
The price is AU$517
includes taxes & fees
20 Sept - 21 Sept
Historic 1805 Main Street 2BR

14. Historic Main St. Customs House Upstairs Apartment

Historic Main St. Customs House Upstairs Apartment
St. Charles Historic District
9.6 out of 10, Exceptional, (39 reviews)
"Lovely place to stay!"
United States
Margaret A.
The price is AU$502
includes taxes & fees
9 Sept - 10 Sept
Historic Main St. Customs House Upstairs Apartment

15. Home Near Main Street-Covered Patio-Hot Tub!

Home Near Main Street-Covered Patio-Hot Tub!
Saint Charles
9.6 out of 10, Exceptional, (39 reviews)
"Great house and great location"
United States
Mike L.
The price is AU$948
includes taxes & fees
8 Sept - 9 Sept
Home Near Main Street-Covered Patio-Hot Tub!

16. Walk to Main | Pet-Friendly Yard & Workspace

Walk to Main | Pet-Friendly Yard & Workspace
St. Charles Historic District
10.0 out of 10, Exceptional, (11 reviews)
"I will stay here again. It was a great location for my visit. Lots of room and amenities. Highly recommend this location if you are visiting the St Louis area. Barely a mile to get to Hwy 70, so easy access to St Louis, St Peter's, Wentzville etc. Maybe two blocks from Historic St Charles and Ameristar Casino."
United States
Karen M.
The price is AU$407
includes taxes & fees
20 Sept - 21 Sept
Walk to Main | Pet-Friendly Yard & Workspace

17. Pet-Friendly Duplex | Historic Main

Pet-Friendly Duplex | Historic Main
St. Charles Historic District
10.0 out of 10, Exceptional, (25 reviews)
"Great location"
United States
todd p.
The price is AU$397
includes taxes & fees
9 Sept - 10 Sept
Pet-Friendly Duplex | Historic Main

18. Cottage on Historic Main Street- Low Cleaning fee

Cottage on Historic Main Street- Low Cleaning fee
St. Charles Historic District
10.0 out of 10, Exceptional, (23 reviews)
"Great location to Main Street. "
United States
Daneen H.
The price is AU$437
includes taxes & fees
17 Sept - 18 Sept
Cottage on Historic Main Street- Low Cleaning fee

19. Cottage on Main st- Low Cleaning Fee

Cottage on Main st- Low Cleaning Fee
St. Charles Historic District
10.0 out of 10, Exceptional, (10 reviews)
"Good location. Decorated very nicely. "
United States
Debbie A.
The price is AU$416
includes taxes & fees
20 Sept - 21 Sept
Cottage on Main st- Low Cleaning Fee

20. Music House · Music House on Main Street at The Wine Garden

Music House · Music House on Main Street at The Wine Garden
Saint Charles
9.4 out of 10, Exceptional, (18 reviews)
"Nice area nice place and communication"
United States
Zack P.
The price is AU$889
includes taxes & fees
8 Sept - 9 Sept
Music House · Music House on Main Street at The Wine Garden
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

Find out more about Defiance

Everything you need to know about Defiance holiday rentals

Whether you’re excited for the perfect family holiday, a romantic getaway for two, or the ultimate city break, we’ve got the Defiance holiday rental for you. At Expedia, you can take your pick from private holiday homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Defiance holiday rental for you by simply entering your desired dates. Then check your favourite filters to narrow down your search. 

Defiance holiday rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Defiance. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depend on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Defiance holiday rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a holiday rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Defiance holiday rentals we have selected for you start as low as per night. Entering your travel dates in the search wizard might find you even better deals!

How to find incredible deals on Defiance rentals

At Expedia, we put the best Defiance holiday rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top Defiance rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Defiance holiday.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Defiance. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. 

Frequently asked questions

Can I find holiday rentals in Defiance?

Yes, there are holiday rentals close to the most popular sights in Defiance, or you can select a more secluded option if you're looking for a relaxing stay. Defiance is known for its wineries and parks.

What are some of the best holiday rentals that Defiance has to offer?

Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!: This holiday home rental outside of Defiance is equipped with a BBQ, air conditioning and laundry facilities to help you feel comfortable during your stay. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family.

How many holiday rentals will I find in Defiance?

With 3 Expedia holiday rentals, you're guaranteed to find just the right place for your Defiance stay.

What’s there to see and do in Defiance?

August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. Other places in town to visit include Chandler Hill Vineyards and Sugar Creek Winery.

What’s a holiday rental in Defiance like?

Holiday rentals are private properties where you can stay for a few weeks, or just a few days, in Defiance. Holiday rentals feature amenities such as hot tubs, fire pits and patios so you'll have everything you want. If you're concerned about a sanitised environment, holiday rentals can offer a sense of security away from shared hotel lifts and lobbies bustling with people while still allowing you the enjoyment of travel. You'll also have more space in a holiday rental than in a traditional hotel, which makes a holiday rental an attractive option for families.