Cheap flights from Madrid to Panama City

View AU$561 flight on Fri, 12 Sep. 2025Opens in a new window

Popular airlines from Madrid to Panama City

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Cheap Flights from Madrid (MAD) to Panama City (PTY)

Prices were available within the past 7 days for one-way flights and round trip tickets for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Wed, 1 Oct. - Wed, 8 Oct.
MAD
Madrid
PTY
Panama City
AU$1,256 Return, found 3 hours ago
AU$1,256
Return
found 3 hours ago
Select United flight, departing Wed, 1 Oct. from Madrid to Panama City, returning Wed, 8 Oct., priced at AU$1,256 found 3 hours ago
United
Wed, 1 Oct. - Wed, 8 Oct.
MAD
Madrid
PTY
Panama City
AU$1,292 Return, found 3 hours ago
AU$1,292
Return
found 3 hours ago
Select United flight, departing Wed, 1 Oct. from Madrid to Panama City, returning Wed, 8 Oct., priced at AU$1,292 found 3 hours ago
American Airlines
Wed, 1 Oct. - Wed, 8 Oct.
MAD
Madrid
PTY
Panama City
AU$1,389 Return, found 3 hours ago
AU$1,389
Return
found 3 hours ago
Select American Airlines flight, departing Wed, 1 Oct. from Madrid to Panama City, returning Wed, 8 Oct., priced at AU$1,389 found 3 hours ago
Air Europa
Wed, 1 Oct. - Wed, 8 Oct.
MAD
Madrid
PTY
Panama City
AU$1,406 Return, found 3 hours ago
AU$1,406
Return
found 3 hours ago
Select Air Europa flight, departing Wed, 1 Oct. from Madrid to Panama City, returning Wed, 8 Oct., priced at AU$1,406 found 3 hours ago
KLM
Wed, 1 Oct. - Wed, 8 Oct.
MAD
Madrid
PTY
Panama City
AU$1,431 Return, found 3 hours ago
AU$1,431
Return
found 3 hours ago
Select KLM flight, departing Wed, 1 Oct. from Madrid to Panama City, returning Wed, 8 Oct., priced at AU$1,431 found 3 hours ago
avianca
Wed, 1 Oct. - Wed, 8 Oct.
MAD
Madrid
PTY
Panama City
AU$1,549 Return, found 3 hours ago
AU$1,549
Return
found 3 hours ago
Select avianca flight, departing Wed, 1 Oct. from Madrid to Panama City, returning Wed, 8 Oct., priced at AU$1,549 found 3 hours ago

Find the cheapest month to fly from Madrid (MAD) to Panama City (PTY)

May is typically the cheapest month to fly

From AU$822 - AU$1,392 per traveller.

Graph displaying average flight prices per month

*Available to Expedia members.