Cheap flights from Chicago to Upstate South Carolina

View AU$200 flight on Mon, 6 Oct. 2025Opens in a new window

Popular airlines from Chicago to Upstate South Carolina

  • Delta

    Delta

  • Southwest Airlines

    Southwest Airlines

  • American Airlines

    American Airlines

  • United

    United

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Cheap Flights from Chicago (CHI) to Upstate South Carolina (GSP)

Prices were available within the past 7 days for one-way flights and round trip tickets for the period specified. Prices and availability are subject to change. Additional terms apply.

Find the cheapest month to fly from Chicago (CHI) to Greenville (GSP)

August is typically the cheapest month to fly

From AU$272 - AU$866 per traveller.

Graph displaying average flight prices per month

*Available to Expedia members.