Photo by Michelle Hendrix

Holiday Homes in Upstate South Carolina

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
In two months
In three months
In four months

Featured Holiday Homes in Upstate South Carolina

Holiday Home in Woodside Cotton Mill Village Historic District

9.8 out of 10, Exceptional, (81)
"Thand comfortable e bungalow was great ,clean,updated "
United States
Mark
The price is AU$299
includes taxes & fees
7 Dec - 8 Dec
The Blue Bungalow by Unity Park - Newly Renovated

Holiday Home in Spartanburg

10.0 out of 10, Exceptional, (3)
"SHEENA WAS AN AWESOME HOSTESS!."
United States
TOM w.
The price is AU$597
includes taxes & fees
6 Jan - 7 Jan 2026
Cozy Stays King Size Bed Full Kitchen Work

Holiday Home in Greer

10.0 out of 10, Exceptional, (3)
"House was perfect for our needs. Spacious and clean. Easy to access, good parking and good communication with host. "
United States
Christopher A.
The price is AU$529
includes taxes & fees
12 Dec - 13 Dec
Cozy, Updated 2BR/2.5BA End-Unit Townhome, Greer SC

Holiday Home in Greenville

10.0 out of 10, Exceptional, (2)
"delightful house on a very mellow street. super easy access to downtown, a grocery store close, beautiful backyard for the dog, lovely kitchen. i was in town for my anniversary week and my partner and i enjoyed the stay very much. hosts were helpful and communicative, the house was exactly as described and we literally had zero issues. i have no problem recommending this house strongly! "
United States
jon b.
The price is AU$335
includes taxes & fees
5 Jan - 6 Jan 2026
Cozy 2BR Near Furman & Downtown, Fenced Yard

Holiday Home in Pickens

9.8 out of 10, Exceptional, (30)
"We enjoyed our stay at this lovely home! Checking was easy and kitchen was roomy and met our needs."
United States
Carla B.
The price is AU$397
includes taxes & fees
8 Dec - 9 Dec
Welcome To Downtown Pickens close to Clemson and Lake Keowee

Holiday Home in Woodside Cotton Mill Village Historic District

2.0 star property
10.0 out of 10, Exceptional, (1)
"Check-in was smooth as could, be. The place itself was spotless, clean, and perfect for our stay. Highly recommend Old Europe for coffee and a pastry nearby. "
United States
Matthew K.
The price is AU$335
includes taxes & fees
27 Dec - 28 Dec
Skyline Split A Retreat Close to Everything You Need! Quiet, Clean & Convenient.

Holiday Home in cleveland

9.6 out of 10, Exceptional, (7)
"The place is awesome! I don’t usually leave comments but this place is worth the visit."
United States
Michael
The price is AU$509
includes taxes & fees
8 Dec - 9 Dec
Secluded Yurt Hideaway 10 min to Table Rock

Holiday Home in Greenville

10.0 out of 10, Exceptional, (11)
"It was clean and quiet..I will stay here again. "
United States
Kimberly S.
The price is AU$252
includes taxes & fees
7 Dec - 8 Dec
Apt. near Downtown Greenville (2BR/1BA, 3 beds)

Holiday Home in Gaffney

9.8 out of 10, Exceptional, (24)
"It is a really nice place and in a quiet area. Very cute backyard. Would stay again!! "
United States
Jessica S.
The price is AU$308
includes taxes & fees
20 Dec - 21 Dec
Private family, pet friendly with fenced yard near Limestone College and Outlets

Holiday Home in Cleveland

10.0 out of 10, Exceptional, (1)
"Accurate listing, easy to find! "
United States
Beth T.
The price is AU$401
includes taxes & fees
8 Dec - 9 Dec
Pet-Friendly Cabin in Marietta w/ Porch Swings

Holiday Home in Marietta

10.0 out of 10, Exceptional, (50)
"Very well appointed."
United States
Sara P.
The price is AU$239
includes taxes & fees
10 Dec - 11 Dec
Hobbit Hideaway - Do Something Different!

Holiday Home in Spartanburg

9.6 out of 10, Exceptional, (7)
"Perfect location if you are needing to go downtown area. Comfortable beds & communication with the owner was great! "
United States
Josey W.
The price is AU$395
includes taxes & fees
7 Dec - 8 Dec
Carolina Cottage-Entire Home-Close to Downtown Spartanburg

Holiday Home in Greenville

9.6 out of 10, Exceptional, (4)
"Great for our visit"
United States
Robert B.
The price is AU$447
includes taxes & fees
8 Dec - 9 Dec
Chic 3BR Home: Pet Friendly, Near Furman & Parks

Holiday Home in Pendleton

10.0 out of 10, Exceptional, (4)
"Clean and comfortable. Close to campus"
United States
Russ C.
The price is AU$606
includes taxes & fees
6 Jan - 7 Jan 2026
6 Min>Clemson - 1kMbps - Keyless Entry - Office Space

Holiday Home in Travelers Rest

10.0 out of 10, Exceptional, (16)
"Great location, clean place, great communication would come back again."
United States
Jeff S.
The price is AU$504
includes taxes & fees
5 Jan - 6 Jan 2026
Spacious 4-bedroom home in charming Travelers Rest with WiFi & Firepit.

Holiday Home in Pickens

10.0 out of 10, Exceptional, (16)
"The perfect spot to relax and reset. Do yourself a favor and book a massage during your stay. "
United States
Ashley P.
The price is AU$348
includes taxes & fees
8 Dec - 9 Dec
Vacation Rental, Spa & Salt Room Table Rock State Park Fire-Pit ,Pet Friendly

Holiday Home in Pendleton

10.0 out of 10, Exceptional, (10)
"Cozy, clean and quiet! Loved that we could have our dogs stay with us! "
United States
Jennifer T.
The price is AU$434
includes taxes & fees
8 Dec - 9 Dec
The Rustic Rectangle

Holiday Home in Anderson

4.0 star property
The price is AU$506
includes taxes & fees
1 Jan - 2 Jan 2026
Lake Hartwell Frank Howard Home Clemson

Holiday Home in Lyman

10.0 out of 10, Exceptional, (40)
"We loved this place! Clean and beautiful. The snacks and the candle were just perfect to make our stay the best."
United States
Molly M.
The price is AU$312
includes taxes & fees
16 Dec - 17 Dec
⭐️Hot Tub⭐️ Luxury Getaway Near GSP Airport Downtown Greer Greenville Spartanburg

Holiday Home in Greenville

9.6 out of 10, Exceptional, (110)
"The best! Our home-away-from-home when visiting our son at Furman. Thank you, Yamileth! "
United States
Aletta M.
The price is AU$479
includes taxes & fees
8 Dec - 9 Dec
Private, pet-friendly adorable getaway mins to downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Upstate South Carolina Hotel Reviews

Find out more about Upstate South Carolina

Upstate South Carolina Holiday Homes information

Number of reviews
410
Accommodation
856 Holiday Homes
Lowest Price
AU$239
Highest Price
AU$606

Explore a world of travel with Expedia