Holiday Homes in Upstate South Carolina
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Check prices for these dates
Next weekend
In two weeks
In one month
In two months
Featured Holiday Homes in Upstate South Carolina

Keowee Key Townhome - Pet Friendly, View of Golf Course plus Amenities
Keowee Key Townhome - Pet Friendly, View of Golf Course plus Amenities
9.8 out of 10, Exceptional, (71)

Lake Living at its finest!
Lake Living at its finest!
10.0 out of 10, Exceptional, (47)

New Construction Townhome Less Than 1 Mile From The Heart Of Downtown Greenville
New Construction Townhome Less Than 1 Mile From The Heart Of Downtown Greenville
9.6 out of 10, Exceptional, (58)

The Sanctuary at Tubbs Mountain
The Sanctuary at Tubbs Mountain
10.0 out of 10, Exceptional, (6)

Close to Lake Hartwell, Clemson, and Anderson
Close to Lake Hartwell, Clemson, and Anderson
10.0 out of 10, Exceptional, (53)

NEW LakeHome On The Water, LUXURY Sleeps 18, Pool, Dock, Beach, Close To Clemson
NEW LakeHome On The Water, LUXURY Sleeps 18, Pool, Dock, Beach, Close To Clemson

A charming lakefront Lake Keowee home!
A charming lakefront Lake Keowee home!
10.0 out of 10, Exceptional, (118)

Lake Keowee Lakefront Cove, Private Dock, Deep Water Access, Kayaks & more
Lake Keowee Lakefront Cove, Private Dock, Deep Water Access, Kayaks & more
10.0 out of 10, Exceptional, (2)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Find out more about Upstate South Carolina
Find out more about Upstate South Carolina
Upstate South Carolina Holiday Homes information
Number of reviews | 1,093 |
---|---|
Accommodation | 979 Holiday Homes |
Lowest Price | AU$358 |
Highest Price | AU$491 |
Recent Reviews in Upstate South Carolina
Recent Reviews in Upstate South Carolina

Hyatt Regency Greenville
5/5 Excellent
"Everything about our stay was fantastic. The only small challenge is that the room air conditioning would not go below 71°."
A verified traveller stayed at Hyatt Regency Greenville
Posted 23 hours ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Popular Destinations
More accommodation types in Upstate South Carolina
- Apartments in Upstate South Carolina
- Cottages in Upstate South Carolina
- Cabin Rentals in Upstate South Carolina
- Condo Rentals in Upstate South Carolina
- Motels in Upstate South Carolina
- Farmstay in Upstate South Carolina
- Villas in Upstate South Carolina
- B&B in Upstate South Carolina
- Caravan Parks in Upstate South Carolina
- Serviced Apartments in Upstate South Carolina
- Guest Houses in Upstate South Carolina
- Chalets in Upstate South Carolina
- Lodges in Upstate South Carolina
- Condominium Resort in Upstate South Carolina
- Resort in Upstate South Carolina
- Houseboats in Upstate South Carolina
- Hotels
All Accommodation Types
Be inspired: Top Holiday Homes destinations in 2025
- Gold Coast Holiday Houses
- Whitsunday Islands Holiday Houses
- Dunsborough Holiday Houses
- Sunshine Coast Holiday Houses
- Perth Holiday Houses
- Sydney Holiday Houses
- Queenstown Holiday Houses
- New South Wales Holiday Houses
- New Zealand Holiday Houses
- Byron Bay Holiday Houses
- Brisbane Holiday Houses
- Victoria Holiday Houses
- Busselton Holiday Houses
- Adelaide Holiday Houses
- Auckland Holiday Houses
- Port Douglas Holiday Houses
- Margaret River Holiday Houses
- Fiji Holiday Houses
- Mandurah Holiday Houses
- Rarotonga Holiday Houses
More ways to book
Expedia's Latest Trends
Hotels
Cars
Activities
Packages
Holiday Rentals