Our top choices for Upstate South Carolina hotels

1. Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Bonita

includes taxes & fees

9 Aug - 10 Aug

2. Best Western Plus Greenville I-385 Inn & Suites

Greenville

Terri

includes taxes & fees

9 Aug - 10 Aug

3. Drury Inn & Suites Greenville

Greenville

Aaron

includes taxes & fees

17 Aug - 18 Aug

4. Hilton Garden Inn Greenville

Greenville

Robert

includes taxes & fees

1 Aug - 2 Aug

5. Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Greenville

Ashli

includes taxes & fees

23 Aug - 24 Aug

6. Courtyard by Marriott Greenville Mauldin

Greenville

Jonathan

includes taxes & fees

2 Aug - 3 Aug

7. La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

Greenville

Kelley

includes taxes & fees

9 Aug - 10 Aug

8. SpringHill Suites by Marriott Greenville Downtown

Greenville Downtown

Robert

includes taxes & fees

9 Aug - 10 Aug

9. Holiday Inn Express & Suites Greenville - Taylors by IHG

Greenville

Elizabeth

includes taxes & fees

2 Aug - 3 Aug

10. Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

Greenville

Steven

includes taxes & fees

10 Aug - 11 Aug

11. Clarion Greenville Airport Inn

Greenville

Gladys

includes taxes & fees

15 Aug - 16 Aug

12. Comfort Inn Greenville - Haywood Mall

Greenville

Brittney

includes taxes & fees

2 Aug - 3 Aug

13. DoubleTree by Hilton Greenville Woodruff Road

Greenville

Jennifer

includes taxes & fees

2 Aug - 3 Aug

14. Homewood Suites by Hilton Greenville Downtown

Greenville Downtown

Christion

includes taxes & fees

13 Aug - 14 Aug

15. Hilton Greenville

Greenville

Thomas

includes taxes & fees

9 Aug - 10 Aug

16. Hyatt Place Greenville/Haywood

Greenville

Juan

includes taxes & fees

20 Aug - 21 Aug

17. Aloft by Marriott Greenville Downtown

Greenville Downtown

Johari

includes taxes & fees

2 Aug - 3 Aug

Egyptian cotton sheets, premium bedding, pillow-top beds, in-room safe

18. Days Inn by Wyndham Greenville South/Mauldin

Mauldin

Scott

includes taxes & fees

2 Aug - 3 Aug

19. Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG

Simpsonville

Alicia

includes taxes & fees

14 Aug - 15 Aug

20. Extended Stay America Premier Suites Greenville Woodruff Rd

Greenville

Joe

includes taxes & fees

2 Aug - 3 Aug

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Holiday Rentals in Upstate South Carolina

Aparthotel

Coffee/tea maker, full-sized fridge, microwave, oven

stayAPT Suites Greenville-Haywood Mall

Greenville

"This is a great hotel for the price!!"

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Love the location. Room was great."

Cottage

Cozy Home in Historic Area ~ 2 Mi to Main St!

Greenville

"Absolutely adorable property. Little bit of an interesting part of town. We weren’t spending a bunch of time on property so it didn’t mater. Super close to down town and the house is well kept. "

Apartment

Landing Apartments Greer - Sugar Creek

Greer

"Very good check in instructions. Very roomy and very quiet. Much more relaxing than a hotel room. Worth every penny."

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Cabin very cozy, pet friendly… great place to be disconnected for a couple days!! "

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cottage

2 Mi to Downtown: Luxe Greenville Retreat!

Greenville

"Great house! Very clean and comfortable. Outstanding amenities. Conveniently located. "

Cottage

Cozy Greenville Bungalow ~ 2 Mi to Downtown!

Greenville

"Amazing place. Great host. "

Cottage

Stay at Jos Taylor Retreat: 9 Mi to Greenville!

Taylors

"This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer."

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

Cottage

Home w/ Lake Keowee Access: Sleeps 7, Coffee Bar

Seneca

"The best, perfect "

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Enjoy the student vibe around Clemson University, a top university in Clemson. Experience the area's theatre scene or attend a football match.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina

An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Top Upstate South Carolina Hotel Reviews

Recent Reviews in Upstate South Carolina

Hyatt Place Greenville Downtown

8/10 Good

"It was an okay place to stay for the night. Would've been even better if the cleaning staff had not been so loud in the hallway at 8 am on a Sunday morning. Would've liked to have slept in a little longer. Other than that, it is a nice hotel."

Embassy Suites by Hilton Greenville Downtown Riverplace

10/10 Excellent

"We stayed in a room with a balcony facing the water. There’s a large parking deck and it’s not crazy expensive (we paid $10 for an overnight stay). The hotel is in an excellent location and offers quite a few amenities. For example, you are offered two free drinks and snacks each evening. The complimentary breakfast includes an omelette bar, as well as other hot and cold options. There are a couple of restaurants right in the building- a steakhouse and a rooftop restaurant with great views. Beds are comfortable with decent pillows. Very walkable location near Falls Park and the suspension bridge. Couple small cons- the water pressure in the shower left a bit to be desired, and it’s a bit expensive given where it’s located and the amenities that are offered The water pressure in the showers"

Hilton Greenville

10/10 Excellent

"Hilton Greenville was excellent! The room was clean, comfortable and accessible. The hotel itself was clean, looked expensive and was in a nice area. I will say, there was only 1 of 3 elevators working at the time and it was incredibly slow. The hotel was allowing customers to use the service elevator at the time which was nice, but also slow due to so many people using it. We went up and down the stairs which was totally fine with us tho! Overall, we had a wonderful experience. We will definitely be staying here more in the future. 9/10 recommend!"