Photo by Visit Greenville, South Carolina

Search Upstate South Carolina hotels

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Go beyond your typical stay in Upstate South Carolina

spa pool image
Spa pool
Spa pool
spa image
Spa
Spa

Check prices for these dates

Tonight
4 Nov - 5 Nov
Tomorrow
5 Nov - 6 Nov
This weekend
6 Nov - 8 Nov
Next weekend
13 Nov - 15 Nov

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Upstate South Carolina hotels

A modern restaurant interior with round tables and chairs, a kitchen area, and large windows offering a view of parked cars outside.

1. Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites
2.5 star property
Greenville
9.2 out of 10, Wonderful, (1,605 reviews)
"Great stay"
United States
Rubin
The price is AU$123
includes taxes & fees
8 Nov - 9 Nov
Best Western Plus Greenville I-385 Inn & Suites
A hotel patio with outdoor seating, stone pillars, and a modern building in the background.

2. DoubleTree by Hilton Greenville Woodruff Road

DoubleTree by Hilton Greenville Woodruff Road
3.0 star property
Greenville
9.2 out of 10, Wonderful, (1,005 reviews)
"Wonderful stay. It’s a very nice hotel. We would visit again."
United States
Angie
The price is AU$172
includes taxes & fees
29 Nov - 30 Nov
DoubleTree by Hilton Greenville Woodruff Road
A multi-level hotel lobby with a central atrium, multiple dining areas, and a reception desk.

3. Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center
3.5 star property
Greenville
9.0 out of 10, Wonderful, (1,457 reviews)
"Very great stay"
United States
Ivan
The price is AU$159
includes taxes & fees
23 Nov - 24 Nov
Embassy Suites Greenville Golf Resort & Conference Center
An indoor swimming pool with a tiled floor, a covered area, and a seating area with chairs.

4. Drury Inn & Suites Greenville

Drury Inn & Suites Greenville
3.0 star property
Greenville
9.4 out of 10, Exceptional, (1,097 reviews)
"The room was very clean and the staff was very friendly and helpful and the food was delicious"
United States
ruth
The price is AU$182
includes taxes & fees
30 Nov - 1 Dec
Drury Inn & Suites Greenville
A modern hotel room with a large bed, a desk, and a kitchenette.

5. Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd
2.0 star property
Greenville
8.4 out of 10, Very good, (1,002 reviews)
"Clean place to stay"
United States
Maclin
The price is AU$113
includes taxes & fees
19 Nov - 20 Nov
Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd
A spacious lobby with a modern design, featuring a reception desk, seating area with sofas and armchairs, and a large chandelier.

6. Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
3.5 star property
Greenville
8.6 out of 10, Excellent, (1,002 reviews)
"Really a great stay ."
United States
George
The price is AU$158
includes taxes & fees
23 Nov - 24 Nov
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
A spacious lobby with a large beige sofa, a fireplace, and a modern chandelier.

7. Hilton Garden Inn Greenville

Hilton Garden Inn Greenville
3.0 star property
Greenville
8.8 out of 10, Excellent, (1,000 reviews)
"The staff and breakfast was really nice"
United States
Valerie
The price is AU$167
includes taxes & fees
27 Nov - 28 Nov
Hilton Garden Inn Greenville
A hotel room with a large bed, a television on a dresser, a nightstand with a lamp, and a window with curtains.

8. Hampton Inn Greenville I-385 - Woodruff Rd.

Hampton Inn Greenville I-385 - Woodruff Rd.
3.0 star property
Greenville
8.8 out of 10, Excellent, (881 reviews)
"Very convenient area to exit and enter Lots of food and entertainment accommodation the available entrance to begin travel is ideal and the amenities were all in good working condition"
United States
Joseph
The price is AU$165
includes taxes & fees
12 Nov - 13 Nov
Hampton Inn Greenville I-385 - Woodruff Rd.
A modern outdoor seating area with a glass-top coffee table, blue sofas, and orange patterned cushions.

9. Tru by Hilton Greenville Woodruff Road

Tru by Hilton Greenville Woodruff Road
2.5 star property
Greenville
9.2 out of 10, Wonderful, (427 reviews)
"amazing property"
United States
Amy
The price is AU$175
includes taxes & fees
26 Nov - 27 Nov
Tru by Hilton Greenville Woodruff Road
A multi-story hotel with a modern design, featuring a prominent 'La Quinta' sign, a parking lot, and a landscaped entrance area.

10. La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
3.0 star property
Greenville
8.8 out of 10, Excellent, (411 reviews)
"Staff was friendly and professional. Parking was always available and property was well maintained."
United States
Sam
The price is AU$156
includes taxes & fees
1 Dec - 2 Dec
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
A spacious lobby with modern furniture, a chandelier, and potted plants.

11. Hilton Greenville

Hilton Greenville
3.5 star property
Greenville
8.4 out of 10, Very good, (1,036 reviews)
"Location is great for getting to/from downtown area"
United States
William
The price is AU$122
includes taxes & fees
30 Nov - 1 Dec
Hilton Greenville
A Comfort Inn hotel with a stone facade, a clear sign indicating a 12'6" clearance, and a well-lit entrance.

12. Comfort Inn Greenville - Haywood Mall

Comfort Inn Greenville - Haywood Mall
2.5 star property
Greenville
8.2 out of 10, Very good, (1,001 reviews)
"Clean room, very convenient to 385, great breakfast, nice staff, plenty of parking."
United States
Paul
The price is AU$139
includes taxes & fees
8 Nov - 9 Nov
Comfort Inn Greenville - Haywood Mall
A modern hotel lobby with a bar area, seating, and a reception desk.

13. Holiday Inn Greenville - Woodruff Road by IHG

Holiday Inn Greenville - Woodruff Road by IHG
3.0 star property
Greenville
8.6 out of 10, Excellent, (739 reviews)
"Great location!"
United States
Rick
The price is AU$191
includes taxes & fees
2 Dec - 3 Dec
Holiday Inn Greenville - Woodruff Road by IHG
Room

14. Clarion Inn

Clarion Inn
2.5 star property
Greenville
7.8 out of 10, Good, (79 reviews)
"Very good place for us to stay. We will be back there again."
United States
Johnny
The price is AU$115
includes taxes & fees
26 Nov - 27 Nov
Clarion Inn
A Holiday Inn Express & Suites with a covered entrance and a clear sky.

15. Holiday Inn Express & Suites Greenville-I-85 & Woodruff Rd by IHG

Holiday Inn Express & Suites Greenville-I-85 & Woodruff Rd by IHG
2.5 star property
Greenville
9.0 out of 10, Wonderful, (1,002 reviews)
"Holiday inn is always my to go hotel when traveling! Rooms are big and clean ."
United States
Jammie
The price is AU$192
includes taxes & fees
25 Nov - 26 Nov
Holiday Inn Express & Suites Greenville-I-85 & Woodruff Rd by IHG
A modern hotel room with a large bed, a TV, a bathroom with a shower, and a painting on the wall.

16. Days Inn by Wyndham Greenville South/Mauldin

Days Inn by Wyndham Greenville South/Mauldin
2.0 star property
Mauldin
7.6 out of 10, Good, (745 reviews)
"Good"
United States
Mark
The price is AU$107
includes taxes & fees
5 Nov - 6 Nov
Days Inn by Wyndham Greenville South/Mauldin
A circular outdoor seating area with a fire pit, surrounded by sofas and chairs, in front of a multi-story building.

17. Courtyard by Marriott Greenville Haywood Mall

Courtyard by Marriott Greenville Haywood Mall
3.0 star property
Greenville
8.8 out of 10, Excellent, (750 reviews)
"Exelente"
United States
alejandro
The price is AU$178
includes taxes & fees
22 Nov - 23 Nov
Courtyard by Marriott Greenville Haywood Mall
A multi-story hotel with a stone facade, large windows, and outdoor seating areas.

18. Hampton Inn & Suites Greenville-Downtown-RiverPlace

Hampton Inn & Suites Greenville-Downtown-RiverPlace
2.5 star property
Greenville Downtown
9.4 out of 10, Exceptional, (1,000 reviews)
"Liked where it was located easy to get to shops and restaurants in walking distance"
United States
Susan
The price is AU$239
includes taxes & fees
22 Nov - 23 Nov
Hampton Inn & Suites Greenville-Downtown-RiverPlace
A hotel room with a large bed, two bedside lamps, a desk with a telephone, and a chair.

19. Candlewood Suites Greenville by IHG

Candlewood Suites Greenville by IHG
2.5 star property
Greenville
8.8 out of 10, Excellent, (293 reviews)
"The location off Interstate 85N and especially the helpful staff."
United States
Lucy
The price is AU$159
includes taxes & fees
15 Nov - 16 Nov
Candlewood Suites Greenville by IHG
An outdoor patio with a stone fire feature, seating, and a view of the city skyline.

20. Courtyard by Marriott Greenville Mauldin

Courtyard by Marriott Greenville Mauldin
3.0 star property
Greenville
9.2 out of 10, Wonderful, (413 reviews)
"Everyone at this property was real friendly. We enjoyed our stay."
United States
James
The price is AU$188
includes taxes & fees
22 Nov - 23 Nov
Courtyard by Marriott Greenville Mauldin
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)
Take a campus tour or just explore the area of Clemson University during your travels in Clemson. Experience the area's theatre scene or attend a football match.
See properties

Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina
An aerial view of a park with a winding path, trees in autumn colors, and a bridge.
Photo by Visit Greenville, South Carolina
Open Photo by Visit Greenville, South Carolina

Explore a world of travel with Expedia