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Business Hotels & Resorts in Southeast Missouri from AU$136

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Check availability on Southeast Missouri Business Hotels

Tonight
4 Dec - 5 Dec
Tomorrow
5 Dec - 6 Dec
This weekend
5 Dec - 7 Dec
Next weekend
12 Dec - 14 Dec

Best Southeast Missouri Business Hotels

Property amenity
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1000)
"Clean room, great location and friendly staff"
United States
Mark
The price is AU$157
includes taxes & fees
9 Dec - 10 Dec
Drury Inn & Suites Sikeston, MO
Front of property
Echo Bluff State Park

Echo Bluff State Park

2.5 star property
Eminence
9.6 out of 10, Exceptional, (216)
"Beautiful location…excellent service and facilities / grounds were clean and well kept."
United States
William
The price is AU$234
includes taxes & fees
8 Dec - 9 Dec
Echo Bluff State Park
Children’s play area – outdoor
Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View

3.0 star property
Mountain View
8.6 out of 10, Excellent, (331)
"Staff was very friendly."
United States
Joyce
The price is AU$157
includes taxes & fees
5 Dec - 6 Dec
Honeysuckle Inn - Mountain View
Exterior
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 star property
Sikeston
8.4 out of 10, Very good, (715)
"Stayed one night. Good rate for the Hotel "
United States
Paul
The price is AU$95
includes taxes & fees
31 Dec - 1 Jan 2026
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1000)
"Great place and staff, very accommodating!"
United States
Megan
The price is AU$154
includes taxes & fees
8 Dec - 9 Dec
Drury Plaza Hotel Cape Girardeau Conference Center
Exterior
Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

2.5 star property
Perryville
9.2 out of 10, Wonderful, (536)
"Clean room and pleasant staff"
United States
David
The price is AU$151
includes taxes & fees
7 Dec - 8 Dec
Holiday Inn Express & Suites Perryville by IHG
Lobby
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (955)
"Delicious, well-ran breakfast and quiet peaceful hotel. "
United States
Janene
The price is AU$179
includes taxes & fees
27 Dec - 28 Dec
Drury Inn & Suites Poplar Bluff
Fridge, microwave, coffee/tea maker
Shepherd Mountain Inn

Shepherd Mountain Inn

2.5 star property
Ironton
9.4 out of 10, Exceptional, (304)
" Nice room, nice bed, convenient location"
United States
Burton
Shepherd Mountain Inn
Breakfast, lunch, dinner served; Italian cuisine
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (695)
"Amazing place"
United States
Mladen
The price is AU$170
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Poplar Bluff by IHG
Business centre
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 star property
Farmington
8.0 out of 10, Very good, (1004)
"Room was clean and big. Breakfast was awesome!"
United States
Ashley
The price is AU$94
includes taxes & fees
30 Dec - 31 Dec
Baymont Inn and Suites by Wyndham Farmington, MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southeast Missouri Hotel Reviews

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
Brian 1-night trip
Posted 1 day ago
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Frequently asked questions

How much do business-friendly hotels in Southeast Missouri cost?
Prices for business hotels in Southeast Missouri range between AU$136 and AU$234 per night. Whatever your budget, Expedia is here to help you find the ideal space for a successful work trip. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
How many business-friendly hotels are there in Southeast Missouri?
Southeast Missouri has 50 business-friendly hotels to pick from. Whether you're attending a conference or meeting or simply working remotely, these stays have the amenities you need to keep you productive and comfortable.
What is there to do in Southeast Missouri near my business-friendly hotel?
The best travel accessory for your Southeast Missouri work trip is an awesome itinerary for when you have some free time! Isle Casino Cape Girardeau, Cape Rock Park and Fort D Historic Site are some of the leading sights if you're headed to Cape Girardeau. Ste Genevieve also has plenty of superb attractions, such as Sainte Genevieve Winery, Bolduc House Museum and Felix Valle House State Historic Site.

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