A group of men in red uniforms with gold accents, holding rifles and wearing kilts.

Business Hotels & Resorts in Southeast Missouri from AU$89

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southeast Missouri Business Hotels

Tonight
7 Oct - 8 Oct
Tomorrow
8 Oct - 9 Oct
This weekend
9 Oct - 11 Oct
Next weekend
16 Oct - 18 Oct

Our top choices for Southeast Missouri business-friendly hotels

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.
A compact kitchen with wooden cabinets, a stainless steel refrigerator, and a microwave.
A building with a red awning labeled "Shepherd Mountain Inn."
A hotel room with two beds, a lamp, and a painting on the wall.

1. Shepherd Mountain Inn

Shepherd Mountain Inn
Ironton
United States
Michael
AU$193
includes taxes & fees
12 Oct - 13 Oct
Shepherd Mountain Inn
A modern kitchen with a coffee machine, a refrigerator, and a microwave.
A long, narrow hallway with patterned carpet, doors on both sides, and a ceiling light.
A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.
A laundry room with a front-loading washer and dryer, a door, and a light fixture.

2. Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington
Farmington
United States
Marisa
AU$97
includes taxes & fees
18 Oct - 19 Oct
Super 8 by Wyndham Farmington
A motel with a covered entrance, a flag, and a phone number.
A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.
A living room with a black leather sofa, a wooden coffee table with a vase of flowers, a green potted plant, and a lamp.
A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

3. Madison Inn Lodge

Madison Inn Lodge
Fredericktown
United States
Bawan
AU$127
includes taxes & fees
3 Nov - 4 Nov
Madison Inn Lodge
An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.
A spacious hotel lobby with a dining area, kitchen, and large windows.
A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.
A modern bathroom with a bathtub, a window with curtains, and a view of a green landscape.

4. Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
Farmington
United States
CURTIS
AU$180
includes taxes & fees
25 Oct - 26 Oct
Crown Pointe Lodge, BW Signature Collection
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.
A hotel room with two beds, a brick wall, and a wooden headboard.
A restaurant with a brick wall, a flat-screen TV, and a bar area.

5. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson
United States
Debra S
AU$121
includes taxes & fees
13 Oct - 14 Oct
Drury Inn & Suites Jackson MO
An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.
A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".
A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.
An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

6. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
Sikeston
United States
Allen
AU$165
includes taxes & fees
15 Oct - 16 Oct
Fairfield Inn & Suites by Marriott Sikeston
A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.
A gym with cardio equipment, a bench press, and a squat rack.
A hotel room with a large bed, two sofas, a desk with a lamp, a microwave, and a TV.
A parking lot with a tree in bloom, a red fire hydrant, and a building in the background.

7. Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
Farmington
United Kingdom
Mark
AU$89
includes taxes & fees
1 Nov - 2 Nov
Baymont Inn and Suites by Wyndham Farmington, MO
A hotel room with a bed, a sofa, a desk, and a chair.
An indoor swimming pool with a tiled edge, surrounded by lounge chairs and potted plants.
A modern living room with a sofa, armchairs, a coffee table, and a painting on the wall.
A hotel lobby with a central reception desk, multiple seating areas, and a tiled floor.

8. Holiday Inn Express & Suites Farmington by IHG

Holiday Inn Express & Suites Farmington by IHG
Farmington
United States
Sheila
AU$200
includes taxes & fees
11 Oct - 12 Oct
Holiday Inn Express & Suites Farmington by IHG
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.
A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

9. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
United States
Mary
AU$162
includes taxes & fees
12 Oct - 13 Oct
Drury Plaza Hotel Cape Girardeau Conference Center
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.
A hotel room with two beds, a desk, a chair, and a view of the city.
A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

10. The Riverview

The Riverview
Cape Girardeau
United States
Alyssa
AU$166
includes taxes & fees
13 Oct - 14 Oct
The Riverview
View all properties

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"We love staying in this hotel when we are traveling through the area. The staff are great, the rooms are consistently clean and the beds are very comfortable. We enjoy the complementary wine that is served each evening as well. Breakfast is good too."
Tamara 1-night trip
Posted 6 hours ago
Drury Inn & Suites Sikeston, MO
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Wonderful. Very clean, spacious and lovely staff. Breakfast was delicious also."
Mary 2-night trip
Posted 19 hours ago
Drury Plaza Hotel Cape Girardeau Conference Center
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

8/10 Good
"Everything was good about the room except the bathroom. The stopper on the sink did not work and there was a dent in the wall. The face/wash towels need to be changed out. They are no longer white. They are dull in color. The couch needs to be cleaned and freshen. The staff was excellent and everything else is good. I just wish that breakfast offered hot eggs and meat vs. only waffles. Otherwise the room was good."
James 3-night trip
Posted 22 hours ago
Days Inn and Suites by Wyndham Sikeston
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

8/10 Good
"These stay was good. Breakfast was your average Hotel breakfast no complaints other than staff continually let the coffee run out every morning. Staff at front desk were conversing with what must have been someone they knew because of the colorful language they were using. Very unprofessional."
Glenn 2-night trip
Posted 2 days ago
Comfort Inn Festus - St Louis South
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"No exhaust fan in the bathroom. Other than that very clean comfortable hotel"
Judith 1-night trip
Posted 2 days ago
Drury Inn & Suites Cape Girardeau
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent
"Great place"
BRANDY 1-night trip
Posted 4 days ago
Super 8 by Wyndham Sikeston/Miner Area
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

10/10 Excellent
"The food & drinks were great & the staff was very friendly. Room was very nice."
Cynthia 1-night trip
Posted 4 days ago
Drury Inn & Suites Hayti Caruthersville
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

8/10 Good
"I usually stay here if I need to because I travel back and forth from northern IL and I usually have a lot of food to take home to southern MS. The full size fridge and freezer is very nice to have available and you don’t have to book a super fancy room to get one. Housekeeping can be hard work, but missing a rather large blood stain on the wall behind the door is disturbing. Thankfully I always travel with Lysol wipes and cleaned it up."
Jacqueline 1-night trip
Posted 4 days ago
Candlewood Suites Cape Girardeau by IHG
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

10/10 Excellent
"Terrific base accommodation. Clean, efficient. I use this place whenever I’m in the area. I’m"
Herman 1-night trip
Posted 5 days ago
Motel 6 Poplar Bluff, MO

Frequently asked questions

How much do business-friendly hotels in Southeast Missouri cost?
Prices for business hotels in Southeast Missouri range between AU$89 and AU$200 per night. Whatever your budget, Expedia is here to help you find the ideal space for a successful work trip. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
How many business-friendly hotels are there in Southeast Missouri?
Southeast Missouri has 50 business-friendly hotels to pick from. Whether you're attending a conference or meeting or simply working remotely, these stays have the amenities you need to keep you productive and comfortable.
What is there to do in Southeast Missouri near my business-friendly hotel?
The best travel accessory for your Southeast Missouri work trip is an awesome itinerary for when you have some free time! Isle Casino Cape Girardeau, Cape Rock Park and Fort D Historic Site are some of the leading sights if you're headed to Cape Girardeau. Ste Genevieve also has plenty of superb attractions, such as Sainte Genevieve Winery, Bolduc House Museum and Felix Valle House State Historic Site.

Explore a world of travel with Expedia