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Business Hotels & Resorts in Southeast Missouri from AU$88

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Check availability on Southeast Missouri Business Hotels

Our top choices for Southeast Missouri business-friendly hotels

Indoor pool, outdoor pool

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,002 reviews)
"Great place!"
United States
Jennifer
The price is AU$184
includes taxes & fees
12 July - 13 July
Drury Inn & Suites Sikeston, MO
Desk, iron/ironing board, free cots/infant beds, rollaway beds

Comfort Inn Willow Springs US 60 and US 63

Comfort Inn Willow Springs US 60 and US 63
2.5 star property
Willow Springs
9.2 out of 10, Wonderful, (596 reviews)
"Always clean room & quality service"
United States
Dennis
The price is AU$154
includes taxes & fees
26 July - 27 July
Comfort Inn Willow Springs US 60 and US 63
Lobby

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1,000 reviews)
"The breakfast and nightly gathering makes this location a fantastic value and will be our choice of stops when heading south again!"
United States
William
The price is AU$153
includes taxes & fees
26 July - 27 July
Drury Inn & Suites Jackson MO
Desk, blackout curtains, free cots/infant beds, rollaway beds

Super 8 by Wyndham Cuba

Super 8 by Wyndham Cuba
2.0 star property
Cuba
8.8 out of 10, Excellent, (1,000 reviews)
"Staff were good - fairly clean room - good nights sleep very basic breakfast but for price still a great deal and good location"
United Kingdom
Christopher
The price is AU$124
includes taxes & fees
20 July - 21 July
Super 8 by Wyndham Cuba
Lobby

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,003 reviews)
"Wonderful room and food offerings were extra thoughtful."
United States
Jonna
The price is AU$179
includes taxes & fees
5 July - 6 July
Drury Plaza Hotel Cape Girardeau Conference Center
Exterior

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
2.5 star property
Murphysboro
9.4 out of 10, Exceptional, (559 reviews)
"Great place and folks!! Breakfast was on point, and the staff is very nice and friendly. Will be back!"
United States
Mark
The price is AU$189
includes taxes & fees
12 July - 13 July
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
Lobby

Quality Inn West Plains

Quality Inn West Plains
2.5 star property
West Plains
8.6 out of 10, Excellent, (727 reviews)
"A great place to stay"
United States
Aaron
The price is AU$161
includes taxes & fees
11 July - 12 July
Quality Inn West Plains
Lobby lounge

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (204 reviews)
"The room was clean, the staff was extremely helpful with our check in!"
United States
Travis
The price is AU$167
includes taxes & fees
15 July - 16 July
Fairfield Inn & Suites by Marriott Cape Girardeau
Property grounds

Country Inn Motel

Country Inn Motel
2.0 star property
Licking
7.2 out of 10, Good, (350 reviews)
"The accommodations were nice and the staff friendly "
United States
Allison
The price is AU$88
includes taxes & fees
5 July - 6 July
Country Inn Motel
Reception

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
7.8 out of 10, Good, (1,401 reviews)
"Will definitely stay again!"
United States
Trevor
The price is AU$157
includes taxes & fees
6 July - 7 July
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southeast Missouri Hotel Reviews

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

10/10 Excellent
"A nice hotel that is pet friendly with good parking and friendly staff."
Mark 1-night trip
Posted 1 hour ago
Pear Tree Inn Cape Girardeau West

Frequently asked questions

How much do business-friendly hotels in Southeast Missouri cost?
Prices for business hotels in Southeast Missouri range between AU$88 and AU$189 per night. Whatever your budget, Expedia is here to help you find the ideal space for a successful work trip. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
How many business-friendly hotels are there in Southeast Missouri?
Southeast Missouri has 50 business-friendly hotels to pick from. Whether you're attending a conference or meeting or simply working remotely, these stays have the amenities you need to keep you productive and comfortable.
What is there to do in Southeast Missouri near my business-friendly hotel?
The best travel accessory for your Southeast Missouri work trip is an awesome itinerary for when you have some free time! Isle Casino Cape Girardeau, Cape Rock Park and Fort D Historic Site are some of the leading sights if you're headed to Cape Girardeau. Ste Genevieve also has plenty of superb attractions, such as Sainte Genevieve Winery, Bolduc House Museum and Felix Valle House State Historic Site.