
Southeast Missouri Holidays
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Your Southeast Missouri Holiday
Book a holiday package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Centre. Sikeston is another city that lures travellers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri holiday today.
Southeast Missouri Holiday
Southeast Missouri Essential Information
Language | English |
---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
Top Sights | Meramec Caverns, Mark Twain National Forest and Elephant Rocks State Park |
Our pick of the best Southeast Missouri Hotel Deals

Baymont Inn and Suites by Wyndham Farmington, MO
Reviewed on 6 Oct 2025

Drury Plaza Hotel Cape Girardeau Conference Center
Reviewed on 3 Oct 2025

The Riverview
Reviewed on 30 Sept 2025
Discover the most popular places to visit in Southeast Missouri

Rocky Falls
Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting.
Southeast Missouri State University
Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
Riverfront Bridge Park
Riverfront Bridge Park is just one of the places to see in Cape Girardeau, so why not enjoy the other things to explore during your travels? While in this family-friendly area, you can savour the top-notch restaurants.
What to do in Southeast Missouri

St Louis: City Museum General Admission Ticket

St. Louis Ghost Tour: Sinister Sins & Shadows
Frequently asked questions
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Lodging
- Caravan Parks in Advance
- Holiday Homes in Advance
- Cheap Hotels in Advance
- Hotels with Pool in Advance
- Family Hotels in Annapolis
- Hotels with Pool in Annapolis
- Annapolis Hotels
- B&B in Arcadia
- Caravan Parks in Arcadia
- Holiday Homes in Arcadia
- Hotels with Pool in Arcadia
- Luxury Hotels in Arcadia
- Arcadia Hotels
- Motels in Arcadia
- Belleview Hotels
- Hotels near Big River
- Bismarck Hotels
- Caravan Parks in Black
- Cheap Hotels in Black
- Black Hotels
- Lodges in Black
- Cheap Hotels in Caledonia
- Caledonia Hotels
- Holiday Homes in Des Arc
- Desloge Hotels
- Doe Run Hotels
- Hotels near Elephant Rocks State Park
- Farmstay in Ellington
- Cheap Hotels in Ellington
- Ellington Hotels
- Pet Friendly Hotels in Farmington
- Farmington Hotels
- Flat River Hotels
- Cheap Hotels in Fredericktown
- Fredericktown Hotels
- Motels in Fredericktown
- Hotels near Johnson's Shut-ins State Park
- Junction City Hotels
- B&B in Leadwood
- Leadwood Hotels
- Lesterville Hotels
- Marble Hill Hotels
- Middle Brook Hotels
- Farmstay in Park Hills
- Park Hills Hotels
- Cheap Hotels in Patterson
- Patterson Hotels
- Piedmont Hotels
- Pilot Knob Hotels
- Motels in Pilot Knob
- Van Buren Hotels
- Wappapello Hotels
Packages
- Caledonia Holidays
- Chandler Hill Vineyards
- Chapel of St. Timothy And St. Titus
- Citygarden
- Eureka Holidays
- Forest Park
- French Village Holidays
- Gateway Arch
- Grant's Farm
- Green Park Holidays
- Lone Elk Park
- Magic House - St. Louis Children's Museum
- Meramec Caverns
- Missouri Botanical Gardens and Arboretum
- Montelle Winery
- Myseum
- Ozark National Scenic Riverways
- Pacific Holidays
- Risco Holidays
- Rocky Falls
- Senath Holidays
- Shaw Nature Reserve
- Six Flags St. Louis
- Southeast Missouri State University
- St. James Holidays
- St. Louis Holidays
- Success Holidays
- Sullivan Holidays
- Taum Sauk Mountain State Park
- Union Holidays