Southeast Missouri Holidays

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

    • Better together

    Save up to AU$703 when you book a flight and hotel together*

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

    Rest easy

    Plan, book, and manage your trip all in one place

Your Southeast Missouri Holiday

Book a holiday package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Centre. Sikeston is another city that lures travellers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri holiday today.

Southeast Missouri Holiday

Southeast Missouri Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Lambert-St. Louis Intl. Airport (STL)
Top Sights
Meramec Caverns, Mark Twain National Forest and Elephant Rocks State Park

Our pick of the best Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is AU$156 per night from 26 Oct to 27 Oct
AU$156
26 Oct - 27 Oct
includes taxes & fees
9.4/10 Exceptional! (1,017 reviews)
Excellent service and clean hotel !
"Stayed at the same Drury we’ve been staying at for several years when traveling fro lower Alabama to Kansas City. We always plan our travel times to stay here. Clean, friendly people working and nice rooms."

Reviewed on 15 Oct 2025

Drury Plaza Hotel Cape Girardeau Conference Center
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St, Farmington, MO
Fully refundableReserve now, pay when you stay
The price is AU$98 per night from 26 Oct to 27 Oct
AU$98
26 Oct - 27 Oct
includes taxes & fees
8/10 Very Good! (1,019 reviews)
Quick night stay
"Clean room."

Reviewed on 18 Oct 2025

Baymont Inn and Suites by Wyndham Farmington, MO
The Riverview

The Riverview

4 out of 5
777 Main St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is AU$177 per night from 2 Nov to 3 Nov
AU$177
2 Nov - 3 Nov
includes taxes & fees
9.2/10 Wonderful! (433 reviews)
"Newer hotel so clean. Walk-in shower with no door but works. Control is on opposite side of shower head so alittle awkward. Starbucks was nice. Front desk very accommodating. Close to old downtown but too far to walk. Railroad tracks on east side but didn’t reallly hear."

Reviewed on 7 Oct 2025

The Riverview
See all 594 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
All Inclusive Holidays
Cheap Holidays
Cheap Holidays
Cheap Holidays
beach holidays
Beach Holidays
Beach Holidays

Discover the most popular places to visit in Southeast Missouri

Rocky Falls

Rocky Falls

Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting.

Rocky Falls

Southeast Missouri State University

Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.

Southeast Missouri State University

Riverfront Bridge Park

Riverfront Bridge Park is just one of the places to see in Cape Girardeau, so why not enjoy the other things to explore during your travels? While in this family-friendly area, you can savour the top-notch restaurants.

Riverfront Bridge Park

What to do in Southeast Missouri

St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

AU$49
per adult
St. Louis Ghost Tour: Sinister Sins & Shadows
Step into the shadows and discover the haunting tales of our city's past.

St Louis Ghost Tours: Sinister Sins & Shadows Ghost Tour

AU$49
per adult
100% of travellers recommend
St Louis Ghost Tours: Sinister Sins & Shadows Ghost Tour
Lemp Haunted Neighborhood Walking Tour

Lemp Haunted Neighborhood Walking Tour

AU$41
per adult
84% of travellers recommend
Lemp Haunted Neighborhood Walking Tour
See all activities in Southeast Missouri

Frequently asked questions

Can I cancel my flight booking to Southeast Missouri due to COVID-19?
Many airlines now offer greater flexibility due to COVID-19. Our handy Customer Service Portal will help you answer most queries about which policies apply to your Southeast Missouri flight. It's also wise to check the terms and conditions of your fare — preferably before locking in your tickets!
What's the best way to find cheap flights to Southeast Missouri that have flexible change policies?
It's as easy as counting to three with Expedia. Step 1: Enter your travel details and click on the "Search" button. Step 2? Check "No change fee" directly underneath the "Flexible change policies" filter to the left of your screen. Step 3. Book your flexible and cheap ticket to Southeast Missouri.
What are some of the general tips for travellers to Southeast Missouri during the COVID-19 outbreak?
With new rules, restrictions and safety measures to adhere to, travel looks a little different right now. Here's what you should know before you hop on that plane to Southeast Missouri:
  • Find out what, if any, rules or restrictions apply to both your origin and destination. It may not be possible to travel depending on local circumstances, so be sure to check before you lock in your flight.
  • When you pass through airport screening, keep your face mask on. You will be asked to lower it briefly for identification purposes. Those who refuse to wear a mask may be fined and denied entry.
  • Instead of handing a TSA agent your boarding pass, position it straight on the reader yourself. Once that's done, hold it up for inspection.
  • One container of liquid hand sanitizer is now permitted in your carry-on baggage. It must be no bigger than 12 oz (350 ml), and you'll need to take it out of your bag for scanning.
  • Empty your personal items from your pockets, like your keys, phone and wallet, and put them in your carry-on instead of the bins. This will minimize handling during screening.
  • Separate any food you have for screening. Food items often set off the alarm. Placing them in a clear plastic bag and into a bin reduces the need for a TSA officer to touch and inspect your belongings.

Which airlines fly to Southeast Missouri?
Contour Aviation is a major airline servicing Southeast Missouri. Search for a fare to Waynesville Regional Airport (TBN) and you'll have 56 Contour Aviation flights a month to pick from.
How can I find cheap tickets to Southeast Missouri?
You'll always score an unbeatable deal with Expedia, but our "flexible dates" search function makes it that much easier. Enter your preferred flight date, then tick the flexible dates box above to see a list of prices for nearby days. was the lowest price for a flight to Southeast Missouri in the last seven days.
How much is a flight to Southeast Missouri?
If you were jetting one way from (), you could've snapped up a cheap fare for just in the last seven days. Return flights to Southeast Missouri ranged from to over the same period.
What are the most popular airports to fly into in Southeast Missouri?
Southeast Missouri's main entryway is Waynesville Regional Airport (TBN). Get your next big journey underway by reserving a ticket on one of the 56 flights a month to this destination.
When is the cheapest time to fly to Southeast Missouri?
If you'd rather spend your holiday savings enjoying the best of Southeast Missouri rather than on your flight there, depart earlier in the week. The most cost-effective day to travel is normally Tuesday, with Monday a close second. With many folks travelling on the weekend, Saturday often has the highest airfares.
How much is a plane ticket to Southeast Missouri?
In the last seven days, plane tickets varied between and . Browse through our fantastic deals to Southeast Missouri, make a booking and then start packing your things!
Which airlines with flights to Southeast Missouri employ COVID-19 cleanliness policies?
In response to the global COVID-19 pandemic, airlines have implemented new rules and standards to help their passengers fly with extra peace of mind. Check out what these carriers are doing:
  • Southwest Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.