
Southeast Missouri Holidays
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Your Southeast Missouri Holiday
Book a holiday package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Centre. Sikeston is another city that lures travellers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri holiday today.
Southeast Missouri Holiday
Southeast Missouri Essential Information
Language | English |
---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
Top Sights | Meramec Caverns, Mark Twain National Forest and Elephant Rocks State Park |
Our pick of the best Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is AU$156 per night from 26 Oct to 27 Oct
AU$156
26 Oct - 27 Oct
includes taxes & fees
9.4/10 Exceptional! (1,017 reviews)
Excellent service and clean hotel !
"Stayed at the same Drury we’ve been staying at for several years when traveling fro lower Alabama to Kansas City. We always plan our travel times to stay here. Clean, friendly people working and nice rooms."
Reviewed on 15 Oct 2025

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St, Farmington, MO
Fully refundableReserve now, pay when you stay
The price is AU$98 per night from 26 Oct to 27 Oct
AU$98
26 Oct - 27 Oct
includes taxes & fees
8/10 Very Good! (1,019 reviews)
Quick night stay
"Clean room."
Reviewed on 18 Oct 2025

The Riverview
777 Main St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is AU$173 per night from 2 Nov to 3 Nov
AU$173
2 Nov - 3 Nov
includes taxes & fees
9.2/10 Wonderful! (433 reviews)
"Newer hotel so clean. Walk-in shower with no door but works. Control is on opposite side of shower head so alittle awkward. Starbucks was nice. Front desk very accommodating. Close to old downtown but too far to walk. Railroad tracks on east side but didn’t reallly hear."
Reviewed on 7 Oct 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
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Lodging
- Caravan Parks in Advance
- Holiday Homes in Advance
- Cheap Hotels in Advance
- Hotels with Pool in Advance
- Family Hotels in Annapolis
- Hotels with Pool in Annapolis
- Annapolis Hotels
- B&B in Arcadia
- Caravan Parks in Arcadia
- Holiday Homes in Arcadia
- Hotels with Pool in Arcadia
- Luxury Hotels in Arcadia
- Arcadia Hotels
- Motels in Arcadia
- Belleview Hotels
- Hotels near Big River
- Bismarck Hotels
- Caravan Parks in Black
- Cheap Hotels in Black
- Black Hotels
- Lodges in Black
- Cheap Hotels in Caledonia
- Caledonia Hotels
- Holiday Homes in Des Arc
- Desloge Hotels
- Doe Run Hotels
- Hotels near Elephant Rocks State Park
- Farmstay in Ellington
- Cheap Hotels in Ellington
- Ellington Hotels
- Pet Friendly Hotels in Farmington
- Farmington Hotels
- Flat River Hotels
- Cheap Hotels in Fredericktown
- Fredericktown Hotels
- Motels in Fredericktown
- Hotels near Johnson's Shut-ins State Park
- Junction City Hotels
- B&B in Leadwood
- Leadwood Hotels
- Lesterville Hotels
- Marble Hill Hotels
- Middle Brook Hotels
- Farmstay in Park Hills
- Park Hills Hotels
- Cheap Hotels in Patterson
- Patterson Hotels
- Piedmont Hotels
- Pilot Knob Hotels
- Motels in Pilot Knob
- Van Buren Hotels
- Wappapello Hotels
Packages
- Caledonia Holidays
- Chandler Hill Vineyards
- Chapel of St. Timothy And St. Titus
- Citygarden
- Eureka Holidays
- Forest Park
- French Village Holidays
- Gateway Arch
- Grant's Farm
- Green Park Holidays
- Lone Elk Park
- Magic House - St. Louis Children's Museum
- Meramec Caverns
- Missouri Botanical Gardens and Arboretum
- Montelle Winery
- Myseum
- Ozark National Scenic Riverways
- Pacific Holidays
- Risco Holidays
- Rocky Falls
- Senath Holidays
- Shaw Nature Reserve
- Six Flags St. Louis
- Southeast Missouri State University
- St. James Holidays
- St. Louis Holidays
- Success Holidays
- Sullivan Holidays
- Taum Sauk Mountain State Park
- Union Holidays
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.