Southeast Missouri Hotel & Accommodation Deals 2026 from AU$89 - Compare prices by date

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Go beyond your typical stay in Southeast Missouri

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Our top choices for Southeast Missouri hotels

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

A building with a red awning labeled "Shepherd Mountain Inn."

A bathroom with a white sink, a large mirror, a hairdryer, a coffee maker, and a microwave.

A hotel room with two beds, a lamp, and a painting on the wall.

1. Shepherd Mountain Inn

Ironton

Michael

AU$193

includes taxes & fees

7 Oct - 8 Oct

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

2. Hampton Inn & Suites By Hilton Festus

Festus

Abram

AU$147

includes taxes & fees

29 Oct - 30 Oct

A modern kitchen with a coffee machine, a refrigerator, and a microwave.

A long, narrow hallway with patterned carpet, doors on both sides, and a ceiling light.

A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.

A hotel room with a large bed, a smaller bed, a nightstand with a lamp, and two large framed pictures on the wall.

3. Super 8 by Wyndham Farmington

Farmington

Marisa

AU$98

includes taxes & fees

18 Oct - 19 Oct

A motel with a covered entrance, a flag, and a phone number.

A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.

A living room with a black leather sofa, a wooden coffee table with a vase of flowers, a green potted plant, and a lamp.

4. Madison Inn Lodge

Fredericktown

Bawan

AU$127

includes taxes & fees

3 Nov - 4 Nov

An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

A modern bathroom with a bathtub, a window with curtains, and a view of a green landscape.

A lobby with a stone fireplace, two sofas, a coffee table, and two lamps.

5. Crown Pointe Lodge, BW Signature Collection

Farmington

CURTIS

AU$180

includes taxes & fees

14 Oct - 15 Oct

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

A hotel room with two beds, a brick wall, and a wooden headboard.

A restaurant with a brick wall, a flat-screen TV, and a bar area.

An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

6. Drury Inn & Suites Jackson MO

Jackson

Thomas

AU$121

includes taxes & fees

13 Oct - 14 Oct

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

7. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Allen

AU$165

includes taxes & fees

15 Oct - 16 Oct

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

A hotel room with a large bed, two sofas, a desk with a lamp, a microwave, and a TV.

A parking lot with a tree in bloom, a red fire hydrant, and a building in the background.

A hotel reception area with a glass partition, a reception desk, and a digital kiosk.

8. Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

Mark

AU$89

includes taxes & fees

1 Nov - 2 Nov

A living room with a blue wall, a fireplace, a sofa, and a chair.

A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.

A brick building with a sign reading "Mercantile & Hotel".

A bar area with stools and a counter where a bartender is serving drinks.

9. EC Reed's Mercantile and Hotel

Marble Hill

JANEEN

AU$164

includes taxes & fees

13 Oct - 14 Oct

A hotel room with a bed, a sofa, a desk, and a chair.

An indoor swimming pool with a tiled edge, surrounded by lounge chairs and potted plants.

A modern living room with a sofa, armchairs, a coffee table, and a painting on the wall.

A coffee station with two coffee machines, a coffee press, and various coffee-related items on a wooden counter.

10. Holiday Inn Express & Suites Farmington by IHG

Farmington

Sheila

AU$200

includes taxes & fees

11 Oct - 12 Oct

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

An outdoor pool area with lounge chairs and an umbrella.

A hotel room with a television, a desk, a chair, a dresser, a radiator, and a bathroom visible through an open door.

A two-story building with a green roof and a large circular sign that reads "Port David Restaurant".

11. Fort Davidson Hotel

Ironton

richard

AU$196

includes taxes & fees

7 Oct - 8 Oct

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

12. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Sandra

AU$162

includes taxes & fees

11 Oct - 12 Oct

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

13. Hampton Inn Poplar Bluff

Poplar Bluff

Rhonda

AU$146

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.

A hotel room with two beds, a desk, a chair, and a view of the city.

14. The Riverview

Cape Girardeau

Alyssa

AU$167

includes taxes & fees

15 Oct - 16 Oct

A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.

A room with a brown leather sofa, a red chair, and a cityscape painting on the wall.

A modern kitchen with a built-in microwave, a black refrigerator, and a wooden countertop.

A modern kitchen with a stone backsplash, a dining area with red chairs, and a red accent wall with a framed picture.

15. Super 8 By Wyndham Marston

Marston

Brenda

AU$92

includes taxes & fees

7 Oct - 8 Oct

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

A spacious lobby with a polished floor, seating areas, and modern lighting fixtures.

A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.

16. Drury Inn & Suites Sikeston, MO

Sikeston

Scott

AU$155

includes taxes & fees

29 Oct - 30 Oct

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.

A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

17. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Carlos

AU$164

includes taxes & fees

15 Oct - 16 Oct

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.

A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.

A Dear Tree Inn building with a covered entrance and a clear sky at dusk.

18. Pear Tree Inn Cape Girardeau West

Cape Girardeau

Elizabeth

AU$117

includes taxes & fees

11 Oct - 12 Oct

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

A hotel room with two beds, a nightstand, a lamp, and a chair.

A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.

A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.

19. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

Elaine

AU$125

includes taxes & fees

1 Nov - 2 Nov

A hotel room with a large bed, a nightstand, a lamp, a chair, and a mirror.

A hotel lobby with a seating area, a reception desk, and a bar.

A buffet with various food items, including omelets and other dishes, served in metal containers with glass lids.

A kitchen counter with a coffee machine, a kettle, and storage boxes.

20. Holiday Inn Express & Suites Perryville by IHG

Perryville

Lisa

AU$166

includes taxes & fees

1 Nov - 2 Nov

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Holiday Rentals in Southeast Missouri

Cabin

A room with two bunk beds, a single bed, a ceiling fan, and a window with blinds.

Sam A Baker State Park

Patterson

"Pet friendly, great staff. "

Aparthotel

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A hallway with exposed brick walls, wooden flooring, and a white door.

A bedroom with a bed, a bench, a ceiling fan, a mirror, and a wooden floor.

A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

Urban Lofts

Perryville

"Beautiful place and staff was amazing!"

Cabin

A bedroom with a bed, a wooden headboard, a window with a view of greenery, and a tray with breakfast items.

A rustic cabin with a wooden exterior, a small deck, and a picnic table.

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"The stay here gets better every time."

Cottage

A dining area with a checkered tablecloth, wooden chairs, and a red rug.

A two-story house with a red exterior, a front porch, and a well-maintained lawn.

A swimming pool with a wooden deck, surrounded by a white picket fence, and featuring colorful umbrellas.

A modern kitchen with wooden cabinets, a microwave, and a refrigerator. There is a staircase leading to another level. A gray sofa with a red pillow is in the living area, and a checkered curtain covers a window.

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Ironton

"Stroller, pack n play and high chair. This was amazing "

Aparthotel

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

A bedroom with a brick wall, a bed with patterned bedding, and a shelf with decorative items.

A building with a sign that reads "The Atrium Boutique Hotel".

A building with a dark exterior, a large window, and a sign that reads "The Atrium."

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Holiday Home

A wooden deck with two Adirondack chairs and a hammock.

A spacious living room with a wooden ceiling, a fireplace, and a television.

A spacious living room with wooden floors, a stone fireplace, and a mounted television.

A spacious living room with a wooden ceiling, a ceiling fan, a sofa set, a coffee table, and a large window offering a view of the outdoors.

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Cabin

A bedroom with a wooden bed, a bench, and a window.

A calm lake with a wooden dock and a forested island in the distance.

A wooden deck with a railing leading to a building with a metal roof and a brown door.

Lake Wappapello

Williamsville

"Pet friendly. Family-friendly "

Cottage

A bedroom with a large bed, a sofa, a wooden wardrobe, and a ceiling fan.

A covered porch with yellow chairs, a bench, and a small table.

A spacious living area with a kitchen island, dining table, and a television.

A kitchen with wooden cabinets, a central island, and a dining area with a table set for four.

Walk to Dtwn: Ironton Home in Historic District

Ironton

"Clean and comfortable "

Cottage

A wooden deck leading to a house with a wooden door and a small porch area.

A cozy cabin interior with a wooden interior, a fireplace, a television, and a comfortable seating area.

Walk to Current River: Ozarks Adventure Home!

Van Buren

"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."

Cottage

A two-story house with a wooden deck and a gravel driveway.

A spacious living room with a high wooden ceiling, two sofas, a coffee table, a TV, and a bookshelf.

A red house with a wooden deck and stone steps leading to a porch.

A dining area with a glass table and chairs, wooden flooring, and large windows.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

Cottage

A bedroom with a bed, nightstand, lamp, and curtains.

A backyard with a wooden fence, two metal chairs, a metal table, and a house in the background.

A kitchen with granite countertops, white cabinets, a coffee maker, a kettle, and a sink.

A single-story house with a front porch, a small front yard, and a red roof.

Cottage w/ Yard, Walk to Historic Attractions

Ste Genevieve

"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.

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A sunset over a lake with boats and ducks.

Lake Wappapello

8.8/10 (54 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants.

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Century Casino Caruthersville

7.0/10 (57 reviews)

Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

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Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top Southeast Missouri Hotel Reviews

Recent Reviews in Southeast Missouri

Days Inn and Suites by Wyndham Sikeston

8/10 Good

"Everything was good about the room except the bathroom. The stopper on the sink did not work and there was a dent in the wall. The face/wash towels need to be changed out. They are no longer white. They are dull in color. The couch needs to be cleaned and freshen. The staff was excellent and everything else is good. I just wish that breakfast offered hot eggs and meat vs. only waffles. Otherwise the room was good."

Comfort Inn Festus - St Louis South

8/10 Good

"These stay was good. Breakfast was your average Hotel breakfast no complaints other than staff continually let the coffee run out every morning. Staff at front desk were conversing with what must have been someone they knew because of the colorful language they were using. Very unprofessional."

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent

"Perfect location, beds were awesome & staff were friendly & accommodating!"

Drury Inn & Suites Cape Girardeau

10/10 Excellent

"No exhaust fan in the bathroom. Other than that very clean comfortable hotel"

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"The stay here gets better every time."

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent

"Great place"

Drury Inn & Suites Hayti Caruthersville

10/10 Excellent

"The food & drinks were great & the staff was very friendly. Room was very nice."

Candlewood Suites Cape Girardeau by IHG

8/10 Good

"I usually stay here if I need to because I travel back and forth from northern IL and I usually have a lot of food to take home to southern MS. The full size fridge and freezer is very nice to have available and you don’t have to book a super fancy room to get one. Housekeeping can be hard work, but missing a rather large blood stain on the wall behind the door is disturbing. Thankfully I always travel with Lysol wipes and cleaned it up."

Motel 6 Poplar Bluff, MO

10/10 Excellent

"Terrific base accommodation. Clean, efficient. I use this place whenever I’m in the area. I’m"

More cheap accommodation in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

AU$89

1 Nov - 2 Nov

includes taxes & fees

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

AU$108

1 Nov - 2 Nov

includes taxes & fees

7.2/10 Good! (1,001 reviews)

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

AU$117

11 Oct - 12 Oct

includes taxes & fees

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO

AU$119

1 Nov - 2 Nov

includes taxes & fees

7.8/10 Good! (1,003 reviews)

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

AU$127

8 Oct - 9 Oct

includes taxes & fees

8/10 Very good! (1,004 reviews)

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO

AU$146

1 Nov - 2 Nov

includes taxes & fees

9.4/10 Exceptional! (969 reviews)

Explore a world of travel with Expedia

Book Hotels in Southeast Missouri on Expedia.com

Search Southeast Missouri hotels

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Southeast Missouri

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for Southeast Missouri hotels

1. Shepherd Mountain Inn

2. Hampton Inn & Suites By Hilton Festus

3. Super 8 by Wyndham Farmington

4. Madison Inn Lodge

5. Crown Pointe Lodge, BW Signature Collection

6. Drury Inn & Suites Jackson MO

7. Fairfield Inn & Suites by Marriott Sikeston

8. Baymont Inn and Suites by Wyndham Farmington, MO

9. EC Reed's Mercantile and Hotel

10. Holiday Inn Express & Suites Farmington by IHG

11. Fort Davidson Hotel

12. Drury Plaza Hotel Cape Girardeau Conference Center

13. Hampton Inn Poplar Bluff

14. The Riverview

15. Super 8 By Wyndham Marston

16. Drury Inn & Suites Sikeston, MO

17. Fairfield Inn & Suites by Marriott Cape Girardeau

18. Pear Tree Inn Cape Girardeau West

19. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

20. Holiday Inn Express & Suites Perryville by IHG

Holiday Rentals in Southeast Missouri

Sam A Baker State Park

Urban Lofts

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

The Atrium - A Boutique Hotel

Tiny Houses of French Village

Lake Wappapello

Walk to Dtwn: Ironton Home in Historic District

Walk to Current River: Ozarks Adventure Home!

Cozy Belgrade Cottage w/ Wood-burning Stove!

Cottage w/ Yard, Walk to Historic Attractions

Stay near popular Southeast Missouri attractions

Elephant Rocks State Park

Southeast Missouri State University

Lake Wappapello

Century Casino & Hotel Cape Girardeau

Century Casino Caruthersville

Learn more about Southeast Missouri

Top Southeast Missouri Hotel Reviews

Recent Reviews in Southeast Missouri

Days Inn and Suites by Wyndham Sikeston

Comfort Inn Festus - St Louis South

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Drury Inn & Suites Cape Girardeau

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Super 8 by Wyndham Sikeston/Miner Area

Drury Inn & Suites Hayti Caruthersville

Candlewood Suites Cape Girardeau by IHG

Motel 6 Poplar Bluff, MO

More cheap accommodation in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Days Inn and Suites by Wyndham Sikeston

Pear Tree Inn Cape Girardeau West

Comfort Inn Festus - St Louis South

Motel 6 Poplar Bluff, MO

Hampton Inn Poplar Bluff

Explore a world of travel with Expedia

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