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Check prices for these dates

Tonight
5 Oct - 6 Oct
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6 Oct - 7 Oct
This weekend
9 Oct - 11 Oct
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16 Oct - 18 Oct

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Our top choices for Southeast Missouri hotels

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.
A bathroom with a white sink, a large mirror, a hairdryer, a coffee maker, and a microwave.
A hotel room with two beds, a lamp, and a painting on the wall.
A compact kitchen with wooden cabinets, a stainless steel refrigerator, and a microwave.

1. Shepherd Mountain Inn

Shepherd Mountain Inn
Ironton
United States
Michael
AU$194
includes taxes & fees
6 Oct - 7 Oct
Shepherd Mountain Inn
A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

2. Hampton Inn & Suites By Hilton Festus

Hampton Inn & Suites By Hilton Festus
Festus
United States
Abram
AU$147
includes taxes & fees
29 Oct - 30 Oct
Hampton Inn & Suites By Hilton Festus
A motel with a covered entrance, a flag, and a phone number.
A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.
A living room with a black leather sofa, a wooden coffee table with a vase of flowers, a green potted plant, and a lamp.
A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

3. Madison Inn Lodge

Madison Inn Lodge
Fredericktown
United States
Bawan
AU$127
includes taxes & fees
3 Nov - 4 Nov
Madison Inn Lodge
A modern kitchen with a coffee machine, a refrigerator, and a microwave.
A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.
A long, narrow hallway with patterned carpet, doors on both sides, and a ceiling light.
A laundry room with a front-loading washer and dryer, a door, and a light fixture.

4. Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington
Farmington
United States
Marisa
AU$98
includes taxes & fees
11 Oct - 12 Oct
Super 8 by Wyndham Farmington
An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.
A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.
A spacious hotel lobby with a dining area, kitchen, and large windows.
A modern bathroom with a bathtub, a window with curtains, and a view of a green landscape.

5. Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
Farmington
United States
Stephanie
AU$180
includes taxes & fees
14 Oct - 15 Oct
Crown Pointe Lodge, BW Signature Collection
An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.
A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.
An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.
A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

6. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
Sikeston
United States
Allen
AU$164
includes taxes & fees
11 Oct - 12 Oct
Fairfield Inn & Suites by Marriott Sikeston
A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.
A hotel reception area with a glass partition, a reception desk, and a digital kiosk.
A parking lot with a tree in bloom, a red fire hydrant, and a building in the background.
A gym with cardio equipment, a bench press, and a squat rack.

7. Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
Farmington
United Kingdom
Mark
AU$89
includes taxes & fees
1 Nov - 2 Nov
Baymont Inn and Suites by Wyndham Farmington, MO
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.
An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.
A restaurant with a brick wall, a flat-screen TV, and a bar area.

8. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson
United States
Thomas
AU$122
includes taxes & fees
11 Oct - 12 Oct
Drury Inn & Suites Jackson MO
A living room with a blue wall, a fireplace, a sofa, and a chair.
A hotel room with two beds, a vanity with a mirror, a chair, and a dresser.
A brick building with a sign reading "Mercantile & Hotel".
A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.

9. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
Marble Hill
United States
JANEEN
AU$165
includes taxes & fees
6 Oct - 7 Oct
EC Reed's Mercantile and Hotel
A hotel room with two beds, a desk, a chair, a TV, and a lamp.
A reception desk with a woman standing behind it, a man with a suitcase, and another person standing to the left.
An outdoor pool area with lounge chairs and an umbrella.
A two-story building with a green roof and a large circular sign that reads "Port David Restaurant".

10. Fort Davidson Hotel

Fort Davidson Hotel
Ironton
United States
richard
AU$188
includes taxes & fees
27 Oct - 28 Oct
Fort Davidson Hotel
A hotel room with a bed, a sofa, a desk, and a chair.
A hotel lobby with a central reception desk, multiple seating areas, and a tiled floor.
An indoor swimming pool with a tiled edge, surrounded by lounge chairs and potted plants.
A modern living room with a sofa, armchairs, a coffee table, and a painting on the wall.

11. Holiday Inn Express & Suites Farmington by IHG

Holiday Inn Express & Suites Farmington by IHG
Farmington
United States
Sheila
AU$201
includes taxes & fees
11 Oct - 12 Oct
Holiday Inn Express & Suites Farmington by IHG
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.
A hotel room with two beds, a desk, a chair, and a view of the city.
A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.

12. The Riverview

The Riverview
Cape Girardeau
United States
Alyssa
AU$167
includes taxes & fees
13 Oct - 14 Oct
The Riverview
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.
A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

13. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
United States
Sandra
AU$162
includes taxes & fees
11 Oct - 12 Oct
Drury Plaza Hotel Cape Girardeau Conference Center
An indoor swimming pool with clear water, surrounded by lounge chairs and a tiled floor.
A modern hotel lobby with multiple seating areas, a large flat-screen TV mounted on the wall, and a visible exit sign.
A hotel room with two beds, a flat-screen TV, a desk, and a window with blinds.
A reception desk with a wooden panel design, a bicycle mounted on the wall, and a sign reading "Hilton Honors".

14. Hampton Inn Farmington

Hampton Inn Farmington
Farmington
United States
Charlie
AU$172
includes taxes & fees
25 Oct - 26 Oct
Hampton Inn Farmington
A bedroom with a bed, a wooden headboard, a window with a view of greenery, and a tray with breakfast items.
A cabin with two Adirondack chairs outside, a picnic table, and a small black structure with a window and a sign.
A rustic cabin with a wooden exterior, a small deck, and a picnic table.
Property amenity

15. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
French Village
United States
cynthia
AU$230
includes taxes & fees
3 Nov - 4 Nov
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.
A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.
An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.
A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

16. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
United States
Carlos
AU$164
includes taxes & fees
11 Oct - 12 Oct
Fairfield Inn & Suites by Marriott Cape Girardeau
A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.
A corner market with a refrigerated display case and a pantry area.
A reception area with a wooden counter, a coffee machine, and a display of pastries.
An outdoor patio with a table and chairs, a large umbrella, and a glass door leading to an interior space.

17. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
Poplar Bluff
United States
Nancy
AU$164
includes taxes & fees
18 Oct - 19 Oct
Fairfield Inn & Suites by Marriott Poplar Bluff
A hotel room with a large bed, a desk with a chair, a television, and a window with curtains.
An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.
An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.
A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

18. Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
Sikeston
United States
Scott
AU$155
includes taxes & fees
11 Oct - 12 Oct
Drury Inn & Suites Sikeston, MO
A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.
A modern kitchen with a built-in microwave, a black refrigerator, and a wooden countertop.
A room with a brown leather sofa, a red chair, and a cityscape painting on the wall.
A modern kitchen with a stone backsplash, a dining area with red chairs, and a red accent wall with a framed picture.

19. Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
Marston
United States
Brenda
AU$92
includes taxes & fees
6 Oct - 7 Oct
Super 8 By Wyndham Marston
A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.
A spacious lobby with a checkered floor, two sofas with patterned cushions, a computer desk, and a reception area with a glass door.
A hotel room with a kitchenette, a large mirror, a sofa, and a patterned carpet.
A hotel lobby with two sofas, a coffee table, lamps, and a large window with a plant.

20. Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville
Perryville
United States
paulette
AU$113
includes taxes & fees
22 Oct - 23 Oct
Super 8 by Wyndham Perryville
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Holiday Rentals in Southeast Missouri

Cabin
A rustic log cabin with a stone foundation, surrounded by trees and a wooden fence.
A view through a window with a stone wall and a wooden structure in the background.
A room with two bunk beds, a single bed, a ceiling fan, and a window with blinds.
A compact kitchen with wooden cabinets, a dishwasher, a refrigerator, and a coffee maker.

Sam A Baker State Park

Sam A Baker State Park
Patterson
"Pet friendly, great staff. "
Sam A Baker State Park
Aparthotel
A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.
A hallway with exposed brick walls, wooden flooring, and a white door.
A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.
A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.

Urban Lofts

Urban Lofts
Perryville
"Beautiful place and staff was amazing!"
Urban Lofts
Cabin
A bedroom with a bed, a wooden headboard, a window with a view of greenery, and a tray with breakfast items.
A cabin with two Adirondack chairs outside, a picnic table, and a small black structure with a window and a sign.
A rustic cabin with a wooden exterior, a small deck, and a picnic table.
Property amenity

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
French Village
"The stay here gets better every time."
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Cottage
A dining area with a checkered tablecloth, wooden chairs, and a red rug.
A modern kitchen with wooden cabinets, a microwave, and a refrigerator. There is a staircase leading to another level. A gray sofa with a red pillow is in the living area, and a checkered curtain covers a window.
A two-story house with a red exterior, a front porch, and a well-maintained lawn.
A swimming pool with a wooden deck, surrounded by a white picket fence, and featuring colorful umbrellas.

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

'turtle Rock' - Ironton Cabin w/ Furnished Patio!
Ironton
"Stroller, pack n play and high chair. This was amazing "
'turtle Rock' - Ironton Cabin w/ Furnished Patio!
Aparthotel
A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.
A fireplace with a decorative mantel, a framed sign, and a small table with plants.
A building with a dark exterior, a large window, and a sign that reads "The Atrium."
A building with a sign that reads "The Atrium Boutique Hotel".

The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel
Perryville
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."
The Atrium - A Boutique Hotel
Holiday Home
A wooden deck with two Adirondack chairs and a hammock.
A spacious living room with wooden floors, a stone fireplace, and a mounted television.
A spacious living room with a wooden ceiling, a ceiling fan, a sofa set, a coffee table, and a large window offering a view of the outdoors.
A spacious living room with a wooden ceiling, a fireplace, and a television.

Tiny Houses of French Village

Tiny Houses of French Village
French Village
"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "
Tiny Houses of French Village
Cabin
A rustic cabin with a metal roof, surrounded by a wooden deck and picnic tables, set in a forested area.
A calm lake with a wooden dock and a forested island in the distance.
Front of property
A bedroom with a wooden bed, a bench, and a window.

Lake Wappapello

Lake Wappapello
Williamsville
"Pet friendly. Family-friendly "
Lake Wappapello
Cottage
A bedroom with a large bed, a sofa, a wooden wardrobe, and a ceiling fan.
A spacious living area with a kitchen island, dining table, and a television.
A covered porch with yellow chairs, a bench, and a small table.
A kitchen with wooden cabinets, a central island, and a dining area with a table set for four.

Walk to Dtwn: Ironton Home in Historic District

Walk to Dtwn: Ironton Home in Historic District
Ironton
"Clean and comfortable "
Walk to Dtwn: Ironton Home in Historic District
Cottage
Interior
Interior
Interior
A wooden deck leading to a house with a wooden door and a small porch area.

Walk to Current River: Ozarks Adventure Home!

Walk to Current River: Ozarks Adventure Home!
Van Buren
"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."
Walk to Current River: Ozarks Adventure Home!
Cottage
A spacious living room with a high wooden ceiling, two sofas, a coffee table, a TV, and a bookshelf.
A red house with a wooden deck and stone steps leading to a porch.
A red house with a wooden deck, large sliding glass doors, and a chimney.
A bedroom with a bed, two bedside tables, a dresser, a ceiling fan, and a window with curtains.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Cozy Belgrade Cottage w/ Wood-burning Stove!
Belgrade
Cozy Belgrade Cottage w/ Wood-burning Stove!
Cottage
A bedroom with a bed, nightstand, lamp, and curtains.
A kitchen with granite countertops, white cabinets, a coffee maker, a kettle, and a sink.
A living room with a sofa, coffee table, TV stand, and ceiling fan.
A backyard with a wooden fence, two metal chairs, a metal table, and a house in the background.

Cottage w/ Yard, Walk to Historic Attractions

Cottage w/ Yard, Walk to Historic Attractions
Ste Genevieve
"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "
Cottage w/ Yard, Walk to Historic Attractions
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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.
Photo by Pat Long

Elephant Rocks State Park

9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
See properties
A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
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A sunset over a lake with boats and ducks.
Photo by JG Morris

Lake Wappapello

8.8/10 (54 reviews)
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)
Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants.
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Century Casino Caruthersville

7.0/10 (57 reviews)
Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants.
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Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri
A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.
Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

Recent Reviews in Southeast Missouri

The Riverview

The Riverview

8/10 Good
"Rated a 4/5 as there is no place to get a hot breakfast, menu at open restaurant is in my opinion uneventful. The other dinner resturant is open 3 evenings only. Staff was nice and property is quiet. Ty"
Jill 2-night trip
Posted 3 hours ago
The Riverview
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent
"Perfect location, beds were awesome & staff were friendly & accommodating!"
Rebecca 3-night trip
Posted 15 hours ago
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"No exhaust fan in the bathroom. Other than that very clean comfortable hotel"
Judith 1-night trip
Posted 15 hours ago
Drury Inn & Suites Cape Girardeau
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

8/10 Good
"Needs some more luxurious bedding. My sheets were worn and scratchy."
Suzanne 2-night trip
Posted 18 hours ago
Drury Plaza Hotel Cape Girardeau Conference Center
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

10/10 Excellent
"The stay here gets better every time."
cynthia 1-night trip
Posted 2 days ago
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent
"Great place"
BRANDY 1-night trip
Posted 2 days ago
Super 8 by Wyndham Sikeston/Miner Area
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

10/10 Excellent
"The food & drinks were great & the staff was very friendly. Room was very nice."
Cynthia 1-night trip
Posted 3 days ago
Drury Inn & Suites Hayti Caruthersville
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

8/10 Good
"I usually stay here if I need to because I travel back and forth from northern IL and I usually have a lot of food to take home to southern MS. The full size fridge and freezer is very nice to have available and you don’t have to book a super fancy room to get one. Housekeeping can be hard work, but missing a rather large blood stain on the wall behind the door is disturbing. Thankfully I always travel with Lysol wipes and cleaned it up."
Jacqueline 1-night trip
Posted 3 days ago
Candlewood Suites Cape Girardeau by IHG
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

10/10 Excellent
"Terrific base accommodation. Clean, efficient. I use this place whenever I’m in the area. I’m"
Herman 1-night trip
Posted 4 days ago
Motel 6 Poplar Bluff, MO

More cheap accommodation in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO
AU$89
1 Nov - 2 Nov
includes taxes & fees
Baymont Inn and Suites by Wyndham Farmington, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO
AU$109
1 Nov - 2 Nov
includes taxes & fees
Days Inn and Suites by Wyndham Sikeston
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO
AU$117
11 Oct - 12 Oct
includes taxes & fees
Pear Tree Inn Cape Girardeau West
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO
AU$120
1 Nov - 2 Nov
includes taxes & fees
Comfort Inn Festus - St Louis South
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO
AU$127
6 Oct - 7 Oct
includes taxes & fees
8/10 Very good! (1,004 reviews)
Motel 6 Poplar Bluff, MO
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO
AU$146
18 Oct - 19 Oct
includes taxes & fees
9.4/10 Exceptional! (965 reviews)
Hampton Inn Poplar Bluff

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