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Our top choices for Southeast Missouri hotels
Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,002 reviews)
"The breakfast and nightly gathering makes this location a fantastic value and will be our choice of stops when heading south again!"
William
The price is AU$146
includes taxes & fees
28 July - 29 July
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,013 reviews)
"Wonderful room and food offerings were extra thoughtful."
Jonna
The price is AU$162
includes taxes & fees
12 July - 13 July
Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (206 reviews)
"The room was clean, the staff was extremely helpful with our check in!"
Travis
The price is AU$150
includes taxes & fees
19 July - 20 July
Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (929 reviews)
"Hotel Staff was very friendly!"
Alice
The price is AU$164
includes taxes & fees
19 July - 20 July
Tru By Hilton Cape Girardeau
Tru By Hilton Cape GirardeauCape Girardeau
9.6 out of 10, Exceptional, (145 reviews)
"This is a clean, quiet, well designed hotel."
Kendra
The price is AU$153
includes taxes & fees
3 Aug - 4 Aug
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (794 reviews)
"Beautiful hotel at a very good price."
Sheldon
The price is AU$144
includes taxes & fees
21 July - 22 July
Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHGSikeston
8.6 out of 10, Excellent, (474 reviews)
"Only stayed one night, no complaints"
Zachary
The price is AU$171
includes taxes & fees
26 July - 27 July
Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (886 reviews)
"Nice quiet overnight stay."
Tammy
The price is AU$166
includes taxes & fees
7 Aug - 8 Aug
Hampton Inn Sikeston
Hampton Inn SikestonSikeston
9.0 out of 10, Wonderful, (587 reviews)
"Staff were great at Check in, room was clean, breakfast was good."
Brandi
The price is AU$184
includes taxes & fees
20 July - 21 July
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (82 reviews)
"The Experience was amazing and we enjoyed the views and the firepit!"
Kenzia
The price is AU$230
includes taxes & fees
19 July - 20 July
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.6 out of 10, Exceptional, (1,007 reviews)
"Great place!"
Jennifer
The price is AU$183
includes taxes & fees
27 July - 28 July
Deerfield Inn & Suites Steele Near Blytheville I 55
Deerfield Inn & Suites Steele Near Blytheville I 55Steele
8.8 out of 10, Excellent, (3 reviews)
"Love it, very peaceful! What else want from me"
Mary
The price is AU$80
includes taxes & fees
9 July - 10 July
Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
9.4 out of 10, Exceptional, (97 reviews)
"Great stay, kind staff, very clean property."
Joni
The price is AU$179
includes taxes & fees
30 July - 31 July
Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature CollectionFarmington
9.0 out of 10, Wonderful, (641 reviews)
"Excellent staff and location was nice and quiet
"
Colleen
The price is AU$172
includes taxes & fees
6 Aug - 7 Aug
Shepherd Mountain Inn
Shepherd Mountain InnIronton
9.4 out of 10, Exceptional, (319 reviews)
"Breakfast was good and rooms were clean"
Shannon
The price is AU$194
includes taxes & fees
8 July - 9 July
The Riverview
The RiverviewCape Girardeau
9.4 out of 10, Exceptional, (619 reviews)
"Always a great place to stay in downtown Cape. Easy access to the local hangouts like Speck Pizza on Broadway."
John
The price is AU$176
includes taxes & fees
5 Aug - 6 Aug
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHGFestus
9.4 out of 10, Exceptional, (751 reviews)
"Great stay."
Delos
The price is AU$194
includes taxes & fees
19 July - 20 July
Honeysuckle Inn - Mountain View
Honeysuckle Inn - Mountain ViewMountain View
8.6 out of 10, Excellent, (371 reviews)
"Simple no frills hotel that we've stayed at a few times while traveling."
Monica
The price is AU$156
includes taxes & fees
28 July - 29 July
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
La Quinta Inn & Suites by Wyndham Festus - St. Louis SouthFestus
7.8 out of 10, Good, (1,004 reviews)
"Clean room, check in was easy. It was a good stopover for 1 night."
Nancy
The price is AU$139
includes taxes & fees
9 July - 10 July
Super 8 By Wyndham Marston
Super 8 By Wyndham MarstonMarston
8.0 out of 10, Very good, (66 reviews)
"Clean room, The receptionist very friendly, good parking."
Temera
The price is AU$121
includes taxes & fees
8 July - 9 July
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Holiday Rentals in Southeast Missouri
Cabin
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (82 reviews)
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Stay near popular Southeast Missouri attractions
Learn more about Southeast Missouri
Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to Walnut Hollow Lake.
Photo by Bill Dillard
Open Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews
Recent Reviews in Southeast Missouri
Drury Plaza Hotel Cape Girardeau Conference Center
10/10 Excellent
More cheap accommodation in Southeast Missouri
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
The price is AU$106 per night from 26 July to 27 July
AU$106
26 July - 27 July
includes taxes & fees
8/10 Very good! (1,012 reviews)
