Photo by Bill Dillard
Search Southeast Missouri hotels
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Southeast Missouri
Apart hotel
Cabin
Check prices for these dates
Our top choices for Southeast Missouri hotels
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (57 reviews)
"I had a great time with my mom there!"
Lily
The price is AU$217
includes taxes & fees
7 Apr - 8 Apr
Tiny Houses of French Village
Tiny Houses of French VillageFrench Village
10.0 out of 10, Exceptional, (5 reviews)
"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "
Chris
The price is AU$206
includes taxes & fees
14 Apr - 15 Apr
Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,003 reviews)
"Great food and pool. Clean and cozy. We will be back! "
Leora
The price is AU$123
includes taxes & fees
27 Apr - 28 Apr
Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (172 reviews)
"Nearby Mexican restaurant, clean room, pleasant staff, good breakfast choices "
Larry
The price is AU$152
includes taxes & fees
3 May - 4 May
Echo Bluff State Park
Echo Bluff State ParkEminence
9.6 out of 10, Exceptional, (237 reviews)
"The lodge was beautiful! Our room was good for our time there. We enjoyed being able to eat at the grille and relax for the weekend! "
Tina
The price is AU$251
includes taxes & fees
8 Apr - 9 Apr
Super 8 By Wyndham Marston
Super 8 By Wyndham MarstonMarston
8.2 out of 10, Very good, (57 reviews)
"The property is beautiful! The rooms are terrific! Staff is amazing! Totally recommend!!
"
Sue
The price is AU$120
includes taxes & fees
10 Apr - 11 Apr
Current River Inn
Current River InnVan Buren
8.2 out of 10, Very good, (169 reviews)
"The room was very clean. The desk help was very good, pleasant, and informative."
Frank
The price is AU$157
includes taxes & fees
7 Apr - 8 Apr
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,010 reviews)
"Great room, staff and breakfast! "
Kenneth
The price is AU$164
includes taxes & fees
26 Apr - 27 Apr
Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MOFarmington
8.0 out of 10, Very good, (1,004 reviews)
"Great staff and nice accommodations "
Lisa
The price is AU$99
includes taxes & fees
13 Apr - 14 Apr
Tru By Hilton Cape Girardeau
Tru By Hilton Cape GirardeauCape Girardeau
9.6 out of 10, Exceptional, (117 reviews)
"Hotel was very clean, quiet and has a great location! "
Dustin
The price is AU$161
includes taxes & fees
20 Apr - 21 Apr
Honeysuckle Inn - Mountain View
Honeysuckle Inn - Mountain ViewMountain View
8.6 out of 10, Excellent, (343 reviews)
"It was a very nice hassle free stay. I will be staying here again."
Michael Grey
The price is AU$150
includes taxes & fees
8 Apr - 9 Apr
Hampton Inn By Hilton Dexter
Hampton Inn By Hilton DexterDexter
10.0 out of 10, Exceptional, (18 reviews)
"Great stay "
Ashley
The price is AU$178
includes taxes & fees
12 Apr - 13 Apr
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.4 out of 10, Exceptional, (1,008 reviews)
"Very nice for overnight stay"
Scott
The price is AU$183
includes taxes & fees
9 Apr - 10 Apr
Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
9.4 out of 10, Exceptional, (68 reviews)
"Nice quiet hotel "
Steven
The price is AU$194
includes taxes & fees
24 Apr - 25 Apr
Super 8 by Wyndham Perryville
Super 8 by Wyndham PerryvillePerryville
8.4 out of 10, Very good, (975 reviews)
"Great place to stay"
Doug
The price is AU$106
includes taxes & fees
23 Apr - 24 Apr
Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature CollectionFarmington
9.0 out of 10, Wonderful, (602 reviews)
"Excellent staff and location was nice and quiet
"
Colleen
The price is AU$197
includes taxes & fees
26 Apr - 27 Apr
New Orleans Inn Portageville
New Orleans Inn PortagevillePortageville
8.0 out of 10, Very good, (757 reviews)
"The staff was great very helpful and friendly "
Javier
The price is AU$81
includes taxes & fees
12 Apr - 13 Apr
EC Reed's Mercantile and Hotel
EC Reed's Mercantile and HotelMarble Hill
9.6 out of 10, Exceptional, (85 reviews)
"Parking was easy. The staff were super friendly and helpful. Room was nice and comfortable. I definetely recommend staying here if you are in this area."
Mehdi
The price is AU$133
includes taxes & fees
8 Apr - 9 Apr
The Riverview
The RiverviewCape Girardeau
9.4 out of 10, Exceptional, (541 reviews)
"Room was perfect"
Derrick
The price is AU$193
includes taxes & fees
8 Apr - 9 Apr
The Farmstead Hotel
The Farmstead HotelCaruthersville
8.6 out of 10, Excellent, (532 reviews)
"Such a wonderful hotel! I highly recommend staying here. I’ve been there multiple times and I’ve never once been disappointed. "
Alexus
The price is AU$155
includes taxes & fees
9 Apr - 10 Apr
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Holiday Rentals in Southeast Missouri
Cabin
10.0 out of 10, Exceptional, (1 review)
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Central United States attractions
Learn more about Southeast Missouri
Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to K Bridge Recreation Area.
Photo by Bill Dillard
Open Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews
Recent Reviews in Southeast Missouri
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
10/10 Excellent
More cheap accommodation in Southeast Missouri
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
The price is AU$99 per night from 13 Apr to 14 Apr
AU$99
13 Apr - 14 Apr
includes taxes & fees
8/10 Very Good! (1,004 reviews)
Explore a world of travel with Expedia
- Caravan Parks in Advance
- Holiday Homes in Advance
- Cheap Hotels in Advance
- Hotels with Pool in Advance
- Family Hotels in Annapolis
- Hotels with Pool in Annapolis
- Annapolis Hotels
- B&B in Arcadia
- Caravan Parks in Arcadia
- Holiday Homes in Arcadia
- Hotels with Pool in Arcadia
- Luxury Hotels in Arcadia
- Arcadia Hotels
- Motels in Arcadia
- Belleview Hotels
- Hotels near Big River
- Bismarck Hotels
- Caravan Parks in Black
- Cheap Hotels in Black
- Black Hotels
- Lodges in Black
- Cottages in Bloomfield
- Luxury Hotels in Bloomfield
- Bonne Terre Hotels
- Lodges in Bunker
- Cheap Hotels in Caledonia
- Caledonia Hotels
- Holiday Homes in Des Arc
- Desloge Hotels
- Doe Run Hotels
- Hotels near Elephant Rocks State Park
- Farmstay in Ellington
- Cheap Hotels in Ellington
- Ellington Hotels
- Pet Friendly Hotels in Farmington
- Farmington Hotels
- Flat River Hotels
- Cheap Hotels in Fredericktown
- Fredericktown Hotels
- Motels in Fredericktown
- Cheap Hotels in Jackson
- Hotels with Parking in Jackson
- Luxury Hotels in Jackson
- Hotels near Johnson's Shut-ins State Park
- Junction City Hotels
- B&B in Leadwood
- Leadwood Hotels
- Lesterville Hotels
- Marble Hill Hotels
- Middle Brook Hotels
- Cheap Hotels in New Offenburg
- New Offenburg Hotels
- Farmstay in Park Hills
- Park Hills Hotels
- Cheap Hotels in Patterson
- Patterson Hotels
- Perryville Hotels
- Piedmont Hotels
- Pilot Knob Hotels
- Motels in Pilot Knob
- Hotels with Pool in Poplar Bluff
- Lgbt Welcoming Hotels in Poplar Bluff
- Poplar Bluff Hotels
- Cabin Rentals in Van Buren
- Van Buren Hotels
- Wappapello Hotels
- Flights to Advance
- Flights to Annapolis
- Flights to Belgrade
- Flights to Bismarck
- Flights to Black
- Flights to Caledonia
- Flights to Clearwater
- Flights to Farmington
- Flights to Flat River
- Flights to Greenville
- Flights to Ozora
- Flights to Pilot Knob
- Flights to Poplar Bluff
- Flights to Whitewater
- Flights from Poplar Bluff Municipal
- Flights from Black
- Flights from Dallas (DFW) to Poplar Bluff (POF)
- Flights from London (LON) to Poplar Bluff (POF)
- Flights from San Antonio (SAT) to Poplar Bluff (POF)
- Flights from San Francisco (SFO) to Poplar Bluff (POF)
- Flights from St. Louis (STL) to Poplar Bluff (POF)
- Flights from Sydney (SYD) to Poplar Bluff (POF)
