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Top hotels and accommodation in Southeast Missouri

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1005)
"Will stay again"
The price is AU$158
includes taxes & fees
14 Aug - 15 Aug
Drury Inn & Suites Sikeston, MO

Pear Tree Inn Sikeston

2.5 star property
9.4 out of 10, Exceptional, (1001)
"Great place to stay with kids "
The price is AU$141
includes taxes & fees
30 July - 31 July
Pear Tree Inn Sikeston

Drury Inn & Suites Hayti Caruthersville

3.0 star property
9.4 out of 10, Exceptional, (1005)
"Great stay!"
The price is AU$164
includes taxes & fees
3 Aug - 4 Aug
Drury Inn & Suites Hayti Caruthersville

Postcard Cabins St. Francois

2.0 star property
10.0 out of 10, Exceptional, (22)
"Had a wonderful time"
The price is AU$203
includes taxes & fees
31 July - 1 Aug
Postcard Cabins St. Francois

Fairfield Inn & Suites by Marriott Poplar Bluff

2.5 star property
9.4 out of 10, Exceptional, (779)
"Excellent choice for a stopping point for group of friends traveling through poplar bluff."
The price is AU$170
includes taxes & fees
3 Aug - 4 Aug
Fairfield Inn & Suites by Marriott Poplar Bluff

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
9.4 out of 10, Exceptional, (1000)
"Great place to stay. "
The price is AU$178
includes taxes & fees
17 Aug - 18 Aug
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express & Suites Perryville by IHG

2.5 star property
9.4 out of 10, Exceptional, (490)
"Good place "
The price is AU$184
includes taxes & fees
14 Aug - 15 Aug
Holiday Inn Express & Suites Perryville by IHG

The Riverview

2.0 star property
9.4 out of 10, Exceptional, (365)
"Wonderful place to stay. Very clean and affordable!"
The price is AU$182
includes taxes & fees
30 July - 31 July
The Riverview

Pear Tree Inn Cape Girardeau West

2.5 star property
9.0 out of 10, Wonderful, (1008)
"We enjoyed the quick check in and how quiet the property was. "
The price is AU$120
includes taxes & fees
10 Aug - 11 Aug
Pear Tree Inn Cape Girardeau West

Hampton Inn Poplar Bluff

2.5 star property
9.4 out of 10, Exceptional, (745)
"Excellent property, great location. "
The price is AU$166
includes taxes & fees
10 Aug - 11 Aug
Hampton Inn Poplar Bluff

Microtel Inn & Suites by Wyndham Sainte Genevieve

2.5 star property
8.8 out of 10, Excellent, (583)
"It was a great stay. Only thimg maybe more variety or hot breakfast."
The price is AU$164
includes taxes & fees
14 Aug - 15 Aug
Microtel Inn & Suites by Wyndham Sainte Genevieve

Hampton Inn Sikeston

2.5 star property
8.8 out of 10, Excellent, (368)
"Great location and clean room. Plenty of food and shopping nearby."
The price is AU$189
includes taxes & fees
23 Aug - 24 Aug
Hampton Inn Sikeston

Shepherd Mountain Inn

2.5 star property
9.2 out of 10, Wonderful, (287)
"Wonderful small town motel in a beautiful & quiet location."
Shepherd Mountain Inn

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

2.5 star property
9.4 out of 10, Exceptional, (658)
"Valid to stay at "
The price is AU$193
includes taxes & fees
3 Aug - 4 Aug
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

The Farmstead Hotel

2.5 star property
8.8 out of 10, Excellent, (394)
"Great stay!"
The price is AU$142
includes taxes & fees
1 Aug - 2 Aug
The Farmstead Hotel

Fairfield Inn & Suites by Marriott Sikeston

2.5 star property
9.8 out of 10, Exceptional, (16)
"Nice hotel "
The price is AU$212
includes taxes & fees
10 Aug - 11 Aug
Fairfield Inn & Suites by Marriott Sikeston

Hampton Inn Cape Girardeau I 55 East

2.5 star property
9.6 out of 10, Exceptional, (730)
"Close distance to good restaurants "
The price is AU$188
includes taxes & fees
10 Aug - 11 Aug
Hampton Inn Cape Girardeau I 55 East

Courtyard by Marriott Cape Girardeau Downtown

3.0 star property
9.6 out of 10, Exceptional, (433)
"Very clean and upscale hotel."
The price is AU$210
includes taxes & fees
24 Aug - 25 Aug
Courtyard by Marriott Cape Girardeau Downtown

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (964)
"Love the property. Staff is always amazing."
The price is AU$155
includes taxes & fees
3 Aug - 4 Aug
Drury Inn & Suites Cape Girardeau

Tru By Hilton Cape Girardeau

2.5 star property
9.6 out of 10, Exceptional, (49)
"Great overall stay"
The price is AU$161
includes taxes & fees
10 Aug - 11 Aug
Tru By Hilton Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Southeast Missouri, MO

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Stay near top Southeast Missouri attractions

Elephant Rocks State Park
Elephant Rocks State Park

Elephant Rocks State Park

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Rocky Falls
Rocky Falls

Rocky Falls

Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting.

Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to K Bridge Recreation Area.

Top Southeast Missouri Hotel Reviews