Southeast Missouri Hotel & Accommodation Deals 2026 from AU$89 - Compare prices by date

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Go beyond your typical stay in Southeast Missouri

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Our top choices for Southeast Missouri hotels

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

A building with a red awning labeled "Shepherd Mountain Inn."

A bathroom with a white sink, a large mirror, a hairdryer, a coffee maker, and a microwave.

A hotel room with two beds, a lamp, and a painting on the wall.

1. Shepherd Mountain Inn

Ironton

Michael

AU$194

includes taxes & fees

6 Oct - 7 Oct

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

2. Hampton Inn & Suites By Hilton Festus

Festus

Abram

AU$147

includes taxes & fees

29 Oct - 30 Oct

A motel with a covered entrance, a flag, and a phone number.

A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.

A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

A spacious kitchen with a dining area, featuring a ceiling fan, a TV mounted on the wall, and a large rug in the center.

3. Madison Inn Lodge

Fredericktown

Bawan

AU$127

includes taxes & fees

3 Nov - 4 Nov

A modern kitchen with a coffee machine, a refrigerator, and a microwave.

A hotel room with a large bed, a smaller bed, a nightstand with a lamp, and two large framed pictures on the wall.

A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.

A long, narrow hallway with patterned carpet, doors on both sides, and a ceiling light.

4. Super 8 by Wyndham Farmington

Farmington

Marisa

AU$98

includes taxes & fees

11 Oct - 12 Oct

An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

A spacious hotel lobby with a dining area, kitchen, and large windows.

A modern bathroom with a bathtub, a window with curtains, and a view of a green landscape.

A lobby with a stone fireplace, two sofas, a coffee table, and two lamps.

5. Crown Pointe Lodge, BW Signature Collection

Farmington

Stephanie

AU$180

includes taxes & fees

14 Oct - 15 Oct

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

6. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Allen

AU$164

includes taxes & fees

11 Oct - 12 Oct

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

A hotel room with a large bed, two sofas, a desk with a lamp, a microwave, and a TV.

A hotel reception area with a glass partition, a reception desk, and a digital kiosk.

A parking lot with a tree in bloom, a red fire hydrant, and a building in the background.

7. Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

Mark

AU$89

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

A restaurant with a brick wall, a flat-screen TV, and a bar area.

An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.

8. Drury Inn & Suites Jackson MO

Jackson

Thomas

AU$122

includes taxes & fees

11 Oct - 12 Oct

A living room with a blue wall, a fireplace, a sofa, and a chair.

A hotel room with two beds, a vanity with a mirror, a chair, and a dresser.

A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.

A bar area with stools and a counter where a bartender is serving drinks.

9. EC Reed's Mercantile and Hotel

Marble Hill

JANEEN

AU$165

includes taxes & fees

6 Oct - 7 Oct

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

An outdoor pool area with lounge chairs and an umbrella.

A reception desk with a woman standing behind it, a man with a suitcase, and another person standing to the left.

A hotel room with a television, a desk, a chair, a dresser, a radiator, and a bathroom visible through an open door.

10. Fort Davidson Hotel

Ironton

richard

AU$188

includes taxes & fees

27 Oct - 28 Oct

A hotel room with a bed, a sofa, a desk, and a chair.

A modern living room with a sofa, armchairs, a coffee table, and a painting on the wall.

An indoor swimming pool with a tiled edge, surrounded by lounge chairs and potted plants.

A hotel lobby with a central reception desk, multiple seating areas, and a tiled floor.

11. Holiday Inn Express & Suites Farmington by IHG

Farmington

Sheila

AU$201

includes taxes & fees

11 Oct - 12 Oct

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.

A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.

12. The Riverview

Cape Girardeau

Alyssa

AU$167

includes taxes & fees

13 Oct - 14 Oct

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

13. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Sandra

AU$162

includes taxes & fees

11 Oct - 12 Oct

An indoor swimming pool with clear water, surrounded by lounge chairs and a tiled floor.

A hotel room with two beds, a flat-screen TV, a desk, and a window with blinds.

A hotel room with a wooden desk, a chair, a television, a microwave, and a minibar.

A reception desk with a wooden panel design, a bicycle mounted on the wall, and a sign reading "Hilton Honors".

14. Hampton Inn Farmington

Farmington

Charlie

AU$172

includes taxes & fees

25 Oct - 26 Oct

A bedroom with a bed, a wooden headboard, a window with a view of greenery, and a tray with breakfast items.

A rustic cabin with a wooden exterior, a small deck, and a picnic table.

15. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

cynthia

AU$230

includes taxes & fees

3 Nov - 4 Nov

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.

A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

16. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Carlos

AU$164

includes taxes & fees

11 Oct - 12 Oct

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

An outdoor patio with a table and chairs, a large umbrella, and a glass door leading to an interior space.

A reception area with a wooden counter, a coffee machine, and a display of pastries.

A corner market with a refrigerated display case and a pantry area.

17. Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

Nancy

AU$164

includes taxes & fees

18 Oct - 19 Oct

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.

A spacious lobby with a polished floor, seating areas, and modern lighting fixtures.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

18. Drury Inn & Suites Sikeston, MO

Sikeston

Scott

AU$155

includes taxes & fees

11 Oct - 12 Oct

A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.

A room with a brown leather sofa, a red chair, and a cityscape painting on the wall.

A hotel with a central entrance, multiple parking spaces, and a well-lit facade.

A modern kitchen with a built-in microwave, a black refrigerator, and a wooden countertop.

19. Super 8 By Wyndham Marston

Marston

Brenda

AU$92

includes taxes & fees

6 Oct - 7 Oct

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

A hotel lobby with two sofas, a coffee table, lamps, and a large window with a plant.

A hotel room with a large bed, a desk with a chair, a television, and a small table with a lamp.

A spacious lobby with a checkered floor, two sofas with patterned cushions, a computer desk, and a reception area with a glass door.

20. Super 8 by Wyndham Perryville

Perryville

paulette

AU$113

includes taxes & fees

22 Oct - 23 Oct

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Holiday Rentals in Southeast Missouri

Cabin

A view through a window with a stone wall and a wooden structure in the background.

A room with two bunk beds, a single bed, a ceiling fan, and a window with blinds.

Sam A Baker State Park

Patterson

"Pet friendly, great staff. "

Aparthotel

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.

A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

A bedroom with a bed, a bench, a ceiling fan, a mirror, and a wooden floor.

Urban Lofts

Perryville

"Beautiful place and staff was amazing!"

Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"The stay here gets better every time."

Cottage

A dining area with a checkered tablecloth, wooden chairs, and a red rug.

A two-story house with a red exterior, a front porch, and a well-maintained lawn.

A swimming pool with a wooden deck, surrounded by a white picket fence, and featuring colorful umbrellas.

An outdoor patio with a table and chairs, a grill, and a large umbrella.

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Ironton

"Stroller, pack n play and high chair. This was amazing "

Aparthotel

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

A fireplace with a decorative mantel, a framed sign, and a small table with plants.

A building with a sign that reads "The Atrium Boutique Hotel".

A building with a dark exterior, a large window, and a sign that reads "The Atrium."

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Holiday Home

A wooden deck with two Adirondack chairs and a hammock.

A bedroom with a large bed, wooden ceiling, and a view of the outdoors.

A spacious living room with a wooden ceiling, a fireplace, and a television.

A spacious living room with a wooden ceiling, a ceiling fan, a sofa set, a coffee table, and a large window offering a view of the outdoors.

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Cabin

A wooden deck with a railing leading to a building with a metal roof and a brown door.

A bedroom with a wooden bed, a bench, and a window.

Lake Wappapello

Williamsville

"Pet friendly. Family-friendly "

Cottage

A bedroom with a large bed, a sofa, a wooden wardrobe, and a ceiling fan.

A covered porch with yellow chairs, a bench, and a small table.

A kitchen with wooden cabinets, a central island, and a dining area with a table set for four.

A spacious living area with a kitchen island, dining table, and a television.

Walk to Dtwn: Ironton Home in Historic District

Ironton

"Clean and comfortable "

Cottage

A cozy cabin interior with a wooden interior, a fireplace, a television, and a comfortable seating area.

Walk to Current River: Ozarks Adventure Home!

Van Buren

"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."

Cottage

A spacious living room with a high wooden ceiling, two sofas, a coffee table, a TV, and a bookshelf.

A dining area with a glass table and chairs, wooden flooring, and large windows.

A red house with a wooden deck and stone steps leading to a porch.

A red house with a wooden deck, large sliding glass doors, and a chimney.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

Cottage

A bedroom with a bed, nightstand, lamp, and curtains.

A living room with a sofa, coffee table, TV stand, and ceiling fan.

A single-story house with a front porch, a small front yard, and a red roof.

A kitchen with granite countertops, white cabinets, a coffee maker, a kettle, and a sink.

Cottage w/ Yard, Walk to Historic Attractions

Ste Genevieve

"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.

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A sunset over a lake with boats and ducks.

Lake Wappapello

8.8/10 (54 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants.

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Century Casino Caruthersville

7.0/10 (57 reviews)

Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

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Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top Southeast Missouri Hotel Reviews

Recent Reviews in Southeast Missouri

The Riverview

8/10 Good

"Rated a 4/5 as there is no place to get a hot breakfast, menu at open restaurant is in my opinion uneventful. The other dinner resturant is open 3 evenings only. Staff was nice and property is quiet. Ty"

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent

"Perfect location, beds were awesome & staff were friendly & accommodating!"

Drury Inn & Suites Cape Girardeau

10/10 Excellent

"No exhaust fan in the bathroom. Other than that very clean comfortable hotel"

Drury Plaza Hotel Cape Girardeau Conference Center

8/10 Good

"Needs some more luxurious bedding. My sheets were worn and scratchy."

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"The stay here gets better every time."

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent

"Great place"

Drury Inn & Suites Hayti Caruthersville

10/10 Excellent

"The food & drinks were great & the staff was very friendly. Room was very nice."

Candlewood Suites Cape Girardeau by IHG

8/10 Good

"I usually stay here if I need to because I travel back and forth from northern IL and I usually have a lot of food to take home to southern MS. The full size fridge and freezer is very nice to have available and you don’t have to book a super fancy room to get one. Housekeeping can be hard work, but missing a rather large blood stain on the wall behind the door is disturbing. Thankfully I always travel with Lysol wipes and cleaned it up."

Motel 6 Poplar Bluff, MO

10/10 Excellent

"Terrific base accommodation. Clean, efficient. I use this place whenever I’m in the area. I’m"

More cheap accommodation in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

AU$89

1 Nov - 2 Nov

includes taxes & fees

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

AU$109

1 Nov - 2 Nov

includes taxes & fees

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

AU$117

11 Oct - 12 Oct

includes taxes & fees

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO

AU$120

1 Nov - 2 Nov

includes taxes & fees

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

AU$127

6 Oct - 7 Oct

includes taxes & fees

8/10 Very good! (1,004 reviews)

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO

AU$146

18 Oct - 19 Oct

includes taxes & fees

9.4/10 Exceptional! (965 reviews)

Explore a world of travel with Expedia

Book Hotels in Southeast Missouri on Expedia.com

Search Southeast Missouri hotels

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Southeast Missouri

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for Southeast Missouri hotels

1. Shepherd Mountain Inn

2. Hampton Inn & Suites By Hilton Festus

3. Madison Inn Lodge

4. Super 8 by Wyndham Farmington

5. Crown Pointe Lodge, BW Signature Collection

6. Fairfield Inn & Suites by Marriott Sikeston

7. Baymont Inn and Suites by Wyndham Farmington, MO

8. Drury Inn & Suites Jackson MO

9. EC Reed's Mercantile and Hotel

10. Fort Davidson Hotel

11. Holiday Inn Express & Suites Farmington by IHG

12. The Riverview

13. Drury Plaza Hotel Cape Girardeau Conference Center

14. Hampton Inn Farmington

15. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

16. Fairfield Inn & Suites by Marriott Cape Girardeau

17. Fairfield Inn & Suites by Marriott Poplar Bluff

18. Drury Inn & Suites Sikeston, MO

19. Super 8 By Wyndham Marston

20. Super 8 by Wyndham Perryville

Holiday Rentals in Southeast Missouri

Sam A Baker State Park

Urban Lofts

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

The Atrium - A Boutique Hotel

Tiny Houses of French Village

Lake Wappapello

Walk to Dtwn: Ironton Home in Historic District

Walk to Current River: Ozarks Adventure Home!

Cozy Belgrade Cottage w/ Wood-burning Stove!

Cottage w/ Yard, Walk to Historic Attractions

Stay near popular Southeast Missouri attractions

Elephant Rocks State Park

Southeast Missouri State University

Lake Wappapello

Century Casino & Hotel Cape Girardeau

Century Casino Caruthersville

Learn more about Southeast Missouri

Top Southeast Missouri Hotel Reviews

Recent Reviews in Southeast Missouri

The Riverview

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Drury Inn & Suites Cape Girardeau

Drury Plaza Hotel Cape Girardeau Conference Center

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Super 8 by Wyndham Sikeston/Miner Area

Drury Inn & Suites Hayti Caruthersville

Candlewood Suites Cape Girardeau by IHG

Motel 6 Poplar Bluff, MO

More cheap accommodation in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Days Inn and Suites by Wyndham Sikeston

Pear Tree Inn Cape Girardeau West

Comfort Inn Festus - St Louis South

Motel 6 Poplar Bluff, MO

Hampton Inn Poplar Bluff

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