
Sikeston Holidays
Book a Hotel + Flight or Car together to unlock savings
Photo by Ryan Coleman
- Plan, book, travel with confidence
Better together
Save up to AU$703 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Your Sikeston Holiday
With a reputation for its rich history and rural countryside, Sikeston is an ideal getaway destination. Lock in one of our Sikeston holiday packages and discover all that this lively city has to offer. Fill your schedule with tours of The Book Bug, Sikeston Depot Museum and Central Park, some of the attractions you should see during a trip to Sikeston. Expedia can help you escape your routine. Tailor your holiday to Sikeston to suit your style of travel, whatever that may be!
Sikeston Holiday
Sikeston Essential Information
Language | English |
---|---|
Currency | U.S dollars |
Closest Airport | Cape Girardeau Municipal Airport (CGI) |
Population | 16,400 |
Max Temp Winter | 7ºC |
Max Temp Summer | 29ºC |
Top Sights | Sikeston Depot Museum, Central Park and The Book Bug |
Our pick of the best Sikeston Hotel Deals

Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is AU$158 per night from 16 Oct to 17 Oct
AU$158
16 Oct - 17 Oct
includes taxes & fees
9.4/10 Exceptional! (1,003 reviews)
"Very clean room, friendly staff"
Reviewed on 10 Oct 2025

Best Western Plus Sikeston
120 S Interstate Drive, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is AU$146 per night from 19 Oct to 20 Oct
AU$146
19 Oct - 20 Oct
includes taxes & fees
8.2/10 Very Good! (1,006 reviews)
"Room was clean and relaxing."
Reviewed on 9 Oct 2025

Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is AU$109 per night from 19 Oct to 20 Oct
AU$109
19 Oct - 20 Oct
includes taxes & fees
7.2/10 Good! (1,004 reviews)
"Kayla at the front desk was very helpful and accommodating when I first arrived. The room was very generous in space, clean and comfortable. A very quiet place to spend a night after 12 hours on the saddle."
Reviewed on 8 Oct 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Explore a world of travel with Expedia
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.