Name: Best Western Plus Sikeston I-55
Price range: AU$143
Rating: 8.4

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Your Sikeston Holiday

With a reputation for its rich history and rural countryside, Sikeston is an ideal getaway destination. Lock in one of our Sikeston holiday packages and discover all that this lively city has to offer. Fill your schedule with tours of The Book Bug, Sikeston Depot Museum and Central Park, some of the attractions you should see during a trip to Sikeston. Expedia can help you escape your routine. Tailor your holiday to Sikeston to suit your style of travel, whatever that may be!

Sikeston Holiday

Sikeston Essential Information

Language	English
Currency	U.S dollars
Closest Airport	Cape Girardeau Municipal Airport (CGI)
Population	16,400
Max Temp Winter	7ºC
Max Temp Summer	29ºC
Top Sights	Sikeston Depot Museum, Central Park and The Book Bug

Our pick of the best Sikeston Hotel Deals

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

Fully refundableReserve now, pay when you stay

AU$178

1 May - 2 May

includes taxes & fees

9.4/10 Exceptional! (1,001 reviews)

Amazingly they had dinner and breakfast. For a family this would be great savings. But be parpared for a crowd.

Reviewed on 15 Apr 2026

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

Fully refundableReserve now, pay when you stay

AU$162

3 May - 4 May

includes taxes & fees

9/10 Wonderful! (537 reviews)

You walk in to a fresh & clean smell, that you can’t help but notice! Vibrant & comfy colors, very friendly staff who greet you with a smile, the check-in was took maybe 2 minutes. They had breakfast 6a-10a with a variety of choices. I

Reviewed on 15 Apr 2026

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO

Fully refundableReserve now, pay when you stay

AU$143

19 Apr - 20 Apr

includes taxes & fees

8.4/10 Very Good! (1,000 reviews)

Everything went perfect.

Reviewed on 13 Apr 2026

See all 301 properties in Sikeston

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.