A beach with waves, a boat, and a forested hill in the background.

Luxury Hotels & Resorts in Santa Clara from AU$94

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Santa Clara Luxury Hotels

Tonight
10 Oct - 11 Oct
Tomorrow
11 Oct - 12 Oct
Next weekend
16 Oct - 18 Oct
In two weeks
23 Oct - 25 Oct

Our top choices for Santa Clara luxury hotels

A resort with a pool area, lounge chairs, and a view of a bridge at night.
A formal dining area with round tables, white tablecloths, and blue lace borders.
A reception desk with three staff members, a green patterned wall, a wooden reception area, and a large plant.
A hotel room with a bed, a TV on a wooden cabinet, a nightstand with a lamp, and a view of the outdoors through a glass door.

1. Radisson Hotel Panama Canal

Radisson Hotel Panama Canal
Amador
  • Spectacular waterfront luxury at Panama Canal hotel with premium dining and dual pools.
AU$123
includes taxes & fees
15 Oct - 16 Oct
Radisson Hotel Panama Canal
A hotel with a pool, beach, and palm trees.
A large hotel with multiple towers, a central courtyard with a swimming pool, and surrounding landscaped areas.
A beachfront hotel with a large building, a beach, and a clear sky.
A spacious lobby with a large seating area, a reception desk, and large windows offering a view of the ocean and palm trees.

2. The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
Veracruz
  • Oceanfront luxury beckons with private beach, indulgent spa services, and refined dining at this beachfront Panama retreat.
AU$325
includes taxes & fees
25 Oct - 26 Oct
The Westin Playa Bonita Panama
A rooftop pool with sun loungers and umbrellas, surrounded by palm trees and modern buildings.
A spacious lobby with a central seating area, a chandelier, and a modern ceiling design.
A hotel room with a bed, a TV, a desk, and a view of the cityscape through a window.
A modern living room with a sofa set, a coffee table, and a dining area with chairs and a table.

3. Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
Bella Vista
  • Exclusive Panama City escape offers lavish poolside retreats and gourmet dining experiences.
AU$208
includes taxes & fees
21 Oct - 22 Oct
Hotel Riu Plaza Panama
A buffet with various food items including fruits, juices, and cheeses.
A modern hotel lobby with a sectional sofa, a glass coffee table, and a vibrant green wall mural.
A hotel reception area with a wooden reception desk, seating area with chairs and ottomans, and a large window providing natural light.
A gym with treadmills, weight machines, and dumbbells.

4. Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall
San Antonio
AU$159
includes taxes & fees
30 Oct - 31 Oct
Courtyard by Marriott Panama Metromall
A high-rise building with a modern architectural design, featuring a grid of windows and balconies.
A rooftop pool area with purple lounge chairs and a city skyline in the background.
A modern spa area with a hot tub, seating, and a city view.
An escalator in a hotel lobby with a patterned wall and framed artwork.

5. Megapolis Hotel Panamá

Megapolis Hotel Panamá
San Francisco
  • Experience luxury and elegance in a Panamanian retreat with 2 restaurants, a spa, and casino.
AU$257
includes taxes & fees
31 Oct - 1 Nov
Megapolis Hotel Panamá
A poolside area with lounge chairs and a view of the ocean.
A modern building with a symmetrical facade, multiple balconies, and a central atrium with lighting.
A terrace with seating and a view of the ocean.
A modern bathroom with a large bathtub, two sinks, and a glass-enclosed shower area with a city view.

6. JW Marriott Panama

JW Marriott Panama
San Francisco
  • Unwind in opulent waterfront luxury with 4 pristine pools and ocean-view dining in Panama City.
AU$440
includes taxes & fees
7 Nov - 8 Nov
JW Marriott Panama
A modern hotel room with a sofa, a coffee table, a TV mounted on the wall, and a dining area with a table and chairs.
The exterior of the Renaissance Hotel with a modern design, featuring a prominent 'R' logo, a geometric ceiling design, and a well-lit entrance area.
A modern lobby with a staircase, marble flooring, and large windows with tropical plants.
An indoor swimming pool with lounge chairs and red chairs, surrounded by lush greenery and a modern interior design.

7. Renaissance Panama City Hotel

Renaissance Panama City Hotel
Bella Vista
  • Lavish escape in city centre Panama City with an outdoor pool, casino thrills, and fine dining, all minutes from top attractions.
AU$213
includes taxes & fees
31 Oct - 1 Nov
Renaissance Panama City Hotel
A restaurant with multiple dining tables, chairs, and a central water feature.
A modern living room with a sofa, a coffee table, and a TV mounted on the wall.
A rooftop terrace with tables and chairs, a view of two white towers, and a building with a large window.
A bar area with multiple seating options, a bar counter, and a fireplace.

8. Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo
Casco Viejo
  • Experience historic luxury in Panama's Casco Viejo district with 5 restaurants and a rooftop pool with spectacular views.
AU$414
includes taxes & fees
18 Oct - 19 Oct
Hotel La Compañía Casco Antiguo
A rooftop pool with lounge chairs and a city skyline view.
A person seated on a wicker chair with a view of a cityscape through large windows.
A hotel room with a bed, a sofa, an ottoman, a wall-mounted lamp, and a wardrobe.
A gym with treadmills, elliptical machines, free weights, and a bench.

9. Hotel Dann Carlton Marinn Place Panama Financial District

Hotel Dann Carlton Marinn Place Panama Financial District
Bella Vista
AU$155
includes taxes & fees
10 Nov - 11 Nov
Hotel Dann Carlton Marinn Place Panama Financial District
A rooftop pool with clear blue water, surrounded by palm trees and a city skyline in the background.
A modern hotel room with a large bed, a wardrobe, a desk with a chair, and a decorative wall piece.
A restaurant with wooden tables and chairs, hanging plants, and circular wall decorations.
A reception area with a modern design, featuring a large wooden panel with abstract carvings, a blue marble section, and a vibrant artificial flower wall.

10. Gran Evenia Panama

Gran Evenia Panama
Bella Vista
  • Indulge in luxurious comfort at this Panama hotel featuring rainfall showers, premium dining, and a stunning outdoor pool.
AU$144
includes taxes & fees
15 Oct - 16 Oct
Gran Evenia Panama
View all properties

Find out more about Santa Clara

Santa Claraand its attractions for luxury travelers

Santa Clara, located in the picturesque Panamá Oeste Province, is a haven for luxury travellers seeking a blend of relaxation and adventure. A visit to the renowned Playa Santa Clara offers pristine white sands and crystal-clear waters, perfect for enjoying a day of sunbathing or indulging in water sports like paddle boarding and jet skiing. Just a short drive away, the exclusive Decameron Golf Club presents a world-class golfing experience amidst stunning tropical scenery, ideal for both seasoned players and beginners alike. For those interested in cultural exploration, the nearby town of Anton boasts charming local markets and artisan shops where you can find unique Panamanian crafts. Adventure seekers will appreciate the nearby the majestic El Valle de Antón, an ancient volcanic crater with hiking trails leading to breathtaking waterfalls and hot springs. After a day of exploration, retreat to one of Santa Clara’s luxurious beachfront resorts, such as the Royal Decameron, where attentive service, gourmet dining, and spa treatments await, ensuring a perfect blend of comfort and indulgence.

Top Santa Clara Hotel Reviews

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

10/10 Excellent
"Beautiful & clean hotel with comfy bed. Washroom was roomy with great water pressure & products. Breakfast was fresh & delicious. Conveniently located 20 min from airport."
DEMETROULA 1-night trip
Posted 6 hours ago
Las Americas Golden Tower Panama
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

8/10 Good
"Nice place for a 1 night stay. Nothing fancy. Rooms and hotel a little outdated but the breakfast was good. So a nice place for a 1 night stay during a layover."
Keith 1-night trip
Posted 8 hours ago
Riande Aeropuerto Hotel & Casino
Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

8/10 Good
"We just didn’t have a microwave. Staff was amazing, breakfast variety was good everyday. Will be back!"
Edilzabeth 5-night trip
Posted 1 day ago
Hotel El Panama by Faranda Grand, a member of Radisson Individuals
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

10/10 Excellent
"Nice Place to Stay in Panama"
Willie 1-night trip
Posted 1 day ago
Courtyard by Marriott Panama Multiplaza Mall

Frequently asked questions

Are you searching for the perfect hotel for your luxury getaway to Santa Clara?
Use Expedia and let us help you arrange a flight to Balboa (BLB-Panama Pacifico Intl.) airport or Panama City (PAC-Marcos A. Gelabert Intl.) airport, and then select from different places to stay that will deliver the luxury you want. Amenities are an important consideration when you plan a trip, so we make it easy to find what you want to make your stay relaxing and comfortable. If you want a posh hotel with a spa, an indoor pool or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Santa Clara has to offer. Santa Clara has some interesting things to see and do including Culebra Cut, so you might want to take in the local sights during your visit.
When can I expect good weather in Santa Clara?
Planning for the weather is an important factor for making your trip to Santa Clara a success, especially when you're splurging. The hottest months are usually April and March, with an average temperature of 26°C, while the coldest months are January and February, with an average of 26°C. The rainiest months in Santa Clara are July, August, November and October, with each month seeing an average of 283 mm of rainfall.
What's there to see and do in Santa Clara?
Experience Santa Clara and visit Albrook Shopping Mall, Gamboa Rainforest Resort and Panama Canal Railway. If you have extra time while you're in the area, you might want to stop by Farfan Beach and El Dorado Mall.

Explore a world of travel with Expedia