Santa Clara Holiday Rentals

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Our top choices for Santa Clara holiday rentals

Arcadia Condo Suites

Arcadia Condo Suites
2.5 star property
Costa del Este
9.4 out of 10, Exceptional, (158)
"Everything was great, helpful staff, great room , clean, excellent service!"
United States
Gregory Walter
The price is AU$175
includes taxes & fees
15 Dec - 16 Dec
Arcadia Condo Suites

Boutique Apartments Panama

Boutique Apartments Panama
3.5 star property
Bella Vista
7.6 out of 10, Good, (215)
"The view was amazing and the place was great could stay here again "
United States
Yonnette
Boutique Apartments Panama

Torres de Alba Hotel & Suites

Torres de Alba Hotel & Suites
3.5 star property
Bella Vista
8.8 out of 10, Excellent, (483)
"The buffet bar and great customer service. "
United States
Kayhiuska
Torres de Alba Hotel & Suites

Casco View Apartments

Casco View Apartments
3.5 star property
Santa Ana
9.2 out of 10, Wonderful, (54)
"Great stay, would recommend."
United States
Brooke
Casco View Apartments

Las Clementinas

Las Clementinas
3.5 star property
Casco Viejo
9.4 out of 10, Exceptional, (170)
"The front desk receptionist was extremely helpful! The room was clean and comfortable! We would definitely stay again!"
United States
april
The price is AU$213
includes taxes & fees
13 Dec - 14 Dec
Las Clementinas

La Isabela Suites

La Isabela Suites
3.5 star property
Casco Viejo
10.0 out of 10, Exceptional, (166)
"The room was spotless, the location perfect, and the staff was absolutely superb!"
United States
Gregory
La Isabela Suites

Boutique Apartments Panamá Coco del Mar

Boutique Apartments Panamá Coco del Mar
3.5 star property
San Francisco
7.4 out of 10, Good, (152)
"Clean room good place to stay "
United States
Gideon
The price is AU$296
includes taxes & fees
14 Dec - 15 Dec
Boutique Apartments Panamá Coco del Mar

La Cuadra by Wynwood House

La Cuadra by Wynwood House
3.5 star property
El Chorrillo
9.2 out of 10, Wonderful, (44)
"Love the property. You are right at the start of the nice part of casco viejo but the blocks around it are rough and ugly. The police are very prominent so it's safe but be on alert"
United States
Carlos
The price is AU$228
includes taxes & fees
14 Dec - 15 Dec
La Cuadra by Wynwood House

Yoo Panamá by Boutique Apartments

Yoo Panamá by Boutique Apartments
3.5 star property
Bella Vista
8.2 out of 10, Very good, (48)
"Great location but not enough towels in the room "
United States
Damion
The price is AU$320
includes taxes & fees
17 Dec - 18 Dec
Yoo Panamá by Boutique Apartments

San Francisco by Wynwood House

San Francisco by Wynwood House
3.0 star property
San Francisco
9.2 out of 10, Wonderful, (56)
"Clean and walkable location"
United States
Tamera
The price is AU$257
includes taxes & fees
14 Dec - 15 Dec
San Francisco by Wynwood House

ESHEL SUITES PANAMA

ESHEL SUITES PANAMA
2.5 star property
San Francisco
10.0 out of 10, Exceptional, (5)
"Loved the property and the location, it was clean , nice and I really enjoyed my stay there"
United States
Aron
ESHEL SUITES PANAMA

Boutique Apartments Atlapa

Boutique Apartments Atlapa
3.0 star property
San Francisco
8.0 out of 10, Very good, (26)
"I had an excellent stay here ! It was a very amazing the host is an amazing person thank you for making My stay great❤️"
United States
Shamia
Boutique Apartments Atlapa

Yoo Panama & Arts Tower

Yoo Panama & Arts Tower
3.0 star property
Bella Vista
9.4 out of 10, Exceptional, (46)
"Nice stay"
United States
ANGEL
Yoo Panama & Arts Tower

Casa Mallet by Wynwood House

Casa Mallet by Wynwood House
4.0 star property
Casco Viejo
9.8 out of 10, Exceptional, (25)
" It was very relaxing to stay at the historical and cutely renovated apartment. Great aesthetic. Lively apartment, very well decorated! Right the middle of everything in the beautiful town of Casco Veijo. Vibrant lanes, boutique stores, cafes and restaurants near by. We had an amazing time staying for 2 nights at this apartment. "
United States
Navyatha
The price is AU$640
includes taxes & fees
11 Jan - 12 Jan 2026
Casa Mallet by Wynwood House

Casa Contemporanea by Wynwood House

Casa Contemporanea by Wynwood House
4.0 star property
Casco Viejo
8.2 out of 10, Very good, (20)
"Great place!"
United States
Jad
The price is AU$243
includes taxes & fees
14 Dec - 15 Dec
Casa Contemporanea by Wynwood House

La Moderna by Wynwood House

La Moderna by Wynwood House
3.0 star property
Casco Viejo
7.4 out of 10, Good, (40)
"The nightlife around there was incredible"
United States
Felix
The price is AU$139
includes taxes & fees
14 Dec - 15 Dec
La Moderna by Wynwood House

Delightful Ocean View

Delightful Ocean View
3.5 star property
San Francisco
8.0 out of 10, Very good, (2)
"The apartment was in a good location but most of the pictures in this listing were of the lobby and building. The showerheads in both bathrooms kept moving which caused water to go everywhere, and we only had two pillows on the main bed and one on each twin bed, and the linens were lacking, there is also no outdoor furniture and the apartment is right above the pool which occasionally was noisy. Also there aren’t great instructions to check in or check out. There are better places to stay in...
United States
Laura
Delightful Ocean View

La Manzana by Wynwood House

La Manzana by Wynwood House
3.0 star property
Santa Ana
7.2 out of 10, Good, (15)
"Great hotel. Very close to Casco viejo"
United States
LUCILA
The price is AU$162
includes taxes & fees
14 Dec - 15 Dec
La Manzana by Wynwood House

Panama View House – A Hilltop Retreat with Stunning Canal Views

Panama View House – A Hilltop Retreat with Stunning Canal Views
Panama City
The price is AU$147
includes taxes & fees
13 Dec - 14 Dec
Panama View House – A Hilltop Retreat with Stunning Canal Views

Casa Love by Wynwood House

Casa Love by Wynwood House
3.0 star property
Casco Viejo
8.8 out of 10, Excellent, (19)
"It was absolutely wonderful. You just may need to bring your own soap for one of the bathrooms. Perhaps that was not typical though. I especially appreciated the cleanliness of the property, the view of the water, and the easy-to-use AC. "
United States
Tamu
The price is AU$208
includes taxes & fees
16 Dec - 17 Dec
Casa Love by Wynwood House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Clara Hotel Reviews

Find out more about Santa Clara

Everything you need to know about Santa Clara holiday rentals

Whether you’re excited for the perfect family holiday, a romantic getaway for two, or the ultimate city break, we’ve got the Santa Clara holiday rental for you. At Expedia, you can take your pick from private holiday homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santa Clara holiday rental for you by simply entering your desired dates. Then check your favourite filters to narrow down your search. 

Santa Clara holiday rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Santa Clara. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depend on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Santa Clara holiday rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a holiday rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Santa Clara holiday rentals we have selected for you start as low as AU$139 per night. Entering your travel dates in the search wizard might find you even better deals!

How to find incredible deals on Santa Clara rentals

At Expedia, we put the best Santa Clara holiday rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top Santa Clara rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santa Clara holiday.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santa Clara. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. 

Frequently asked questions

Can I find holiday rentals in Santa Clara?

Yes, there are holiday rentals close to the most popular sights in Santa Clara, or you can select a more secluded option if you're looking for a relaxing stay. Santa Clara is known for its monuments.

What are some of the best holiday rentals that Santa Clara has to offer?

Oasis with pool near panama canal: This holiday home rental outside of Santa Clara offers an outdoor pool, a patio and a BBQ to help you feel perfectly comfortable in your new surroundings. It has 4 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. Make the most of garden in this rental home to help you unwind.

What can I see and do in Santa Clara?

While exploring the area, visit family-friendly sights like Summit Botanical Gardens & Zoo, or get outside and enjoy nature at Culebra Cut. In the wider area, you’ll find Albrook Shopping Mall and Gamboa Rainforest Resort.

What are holiday rentals like in Santa Clara?

Holiday rentals are privately owned properties you can book for a few days, or a quick weekend, in Santa Clara. Holiday rentals offer extras like laundry facilities and kitchens so you'll have all the comforts of home. If you're concerned about cleanliness, holiday rentals can provide a sense of privacy away from shared hotel lifts and busy lobbies while still allowing you to travel. You'll also have more space in a holiday rental than in a standard hotel, which makes a holiday rental a popular option for a family trip or a small group gathering.