Aerial view of house in Serra Mesa City in San Diego, California, USA. Green Dry Valley and Villas

Serra Mesa Hotels, San Diego

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Our top choices for Serra Mesa hotels

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.8 km from Serra Mesa
9.4 out of 10, Exceptional, (1,973 reviews)
"Always a great stay"
United States
Jeanette
The price is AU$225
includes taxes & fees
16 June - 17 June
Sycuan Casino Resort

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
28.1 km from Serra Mesa
8.8 out of 10, Excellent, (1,299 reviews)
"Room is nice, clean, & breakfast is good. We always stay here when in the area."
United States
Travis
The price is AU$198
includes taxes & fees
28 June - 29 June
Best Western Americana Inn

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.1 km from Serra Mesa
9.2 out of 10, Wonderful, (3,884 reviews)
"Great stay"
United States
Cameron
The price is AU$280
includes taxes & fees
30 June - 1 July
Best Western Plus Marina Gateway Hotel

Ramada by Wyndham San Diego Poway Miramar

Ramada by Wyndham San Diego Poway Miramar
2.0 star property
18.2 km from Serra Mesa
7.2 out of 10, Good, (1,027 reviews)
"Nice place to stay."
United States
Jacquie
The price is AU$195
includes taxes & fees
14 June - 15 June
Ramada by Wyndham San Diego Poway Miramar

Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
18.5 km from Serra Mesa
9.4 out of 10, Exceptional, (1,233 reviews)
"Room fit our family of 6 and the breakfast was good."
United States
Jamie
The price is AU$256
includes taxes & fees
30 June - 1 July
Holiday Inn Express San Diego South - Chula Vista by IHG

Hampton Inn & Suites San Diego Airport Liberty Station

Hampton Inn & Suites San Diego Airport Liberty Station
2.5 star property
10.6 km from Serra Mesa
9.2 out of 10, Wonderful, (1,731 reviews)
"Good location, clean room and nice staff. A great place to stay."
United States
Patricia
The price is AU$280
includes taxes & fees
30 June - 1 July
Hampton Inn & Suites San Diego Airport Liberty Station

GreenTree Inn San Diego Mission Bay

GreenTree Inn San Diego Mission Bay
2.5 star property
Pacific Beach, 7.3 km from Serra Mesa
8.0 out of 10, Very good, (2,160 reviews)
"THE BED WAS SO SOFT ROOM WAS SO CLEAN BREAKFAST WAS GREAT AND THE PRICE WAS KILLER FOR THE LOCATION really a great place to stay"
United States
Tyson
The price is AU$234
includes taxes & fees
15 June - 16 June
GreenTree Inn San Diego Mission Bay

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
10.1 km from Serra Mesa
8.4 out of 10, Very good, (3,530 reviews)
"Great location and shuttle service to and from the airport."
Canada
Malinda
The price is AU$333
includes taxes & fees
2 July - 3 July
Sheraton San Diego Resort

Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
18.6 km from Serra Mesa
8.2 out of 10, Very good, (1,549 reviews)
"Everything was excellent. Room, breakfast location and staff. This was our second time staying here and we'll be back."
United States
Chris
The price is AU$198
includes taxes & fees
6 July - 7 July
Comfort Inn Chula Vista San Diego South

Valli Hi Motel

Valli Hi Motel
2.5 star property
28.3 km from Serra Mesa
8.4 out of 10, Very good, (1,017 reviews)
"Great place to stay."
United States
Allan
The price is AU$137
includes taxes & fees
11 June - 12 June
Valli Hi Motel

Embassy Suites by Hilton San Diego Bay Downtown

Embassy Suites by Hilton San Diego Bay Downtown
4.0 star property
10.6 km from Serra Mesa
9.0 out of 10, Wonderful, (1,821 reviews)
"We really enjoyed staying here, breakfast was good, staff was great, really clean, we recommend this hotel"
United States
Francesca Elisa
The price is AU$335
includes taxes & fees
7 July - 8 July
Embassy Suites by Hilton San Diego Bay Downtown

Best Western San Diego/Miramar Hotel

Best Western San Diego/Miramar Hotel
2.5 star property
10.1 km from Serra Mesa
8.0 out of 10, Very good, (1,383 reviews)
"Great stay Really close to the cut water brewery!"
United States
Jessica
The price is AU$208
includes taxes & fees
14 June - 15 June
Best Western San Diego/Miramar Hotel

Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG
3.5 star property
6.4 km from Serra Mesa
8.2 out of 10, Very good, (1,039 reviews)
"Always a great stay."
United States
amanda
The price is AU$205
includes taxes & fees
29 June - 30 June
Crowne Plaza San Diego - Mission Valley by IHG

Courtyard by Marriott San Diego Airport/Liberty Station

Courtyard by Marriott San Diego Airport/Liberty Station
3.0 star property
10.7 km from Serra Mesa
9.2 out of 10, Wonderful, (1,302 reviews)
"Great location, good parking, great staff."
United States
Rosemary
The price is AU$305
includes taxes & fees
14 June - 15 June
Courtyard by Marriott San Diego Airport/Liberty Station

Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
7.9 km from Serra Mesa
9.2 out of 10, Wonderful, (1,085 reviews)
"Staff was so great nice rooms really great stay"
United States
Amelia
The price is AU$249
includes taxes & fees
15 June - 16 June
Holiday Inn Express San Diego Airport - Old Town by IHG

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
9 km from Serra Mesa
7.4 out of 10, Good, (4,268 reviews)
"Clean room, staff was very helpful, parking was easy and accessible!"
United States
Hector
The price is AU$195
includes taxes & fees
15 June - 16 June
Wyndham Garden San Diego Near SeaWorld

The Rambler Hotel

The Rambler Hotel
3.0 star property
18.7 km from Serra Mesa
9.0 out of 10, Wonderful, (2,163 reviews)
"Cool vibe in an easy spot to get on and off the highway."
United States
Jami
The price is AU$196
includes taxes & fees
11 June - 12 June
The Rambler Hotel

Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
26 km from Serra Mesa
9.8 out of 10, Exceptional, (1,103 reviews)
"Nice place good food for breakfast 👍"
United States
Paul
The price is AU$335
includes taxes & fees
6 July - 7 July
Ayres Hotel San Diego South - Chula Vista

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
9.9 km from Serra Mesa
8.4 out of 10, Very good, (6,175 reviews)
"Enjoyed our stay."
United States
Debra
The price is AU$301
includes taxes & fees
7 July - 8 July
Wyndham San Diego Bayside

Old Town Inn

Old Town Inn
2.5 star property
8.1 km from Serra Mesa
9.2 out of 10, Wonderful, (1,898 reviews)
"Breakfast was good, rooms were decent."
United States
Andrea
The price is AU$254
includes taxes & fees
29 June - 30 June
Old Town Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our guide on where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and USS Midway Museum are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

Get to Pacific Beach after the sun goes down because this is the place to be in San Diego for partying.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.

Top Serra Mesa Hotel Reviews

Frequently asked questions

What's it like in Serra Mesa?
Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
How many hotels can I expect to find in the Serra Mesa area?
Expedia has 38 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.
What can I see and do in this San Diego neighbourhood?
Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Sharp Learning Resource Center and Convoy District are also worth a stop.

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