Serra Mesa Hotels, San Diego

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Our top choices for Serra Mesa hotels

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
28.1 km from Serra Mesa
8.8 out of 10, Excellent, (1,298 reviews)
"Room is nice, clean, & breakfast is good. We always stay here when in the area."
United States
Travis
The price is AU$197
includes taxes & fees
14 June - 15 June
Best Western Americana Inn

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.1 km from Serra Mesa
9.2 out of 10, Wonderful, (3,876 reviews)
"Great stay"
United States
Cameron
The price is AU$280
includes taxes & fees
28 June - 29 June
Best Western Plus Marina Gateway Hotel

Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
26 km from Serra Mesa
9.8 out of 10, Exceptional, (1,103 reviews)
"Nice place good food for breakfast 👍"
United States
Paul
The price is AU$334
includes taxes & fees
6 July - 7 July
Ayres Hotel San Diego South - Chula Vista

Hampton Inn & Suites San Diego Airport Liberty Station

Hampton Inn & Suites San Diego Airport Liberty Station
2.5 star property
10.6 km from Serra Mesa
9.2 out of 10, Wonderful, (1,727 reviews)
"Good location, clean room and nice staff. A great place to stay."
United States
Patricia
The price is AU$280
includes taxes & fees
28 June - 29 June
Hampton Inn & Suites San Diego Airport Liberty Station

Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
18.5 km from Serra Mesa
9.4 out of 10, Exceptional, (1,225 reviews)
"Room fit our family of 6 and the breakfast was good."
United States
Jamie
The price is AU$237
includes taxes & fees
6 July - 7 July
Holiday Inn Express San Diego South - Chula Vista by IHG

Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
18.6 km from Serra Mesa
8.2 out of 10, Very good, (1,541 reviews)
"Everything was excellent. Room, breakfast location and staff. This was our second time staying here and we'll be back."
United States
Chris
The price is AU$198
includes taxes & fees
28 June - 29 June
Comfort Inn Chula Vista San Diego South

Embassy Suites by Hilton San Diego La Jolla

Embassy Suites by Hilton San Diego La Jolla
4.0 star property
University City, 10.3 km from Serra Mesa
8.8 out of 10, Excellent, (1,925 reviews)
"Great location and very comfortable and spacious hotel room"
United States
Carmen
The price is AU$374
includes taxes & fees
21 June - 22 June
Embassy Suites by Hilton San Diego La Jolla

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
10.1 km from Serra Mesa
8.4 out of 10, Very good, (3,557 reviews)
"My family and I truly enjoyed our stay."
United States
Beverly A
The price is AU$331
includes taxes & fees
5 July - 6 July
Sheraton San Diego Resort

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.8 km from Serra Mesa
9.4 out of 10, Exceptional, (1,969 reviews)
"Always a great stay"
United States
Jeanette
The price is AU$224
includes taxes & fees
9 June - 10 June
Sycuan Casino Resort

Courtyard by Marriott San Diego Central

Courtyard by Marriott San Diego Central
3.0 star property
2.6 km from Serra Mesa
8.8 out of 10, Excellent, (1,018 reviews)
"Great hotel and I will stay there again. Good breakfast and very clean and safe."
United States
Natalie
The price is AU$272
includes taxes & fees
5 July - 6 July
Courtyard by Marriott San Diego Central

Best Western San Diego/Miramar Hotel

Best Western San Diego/Miramar Hotel
2.5 star property
10.1 km from Serra Mesa
8.0 out of 10, Very good, (1,377 reviews)
"Great stay Really close to the cut water brewery!"
United States
Jessica
The price is AU$207
includes taxes & fees
14 June - 15 June
Best Western San Diego/Miramar Hotel

La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
18.7 km from Serra Mesa
8.6 out of 10, Excellent, (1,636 reviews)
"Great place to stay at, would definitely stay there again."
United States
Jose
The price is AU$167
includes taxes & fees
14 June - 15 June
La Quinta Inn by Wyndham San Diego Chula Vista

Country Inn & Suites by Radisson, San Diego North, CA

Country Inn & Suites by Radisson, San Diego North, CA
3.0 star property
11.7 km from Serra Mesa
9.0 out of 10, Wonderful, (1,509 reviews)
"Very great stay"
United States
Phillip
The price is AU$298
includes taxes & fees
21 June - 22 June
Country Inn & Suites by Radisson, San Diego North, CA

HYATT house San Diego/Sorrento Mesa

HYATT house San Diego/Sorrento Mesa
3.0 star property
11.8 km from Serra Mesa
9.2 out of 10, Wonderful, (1,018 reviews)
"Amazing stay"
United States
Kevin
The price is AU$297
includes taxes & fees
21 June - 22 June
HYATT house San Diego/Sorrento Mesa

Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
7.9 km from Serra Mesa
9.2 out of 10, Wonderful, (1,075 reviews)
"Staff was so great nice rooms really great stay"
United States
Amelia
The price is AU$264
includes taxes & fees
1 July - 2 July
Holiday Inn Express San Diego Airport - Old Town by IHG

Ramada by Wyndham San Diego Poway Miramar

Ramada by Wyndham San Diego Poway Miramar
2.0 star property
18.2 km from Serra Mesa
7.2 out of 10, Good, (1,021 reviews)
"Nice place to stay."
United States
Jacquie
The price is AU$193
includes taxes & fees
14 June - 15 June
Ramada by Wyndham San Diego Poway Miramar

Hampton Inn Cardiff Beach Encinitas, CA Near Del Mar

Hampton Inn Cardiff Beach Encinitas, CA Near Del Mar
3.0 star property
28 km from Serra Mesa
9.2 out of 10, Wonderful, (1,040 reviews)
"Great location and comfortable beds!"
United States
Michael
The price is AU$286
includes taxes & fees
14 June - 15 June
Hampton Inn Cardiff Beach Encinitas, CA Near Del Mar

Hilton Garden Inn San Diego Old Town/SeaWorld Area

Hilton Garden Inn San Diego Old Town/SeaWorld Area
3.0 star property
Old Town San Diego, 7.4 km from Serra Mesa
8.8 out of 10, Excellent, (1,468 reviews)
"Hotel is lovely mission style in keeping with the area. The location is very convenient to local attractions."
United States
Toni
The price is AU$260
includes taxes & fees
28 June - 29 June
Hilton Garden Inn San Diego Old Town/SeaWorld Area

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay, 7.2 km from Serra Mesa
8.6 out of 10, Excellent, (1,468 reviews)
"Great resort!"
United States
Jean-Michelle
The price is AU$546
includes taxes & fees
14 June - 15 June
San Diego Mission Bay Resort

Courtyard by Marriott San Diego Airport/Liberty Station

Courtyard by Marriott San Diego Airport/Liberty Station
3.0 star property
10.7 km from Serra Mesa
9.2 out of 10, Wonderful, (1,300 reviews)
"Great location, good parking, great staff."
United States
Rosemary
The price is AU$290
includes taxes & fees
14 June - 15 June
Courtyard by Marriott San Diego Airport/Liberty Station
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our guide on where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and USS Midway Museum are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

Get to Pacific Beach after the sun goes down because this is the place to be in San Diego for partying.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Top Serra Mesa Hotel Reviews

Frequently asked questions

What's it like in Serra Mesa?
Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
How many hotels can I expect to find in the Serra Mesa area?
Expedia has 38 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.
What can I see and do in this San Diego neighbourhood?
Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Sharp Learning Resource Center and Convoy District are also worth a stop.

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