A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Holiday Homes in Defiance

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Check prices for these dates

In two weeks
25 Sept - 27 Sept
In two months
6 Nov - 8 Nov
In three months
4 Dec - 6 Dec
In four months
1 Jan - 3 Jan

Our top choices for Defiance holiday homes

A porch with two turquoise Adirondack chairs and a small table, surrounded by well-maintained greenery and a white house with black shutters.

1. WELCOME TO THE OWL'S NEST - 2 BEDROOM HOME IN AUGUSTA, WINERIES & THE KATY TRAIL

WELCOME TO THE OWL'S NEST - 2 BEDROOM HOME IN AUGUSTA, WINERIES & THE KATY TRAIL
Augusta
10.0 out of 10, Exceptional, (39 reviews)
"Comfortable place to stay. We appreciated the snacks and that there is a pack n play!"
United States
Samantha E.
The price is AU$407
includes taxes & fees
8 Sept - 9 Sept
WELCOME TO THE OWL'S NEST - 2 BEDROOM HOME IN AUGUSTA, WINERIES & THE KATY TRAIL

2. Historic Craftsman • Hot Tub • Walk to Wineries • Katy Trail

Historic Craftsman • Hot Tub • Walk to Wineries • Katy Trail
AUGUSTA
10.0 out of 10, Exceptional, (4 reviews)
"We were in town for a wedding, and found this house to stay in. It was perfect!! The little town was adorable and fun to walk the dogs through. The hot tub was obviously a nice plus. The grill was nice and had plenty of propane. No complaints at all! We even added another night to our stay to enjoy it longer. The Miss Augusta riverboat cruise was fun! The wineries were obviously fun also. We really enjoyed picking apples at the orchard too. We really wanted to try the restaurant right down the...
United States
Lola W.
The price is AU$569
includes taxes & fees
8 Sept - 9 Sept
Historic Craftsman • Hot Tub • Walk to Wineries • Katy Trail
A spacious living area with a high ceiling, wooden beams, a fireplace, a dining area, and a cozy seating arrangement.

3. 3+ acres, fast wi-fi, garage parking, Koi pond

3+ acres, fast wi-fi, garage parking, Koi pond
Wildwood
10.0 out of 10, Exceptional, (3 reviews)
"This is a beautiful home in a quiet beautiful setting. The host was great to work with and responded quickly to any questions we had. Would highly recommend!"
United States
Jennifer M.
The price is AU$561
includes taxes & fees
8 Sept - 9 Sept
3+ acres, fast wi-fi, garage parking, Koi pond
A kitchen with a view to a patio, a refrigerator, and a trash can.

4. Private Entry Basement Suite • Pond & Farm View • Pet Friendly • St Peters

Private Entry Basement Suite • Pond & Farm View • Pet Friendly • St Peters
St. Peters
10.0 out of 10, Exceptional, (16 reviews)
"A wonderful location, description is spot-on, and the host is delightful. The VRBO is spotless with subtle decorations. The location is within two miles of shopping and restaurants. Beautiful neighborhood plus walking/running trails close-by.If we ever travel this way again, we will hope to return to this location."
United States
Ruth R.
The price is AU$363
includes taxes & fees
8 Sept - 9 Sept
Private Entry Basement Suite • Pond & Farm View • Pet Friendly • St Peters
A dining table with a vase of flowers, black chairs, and a window with a view of trees.

5. Private 8 acre Ranch backs to 1850 wooded acre Missouri conservation reservation

Private 8 acre Ranch backs to 1850 wooded acre Missouri conservation reservation
Wildwood
10.0 out of 10, Exceptional, (6 reviews)
"Beautiful property and nice house set up! Very quiet and peaceful. Really enjoyed our stay."
United States
Bruce L.
The price is AU$689
includes taxes & fees
8 Sept - 9 Sept
Private 8 acre Ranch backs to 1850 wooded acre Missouri conservation reservation
A two-story house with a covered porch, a stone facade, and a well-maintained lawn.

6. Kid and pet friendly 2 nd floor duplex

Kid and pet friendly 2 nd floor duplex
Pacific
9.0 out of 10, Wonderful, (30 reviews)
"The house was clean and comfortable. Would stay there again."
United States
Jason T.
The price is AU$277
includes taxes & fees
8 Sept - 9 Sept
Kid and pet friendly 2 nd floor duplex
A spacious kitchen with white cabinets, a central island with bar stools, a stainless steel refrigerator, and a microwave.

7. Spacious, 3 bedroom home, finished basement on quiet court

Spacious, 3 bedroom home, finished basement on quiet court
St. Peters
9.8 out of 10, Exceptional, (54 reviews)
"It was a perfect choice for our family to celebrate Christmas. "
United States
Leanne S.
The price is AU$500
includes taxes & fees
15 Sept - 16 Sept
Spacious, 3 bedroom home, finished basement on quiet court
A two-story house with a covered porch, stone exterior, and a large tree in the foreground.

8. Pet and kid friendly duplex with 2 bedrooms

Pet and kid friendly duplex with 2 bedrooms
Pacific
9.6 out of 10, Exceptional, (49 reviews)
"Enjoyed our stay"
United States
Jason R.
The price is AU$275
includes taxes & fees
21 Sept - 22 Sept
Pet and kid friendly duplex with 2 bedrooms
A wooden pergola with a 'GARDEN' sign, a pathway leading to a house, and a lush garden with various plants and flowers.

9. Cozy little house blocks from the Park & Fair Grounds.

Cozy little house blocks from the Park & Fair Grounds.
Washington
10.0 out of 10, Exceptional, (74 reviews)
"Super cute spot in Washington. Very clean and stocked with all the things you need for cooking and entertainment."
United States
Blair O.
The price is AU$350
includes taxes & fees
8 Sept - 9 Sept
Cozy little house blocks from the Park & Fair Grounds.
A modern kitchen with white cabinets, stainless steel appliances, and a wooden dining table.

10. Centrally located, spacious 4 bdrm, on quiet Ct

Centrally located, spacious 4 bdrm, on quiet Ct
O'Fallon
10.0 out of 10, Exceptional, (25 reviews)
"Great host and beautiful of house"
United States
William M.
The price is AU$688
includes taxes & fees
14 Sept - 15 Sept
Centrally located, spacious 4 bdrm, on quiet Ct
A modern living room with a grey sofa, a coffee table, and a patterned rug. There is a dining area with yellow chairs and a small table.

11. Cozy Historic WashMo home

Cozy Historic WashMo home
Washington
9.4 out of 10, Exceptional, (28 reviews)
"Great location and easy to work with host"
United States
melissa G.
The price is AU$419
includes taxes & fees
15 Sept - 16 Sept
Cozy Historic WashMo home
A hotel room with a large bed, a nightstand with a lamp, a painting on the wall, and a window with curtains.

12. Pet-Friendly 2BR Townhome | Workspace

Pet-Friendly 2BR Townhome | Workspace
O Fallon
9.8 out of 10, Exceptional, (16 reviews)
"Great quiet neighborhood close to everything!"
United States
Jen D.
The price is AU$521
includes taxes & fees
14 Sept - 15 Sept
Pet-Friendly 2BR Townhome | Workspace
A house with a red door, a welcome sign, and numbered steps leading to the entrance.

13. Home in the heart of downtown Pacific. Walkable shops and restaurants

Home in the heart of downtown Pacific. Walkable shops and restaurants
Pacific
9.8 out of 10, Exceptional, (33 reviews)
"Great location, very charming house within walking distance to some great restaurants. "
United States
James A.
The price is AU$365
includes taxes & fees
8 Sept - 9 Sept
Home in the heart of downtown Pacific. Walkable shops and restaurants
A bedroom with a bed, dresser, and a mirror.

14. Serene 2-bedroom private basement in charming Wentzville

Serene 2-bedroom private basement in charming Wentzville
Wentzville
Serene 2-bedroom private basement in charming Wentzville
A modern kitchen with white cabinets, stainless steel appliances, and a wooden floor.

15. Charming 3-bedroom house in delightful Ballwin and basement is not included

Charming 3-bedroom house in delightful Ballwin and basement is not included
Ballwin
7.2 out of 10, Good, (7 reviews)
"House is located in quiet neighborhood. As described with 3 bedrooms 1 bath. Had adequate towels and supplies in kitchen. Cleanish, was not sure if sheets had been cleaned. Overall, a decent place to stay."
United States
Stephanie N.
The price is AU$367
includes taxes & fees
8 Sept - 9 Sept
Charming 3-bedroom house in delightful Ballwin and basement is not included
A bedroom with two beds, a ceiling fan, and a window with blue curtains.

16. 4BR Marvel House Game Room, Sleeps 14

4BR Marvel House Game Room, Sleeps 14
St. Peters
10.0 out of 10, Exceptional, (2 reviews)
"Decorated nicely and everything was new. Very clean and beds were so comfortable. Lots of extras included by host. Pet friendly and fenced in yard was wonderful for dogs"
United States
Ann S.
The price is AU$675
includes taxes & fees
8 Sept - 9 Sept
4BR Marvel House Game Room, Sleeps 14
A dining area with a wooden table, six chairs, a chandelier, and a modern kitchen in the background.

17. Renovated 5BR | Group Space + Large Yard

Renovated 5BR | Group Space + Large Yard
Wentzville
10.0 out of 10, Exceptional, (17 reviews)
"Great place and people really helped the stay"
United States
Rustin N.
The price is AU$879
includes taxes & fees
13 Sept - 14 Sept
Renovated 5BR | Group Space + Large Yard
A living room with a glass coffee table, two beige sofas, a wooden cabinet, and a ceiling fan.

18. Spacious 5-bedroom house in serene O'Fallon with AC

Spacious 5-bedroom house in serene O'Fallon with AC
O'Fallon
9.8 out of 10, Exceptional, (9 reviews)
"Nice place "
United States
RAMONA O E.
The price is AU$847
includes taxes & fees
8 Sept - 9 Sept
Spacious 5-bedroom house in serene O'Fallon with AC
A living room with a flat-screen TV, a grey sofa, a coffee table, and a large window with blinds.

19. Pet Friendly 3-bedroom house in Pacific

Pet Friendly 3-bedroom house in Pacific
Pacific
10.0 out of 10, Exceptional, (14 reviews)
"Had great time, and place was very comfortable. "
United States
Tyler W.
The price is AU$502
includes taxes & fees
8 Sept - 9 Sept
Pet Friendly 3-bedroom house in Pacific
A room with a mural depicting St. Louis landmarks, a red table tennis table, and a door.

20. 4BR Fenced Yard, Pet-Friendly, Games & Ping Pong

4BR Fenced Yard, Pet-Friendly, Games & Ping Pong
Ballwin
9.6 out of 10, Exceptional, (4 reviews)
"Comfortable beds, plenty of towels and bedding, fun and welcoming space for the family, and all the storage containers we needed for leftovers!!"
United States
Holly R.
The price is AU$604
includes taxes & fees
8 Sept - 9 Sept
4BR Fenced Yard, Pet-Friendly, Games & Ping Pong
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

10/10 Excellent
"Na"
Yvette 1-night trip
Posted 8 hours ago
Hollywood Casino & Hotel St. Louis

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