Aerial view of house in Serra Mesa City in San Diego, California, USA. Green Dry Valley and Villas

Serra Mesa Hotels, San Diego

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Our top choices for Serra Mesa hotels

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.8 km from Serra Mesa
9.4 out of 10, Exceptional, (1,980 reviews)
"Always a great stay"
United States
Jeanette
The price is AU$224
includes taxes & fees
23 June - 24 June
Sycuan Casino Resort

Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
26 km from Serra Mesa
9.8 out of 10, Exceptional, (1,103 reviews)
"Nice place good food for breakfast 👍"
United States
Paul
The price is AU$308
includes taxes & fees
28 June - 29 June
Ayres Hotel San Diego South - Chula Vista

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.1 km from Serra Mesa
9.2 out of 10, Wonderful, (3,886 reviews)
"Great stay"
United States
Cameron
The price is AU$280
includes taxes & fees
28 June - 29 June
Best Western Plus Marina Gateway Hotel

Hampton Inn & Suites San Diego Airport Liberty Station

Hampton Inn & Suites San Diego Airport Liberty Station
2.5 star property
10.6 km from Serra Mesa
9.2 out of 10, Wonderful, (1,733 reviews)
"Good location, clean room and nice staff. A great place to stay."
United States
Patricia
The price is AU$279
includes taxes & fees
29 June - 30 June
Hampton Inn & Suites San Diego Airport Liberty Station

Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
18.6 km from Serra Mesa
8.2 out of 10, Very good, (1,551 reviews)
"Everything was excellent. Room, breakfast location and staff. This was our second time staying here and we'll be back."
United States
Chris
The price is AU$185
includes taxes & fees
12 July - 13 July
Comfort Inn Chula Vista San Diego South

Courtyard by Marriott San Diego El Cajon

Courtyard by Marriott San Diego El Cajon
3.0 star property
16.6 km from Serra Mesa
9.2 out of 10, Wonderful, (1,005 reviews)
"Staff was friendly. Place was very clean and spacious"
United States
Lucy
The price is AU$295
includes taxes & fees
14 June - 15 June
Courtyard by Marriott San Diego El Cajon

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
9 km from Serra Mesa
7.4 out of 10, Good, (4,274 reviews)
"Clean room, staff was very helpful, parking was easy and accessible!"
United States
Hector
The price is AU$194
includes taxes & fees
15 June - 16 June
Wyndham Garden San Diego Near SeaWorld

Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
18.5 km from Serra Mesa
9.4 out of 10, Exceptional, (1,237 reviews)
"Room fit our family of 6 and the breakfast was good."
United States
Jamie
The price is AU$256
includes taxes & fees
28 June - 29 June
Holiday Inn Express San Diego South - Chula Vista by IHG

Country Inn & Suites by Radisson, San Diego North, CA

Country Inn & Suites by Radisson, San Diego North, CA
3.0 star property
11.7 km from Serra Mesa
9.0 out of 10, Wonderful, (1,519 reviews)
"Very great stay"
United States
Phillip
The price is AU$322
includes taxes & fees
21 June - 22 June
Country Inn & Suites by Radisson, San Diego North, CA

Kings Inn San Diego

Kings Inn San Diego
2.5 star property
6 km from Serra Mesa
8.8 out of 10, Excellent, (3,736 reviews)
"Clean room, friendly staff, and my kid loved the pool!"
United States
Mark
The price is AU$159
includes taxes & fees
15 June - 16 June
Kings Inn San Diego

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
28.1 km from Serra Mesa
8.8 out of 10, Excellent, (1,303 reviews)
"Room is nice, clean, & breakfast is good. We always stay here when in the area."
United States
Travis
The price is AU$197
includes taxes & fees
28 June - 29 June
Best Western Americana Inn

GreenTree Inn San Diego Mission Bay

GreenTree Inn San Diego Mission Bay
2.5 star property
Pacific Beach, 7.3 km from Serra Mesa
8.0 out of 10, Very good, (2,163 reviews)
"THE BED WAS SO SOFT ROOM WAS SO CLEAN BREAKFAST WAS GREAT AND THE PRICE WAS KILLER FOR THE LOCATION really a great place to stay"
United States
Tyson
The price is AU$227
includes taxes & fees
15 June - 16 June
GreenTree Inn San Diego Mission Bay

Best Western Plus Hacienda Hotel Old Town

Best Western Plus Hacienda Hotel Old Town
3.0 star property
Old Town San Diego, 7.6 km from Serra Mesa
8.4 out of 10, Very good, (2,059 reviews)
"Excellent stay! Beautiful grounds and friendly staff."
United States
Rebecca
The price is AU$259
includes taxes & fees
14 June - 15 June
Best Western Plus Hacienda Hotel Old Town

The Encinitan Hotel & Suites

The Encinitan Hotel & Suites
3.0 star property
30.8 km from Serra Mesa
8.2 out of 10, Very good, (1,575 reviews)
"Great place to stay"
United States
joshua
The price is AU$274
includes taxes & fees
15 June - 16 June
The Encinitan Hotel & Suites

La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
18.7 km from Serra Mesa
8.6 out of 10, Excellent, (1,640 reviews)
"Great place to stay at, would definitely stay there again."
United States
Jose
The price is AU$179
includes taxes & fees
5 July - 6 July
La Quinta Inn by Wyndham San Diego Chula Vista

The Alcala Hotel Mission Valley/Seaworld

The Alcala Hotel Mission Valley/Seaworld
2.5 star property
6.6 km from Serra Mesa
8.2 out of 10, Very good, (198 reviews)
"Staff was great and rooms were nice."
United States
Brittney
The price is AU$172
includes taxes & fees
15 June - 16 June
The Alcala Hotel Mission Valley/Seaworld

Pleasant Inn

Pleasant Inn
2.5 star property
4.8 km from Serra Mesa
8.6 out of 10, Excellent, (1,442 reviews)
"Pleasant Inn was clean and the service was great!"
United States
Shirley
The price is AU$150
includes taxes & fees
7 July - 8 July
Pleasant Inn

Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
7.9 km from Serra Mesa
9.2 out of 10, Wonderful, (1,086 reviews)
"Breakfast was great!! Everything was wonderful, clean and the nicest staff"
United States
Ronald
The price is AU$279
includes taxes & fees
16 June - 17 June
Holiday Inn Express San Diego Airport - Old Town by IHG

Ramada by Wyndham San Diego Poway Miramar

Ramada by Wyndham San Diego Poway Miramar
2.0 star property
18.2 km from Serra Mesa
7.2 out of 10, Good, (1,028 reviews)
"Nice place to stay."
United States
Jacquie
The price is AU$188
includes taxes & fees
14 June - 15 June
Ramada by Wyndham San Diego Poway Miramar

The Rambler Hotel

The Rambler Hotel
3.0 star property
18.7 km from Serra Mesa
9.0 out of 10, Wonderful, (2,166 reviews)
"Cool vibe in an easy spot to get on and off the highway."
United States
Jami
The price is AU$247
includes taxes & fees
28 June - 29 June
The Rambler Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our guide on where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

Get to Pacific Beach after the sun goes down because this is the place to be in San Diego for partying.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.

Top Serra Mesa Hotel Reviews

Frequently asked questions

What's it like in Serra Mesa?
Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
How many hotels can I expect to find in the Serra Mesa area?
Expedia has 38 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.
What can I see and do in this San Diego neighbourhood?
Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Sharp Learning Resource Center and Convoy District are also worth a stop.

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