Cheap flights from Antofagasta Region

View AU$44 flight on Mon, 15 June 2026Opens in a new window

Popular airlines from Antofagasta Region

  • LATAM Airlines Group

  • B & H Airlines

  • Sky Airlines

  • Delta

  • American Airlines

  • Iberia

  • Qantas Airways

  • Be in the know

    Get alerts if flight prices drop or rise*

  • Book smarter

    Save up to 35% on select hotels after you book a flight*

  • Earn twice

    Earn your airline miles on top of our rewards
    Sign in

Cheapest flights from Antofagasta Region

These prices were available within the past 7 days. Prices quoted are per person, return, for the period specified. Prices and availability are subject to change. Additional terms apply.

Jetsmart SPA
Tue, 16 June - Thu, 18 June
ANF
Antofagasta
SCL
Santiago
AU$88 Return, found 1 day ago
AU$88
Return
found 1 day ago
Select Jetsmart SPA flight, departing Tue, 16 June from Antofagasta to Santiago, returning Thu, 18 June, priced at AU$88 found 1 day ago
Jetsmart SPA
Tue, 16 June - Thu, 18 June
ANF
Antofagasta
SCL
Santiago
AU$102 Return, found 1 day ago
AU$102
Return
found 1 day ago
Select Jetsmart SPA flight, departing Tue, 16 June from Antofagasta to Santiago, returning Thu, 18 June, priced at AU$102 found 1 day ago
Jetsmart SPA
Tue, 16 June - Thu, 18 June
ANF
Antofagasta
SCL
Santiago
AU$113 Return, found 1 day ago
AU$113
Return
found 1 day ago
Select Jetsmart SPA flight, departing Tue, 16 June from Antofagasta to Santiago, returning Thu, 18 June, priced at AU$113 found 1 day ago
Jetsmart SPA
Sun, 12 July - Fri, 17 July
CJC
Calama
SCL
Santiago
AU$125 Return, found 1 day ago
AU$125
Return
found 1 day ago
Select Jetsmart SPA flight, departing Sun, 12 July from Calama to Santiago, returning Fri, 17 July, priced at AU$125 found 1 day ago
Jetsmart SPA
Tue, 16 June - Thu, 18 June
ANF
Antofagasta
SCL
Santiago
AU$127 Return, found 1 day ago
AU$127
Return
found 1 day ago
Select Jetsmart SPA flight, departing Tue, 16 June from Antofagasta to Santiago, returning Thu, 18 June, priced at AU$127 found 1 day ago
Jetsmart SPA
Fri, 12 June - Fri, 19 June
CJC
Calama
SCL
Santiago
AU$128 Return, found 5 days ago
AU$128
Return
found 5 days ago
Select Jetsmart SPA flight, departing Fri, 12 June from Calama to Santiago, returning Fri, 19 June, priced at AU$128 found 5 days ago
Jetsmart SPA
Sat, 27 June - Sun, 28 June
CJC
Calama
SCL
Santiago
AU$128 Return, found 1 hour ago
AU$128
Return
found 1 hour ago
Select Jetsmart SPA flight, departing Sat, 27 June from Calama to Santiago, returning Sun, 28 June, priced at AU$128 found 1 hour ago
Jetsmart SPA
Sat, 5 Sept - Wed, 9 Sept
CJC
Calama
SCL
Santiago
AU$131 Return, found 6 days ago
AU$131
Return
found 6 days ago
Select Jetsmart SPA flight, departing Sat, 5 Sept from Calama to Santiago, returning Wed, 9 Sept, priced at AU$131 found 6 days ago
LATAM Airlines Group
Tue, 16 June - Thu, 18 June
ANF
Antofagasta
SCL
Santiago
AU$188 Return, found 1 day ago
AU$188
Return
found 1 day ago
Select LATAM Airlines Group flight, departing Tue, 16 June from Antofagasta to Santiago, returning Thu, 18 June, priced at AU$188 found 1 day ago
SKY AIRLINE
Tue, 16 June - Thu, 18 June
ANF
Antofagasta
SCL
Santiago
AU$237 Return, found 1 day ago
AU$237
Return
found 1 day ago
Select SKY AIRLINE flight, departing Tue, 16 June from Antofagasta to Santiago, returning Thu, 18 June, priced at AU$237 found 1 day ago
*Available to Expedia members.