Cheap flights from Antofagasta Region

View AU$54 flight on Sun, 2 Aug 2026Opens in a new window

Flight 1

Popular airlines from Antofagasta Region

  • LATAM Airlines Group

  • Sky Airlines

  • B & H Airlines

  • American Airlines

  • Delta

  • Iberia

  • Qantas Airways

  • Be in the know

    Get alerts if flight prices drop or rise*

  • Book smarter

    Save up to 35% on select hotels after you book a flight*

  • Earn twice

    Earn your airline miles on top of our rewards
    Sign in

Cheapest flights from Antofagasta Region

These prices were available within the past 7 days. Prices quoted are per person, return, for the period specified. Prices and availability are subject to change. Additional terms apply.

Jetsmart SPA
Fri, 28 Aug - Sun, 30 Aug
CJC
Calama
SCL
Santiago
AU$108 Return, found 1 day ago
AU$108
Return
found 1 day ago
Select Jetsmart SPA flight, departing Fri, 28 Aug from Calama to Santiago, returning Sun, 30 Aug, priced at AU$108 found 1 day ago
Jetsmart SPA
Sat, 29 Aug - Fri, 4 Sept
CJC
Calama
SCL
Santiago
AU$108 Return, found 4 days ago
AU$108
Return
found 4 days ago
Select Jetsmart SPA flight, departing Sat, 29 Aug from Calama to Santiago, returning Fri, 4 Sept, priced at AU$108 found 4 days ago
Jetsmart SPA
Sat, 29 Aug - Fri, 4 Sept
CJC
Calama
SCL
Santiago
AU$121 Return, found 4 days ago
AU$121
Return
found 4 days ago
Select Jetsmart SPA flight, departing Sat, 29 Aug from Calama to Santiago, returning Fri, 4 Sept, priced at AU$121 found 4 days ago
Jetsmart SPA
Wed, 14 Oct - Thu, 15 Oct
CJC
Calama
SCL
Santiago
AU$126 Return, found 1 day ago
AU$126
Return
found 1 day ago
Select Jetsmart SPA flight, departing Wed, 14 Oct from Calama to Santiago, returning Thu, 15 Oct, priced at AU$126 found 1 day ago
Jetsmart SPA
Wed, 14 Oct - Thu, 15 Oct
CJC
Calama
SCL
Santiago
AU$129 Return, found 1 day ago
AU$129
Return
found 1 day ago
Select Jetsmart SPA flight, departing Wed, 14 Oct from Calama to Santiago, returning Thu, 15 Oct, priced at AU$129 found 1 day ago
Jetsmart SPA
Wed, 25 Nov - Sun, 29 Nov
CJC
Calama
SCL
Santiago
AU$133 Return, found 2 days ago
AU$133
Return
found 2 days ago
Select Jetsmart SPA flight, departing Wed, 25 Nov from Calama to Santiago, returning Sun, 29 Nov, priced at AU$133 found 2 days ago
Jetsmart SPA
Sat, 29 Aug - Fri, 4 Sept
CJC
Calama
SCL
Santiago
AU$133 Return, found 4 days ago
AU$133
Return
found 4 days ago
Select Jetsmart SPA flight, departing Sat, 29 Aug from Calama to Santiago, returning Fri, 4 Sept, priced at AU$133 found 4 days ago
Jetsmart SPA
Wed, 9 Sept - Thu, 24 Sept
ANF
Antofagasta
SCL
Santiago
AU$138 Return, found 4 days ago
AU$138
Return
found 4 days ago
Select Jetsmart SPA flight, departing Wed, 9 Sept from Antofagasta to Santiago, returning Thu, 24 Sept, priced at AU$138 found 4 days ago
LATAM Airlines Group
Fri, 28 Aug - Sun, 30 Aug
CJC
Calama
SCL
Santiago
AU$189 Return, found 1 day ago
AU$189
Return
found 1 day ago
Select LATAM Airlines Group flight, departing Fri, 28 Aug from Calama to Santiago, returning Sun, 30 Aug, priced at AU$189 found 1 day ago
SKY AIRLINE
Wed, 9 Sept - Thu, 24 Sept
ANF
Antofagasta
SCL
Santiago
AU$212 Return, found 4 days ago
AU$212
Return
found 4 days ago
Select SKY AIRLINE flight, departing Wed, 9 Sept from Antofagasta to Santiago, returning Thu, 24 Sept, priced at AU$212 found 4 days ago

Explore a world of travel with Expedia

*Available to Expedia members.