Popular airlines from Southampton to São Tomé Island
Jetstar
Qantas Airways
Virgin Australia
Scoot
American Airlines
Emirates
United
- Plan, book, fly with confidence
- Be in the knowGet alerts if flight prices drop or rise*
- Book smarterSave up to 35% on select hotels after you book a flight*
Top Routes to São Tomé Island
Expedia's Latest Trends
Hotels
- Hotels in Mallorca Island
- Hotels in Japan
- Hotels in Tuban
- Whale Beach Secluded Self Contained Cottage, Spa and Fire Pit. Pet friendly.
- Hotels in Lennox Head
- Hotels in Kerikeri
- Attika Hotel
- Mallacoota's Shady Gully Caravan Park
- Coolangatta Estate
- InterContinental Resort Tahiti by IHG
- NH Venezia Santa Lucia
- Hotels in New York
- Hotels in Downtown Calgary
Flights
Activities
General
*Available to Expedia members.