Cheap flights from Chicago to Southeast Missouri

View AU$72 flight on Thu, 21 Aug. 2025Opens in a new window

Popular airlines from Chicago to Southeast Missouri

  • Jetstar

    Jetstar

  • Qantas Airways

    Qantas Airways

  • Virgin Australia

    Virgin Australia

  • Scoot

    Scoot

  • American Airlines

    American Airlines

  • Emirates

    Emirates

  • United

    United

  • Plan, book, fly with confidence

  • trending down icon

    Be in the know

    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon

    Book smarter

    Save up to 35% on select hotels after you book a flight*
  • payments icon

    Earn twice

    Earn your airline miles on top of our rewards
    Sign in

Cheap Flights from Chicago (CHI) to Southeast Missouri (STL)

Prices were available within the past 7 days for one-way flights and round trip tickets for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, 20 Aug. - Thu, 21 Aug.
ORD
Chicago
STL
St. Louis
AU$141 Return, found 6 days ago
AU$141
Return
found 6 days ago
Select American Airlines flight, departing Wed, 20 Aug. from Chicago to St. Louis, returning Thu, 21 Aug., priced at AU$141 found 6 days ago
United
Tue, 26 Aug. - Sat, 6 Sep.
ORD
Chicago
STL
St. Louis
AU$211 Return, found 6 days ago
AU$211
Return
found 6 days ago
Select United flight, departing Tue, 26 Aug. from Chicago to St. Louis, returning Sat, 6 Sep., priced at AU$211 found 6 days ago
American Airlines
Wed, 20 Aug. - Thu, 21 Aug.
ORD
Chicago
STL
St. Louis
AU$232 Return, found 6 days ago
AU$232
Return
found 6 days ago
Select American Airlines flight, departing Wed, 20 Aug. from Chicago to St. Louis, returning Thu, 21 Aug., priced at AU$232 found 6 days ago
United
Wed, 20 Aug. - Thu, 21 Aug.
ORD
Chicago
STL
St. Louis
AU$242 Return, found 6 days ago
AU$242
Return
found 6 days ago
Select United flight, departing Wed, 20 Aug. from Chicago to St. Louis, returning Thu, 21 Aug., priced at AU$242 found 6 days ago
Southern Airways Express
Fri, 29 Aug. - Mon, 1 Sep.
ORD
Chicago
STL
St. Louis
AU$261 Return, found 6 days ago
AU$261
Return
found 6 days ago
Select Southern Airways Express flight, departing Fri, 29 Aug. from Chicago to St. Louis, returning Mon, 1 Sep., priced at AU$261 found 6 days ago
Delta
Wed, 20 Aug. - Thu, 21 Aug.
MDW
Chicago
STL
St. Louis
AU$272 Return, found 6 days ago
AU$272
Return
found 6 days ago
Select Delta flight, departing Wed, 20 Aug. from Chicago to St. Louis, returning Thu, 21 Aug., priced at AU$272 found 6 days ago
*Available to Expedia members.