Holiday Homes in Upstate South Carolina

Start date: Check-in selected.
To Date
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
In one month
In two months
In three months

Featured Holiday Homes in Upstate South Carolina

Luxurious Ladson House-B in Greenville, South Carolina

9.8 out of 10, Exceptional, (16)
"Great location, spacious and clean. Good communication with host. Would recommend!"
Luxurious Ladson House-B in Greenville, South Carolina

Brand New 6BR/6BA Luxury, 20min to Clemson. Wooded flat lot/firepit/pool table!

10.0 out of 10, Exceptional, (27)
"Truly a magnificent property on Lake Keowee. We had plenty of room for eight of us and activities abound! It's a magical place, we look forward to returning. "
Brand New 6BR/6BA Luxury, 20min to Clemson. Wooded flat lot/firepit/pool table!

Travelers Rest Treasure - Pets Welcome Sleeps 8 - 3 Bedroom 2 Bath

10.0 out of 10, Exceptional, (22)
"We were in awe as we opened the door!Very clean… very well stocked…very warm and inviting. Highly recommend!!"
Travelers Rest Treasure - Pets Welcome Sleeps 8 - 3 Bedroom 2 Bath

Charming pet-friendly Greenville house with mountain setting and fenced yard

10.0 out of 10, Exceptional, (7)
"Excellent place to stay. Quiet, wooded and out of the way house. But still close to Travelers Rest and Greenville. "
The price is AU$333
includes taxes & fees
1 Oct - 2 Oct
Charming pet-friendly Greenville house with mountain setting and fenced yard

Whimsical 4 bedroom house with a cozy backyard

10.0 out of 10, Exceptional, (34)
"Exactly what we needed for our family for a wedding in the area."
Whimsical 4 bedroom house with a cozy backyard

Fairview Luxury Oasis

10.0 out of 10, Exceptional, (23)
"Very clean and nice property and neighborhood. My employees enjoyed the stay."
The price is AU$576
includes taxes & fees
30 Sept - 1 Oct
Fairview Luxury Oasis

Lake Keowee Lakefront Cove, Private Dock, Deep Water Access, Kayaks & more

10.0 out of 10, Exceptional, (5)
"We found this place last minute and was blown away at how great it was. Within 10 minutes of arriving I caught a fish off the dock and my kids were enjoying a little paddle boarding! The house has everything you need in the kitchen, bathrooms, and bedrooms. It was easy to relax and enjoy the lake without worry about anything. The beds were comfortable, the porch was relaxing, and the cove was quiet. Two king beds made it perfect for two families as the adults had great sleeping arrangements. We...
Lake Keowee Lakefront Cove, Private Dock, Deep Water Access, Kayaks & more

Luxury 4BR/4BA Lake Keowee Retreat- Mountain Cabin Vibes + Private Dock

10.0 out of 10, Exceptional, (6)
Luxury 4BR/4BA Lake Keowee Retreat- Mountain Cabin Vibes + Private Dock

Upper Lake Keowee Waterfront! Covered Dock/Jetports. Mountain Serenity.

10.0 out of 10, Exceptional, (94)
"What an outstanding property ! This was my second stay here and I cannot wait to schedule another week . Thanks to our hosts for creating such a quiet and restful space!"
Upper Lake Keowee Waterfront! Covered Dock/Jetports. Mountain Serenity.

Keowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson!

10.0 out of 10, Exceptional, (54)
"Great location on the lake. Easy to get to the marina and rent a boat. First time on the lake and we had an awesome time. "
Keowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson!

Blues Brothers Hideaway - Lakefront - Fenced yard - Pets Welcome - Clemson 20 mi

8.8 out of 10, Excellent, (51)
"Older folks may find it difficult to get up and down the hill to the lake. Everything else was superb. "
Blues Brothers Hideaway - Lakefront - Fenced yard - Pets Welcome - Clemson 20 mi

Private, pet-friendly adorable getaway mins to downtown

9.6 out of 10, Exceptional, (107)
"House was clean and cozy. Yard was big and perfect for our dogs. Location was great less than 10 min drive to most parks, shopping and restauraunts. Had a great time!"
The price is AU$483
includes taxes & fees
28 Sept - 29 Sept
Private, pet-friendly adorable getaway mins to downtown

Make Memories on Mulberry

10.0 out of 10, Exceptional, (93)
"Very cozy home. Very clean. Could tell it was important to owners for us to hsve s good time."
The price is AU$379
includes taxes & fees
7 Oct - 8 Oct
Make Memories on Mulberry

Lake Hartwell Waterfront w/Dock, Gameroom, Firepit, Pets, Clemson & Fenced Yard

10.0 out of 10, Exceptional, (7)
"This lakefront rental was absolutely beautiful and relaxing—just what we needed. The whole vibe was perfect, from peaceful mornings by the water to cozy evenings surrounded by nature. And the hosts were amazing—super helpful and great with communication. A truly memorable stay!"
Lake Hartwell Waterfront w/Dock, Gameroom, Firepit, Pets, Clemson & Fenced Yard

Grand Greenville Estate ~ walk to Furman & Swamp Rabbit Trail!

10.0 out of 10, Exceptional, (19)
"My family stayed here while attending a wedding. It was a perfect place for us. It was close to downtown and lots of restaurants."
The price is AU$695
includes taxes & fees
29 Sept - 30 Sept
Grand Greenville Estate ~ walk to Furman & Swamp Rabbit Trail!

STRATHAM STATION: 4Bd/2.5Ba in Downtown Greenville, SC

9.6 out of 10, Exceptional, (45)
"Enjoys our getaway in Greenville. Spacious house, easy check in. "
The price is AU$568
includes taxes & fees
28 Sept - 29 Sept
STRATHAM STATION: 4Bd/2.5Ba in Downtown Greenville, SC

Beautiful home in the Heart of Five Forks, Simpsonville!

10.0 out of 10, Exceptional, (38)
"Amazing stay!"
Beautiful home in the Heart of Five Forks, Simpsonville!

Beautiful private farm house in the middle of the city

9.8 out of 10, Exceptional, (12)
"There were 2 dads and 2 teenage boys staying for a week-long baseball tournament in Greenville. Perfect location since games were spread out across the Greenville area. Close to downtown and restaurants as well. Plenty of room to spread out and a very nice, clean house."
Beautiful private farm house in the middle of the city

New Construction Townhome Less Than 1 Mile From The Heart Of Downtown Greenville

9.6 out of 10, Exceptional, (62)
"Fully equipped kitchen, comfortable beds, close to downtown, easy to communicate with VRBO owner. All 4 adults were very happy with property. "
New Construction Townhome Less Than 1 Mile From The Heart Of Downtown Greenville

Delightful 2-bedroom house with AC in charming Easley

10.0 out of 10, Exceptional, (3)
"This home was newly renovated. The furnishings and decor were fantastic. Very close to a lot of food and event locations. "
Delightful 2-bedroom house with AC in charming Easley
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Upstate South Carolina Hotel Reviews

Find out more about Upstate South Carolina

Find out more about Upstate South Carolina

Upstate South Carolina Holiday Homes information

Number of reviews
699
Accommodation
861 Holiday Homes
Lowest Price
AU$333
Highest Price
AU$695

Explore a world of travel with Expedia

Explore a world of travel with Expedia