Photo by Ryan Watts

Holiday Homes in Upstate South Carolina

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
In two months
In three months
In four months

Our top choices for Upstate South Carolina holiday homes

10.0 out of 10, Exceptional, (2)
"delightful house on a very mellow street. super easy access to downtown, a grocery store close, beautiful backyard for the dog, lovely kitchen. i was in town for my anniversary week and my partner and i enjoyed the stay very much. hosts were helpful and communicative, the house was exactly as described and we literally had zero issues. i have no problem recommending this house strongly! "
United States
jon b.
The price is AU$336
includes taxes & fees
20 Jan - 21 Jan 2026
Cozy 2BR Near Furman & Downtown, Fenced Yard
9.6 out of 10, Exceptional, (7)
"The place is awesome! I don’t usually leave comments but this place is worth the visit."
United States
Michael
The price is AU$492
includes taxes & fees
12 Jan - 13 Jan 2026
Secluded Yurt Hideaway 10 min to Table Rock

Holiday Home in Woodside Cotton Mill Village Historic District

The Blue Bungalow by Unity Park - Newly Renovated
9.8 out of 10, Exceptional, (82)
"The house was super clean and nice! The host was awesome. We thoroughly enjoyed our stay. Convenient to everything. We will definitely stay again!"
United States
Lisa
The price is AU$296
includes taxes & fees
29 Dec - 30 Dec
The Blue Bungalow by Unity Park - Newly Renovated

Holiday Home in Woodside Cotton Mill Village Historic District

Skyline Split A Retreat Close to Everything You Need! Quiet, Clean & Convenient.
2.0 star property
10.0 out of 10, Exceptional, (1)
"Check-in was smooth as could, be. The place itself was spotless, clean, and perfect for our stay. Highly recommend Old Europe for coffee and a pastry nearby. "
United States
Matthew K.
Skyline Split A Retreat Close to Everything You Need! Quiet, Clean & Convenient.
10.0 out of 10, Exceptional, (1)
"Accurate listing, easy to find! "
United States
Beth T.
The price is AU$391
includes taxes & fees
28 Jan - 29 Jan 2026
Pet-Friendly Cabin in Marietta w/ Porch Swings
9.8 out of 10, Exceptional, (30)
"We enjoyed our stay at this lovely home! Checking was easy and kitchen was roomy and met our needs."
United States
Carla B.
The price is AU$396
includes taxes & fees
29 Dec - 30 Dec
Welcome To Downtown Pickens close to Clemson and Lake Keowee
10.0 out of 10, Exceptional, (4)
"Very clean. Wonderful location and private. "
United States
Paula
The price is AU$452
includes taxes & fees
19 Jan - 20 Jan 2026
Sleek 3BR Pet-Friendly Oasis, Close to City
10.0 out of 10, Exceptional, (4)
"House was perfect for our needs. Spacious and clean. Easy to access, good parking and good communication with host. "
United States
Christopher A.
The price is AU$528
includes taxes & fees
4 Jan - 5 Jan 2026
Cozy, Updated 2BR/2.5BA End-Unit Townhome, Greer SC
10.0 out of 10, Exceptional, (11)
"It was clean and quiet..I will stay here again. "
United States
Kimberly S.
The price is AU$249
includes taxes & fees
29 Dec - 30 Dec
Apt. near Downtown Greenville (2BR/1BA, 3 beds)

Holiday Home in Easley

Downtown Easley Home
8.0 out of 10, Very good, (7)
"The house was great for our one night stay. The house was clean and stocked. We had to leave early and didn't spend the entire night. But the host was gracious and easy to communicate with. Would recommend!"
United States
CANDY B.
The price is AU$376
includes taxes & fees
11 Jan - 12 Jan 2026
Downtown Easley Home
10.0 out of 10, Exceptional, (4)
"Clean and comfortable. Close to campus"
United States
Russ C.
The price is AU$593
includes taxes & fees
29 Dec - 30 Dec
6 Min>Clemson - 1kMbps - Keyless Entry - Office Space
9.0 out of 10, Wonderful, (9)
"Perfect location if you are needing to go downtown area. Comfortable beds & communication with the owner was great! "
United States
Josey W.
The price is AU$399
includes taxes & fees
29 Dec - 30 Dec
Carolina Cottage-Entire Home-Close to Downtown Spartanburg
10.0 out of 10, Exceptional, (50)
"Very well appointed."
United States
Sara P.
The price is AU$236
includes taxes & fees
8 Jan - 9 Jan 2026
Hobbit Hideaway - Do Something Different!
9.8 out of 10, Exceptional, (25)
"It is a really nice place and in a quiet area. Very cute backyard. Would stay again!! "
United States
Jessica S.
The price is AU$305
includes taxes & fees
2 Jan - 3 Jan 2026
Private family, pet friendly with fenced yard near Limestone College and Outlets
10.0 out of 10, Exceptional, (49)
"The place was perfect for our overnight stay. It’s very quiet and I love the gated driveway. The place is very clean. "
United States
Linsey V.
The price is AU$319
includes taxes & fees
4 Jan - 5 Jan 2026
~2 Bedroom Cozy Gem 💎 5 minutes from Downtown Spartanburg~
10.0 out of 10, Exceptional, (3)
"Very clean and spacious house with everything we needed. Great location near restaurants and grocery store. House was way better than the photos depicted. Will definitely stay again. Nice touches such as water bottles in refrigerator, nice supply of kuerig coffee pods, and snacks on the counter. Couldn’t have been better! "
United States
Andrea B.
The price is AU$493
includes taxes & fees
11 Jan - 12 Jan 2026
Pet-Friendly Greer Home: Near Airport & Downtown

Holiday Home in Pendleton

The Rustic Rectangle
10.0 out of 10, Exceptional, (10)
"Cozy, clean and quiet! Loved that we could have our dogs stay with us! "
United States
Jennifer T.
The price is AU$437
includes taxes & fees
29 Dec - 30 Dec
The Rustic Rectangle

Holiday Home in Pickens

Country Apple Cottage
10.0 out of 10, Exceptional, (31)
"The cottage was so cozy. So cute and well stocked with all we needed. Loved our stay. "
United States
Kat C.
The price is AU$251
includes taxes & fees
29 Dec - 30 Dec
Country Apple Cottage
10.0 out of 10, Exceptional, (40)
"We loved this place! Clean and beautiful. The snacks and the candle were just perfect to make our stay the best."
United States
Molly M.
The price is AU$311
includes taxes & fees
5 Jan - 6 Jan 2026
⭐️Hot Tub⭐️ Luxury Getaway Near GSP Airport Downtown Greer Greenville Spartanburg
9.6 out of 10, Exceptional, (30)
"We had a great stay at Casita Gaffney. House was clean and comfortable. Convenient location and quiet neighborhood."
United States
Michelle R.
The price is AU$340
includes taxes & fees
3 Jan - 4 Jan 2026
Cozy 2 bedroom home near downtown Gaffney.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Upstate South Carolina Hotel Reviews

Find out more about Upstate South Carolina

Upstate South Carolina Holiday Homes information

Number of reviews
387
Accommodation
856 Holiday Homes
Lowest Price
AU$236
Highest Price
AU$593

Explore a world of travel with Expedia